In Vivo Effect of Cyclic AMP and Related Drugs on Platelet Function

  • F. J. Pareti
  • P. M. Mannucci
Conference paper

Abstract

Several inhibitors of platelet aggregation have been shown to increase the intracellular level of cyclic AMP in other tissues either by stimulation of adenylate cyclase (PGE1, adenosine, and isoprenaline) or by inhibition of cyclic AMP phosphodiesterase (Robinson et al., 1971). The existence of a hormonally responsive adenylate cyclase in platelets has also been reported in vitro. The inhibitory effect of PGE1, adenosine, and isoprenaline has been shown to be associated with an increase of intracellular formation of cyclic AMP. This effect is greatly enhanced by the simultaneous addition of an inhibitor of cyclic AMP phosphodiesterase, like papaverine, theophylline, and pyrimido-pyrimidine compounds (Mills and Smith, 1972).

Keywords

Adenosine Adrenaline PGE1 Theophylline Glucagon 

References

  1. Mills, D.C.B., Smith, J.B.: The control of platelet responsiveness by agents that influence cyclic AMP metabolism. Ann. N.Y. Acad. Sci. 201, 291 (1972)CrossRefGoogle Scholar
  2. Robinson, G.A., Butcher, R.W., Sutherland, E.W.: Cyclic AMP. New York and London: Academic Press 1971Google Scholar
  3. Ryan, W.L., Durick, M.A.: Adenosine 3′-5′ monophosphate and N6–2′-O-dibutyryl-adenosine 3′-5′ monophosphate transport in cells. Science 177, 1002 (1972)PubMedCrossRefGoogle Scholar
  4. Salzman, E.W.: Cyclic AMP and platelet function. New Engl. J. Med. 286, 358 (1972)PubMedCrossRefGoogle Scholar
  5. Salzman, E.W., Levine, L.: Cyclic 3′-5′-adenosine monophosphate in human blood platelet II. Effects of N6 – 2′-O-dibutyryl cyclic 3′-5′-adenosine monophosphate on platelet function. J. clin. Invest. 50, 131 (1971)PubMedCrossRefGoogle Scholar
  6. Song, Y., Cheung, W.Y.: Cyclic 3′-5′ nucleotide phosphodiesterase properties of the enzyme of human blood platelets. Biochem. biophys. Acta 242, 593 (1973)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1977

Authors and Affiliations

  • F. J. Pareti
  • P. M. Mannucci

There are no affiliations available

Personalised recommendations