Responses of Cortical Vein Wedge Pressure, Ventricular Fluid Pressure, and Brain Tissue Pressure to Elevation of Arterial Blood Pressure Under Conditions of Hyperventilation and Freezing Injury to the Brain

Abstract

As observed in a previous study (1), rises of cortical vein wedge pressure and ventricular fluid pressure concomitant to elevation of arterial blood pressure are increased after infliction of a freezing injury to the brain due to impairment of vasomotor autoregulation and consequent increased propagation of arterial blood pressure into the capillary bed of the cold-injured region. Since the impairment of vasomotor autoregulation seems to enhance the deleterious effect of the arterial blood pressure upon the development of vasogenic brain, edema, it was the aim of this study to investigate whether hyperventilation might influence vasomotor activity under the conditions of brain injury.