Studies on the Gramicidin Channel

  • E. Bamberg
  • H. Alpes
  • H.-J. Apell
  • R. Benz
  • K. Janko
  • H.-A. Kolb
  • P. Läuger
  • E. Gross
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Abstract

There is now considerable evidence that the ion permeability of biological membranes is not a diffuse property of the whole membrane but depends on the presence of specialized components in the membrane. Such a functional component may be a mobile carrier molecule that mediates the transport of ions in a sequence of complexation, translocation, and decomplexation steps. The second limiting case of an ion transport mechanism consists of a porelike channel that offers to the ion a hydrophilic pathway through the apolar core of the membrane. The formation of channels in lipid membranes and the mechanism of ion transport through channels may be studied in experiments with certain hydrophobic peptides such as gramicidin.

Keywords

Hydrocarbon Glycine Bacillus Tryptophane Autocorrelation 

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References

  1. Apell, H.J., Bamberg, E., Alpes, H., Läuger, P.: J. Membrane Biol. (in press)Google Scholar
  2. Bamberg, E., Benz, R.: Biochim. Biophys. Acta 426, 570–580 (1976)PubMedCrossRefGoogle Scholar
  3. Bamberg, E., Janko, K.: Biochim. Biophys. Acta (in press)Google Scholar
  4. Bamberg, E., Läuger, P.: J. Membrane Biol. 11, 177–194 (1973)CrossRefGoogle Scholar
  5. Bamberg, E., Läuger, P.: Biochim. Biophys. Acta 367, 127–133 (1974)PubMedCrossRefGoogle Scholar
  6. Bamberg, E., Noda, K., Gross, E., Läuger, P.: Biochim. Biophys. Acta 419, 223–228 (1976)PubMedCrossRefGoogle Scholar
  7. Benz, R.: in preparation (1976)Google Scholar
  8. Byrn, S.R.: Biochemistry 13, 5186–5193 (1974)PubMedCrossRefGoogle Scholar
  9. Drouin, H., Neumcke, B.: Pflügers Arch. 351, 207–229 (1974)PubMedCrossRefGoogle Scholar
  10. Eisenman, G., Sandblom, J., Neher, E.: In: Metal-Ligand Interactions in Organic and Biochemistry, Pullman, B. (ed.). Dortrecht: D. Reidel, Publ. Co. (in press)Google Scholar
  11. Feher, G., Weissman, M.: Proc. Natl. Acad. Sci. U.S. 70, 870–875 (1973)CrossRefGoogle Scholar
  12. Fossel, E.T., Veatch, W.R., Ovchinnikov, Yu.A., Blout, E.R.: Biochemistry 13, 5264–5275 (1974)PubMedCrossRefGoogle Scholar
  13. Goodall, M.C.: Biochem. Biophys. Acta 219, 471–478 (1970)PubMedCrossRefGoogle Scholar
  14. Goodall, M.C.: Arch. Biochem. Biophys. 147, 129–135 (1971)PubMedCrossRefGoogle Scholar
  15. Goodall, M.C.: Arch. Biochem. Biophys. 157, 514–519 (1973)PubMedCrossRefGoogle Scholar
  16. Goodall, M.C., Urry, D.W.: Biochim. Biophys. Acta 291, 317–320 (1973)PubMedCrossRefGoogle Scholar
  17. Gordon, L.G.M.: J. Membrane Biol. 12, 207–216 (1973)CrossRefGoogle Scholar
  18. Gross, E., Witkop, B.: Biochemistry 4, 2495–2501 (1965)CrossRefGoogle Scholar
  19. Henderson, P. J.F., McGivan, J.D., Chappel, J.B.: Biochem. J. 111, 521–535 (1969)PubMedGoogle Scholar
  20. Hille, B., Woodhull, A.M., Shapiro, B.J.: Phil. Trans. Roy. Soc. Ser. B, 270, 301–318 (1975)CrossRefGoogle Scholar
  21. Hladky, S.B., Haydon, D.A.: Nature (London) 225, 451–453 (1970)CrossRefGoogle Scholar
  22. Hladky, S.B., Haydon, D.A.: Biochim. Biophys. Acta 274, 294–312 (1972)PubMedCrossRefGoogle Scholar
