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Dynamics of Brain Edema pp 187–192Cite as

Monoamines in Cerebral Ischemia in Relation to Brain Edema

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Summary

Cerebral ischemia was produced by unilateral ligation of the common carotid artery in Mongolian gerbils. Levels of monoamines and their metabolites, with and without pretreatment with modulators of monoamine turnover, were measured. The results suggest that cerebral ischemia is accompanied by: (1) decreased rate of monoamine synthesis, (2) increased synaptosomal release of monoamines, and (3) accumulation of monoamine metabolites due to changes in the active transport of these substances out of the brain.

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Author information

Authors and Affiliations

  1. Laboratory of Neurochemistry, Institute of Biochemistry, School of Medicine, Belgrade, Yugoslavia

    B. B. Mršulja, B. J. Mršulja, M. Spatz & I. Klatzo

  2. Laboratory of Neuropathology and Neuroanatomical Sciences, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Md., USA

    B. B. Mršulja, B. J. Mršulja, M. Spatz & I. Klatzo

Authors
  1. B. B. Mršulja
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  2. B. J. Mršulja
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  3. M. Spatz
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  4. I. Klatzo
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Editor information

Editors and Affiliations

  1. Dept. of Neurology and Neurosurgery, McGill University, 3801 University Street, H3A 2B4, Montreal, Que., Canada

    Hanna M. Pappius Ph. D. (Associate Professor, Associate Neurochemist) & William Feindel M. D., D. Phil., F.R.S.C. (Professor, Director) (Associate Professor, Associate Neurochemist) &  (Professor, Director)

  2. Montreal Neurological Institute, 3801 University Street, H3A 2B4, Montreal, Que., Canada

    Hanna M. Pappius Ph. D. (Associate Professor, Associate Neurochemist) & William Feindel M. D., D. Phil., F.R.S.C. (Professor, Director) (Associate Professor, Associate Neurochemist) &  (Professor, Director)

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© 1976 Springer-Verlag Berlin · Heidelberg

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Mršulja, B.B., Mršulja, B.J., Spatz, M., Klatzo, I. (1976). Monoamines in Cerebral Ischemia in Relation to Brain Edema. In: Pappius, H.M., Feindel, W. (eds) Dynamics of Brain Edema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66524-0_31

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  • DOI: https://doi.org/10.1007/978-3-642-66524-0_31

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-08009-1

  • Online ISBN: 978-3-642-66524-0

  • eBook Packages: Springer Book Archive

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