Abstract
Although the efficacy of dexamethasone upon brain edema in brain tumors and abscesses is well established, the question is still open, whether a similar favourable effect is exerted in severe head injury. Controlled and statistically significant results were not available in the literature when this study was planned. Experimental studies, however, with cold injury as a model of brain lesion showed a favourable influence of steroids on brain edema, if very early and high dose administration was used (2, 3, 4, 6). Therefore, a double-blind study was performed comparing placebo with low and high dose of dexamethasone.
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References
GOBIET, W.: Die Behandlung des akuten traumatischen Hirnödems. Notfallmed. 2, 98–103 (1976).
HERRMANN, H.D., NEUENFELDT, D., DITTMANN, J., PALLESKE, H.: The influence of dexamethasone on water content, electrolyte, BBB and glucose metabolism in cold injury edema. In: Steroids and Brain Edema (eds. H.J. Reulen and K. Schürmann), pp. 77–85. Berlin-Heidelberg-New York: Springer 1972.
KOBRINE, A.I., KEMPE, L.G.: Studies in Head Injury. Part II. Effect of Dexamethasone on Traumatic Brain Swelling. Surg. Neurol. 1, 38–42 (1973).
LONG, D.M., MAXWELL, R.E., CHOI, K.S., COLE, H.O., FRENCH, L.A.: Multiple therapeutic approaches in the treatment of brain edema induced by a standard cold lesion. In: Steroids and Brain Edema (eds. H.J. Reulen and K. Schürmann), pp. 87–95. Berlin-Heidelberg-New York: Springer 1972.
PATTEN, B.M., MENDEL, J., BRAUN, B., CURTIN, W., CARTER, S.: Double blind study of the effect of dexamethasone on acute stroke. In: Steroids and Brain Edema (eds. H.J. Reulen and K. Schürmann), pp. 259–266. Berlin-Heidelberg-New York: Springer 1972.
RANSOHOFF, J.: The effects of steroids on brain edema in man. In: Steroids and Brain Edema (eds. H.J. Reulen and K. Schürmann), pp. 211–217. Berlin-Heidelberg-New York: Springer 1972.
REULEN, H.J.: Die Überwachung und Behandlung des Schwer-Schädel-Hirn-Verletzten im Allgemeinen Krankenhaus. Langenbecks Arch. Chir. 334, 385–396 (1973).
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Faupel, G., Reulen, HJ., Müller, D., Schürmann, K. (1977). Clinical Double-Blind-Study on the Effects of Dexamethasone on Severe Closed Head Injuries. In: Wüllenweber, R., Brock, M., Hamer, J., Klinger, M., Spoerri, O. (eds) Lumbar Disc Adult Hydrocephalus. Advances in Neurosurgery, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66578-3_32
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DOI: https://doi.org/10.1007/978-3-642-66578-3_32
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