Abstract
Bell and Alton proved in 1954, that an outstanding characteristic of the brain tissue is its high thromboplastin concentration. After a severe brain injury and due to a simultaneous alteration of the blood-brain barrier, tissue thromboplastin can enter the systemic circulation, activating first factor VII (proconvertin) and in a later phase factors X (Stuart) and V (proaccelerin). Under the influence of the platelets phospholipids, prothrombin is converted to thrombin and fibrinogen to fibrin (Fig. 1). At the same time an increase in the activity of the fibrinolytic system takes place.
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Mauersberger, W., Fuchs, E.C., Grimmer, A. (1977). Secondary Blood Coagulation Disturbances after Severe Brain Injury. In: Wüllenweber, R., Brock, M., Hamer, J., Klinger, M., Spoerri, O. (eds) Lumbar Disc Adult Hydrocephalus. Advances in Neurosurgery, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66578-3_31
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DOI: https://doi.org/10.1007/978-3-642-66578-3_31
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