Abstract
Fifteen years after Mitchell (1961) first proposed the chemiosmotic hypothesis of oxidative phosphorylation, it has been experimentally established that redox chains and ATPase complexes of energy-transducing membranes directly convert metabolic energy into a transmembrane thermodynamic potential difference of protons (for review, see: Mitchell, 1972; Papa, 1976). The mechanism of the redox and the hydrolytic pumps and their role in ATP formation remain, however, yet to be understood (Papa, 1976).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Albracht, S.P.J., Slater, E.C.: EPR studies at 20°K on the mitochondrial respiratory chain. Biochim. Biophys. Acta 245, 503–507 (1971)
Baum, H., Rieske, J.S., Silman, H.I., Lipton, S.H.: On the mechanism of electron transfer in complex III of the electron transfer chain. Proc. Natl Acad. Sci. U.S. 57, 798–805 (1967)
Brand, M.D., Reynafarje, B., Lehninger, A.L.: The stoichiometry, relationship between energy-dependent proton ejection and electron transport in mitochondria. Proc. Natl. Acad. Sci. U.S. 73, 1–18 (1976)
Chance, B.: The nature of electron transfer and energy coupling reactions. FEBS Lett. 23, 3–20 (1972)
Clark, W.M.: Oxidation-Reduction Potentials of Organic Systems. Baltimore Md.: Waverley Press, 1960
Das Gupta, U., Rieske, J.S.: Identification of a protein component of the antimycin-binding site of the respiratory chain by photoaffinity labeling. Biochem. Biophys. Res. Commun. 54, 1247–1254 (1973)
Douglas, M.G., Cockrell, R.S.: Mitochondrial cation-hydrogen ion exchange -Sodium selective transport by mitochondria and submitochondrial particles J. Biol. Chem. 249, 5464–5471 (1974)
Dutton, P.L., Wilson, D.F.: Redox potentiometry in mitochondrial and photosynthetic bioenergetics. Biochim. Biophys. Acta 346, 165–212 (1974)
Gellerfors, P., Nelson, B.D.: Analysis of the peptide composition of purified beef-heart complex III by dodecylsulfate electrophoresis. Europ. J. Biochem. 52, 433–443 (1975)
Green, D.E., Järnefelt, J., Tisdale, H.D.: Studies on the electron transport system. XIV. The isolation and properties of soluble cytochromec. Biochim. Biophys. Acta 31, 34–46 (1959)
Guerrieri, F., Nelson, B.D.: Studies on the characteristics of a proton pump in phospholipid vesicles inlayed with purified complex III from beef-heart mitochondria. FEBS Lett. 54, 339–342 (1975)
Hinkle, P.C., Kim, J.J.: Chemiosmotic coupling in cytochrome oxidase vesicles. In: Mechanisms in Bioenergetics. Azzone, G.F., Ernster, L., Papa, S., Quagliariello, E., Siliprandi, N. (eds.). London: Academic Press, 1973; pp. 53–60
Jencks, W.P.: Catalysts in Chemistry and Enzymology. New York: McGraw Hill, 1969, pp. 243–281
Kilmartin, J.V., Rossi-Bernardi, L.: Interaction of hemoglobin with hydrogen ions, carbon dioxide and organic phosphates. Physiol. Rev. 53, 836–889 (1973)
Klingenberg, M.: The respiratory chain. In: Biological Oxidation. Singer, P.T. (ed.). New York: Interscience (1968), pp. 1–49
Lawford, H.G., Garland, P.B.: Proton translocation coupled to quinol oxidation in ox-heart mitochondria. Biochem J. 136, 711–720 (1973)
Mitchell, P.: Coupling of phosphorylation to electron and hydrogen transfer by a chemiosmotic type of mechanism. Nature (London) 191, 144–148 (1961)
Mitchell, P.: Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. Biol. Rev. 41, 445 (1966)
Mitchell, P.: Structural and functional organisation of energy-transducing membranes and their ion-conducting properties. In: Mitochondria/Biomembranes. In: Proc. 8th FEBS Meeting, Amsterdam. Van Den Bergh, S.G., Borst, P., Van Deenen, L.L.M., Reimersma, J.C., Slater, E.C., Tager, J.M. (eds.). Amsterdam: North Holland-American Elsevier, 1972, Vol. XXVIII, pp. 353–370
Mitchell, P.: Protonmotive redox mechanism of the cytochrome b-c1 complex in the respiratory chain: Protonmotive ubiquinone cycle. FEBS Lett. 56, 1–6 (1975a)
Mitchell, P.: Protonmotive function of cytochrome systems. In: Electron Transfer Chains and Oxidative Phosphorylation. Quagliariello, E., Papa, S., Palmieri, F., Slater, E.C., Siliprandi, N. (eds.). Amsterdam: North Holland, Publ. Co., 1975b, pp. 305–327
Mitchell, P., Moyle, J.: Respiration-driven proton translocation in rat liver mitochondria. Biochem. J. 105, 1147–1162 (1967)
Mitchell, P., Moyle, J.: The intrinsic anisotropy of the cytochrome oxidase region of the mitochondrial respiratory chain and the consequent vectorial property of respiration. In: Electron Transport and Energy Conservation. Tager, J.M., Papa, S., Quagliariello, E., Slater, E.C. (eds.). Bari: Adriatica Editrice, 1970, pp. 575–587
Nicholls, P., Chance, B.: Cytochromec oxidase. In: Molecular Mechanisms of Oxygen Activation. Hayaishi, O. (ed.). New York: Academic Press, 1974, pp. 479–534