  23. Johnstone, R.M.: Biochim. Biophys. Acta 413, 252–264 (1975)PubMedCrossRefGoogle Scholar
  24. Kolb, H.-A., Bamberg, E.: submitted for publication (1976)Google Scholar
  25. Kolb, H.-A., Läuger, P., Bamberg, E.: J. Membrane Biol. 20, 133–154 (1975)CrossRefGoogle Scholar
  26. Krasne, S., Eisenman, G., Szabo, G.: Science 174, 412–415 (1971)PubMedCrossRefGoogle Scholar
  27. Läuger, P.: Science 178, 24–30 (1972)PubMedCrossRefGoogle Scholar
  28. Liberman, E.A., Topaly, V.P.: Biochim. Biophys. Acta 163, 125–136 (1965)Google Scholar
  29. Montal, M., Mueller, P.: Proc. Natl. Acad. Sci. U.S. 69, 3561–3566 (1972)CrossRefGoogle Scholar
  30. Mueller, P., Rudin, D.O.: Biochem. Biophys. Res. Commun. 26, 398–404 (1967)PubMedCrossRefGoogle Scholar
  31. Myers, V.B., Haydon, D.A.: Biochim. Biophys. Acta 274, 313–322 (1972)PubMedCrossRefGoogle Scholar
  32. Neher, E.: Biochim. Biophys. Acta 401, 540–544 (1975)CrossRefGoogle Scholar
  33. Noda, K., Gross, E.: In: Chemistry and Biology of Peptides. Proc. 3rd Am. Peptide Symp. Meienhofer, H. (ed.). Ann Arbor, Michigan: Ann Arbor Science Publishers 1972, p. 671Google Scholar
  34. Ovchinnikov, Yu.A.:aaa In: Federation of European Biochemical Societies. 8th Meeting, Vol. 28. Amsterdam: North Holland 1972, pp. 279–306Google Scholar
  35. Ovchinnikov, Yu.A., Ivanov, V.T., Shkrob, A.M.: Membrane-Active Complexones. Amsterdam: Elsevier 1974Google Scholar
  36. Podleski, T., Changeux, J.-P.: Nature (London) 221, 541–545 (1969)CrossRefGoogle Scholar
  37. Pressman, B.C.: Proc. Natl. Acad. Sci. U.S. 53, 1076–1083 (1965)CrossRefGoogle Scholar
  38. Ramachandran, G.N., Chandrasekaran, R.: Prog. Peptide Res. 2, 195–215 (1972)Google Scholar
  39. Requena, J., Haydon, D.A., Hladky, S.B.: Biophys. J. 15, 77–81 (1975)CrossRefGoogle Scholar
  40. Sarges, R., Witkop, B.: J. Am. Chem. Soc. 87, 2011–2020 (1965)PubMedCrossRefGoogle Scholar
  41. Tosteson, D.C., Andreoli, T.E., Tiefenberg, M., Cook, P.: J. Gen. Physiol. 51, 373S–384S (1968)PubMedGoogle Scholar
  42. Urry, D.W.: Proc. Natl. Acad. Sci. U.S. 68, 672–676 (1971)CrossRefGoogle Scholar
  43. Urry, D.W.: Biochim. Biophys. Acta 265, 115–168 (1972a)PubMedGoogle Scholar
  44. Urry, D.W.: Proc. Natl. Acad. Sci. U.S. 69, 1610–1614 (1972b)CrossRefGoogle Scholar
  45. Urry, D.W., Goodall, M.C., Glickson, J.S., Mayers, D.F.: Proc. Natl. Acad. Sci. U.S. 68, 1907–1911 (1971)CrossRefGoogle Scholar
  46. Veatch, W.R., Blout, E.R.: Biochemistry 13, 5257–5264 (1974)PubMedCrossRefGoogle Scholar
  47. Veatch, W.R., Fossel, E.T., Blout, E.R.: Biochemistry 13, 5249–5256 (1974)PubMedCrossRefGoogle Scholar
  48. Veatch, W.R., Mathies, R., Eisenberg, M., Stryer, L.: J. Mol. Biol., in press (1976)Google Scholar
  49. Wenner, C.E., Hackney, J.H.: Biochemistry 8, 930–938 (1969)PubMedCrossRefGoogle Scholar
  50. Woodhull, A.M.: J. Gen. Physiol. 61, 687–708 (1973)PubMedCrossRefGoogle Scholar
  51. Zingsheim, H.P., Neher, E.: Biophys. Chem. 2, 197–207 (1974)PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1977

Authors and Affiliations

  • E. Bamberg
  • H. Alpes
  • H.-J. Apell
  • R. Benz
  • K. Janko
  • H.-A. Kolb
  • P. Läuger
  • E. Gross

There are no affiliations available

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