The Role of Monoamines in the Development of Cold-Induced Edema
Our results show that even the experimentally induced high concentrations of exogenous 5-HT in the brain tissue during the early phase of edema formation are not able to increase the amount of fluid accumulation in the normal and injured brain tissue. The changes of the endogenous 5-HT levels in the blood and the brain tissue result in similar hemispheric water and RISA differences between the injured and uninjured half of the brain. Moreover, 5-HT concentrations elevated by 100% failed to produce detectable edema in the normal brain tissue of the rat.
We believe, therefore, that our data are convincing enough to change the focus of future 5-HT studies from the site of the blood-brain barrier and the dynamic process of edema formation to the neuronal cell and its functional disturbances after brain injury.
KeywordsBrain Edema Edema Formation Water Sodium Injured Hemisphere Injured Brain Tissue
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- 2.Bulle, P.H.: Effect of reserpine and chlorpromazine in prevention of cerebral edema and reversible cell damage. Proc. Soc. exp. Biol. (N.Y.) 94, 553–556 (1957)Google Scholar
- 3.Carlsson, A.: Drugs which block the storage of 5-hydroxytryptamine and related amines. In: Handbook of Experimental Pharmacology. Eichler, O., Farah, A. (eds.). Berlin-Heidelberg-New York: Springer-Verlag 1966, Vol. XIX, pp. 529–592Google Scholar
- 5.Fenske, A., Kreysch, G., Tack, A., Reulen, H.J.: The influence of 5-hydroxytryptamine on brain edema and microcirculation. In: Pathology of Cerebral Microcirculation. Cervbs-Navarro, J. (ed). Berlin and New York: W. de Gruyter 1974, pp. 380–385Google Scholar
- 6.Grimson, B.S., Robinson, S.C., Danford, E.T., Tindall, G.T., Greenfield, J.C., Jr.: Effect of serotonin on internal and external carotid artery blood flow in the baboon. Amer. J. Physiol. 216, 50–55 (1969)Google Scholar
- 7.Klatzo, I.: Pathophysiological aspects of brain edema. In: Steroids and Brain Edema. Reulen, H.J., Schürmann, K. (eds.). Berlin-Heidelberg-New York: Springer-Verlag 1972, pp. 1–8Google Scholar
- Reulen, H.J., Graham, R., Fenske, A., Tsuyumu, M., Klatzo, I.: The role of tissue pressure and bulk flow in the formation and resolution of cold-induced edema. This volume, pp. 103–112Google Scholar