Summary
In normal animals there seems to be little or no bulk flow across CNS capillaries and through neural tissue. The resistance to volume flow at each of these sites seems to be too great for significant convective transport to take place; yet, during the time course of cerebral edema, relatively large flows of fluid do occur both at the capillaries and through the ECS. Such changes in bulk fluid movement probably involve alterations in the hydraulic conductivity of cerebral blood vessels, the solute reflection coefficients and concentration differences across the blood-brain barrier and the hydraulic conductivity of the tissue ECS (the latter as a result of increases in the size and channel width of the space).
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Fenstermacher, J.D., Patlak, C.S. (1976). The Movements of Water and Solutes in the Brains of Mammals. In: Pappius, H.M., Feindel, W. (eds) Dynamics of Brain Edema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66524-0_16
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DOI: https://doi.org/10.1007/978-3-642-66524-0_16
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