On the Endoendothelial Fibrin Layer, Fibrin(ogen) Polymerization, and Thrombosis

  • A. L. Copley
Conference paper


Two concepts are presented. One concerns the presence of fibrin in the so-called endoendothelial lining on the endothelial cells facing the vascular lumen, as well as fibrin as a constituent of associated structures, such as diaphragms of fenestrae, the stomatal diaphragms of plasmalemmal vesicles and the basement membrane. The other concept concerns the initiation of thrombosis due to an adsorption process of fibrinogen and of other plasma proteins and the polymerization of fibrinogen without thrombin participation upon the application of shearing forces.


Shear Rate Apparent Viscosity Fibrin Coagulation Wall Shear Rate Needed Information 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. COPLEY, A.L.: Hemorheological aspects of the endothelium-plasma interface. Microvasc. Res. 8, 192–212 (1974).PubMedCrossRefGoogle Scholar
  2. COPLEY, A.L., KING, R.G.: Polymolecular layers of fibrinogen systems and the genesis of thrombosis. In: Hemorheology and Thrombosis (ed. A.L. Copley and S. Okamoto). Oxford-New York: Pergamon Press. Thrombosis Res., Suppl. 2, 393–409 (1976).Google Scholar
  3. COPLEY, A.L.: On cement fibrin, a proposed constituent of the capillary basement membrane, and on lesions in the capillary wall in diabetes mellitus. In: Diabetes. Proc. 6. Congr. Internat. Diabetes Fed., Stockholm, 1967 (ed. J. Östman and R.D.G. Milner), 606–609. Amsterdam: Excerpta Medica Foundation 1969.Google Scholar
  4. OKA, S.: Poiseuille award lecture: Present status of hemorheological theory. Biorheology 12, 157–168 (1975).PubMedGoogle Scholar
  5. COPLEY, A.L., SCHEINTHAL, B.M.: Nature of the endoendothelial layer as demonstrated by ruthenium red. Exper. Cell Research 59, 491–492 (1970).CrossRefGoogle Scholar
  6. PALADE, G.E.: Small pore and large pore systems in capillary permeability. In: Hemorheology (ed. A.L. Copley), 703–718. Oxford-New York: Pergamon Press (1968). Personal communication (1975).Google Scholar
  7. COPLEY, A.L., HANIG, J.P., LUCHINI, B.W., ALLEN, R.J. Jr.: On the capillary permeability enhancing activity of isolated fibrinopeptides and their role in the physiology of the blood capillary wall. Bibl. Anat. 8, 475–481 (1967).Google Scholar
  8. COPLEY, A.L.: Non-Newtonian behavior of surface layers of human plasma protein systems and a new concept of the initiation of thrombosis. Biorheology 8, 79–84 (1971).PubMedGoogle Scholar
  9. SMITH, L.E., MORRISSEY, B.W.: Personal communications (1975).Google Scholar
  10. HARTERT, H.H.: New aspects of blood clotting and thrombosis. Investigations with the method of rheosimulation. In: Hemorheology and Thrombosis (ed. A.L. Copley and S. Okamoto). Oxford-New York: Pergamon Press 1976. Thrombosis Res., Suppl. 2, 381-393 (1976).Google Scholar
  11. COPLEY, A.L.: Bleeding time, other in vivo hemostasis tests and the arrest of hemorrhage. Thrombosis Res. 4, 1–23 (1974).CrossRefGoogle Scholar
  12. FLOREY, H.W.: The transport of materials across the capillary wall. Quart. J. Exp. Physiol. 49, 117 (1964).Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1976

Authors and Affiliations

  • A. L. Copley

There are no affiliations available

Personalised recommendations