Bone Mineral Estimation Employing Computer Assisted Transverse Axial Tomography — A Preliminary Study

  • I. Isherwood
  • B. R. Pullan
  • R. A. Rutherford
  • P. H. Adams
Conference paper


The skeleton is a dynamic tissue, continually reconstituted and remodelled by bone resorption and reformation. A net loss in total bone mass occurs with advancing years (19) and bone loss occurs in all women after the menopause (2, 21). There is almost certainly great individual variation in the rate of such loss and the development of osteoporosis (21). The importance of the recognition of bone loss lies in the prevention of those fractures which occur at sites containing predominantly trabecular bone (18), namely vertebral bodies, the femoral neck and the wrist.


Trabecular Bone Bone Mineral Content Attenuation Coefficient Ulnar Styloid Trabecular Space 
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  1. 1.
    ADAMS, P., DAVIES, G.T., SWEETMAN, P.: Observer error and measurements of the metacarpal. British Journal of Radiology 42, 192 (1969).CrossRefGoogle Scholar
  2. 2.
    ADAMS, P., DAVIES, D.P., SWEETMAN, P.: Osteoporosis and the effects of ageing on bone mass in elderly men and women. Quarterly Journal of Medicine 39, 601–615 (1970).Google Scholar
  3. 3.
    ARCHER-HALL, J.A., CARPENTER, P.B., EDWARDS, J.P.M., FRANCOIS, D.E.: A new bone mineral estimation using a conventional x-ray set. British Journal of Radiology 46, 375–380 (1973).CrossRefGoogle Scholar
  4. 4.
    BARNETT, E., NORDIN, B.E.C.: The radiological diagnosis of osteoporosis - a new approach. Clinical Radiology 11, 166–174 (1960).CrossRefGoogle Scholar
  5. 5.
    Editorial: Management of osteoporosis. British Medical Journal 1975/IV, 307–308.Google Scholar
  6. 6.
    CAMERON, J.F., SORENSON, J.: Measurement of bone mineral in vivo: an improved method. Science 142, 230–232 (1963).CrossRefGoogle Scholar
  7. 7.
    CLARKE, R.L., VAN DYKE, G.: A new method for measurement of bone mineral content using both transmitted and scattered beams of gamma rays. Physical and Medical Biology 18, 532–539 (1973).CrossRefGoogle Scholar
  8. 8.
    COHN, S.H., DOMBROWSKI, C.S.: Measurement of total body calcium, sodium chlorine, nitrogen and phosphorus in man by in vivo neutron activation analysis. Journal of Nuclear Medicine 12, 499–505 (1971).Google Scholar
  9. 9.
    DOYLE F.: Clinical Endocrine Metabolism 1, 143–167 (1972).CrossRefGoogle Scholar
  10. 10.
    DOYLE, F.H.: Ulnar bone mineral concentration in metabolic bone diseases. British Journal of Radiology 34, 698–712 (1961).CrossRefGoogle Scholar
  11. 11.
    GARN, S.M.: An annotated bibliography on bone densitometry. American Journal of Clinical Nutrition 10, 59–67 (1962).Google Scholar
  12. 12.
    GARNETT, E.S., KENNETT, T.J., KENYON, D.B., WEBSTER, C.F.: A photon scattering technique for the measurement of absolute bone density in man. Radiology 106, 209 (1973).Google Scholar
  13. 13.
    GUSTAFSSON, L., JACOBSON, B., KUSOFFSKY, L.: X-ray spectrophotometry for bone mineral diterminations. Medical and Biological Engineering 113–119 (1974).Google Scholar
  14. 14.
    HORSMAN, A., SIMPSON, M.: The measurement of sequential changes in cortical bone geometry. British Journal of Radiology 48, 470–476 (1975).CrossRefGoogle Scholar
  15. 15.
    HOUNSFIELD, G.M.: Computerised transverse axial scanning (tomography). British Journal of Radiology 46, 1016–1022 (1973).CrossRefGoogle Scholar
