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The “Low-Flow” State Following Total Cerebral Ischemia

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Dynamics of Brain Edema

Summary

Following 16 min of complete cerebral ischemia, produced in rats by occluding aortic outflow from the heart, cerebral perfusion rate (CPR) measured at a constant hydrostatic pressure was 7.5% of control. Epinephrine added to the perfusate increase CPR to 40.5% of control. Studies in vitro with preparations of bovine cerebral arteries disclosed two populations of these vessels: (i) arteries 0.7 to 2 mm in diameter which have no spontaneous mechanical activity and contract in a dose-related manner with potassium, epinephrine and histamine, and (ii) arteries 0.3 to 0.5 mm in diameter which have intense spontaneous activity and relax in a dose-related manner with increasing potassium concentration but which have a dose-related contraction response to epinephrine and histamine.

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References

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Authors and Affiliations

  1. Department of Anesthesia and Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Canada

    J. G. Wade, W. A. Tweed & W. J. Davidson

Authors
  1. J. G. Wade
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  2. W. A. Tweed
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  3. W. J. Davidson
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Editor information

Editors and Affiliations

  1. Dept. of Neurology and Neurosurgery, McGill University, 3801 University Street, H3A 2B4, Montreal, Que., Canada

    Hanna M. Pappius Ph. D. (Associate Professor, Associate Neurochemist) & William Feindel M. D., D. Phil., F.R.S.C. (Professor, Director) (Associate Professor, Associate Neurochemist) &  (Professor, Director)

  2. Montreal Neurological Institute, 3801 University Street, H3A 2B4, Montreal, Que., Canada

    Hanna M. Pappius Ph. D. (Associate Professor, Associate Neurochemist) & William Feindel M. D., D. Phil., F.R.S.C. (Professor, Director) (Associate Professor, Associate Neurochemist) &  (Professor, Director)

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© 1976 Springer-Verlag Berlin · Heidelberg

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Wade, J.G., Tweed, W.A., Davidson, W.J. (1976). The “Low-Flow” State Following Total Cerebral Ischemia. In: Pappius, H.M., Feindel, W. (eds) Dynamics of Brain Edema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66524-0_34

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  • DOI: https://doi.org/10.1007/978-3-642-66524-0_34

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-08009-1

  • Online ISBN: 978-3-642-66524-0

  • eBook Packages: Springer Book Archive

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