Abstract
There is now considerable evidence that the ion permeability of biological membranes is not a diffuse property of the whole membrane but depends on the presence of specialized components in the membrane. Such a functional component may be a mobile carrier molecule that mediates the transport of ions in a sequence of complexation, translocation, and decomplexation steps. The second limiting case of an ion transport mechanism consists of a porelike channel that offers to the ion a hydrophilic pathway through the apolar core of the membrane. The formation of channels in lipid membranes and the mechanism of ion transport through channels may be studied in experiments with certain hydrophobic peptides such as gramicidin.
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Bamberg, E. et al. (1977). Studies on the Gramicidin Channel. In: Semenza, G., Carafoli, E. (eds) Biochemistry of Membrane Transport. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66564-6_12
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DOI: https://doi.org/10.1007/978-3-642-66564-6_12
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