Development and Resolution of Ischemic Brain Swelling

  • K. A. Hossmann


The pathomechanism of ischemic brain swelling was studied in cats following 1 h of complete ischemia of the total brain. Brain water after ischemia increased from 75.9 to 78.3 ml/100 g, accompanied by an increase in intracranial pressure to 45 mm Hg and a displacement of the cortical surface by 270 µ. Extracellular space during ischemia decreased from 18.9 to 8.5 vol %, and expanded to more than 18% upon recirculation. Post-ischemic brain swelling was due to vasoparalysis and to the equilibration of osmotic and ionic gradients between extracellular fluid and blood. Upon reactivation of the energy-producing metabolism, brain swelling was reversible within 2–3 h.


Intracranial Pressure Extracellular Space Brain Edema Brain Volume Energy Charge 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1976

Authors and Affiliations

  • K. A. Hossmann
    • 1
  1. 1.The Max-Planck-Institute for Brain ResearchCologneW. Germany

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