The Role of Monoamines in the Development of Cold-Induced Edema
Our results show that even the experimentally induced high concentrations of exogenous 5-HT in the brain tissue during the early phase of edema formation are not able to increase the amount of fluid accumulation in the normal and injured brain tissue. The changes of the endogenous 5-HT levels in the blood and the brain tissue result in similar hemispheric water and RISA differences between the injured and uninjured half of the brain. Moreover, 5-HT concentrations elevated by 100% failed to produce detectable edema in the normal brain tissue of the rat.
We believe, therefore, that our data are convincing enough to change the focus of future 5-HT studies from the site of the blood-brain barrier and the dynamic process of edema formation to the neuronal cell and its functional disturbances after brain injury.
KeywordsPermeability Creatinine Serotonin Neurol Tryptophan
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