Abstract
There are two different levels at which mitotic activity can be controlled in higher organisms. The first level concerns the immature (undifferentiated) cells in which the steps of the mitotic cycle are controlled, whereas, control at the other level concerns those processes that lead to terminal differentiation (cell maturation), and thereby to cessation of mitotic activity. For control at this level, studies in the plant endosperm and radiation experiments suggest the existence of a mechanism that enables the cell progenies, under certain environmental conditions, to proceed autonomously through a certain number of mitotic cycles and thereafter to differentiate. In normal cells of higher multicellular organisms, accordingly, the ability to restrain mitotic activity resides within the cells.
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von Wangenheim, KH. (1976). Radiation and Endocellular Control of Cell Proliferation. In: Kiefer, J. (eds) Radiation and Cellular Control Processes. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66455-7_37
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DOI: https://doi.org/10.1007/978-3-642-66455-7_37
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