Summary
The effect of vasogenic brain edema on SH-group levels and the influence of exogenous reduced and oxidized glutathione on the dynamics of development of brain edema were studied. In the first 24 h after cold injury a significant decrease in the total, non-protein and protein, SH groups was observed in the damaged hemisphere. During the next 24 h a slow increase of SH groups in the injured hemisphere to the control level was noted. Intravenously injected reduced glutathione (GSH) reduced the area of the brain edema and decreased the water content of the damaged hemisphere. In animals treated with oxidized glutathione (G-SS-G) foci of the lesion as well as the areas of brain edema were larger than in the control animals, but were not accompanied by increased water content. These results suggest that SH groups may play some protective role in stabilizing cellular membranes in nervous tissue and in that way influence the development of brain edema.
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© 1976 Springer-Verlag Berlin · Heidelberg
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Rap, Z.M., Wideman, J. (1976). Changes in the Sulfhydryl Group Level and Influence of Exogenous Glutathione on Dynamics of Vasogenic Brain Edema. In: Pappius, H.M., Feindel, W. (eds) Dynamics of Brain Edema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66524-0_28
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DOI: https://doi.org/10.1007/978-3-642-66524-0_28
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-08009-1
Online ISBN: 978-3-642-66524-0
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