Abstract
Epithelial cells separate phases of different ionic composition and by transepithelial transport maintain or establish the asymmetric distribution of ions. The epithelia of the small intestine and the proximal tubule are additionally specialized in the (re)absorption of a variety of solutes, such as sugars, amino acids, and phosphate. Such vectorial transports can only be performed if a sidedness of the epithelial cell in respect to the transport properties of the luminal and contraluminal membrane exists. Maintenance of asymmetric distribution of solutes involves active transport processes that are energized by cellular metabolism. The coupling of transepithelial transport to energy can be direct or indirect. In primary active transport the movement of a solute across the cell membrane is directly coupled to an energy-transducing chemical reaction, such as the coupling of sodium transport via the Na+-K+-ATPase to ATP hydrolysis. In secondary active transport the movement of the solute across the membrane is coupled to a flux of a primary actively transported substrate.
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References
Berner, W., Kinne, R.: Transport of p-aminohippuric acid by plasma membrane vesicles isolated from rat kidney cortex. Pflügers Arch. 361, 269–277 (1976)
Berner, W., Kinne, R., Murer, H.: Phosphate transport into brush border membrane vesicles isolated from rat small intestine. Biochem. J., in press (1976)
Frömter, E., Rumrich, G., Ullrich, K.J.: Phenomenologic description of Na+, Cl- and HCO3 - absorption from proximal tubules of the rat kidney. Pflügers Arch. 343, 189–220 (1973)
Hoffmann, N., Thees, M., Kinne, R.: Phosphate transport by isolated renal brush border vesicles. Pflügers Arch. 362, 147–156 (1976)
Hopfer, U., Sigrist-Nelson, K., Murer, H.: Intestinal sugar transport. Studies with isolated plasma membranes. Ann. N.Y. Acad. Sci. 264, 414–426 (1975)
Kinne, R., Murer, H.: Polarity of epithelial cells in relation to transepithelial transport in kidney and intestine. In: Intestinal Ion Transport. Robinson, J.W.L. (ed.). Lancaster: MTP Press Ltd., 1976, pp. 79–95
Kinne, R., Murer, H., Kinne-Saffran, E., Thees, M., Sachs, G.: Sugar transport by renal plasma membrane vesicles. Characterization of the systems in the brush-border microvilli and basal-lateral plasma membranes. J. Membrane Biol. 21, 375–395 (1975)
Murer, H., Hopfer, U.: Demonstration of electrogenic Na+ dependent D-glucose transport in intestinal brush border membranes. Proc. Natl. Acad. Sci. U.S. 71, 484–488 (1974)
Murer, H., Hopfer, U.: The functional polarity of the intestinal epithelial cell. Studies with isolated plasma membrane vesicles. In: Intestinal Permeation. Lauterbach, F., Kramer, M. (eds.). Amsterdam, Excerpta Medica Monographs. In press (1976)
Murer, H., Hopfer, U., Kinne, R.: Sodium/proton antiport in brush-border-membrane vesicles isolated from rat small intestine. Biochem. J. 154, 597–604 (1976)
Murer, H., Hopfer, U., Kinne-Saffran, E., Kinne, R.: Glucose transport in isolated brush-border and lateral-basal plasma-membrane vesicles from intestinal epithelial cells. Biochim. Biophys. Acta 345, 170–179 (1974)
Murer, H., Sigrist-Nelson, K., Hopfer, U.: On the mechanism of sugar and amino acid interaction in intestinal transport. J. Biol. Chem. 250, 7392–7396 (1975)
Schultz, S.G., Curran, P.F.: Intestinal absorption of sodium chloride and water. In: Handbook of Physiology, Vol. III, Section 6. Code, C.F. (ed.). Washington: American Physiological Society 1968, pp. 1245–1275
Sigrist-Nelson, K., Murer, H., Hopfer, U.: Active alanine transport in isolated brush border membranes. J. Biol. Chem. 250, 5674–5680 (1975)
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Murer, H., Kinne, R. (1977). Sidedness and Coupling of Transport Processes in Small Intestinal and Renal Epithelia. In: Semenza, G., Carafoli, E. (eds) Biochemistry of Membrane Transport. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66564-6_21
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DOI: https://doi.org/10.1007/978-3-642-66564-6_21
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