Nishibayashi-Yamashita, H., Cunningham, C., Racker, E.: Resolution and Reconstitution of the Mitochondrial Electron Transport System. III. Order of reconstitution and requirement for a new factor for respiration. J. Biol. Chem. 247, 698–704 (1972)
Ohnishi, T., Wilson, D.F., Asakura, T., Chance, B.: Studies on iron-sulfur proteins in the site I region of the respiratory chain in pigeon heart mitochondria and submitochondrial particles. Biochem. Biophys. Res. Commun. 46, 1631–1638 (1972)
Papa, S.: Coupling mechanism in ion translocation across the inner mitochondrial membrane. In: Energy Transduction in Respiration and Photosynthesis. Quagliariello, E., Papa, S., Rossi, C.S. (eds.). Bari: Adriatica Editrice, 1971, pp. 173–203
Papa, S., Proton translocation reactions in the respiratory chains. Biochim. Biophys. Acta 456, 39–84 (1976)
Papa, S., Guerrieri, F., Lorusso, M., Simone, S.: Proton translocation and energy transduction in mitochondria. Biochimie 55, 703–716 (1973)
Papa, S., Guerrieri, F., Lorusso, M.: Mechanism of respiration-driven proton translocation in the inner mitochondrial membrane. Analysis of proton translocation associated to oxido-reductions of the oxygen-terminal respiratory carriers. Biochim. Biophys. Acta 357, 181–192 (1974a)
Papa, S., Guerrieri, F., Lorusso, M.: The role of respiratory carriers in the mitochondrial proton pump. In: Membrane Proteins in Transport and Phosphorylation. Azzone, G.F., Klingenberg, M.E., Quagliariello, E., Siliprandi, N. (eds.). Amsterdam: North Holland, Publ. Co., 1974b, pp. 177–186
Papa, S., Guerrieri, F., Lorusso, M.: On the mechanism of the mitochondrial proton pump. In: Dynamics of Energy-Transducing Membranes. Ernster, L., Estabrock, R.W., Slater, E.C. (eds.). Amsterdam: Elsevier, 1974c, pp. 417–432
Papa, S., Guerrieri, F., Capuano, F., Izzo, G., Boffoli, D.: On the stoichiometry of the mitochondrial redox-proton pump. 1976, to be submitted
Papa, S., Lorusso, M., Guerrieri, F.: Mechanism of respiration-driven proton translocation in the inner mitochondrial membrane. Analysis of proton translocation associated with oxidation of endogenous ubiquinol. Biochim. Biophys. Acta 387, 425–440 (1975a)
Papa, S., Lorusso, M., Guerrieri, F. Izzo, G.: On the mechanism of electron flow and proton translocation in the ubiquinone-cytochromec span of the respiratory chain. In: Electron Transfer Chains and Oxidative Phosphorylation. Quagliariello, E., Papa, S., Palmieri, F., Slater, E.C., Siliprandi, N. (eds.). Amsterdam: Elsevier, 1975b, pp. 317–327
Pettigrew, G.W., Meyer, T.E., Bartsch, R.G., Kamen, M.D.: pH dependence of the oxidation-reduction potential of cytochrome C2. Biochim. Biophys. Acta 430, 197–208 (1975)
Rodkey, F.L., Ball, E.G.: Oxidation-reduction potentials of the cytochrome c system. Arch. Biochem. 12, 17–28 (1949)
Seki, S., Oda, T.: Studies on cytochrome oxidase. II Ultrastructure of cytochrome oxidase. Arch. Biochem. Biophys. 138, 122–134 (1970)
Slater, E.C.: Electron transfer and energy conservation. In: Dynamics of Energy-Transducing Membranes. Ernster, L., Estabrock, R.W., Slater, E.C. (eds.). Amsterdam: Elsevier 1974, pp. 1–20
Straub, J.P., Colpa-Boonstra, J.P.: The effect of pH on the oxidation-reduction potential of cytochrome b in heart muscle preparations. Biochim. Biophys. Acta 60, 650–652 (1962)
Urban, P.F., Klingenberg, M.: On the redox potentials of ubiquinone and cytochrome b in the respiratory chain. Europ. J. Biochem. 9, 519–525 (1969)
Vanderkooi, G., Senior, A.E., Capaldi, R.A., Hayashi, H.: Biological membrane structure. III. The Lattice structure of membranous cytochrome oxidase. Biochim. Biophys. Acta 274, 38–48 (1972)
Vernon, L.P., Kamen, M.D.: Hematin compounds in photosynthetic bacteria. J. Biol. Chem. 211, 643–675 (1954)
Wikström, M.K.F.: Energy linked change in the redox state and absorption spectrum of cytochrome a in situ. Biochim. Biophys. Acta 283, 385–390 (1972)
Wyman, J.: Regulation in macromolecules as illustrated by haemoglobin. Quart. Rev. Biophys. 1, 35–81 (1968)
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1977 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Papa, S., Guerrieri, F., Lorusso, M., Izzo, G., Boffoli, D., Capuano, F. (1977). The Proton Pump of the Mitochondrial Respiratory Chain. In: Semenza, G., Carafoli, E. (eds) Biochemistry of Membrane Transport. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66564-6_38
Download citation
DOI: https://doi.org/10.1007/978-3-642-66564-6_38
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-66566-0
Online ISBN: 978-3-642-66564-6
eBook Packages: Springer Book Archive