Abstract
The typical subcutaneous granuloma seen in patients with rheumatoid arthritis consists of a central necrotic area surrounded by a zone of fibroblasts and histiocytes. The necrotic area contains collagen fibres in various stages of fragmentation and dissolution, intimately associated with fibrin and other serum proteins. The cells bordering the necrotic zone are characteristically elongated at right angles to its surface in the form of a palisade. More peripherally the tissue is richly vascular with clusters of thin-walled vessels lined by swollen endothelium and surrounded by a mononuclear cell infiltrate in which lymphocytes and plasma cells are conspicuous.
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References
Banerjee, S.K., Glynn, L.E.: Reactions to homologous and heterologous fibrin implants in experimental animals. Ann. N.Y. Acad. Sci. 86, 1064 (1960)
Dumonde, D.C., Glynn, L.E.: The reaction of guinea pigs to autologous and heterologous fibrin implants. J. Path. Bact. 90, 649 (1965)
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© 1977 Springer-Verlag
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Glynn, L.E. (1977). Experimental Subcutaneous Granulomata Simulating R. A. Nodules. In: Glynn, L.E., Schlumberger, H.D. (eds) Experimental Models of Chronic Inflammatory Diseases. Bayer-Symposium, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66573-8_4
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DOI: https://doi.org/10.1007/978-3-642-66573-8_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-66575-2
Online ISBN: 978-3-642-66573-8
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