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Immunological Aspects of Gastro-Intestinal Pathology

  • Conference paper
Pathology of the Gastro-Intestinal Tract

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 63))

Abstract

The bulk of the investigations into the immunological status of patients with gastro-intestinal disease have concerned evaluation of changes in circulating antibodies. In ulcerative colitis and Crohn’s disease for example antibody formation to food antigens (Taylor and Truelove, 1961; Wright and Truelove, 1965, 1966) to bacterial antigens (Lagercrantz et al., 1968; Thayer et al., 1969) and to colonic epithelial cell antigens (Broberger and Perlmann, 1959, 1962; Harrison, 1965; Marcusson and Nerup, 1973) have been described. Similarly, in coeliac disease serum antibodies against gluten, fractions of it, and against reticulin and other proteins have been identified (Seah et al., 1971). There have also been studies of peripheral blood lymphocytes in a variety of disorders. Although lymphocyte numbers do not alter, changes in function have been recorded. Lymphocyte cytotoxicity for colonic epithelium has been described in ulcerative colitis and Crohn’s disease (Watson et al., 1966; Shorter et al., 1968). Transformation of the lymphocyte to a blastoid form in response to non-specific antigens, for example, phytohaemaglutinin and to specific fractions of bacterial and colonic cells has been noted (Hinz et al., 1967; Stefani and Fink, 1967). Other lymphocyte functions such as the skin response to application of dinitrochlorobenzene (DNCB) (Verrier-Jones et al., 1969) to injections of Tuberculin (Fletcher and Hinton, 1967), and Kveim reagent (Mitchell et al., l970; Siltzbach et al., 1971) have also been studied. The results have often been contradictory and have not added significantly to our understanding of the immunological mechanisms concerned in gastro-intestinal diseases.

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Authors
  1. J. M. Skinner
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  2. R. Whitehead
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Editors and Affiliations

  1. Pathology Department, St. Mark’s Hospital, City Road, London, EC1V 2PS, Great Britain

    B. C. Morson (Professor Dr.) (Professor Dr.)

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Skinner, J.M., Whitehead, R. (1976). Immunological Aspects of Gastro-Intestinal Pathology. In: Morson, B.C. (eds) Pathology of the Gastro-Intestinal Tract. Current Topics in Pathology, vol 63. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66481-6_8

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  • DOI: https://doi.org/10.1007/978-3-642-66481-6_8

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