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Experimental Models of Chronic Inflammatory Diseases pp 376–390Cite as

The Action of Anti-Inflammatory Drugs on the Lymphocyte-Macrophage Axis

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Part of the book series: Bayer-Symposium ((BAYER-SYMP,volume 6))

Abstract

In chronic inflammatory diseases such as rheumatoid arthritis (RA), the persistent cellular infiltrate of active lesions shows a predominance of mononuclear cells. Such inflammatory cell populations are reminiscent of the mononuclear cell infiltrate that is characteristic of the delayed hypersensitivity reaction, and hence provide circumstantial evidence of the involvement of cell-mediated reactions in the pathogenesis of diseases such as rheumatoid arthritis. The mononuclear cell infiltrate comprises two cell types, the lymphocyte and the macrophage, and over the last decade substantial progress has been made in relating the activation of lymphocytes and macrophages to the pathological events that are a feature both of delayed hypersensitivity reactions and of active lesions of RA. Although both lymphocytes and macrophages have been shown to be capable of direct cell-mediated cytotoxicity, it is evident that many of the characteristic features of inflammation necessitate the elaboration and secretion of chemical mediators of which three groups are pre-eminent; the lymphokines, lysosomal enzymes and prostaglandins.

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Authors
  1. J. Morley
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  2. M. A. Bray
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  3. D. Gordon
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Editor information

Editors and Affiliations

  1. The Mathilda and Terence Kennedy Institute of Rheumatology, Bute Gardens, Hammersmith, London, W6 7DW, Great Britain

    Leonard Eleazar Glynn

  2. Bayer Pharma-Forschungszentrum, Institut für Immunologie und Onkologie, Aprather Weg, 5600, Wuppertal 1, Fed. Rep. of Germany

    Horst Dieter Schlumberger

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© 1977 Springer-Verlag

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Morley, J., Bray, M.A., Gordon, D. (1977). The Action of Anti-Inflammatory Drugs on the Lymphocyte-Macrophage Axis. In: Glynn, L.E., Schlumberger, H.D. (eds) Experimental Models of Chronic Inflammatory Diseases. Bayer-Symposium, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66573-8_30

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  • DOI: https://doi.org/10.1007/978-3-642-66573-8_30

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-66575-2

  • Online ISBN: 978-3-642-66573-8

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