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Antibody Affinity, Macrophage Function and Immunoregulation in Murine Immune Complex Disease

  • Conference paper
Experimental Models of Chronic Inflammatory Diseases

Part of the book series: Bayer-Symposium ((BAYER-SYMP,volume 6))

Abstract

The investigation of experimentally-induced chronic immune complex disease (ICD) in rabbits receiving daily injection of heterologous serum protein antigens has shown that both quantitative and qualitative variations in antibody response underlie differences in susceptibility to this disease (3, 25). Furthermore, the observations that there are clear inter-strain differences in susceptibility to chronic ICD following neonatal infection of inbred mice with lymphocytic choriomeningitis virus (LCM) indicate that genetically determined factors may underlie these variations in antibody response (19).

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Authors
  1. M. W. Steward
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Editors and Affiliations

  1. The Mathilda and Terence Kennedy Institute of Rheumatology, Bute Gardens, Hammersmith, London, W6 7DW, Great Britain

    Leonard Eleazar Glynn

  2. Bayer Pharma-Forschungszentrum, Institut für Immunologie und Onkologie, Aprather Weg, 5600, Wuppertal 1, Fed. Rep. of Germany

    Horst Dieter Schlumberger

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Steward, M.W. (1977). Antibody Affinity, Macrophage Function and Immunoregulation in Murine Immune Complex Disease. In: Glynn, L.E., Schlumberger, H.D. (eds) Experimental Models of Chronic Inflammatory Diseases. Bayer-Symposium, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66573-8_12

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  • DOI: https://doi.org/10.1007/978-3-642-66573-8_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-66575-2

  • Online ISBN: 978-3-642-66573-8

  • eBook Packages: Springer Book Archive

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