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Drug-Receptor Inactivation: A New Kinetic Model

  • Chapter
Kinetics of Drug Action

Abstract

In this volume Mackay (1977) has reviewed various drug-receptor theories that have been proposed over the past 30 to 40 years. We offer here a new hypothesis for consideration. As a scheme of drug-receptor kinetics it appears to be at least as successful as earlier models in accounting for a variety of experimental phenomena. The resulting explanations are plausible and attractive but certainly not demonstrably correct. Indeed, like many explanations derived from rival theories, they apparently are not susceptible to rigorous proof by any experimental technique available today. The new proposal, however, does offer an alternative way to interprete experimental data on receptor mechanisms. It also serves to reconcile several rival models by incorporating them into a unifying hypothesis.

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Authors
  1. R. E. Gosselin
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Editors and Affiliations

  1. Farmacologisch Instituut, Faculteit der Geneeskunde, Katholieke Universiteit Nijmegen, Geert Grooteplein Noord 21, Nijmegen, The Netherlands

    Jacques M. van Rossum

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Gosselin, R.E. (1977). Drug-Receptor Inactivation: A New Kinetic Model. In: van Rossum, J.M. (eds) Kinetics of Drug Action. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 47. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66537-0_7

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  • DOI: https://doi.org/10.1007/978-3-642-66537-0_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-66539-4

  • Online ISBN: 978-3-642-66537-0

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