Summary
The passage of small and large molecular weight substances across the blood-brain barrier (BBB) was investigated during development of biphasic ischemic edema in the brain. The initial increase in cerebral water content (first phase) preceded increased BBB permeability to Evans blue albumin complex, RISA, dextran, and sucrose. The BBB change for large molecular weight substances was transient and most likely responsible for additional brain swelling (second phase). Moreover, the facilitated transport of 2-deoxy-D-glucose was altered and included an increased passive diffusion of the hexose from blood to brain during the second phase of ischemic cerebral edema.
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Fenstermacher, J.D., Ball, D.P., Patlak, C.S., Levin, V.A.: Ventriculocisternal perfusion as a technique for analysis of brain capillary permeability and extra-cellular transport. In: Capillary Permeability. Crone, C., Lassen, N. (ads.). Copenhagen: Munksgaard 1970, pp. 483–490
Fujimoto, T., Walker, J.T., Jr., Spatz, M., Klatzo, I.: Pathophysiologic aspects of cerebral edema. This volume, pp. 171–180
Go, G.K., Spatz, M., Klatzo, I., Pappius, H.M.: The development of ischemic cerebral edema in gerbils. In: Proc. Internat. Symposium: Pathophysiological, Biochemical and Morphological Aspects of Cerebral Ischemia and Arterial Hypertension. Warsaw, Sept. 18–20, 1975. Neuropath. Pol. In press
Ito, U., Spatz, M., Walker, J.T., Jr., Klatzo, I.: Experimental cerebral ischemia in Mongolian gerbils. I. Light microscopic observations. Acta neuropath. (Berl.) 32, 209–223 (1975)
Ito, U., Go, G.K., Walker, J.T., Jr., Spatz, M., Klatzo, I.: Experimental cerebral ischemia in Mongolian gerbils. III. Behavior of the blood-brain barrier. Acta neuropath. (Berl.) 34, 1–6 (1976)
Kahn, K.: The natural course of experimental cerebral infarction in the gerbil. Neurology (Minneap.) 22, 510–515 (1972)
Klatzo, I.: Presidential Address: Neuropathological aspects of brain edema. J. Neuropath. exp. Neurol. 26, 1–14 (1967)
Mrsulja, B.B., Mrsulja, B.J., Ito, U., Walker, J.T., Jr., Spatz, M., Klatzo, I.: Experimental cerebral ischemia in Mongolian gerbils. II. Changes in carbohydrates. Acta neuropath. (Berl.) 33, 91–103 (1975)
Mrsulja, B.B., Mrsulja, B.J., Spatz, M., Klatzo, I.: Action of cerebral ischemia on decreased levels of 3-methoxy-4-hydroxy-phenylethylglycol sulfate, homovanillic acid and 5-hydroxy-indoleacetic acid produced by pargyline. Brain Res. 98, 388–393 (1975)
Oldendorf, W.H.: Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard. Brain Res. 24, 372–376 (1970)
Spatz, M., Go, G.K., Klatzo, I.: The effect of ischemia on the brain uptake of 14C glucose analogues and 14C sucrose. In: Pathology of Cerebral Microcirculation. Cervós-Navarro, J. (ed.). Berlin: Walter de Gruyter 1974, pp. 361–366
Westergaard, E., Go, G.K., Klatzo, I., Spatz, M.: Increased permeability of cerebral vessels to horseradish peroxidase induced by ischemia in Mongolian gerbils. Acta neuropath. (Berl.). In press, 1976
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Spatz, M., Fujimoto, T., Go, G.K. (1976). Transport Studies in Ischemic Cerebral Edema. In: Pappius, H.M., Feindel, W. (eds) Dynamics of Brain Edema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66524-0_30
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DOI: https://doi.org/10.1007/978-3-642-66524-0_30
Publisher Name: Springer, Berlin, Heidelberg
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