Abstract
Embryonic failure may result from a variety of environmental influences. Certainly experimental mammalian teratogenesis has demonstrated that a broad spectrum of stimuli can induce a variety of morphological developmental defects in experimental animals. There are clearly identifiable environmental teratogenic stimuli, such as rubella, drugs, radiation, etc., which deleteriously affect human embryonic development.
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References
Brinster, R.L., Cross, P.C.: Effect of copper on the pre-implantation mouse embryo. Nature (Lond.) 238, 298–399 (1972).
Carpenter, S.J., Ferm, V.H.: Embryogenesis of sacral-tail malformations in lead-treated hamsters. Anat. Rec. 178, 323 (1974).
Carpenter, S.J., Ferm, V.H., Gale, T.F.: Placental permeability of inorganic lead in the golden hamster: Radioautographic evidence. Experientia (Basel) 29, 311–313 (1973).
Chang, C.C., Tatum, H.I., Kincl, F.A.: The effect of intrauterine copper and other metals on implantation in rats and hamsters. Fertil. and Steril. 21, 274–278 (1970).
Dutt, B., Mills, C.F.: Reproductive failure in rats due to copper deficiency. J. comp. Path. 70, 120–125 (1960).
Ferm, V.H., Carpenter, S.J.: Developmental malformations resulting from the administration of lead salts. Exp. molec. Path. 7, 208–213 (1967).
Ferm, V.H.: Developmental malformations induced by cadmium: A study of timed injections during embryogenesis. Biol. Neonate 19, 101–107 (1971).
Ferm, V.H., Carpenter, S.J.: The relationship of cadmium and zinc in experimental mammalian teratogenesis. Lab. Invest. 18, 429–432 (1968).
Ferm, V.H., Carpenter, S.J.: Teratogenic and embryopathic effects of indium, gallium,and germanium. Toxicol. appl. Pharmacol. 16, 166–170 (1970).
Ferm, V.H., Ferm, D. W.: The specificity of the teratogenic effect of lead. Life Sci. 10, 35–39 (1971).
Ferm, V.H., Hanlon, D.P.: Toxicity of copper salts in hamster embryonic development. Biol. Reprod. 11, 97–101 (1974a).
Ferm, V.H., Hanlon, D.P.: Placental transfer of zinc in early embryogenesis. J. Reprod. and Fertil. 39, 49–52 (1974b).
Ferm, V.H., Hanlon, D.P., Urban, J.: The permeability of the hamster placenta to radioactive cadmium. J. Embryol. exp. Morph. 22, 107–113 (1970).
Ferm, V.H., Saxon, A., Smith, B. W.: The teratogenic profile of sodium arsenate in the golden hamster. Arch. env. Hlth 22, 557–560 (1971).
Grüneberg, H.: The Pathology of Development. Oxford: Blackwell Scientific Publications 1963.
Holmberg, R.E., Ferm, V.H.: Inter-relationships of selenium, cadmium and arsenic in mammalian teratogenesis. Arch. env. Hlth 18, 873–877 (1969).
Hurley, L., Swenerton, H.: Congenital malformations resulting from zinc deficiency in rats. Proc. Soc. exp. Biol. (N.Y.) 123, 692–696 (1966).
O’Dell, B.L.: Trace elements in embryonic development. Fed. Proc. 27, 199–204 (1968).
Zipper, J., Medel, M., Prager, R.: Suppression of fertility by intrauterine copper and zinc in rabbits. Amer. J. Obstet. Gynec. 22, 107–113 (1970).
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Ferm, V.H. (1976). Teratogenic Effects and Placental Permeability of Heavy Metals. In: Gropp, A., Benirschke, K. (eds) Developmental Biology and Pathology. Current Topics in Pathology, vol 62. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66458-8_10
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DOI: https://doi.org/10.1007/978-3-642-66458-8_10
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