  16. 16.
    ISHERWOOD, I., PULLAN, B.R., RUTHERFORD, R.A.: Quantitative aspects of computer tomography. 1st International Symposium on Computer Tomography. Bermuda, 1975.Google Scholar
  17. 17.
    ISHERWOOD, I., RUTHERFORD, R.A., PULLAN, B.R., ADAMS, P.H.: Bone mineral estimation employing computer assisted transverse axial tomography. Lancet 1976/11, 712–715.CrossRefGoogle Scholar
  18. 18.
    KNOWELDEN, J., BUHR, A.J., DUNBAR, O.: Incidence of fractures in persons over 35 years of age. A report to the M.R.C. Working Party on Fractures in the Elderly. British Journal of Preventive Social Medicine 18, 130 (1964).Google Scholar
  19. 19.
    MERZ, A.L., TROTTER, M., PETERSON, P.R.:Estimation of skeleton weight in the living. American Journal of Physical Anthropology 14 589–609 (1956).CrossRefGoogle Scholar
  20. 20.
    MORGAN, D.B., SPIERS, F.W., PULVERTAFT, C.N., FOURMAN, P.: The amount of bone in the metacarpal and the phalanx according to age and sex. Clinical Radiology 18, 101–108 (1967).CrossRefGoogle Scholar
  21. 21.
    NORDIN, B.E.C., GALLAGHER, J.C., AARON, J.E., HORSMAN, A.: Postmenopausal osteopenia and osteoporosis. Frontiers of Hormone Research 3, 131–149 (1975).Google Scholar
  22. 22.
    OLKKONEN, H., KARJALAINEN, P.: A 170Tm gamma scattering technique for the determination of absolute bone density. British Journal of Radiology 48, 594–597 (1975).CrossRefGoogle Scholar
  23. 23.
    REED, G.W.: British Empire Cancer Campaign Annual Report 38, 489 (1960).Google Scholar
  24. 24.
    RUTHERFORD, R.A., PULLAN, B.R., ISHERWOOD, I.: Calibration and response of an EMI scanner. Neuroradiology 11, 7–13 (1976).CrossRefGoogle Scholar
  25. 25.
    RUTHERFORD, R.A., PULLAN, B.R., ISHERWOOD, I.: Measurement of effective atomic number arid electron density using an EMI scanner. Neuroradiology 11, 15–21 (1976).CrossRefGoogle Scholar
  26. 26.
    SHAPIRO, J.R., MOORE, W.T., JORGENSEN, H., REID, J., EPPS, C.H., WHEDON, D.: Osteoporosis: evaluation of diagnosis and therapy. Archives of Internal Medicine 135, 563–567 (1975).CrossRefGoogle Scholar
  27. 27.
    SORENSON, J.A., CAMERON, J.R.: A reliable in vivo measurement of bone mineral content. Journal of Bone and Joint Surgery 49, 481–497 (1967).Google Scholar
  28. 28.
    VIRTAMA, P., HELELA, T.: Acta Radiologica (Suppl.) 293 (1969).Google Scholar
  29. 29.
    WEST, R.R., REED, G.W.: Measurement of bone mineral in vivo by photon beam scanning. British Journal of Radiology 43, 886–893 (1970).CrossRefGoogle Scholar
  30. 30.
    WOOTEN, W.W., JUDY, P.F., GREENFIELD, M.A.: Analysis of the effects of adipose tissue on the absorptiometric measurement of bone mineral mass. Radiology 8, 84–89 (1973).Google Scholar
  31. 31.
    ZEITZ, L.: Effect of subcutaneous fat on bone mineral content measurements with the “single energy” photon absorptiometric technique. Acta Radiologica 11, 401–410 (1972).CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1977

Authors and Affiliations

  • I. Isherwood
    • 1
  • B. R. Pullan
    • 2
  • R. A. Rutherford
    • 2
  • P. H. Adams
    • 3
  1. 1.Department of NeuroradiologyManchester Royal InfirmaryUK
  2. 2.Department of Medical BiophysicsUnivesity of ManchesterUK
  3. 3.Department of MedicineManchester Royal InfirmaryUK

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