Features of Human Spontaneous Vasculitis Reproduced Experimentally in Animals. Effects of Antiglobulins, C-Reactive Protein and Fibrin

  • W. E. Parish
Part of the Bayer-Symposium book series (BAYER-SYMP, volume 6)

Abstract

Much of our knowledge of spontaneous vasculitis in man is based on studies of the Arthus reaction in experimental animals. The Arthus reaction results from local formation of aggregates of precipitating antibody and antigen in the lumen of blood or lymphatic vessels, and in tissue spaces. The acute lesion is a neutrophil-infiltrated vasculitis. Similar lesions can be induced by preformed antigen-antibody complexes which activate complement, if these are deposited in vessel walls from the blood, which gives rise to serum sickness, now termed immune complex disease (ICD).

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© Springer-Verlag 1977

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  • W. E. Parish

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