Abstract
The process of fertilization is a complex series of events, especially when the term is used to include the maturation of the oocyte, and there are numerous points at which irregularities can occur. Errors of fertilization can also arise from anomalies in spermatozoa (and Cohen, 1973, adduces evidence that indeed most spermatozoa are abnormal), and so sperm maturation contributes a further quota of intricacy to the picture. Additional possibilities arise during cleavage. The well-recognized consequence is a variety of chromosomal errors — a hazard that has been appreciated at least since the work of the Hertwigs on the sea urchin nearly a century ago.
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Austin, C.R. (1976). Developmental Anomalies Arising from Errors of Fertilization and Cleavage. In: Gropp, A., Benirschke, K. (eds) Developmental Biology and Pathology. Current Topics in Pathology, vol 62. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66458-8_1
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DOI: https://doi.org/10.1007/978-3-642-66458-8_1
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