Skip to main content

Radiation and Endocellular Control of Cell Proliferation

  • Conference paper
Radiation and Cellular Control Processes

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

  • 53 Accesses

Abstract

There are two different levels at which mitotic activity can be controlled in higher organisms. The first level concerns the immature (undifferentiated) cells in which the steps of the mitotic cycle are controlled, whereas, control at the other level concerns those processes that lead to terminal differentiation (cell maturation), and thereby to cessation of mitotic activity. For control at this level, studies in the plant endosperm and radiation experiments suggest the existence of a mechanism that enables the cell progenies, under certain environmental conditions, to proceed autonomously through a certain number of mitotic cycles and thereafter to differentiate. In normal cells of higher multicellular organisms, accordingly, the ability to restrain mitotic activity resides within the cells.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Baratti, Z., Küntzel, H.: Cooperation of mitochondrial and nuclear genes specifying the mitochondrial genetic apparatus in Neurospora crassa. Proc. Nat. Acad. Sci. USA 69, 1371–1374 (1972)

    Article  Google Scholar 

  • Baugnet-Mahieu, L., Goutier, R., Baes, C.: Comparative sensitivity of the nuclear and mitochondrial DNA syntheses to X-irradiation and to the administration of a sulfhydryl radioprotector (AET) in normal and regenerating rat liver. Biophysik 6, 357–366 (1970)

    Article  PubMed  CAS  Google Scholar 

  • Briggs, R., King, T.J.: Nucleocytoplasmic interactions in eggs and embryos. In: The Cell. Brachet, J., Mirsky, A.E. (ed.). New York, London: Academic Press, 1959, Vol. I, pp. 537–617

    Google Scholar 

  • Chase, J.W.: Mitochondrial RNAs in eggs and embryos of Xenopus. Carnegie Inst. Wash. Yearbook 69, 578–580 (1971)

    Google Scholar 

  • Clowes, F.A.L.: X-irradiation of root meristems. Ann. Botany 27, 343–352 (1963)

    Google Scholar 

  • Clowes, F.A.L., Juniper, B.E.: The fine structure of the quiescent centre and neighbouring tissues in root meristems. J. Exp. Botany 15, 622–630 (1964)

    Article  Google Scholar 

  • Fantes, P.A., Grant, W.D., Pritchard, R.H., Sudbery, P.E., Wheals, A.E.: The regulation of cell size and the control of mitosis. J. Theor. Biol. 50, 213–244 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Glücksmann, A.: Preliminary observations on the quantitative examination of human biopsy material taken from irradiated carcinomata. Brit. J. Radiol. 14, 187–198 (1941)

    Article  Google Scholar 

  • Glücksmann, A.: Histological features in the local radiocurability of carcinomas. In: The Biological and Clinical Basis of Radiosensitivity. Friedman, M. (ed.). Springfield, Ill.: C.C Thomas, 1974, pp. 203–219

    Google Scholar 

  • Haber, A.H., Foard, D.E.: Further studies of gamma irradiated wheat and their relevance to use of mitotic inhibition for developmental studies. Amer. J. Botany 51, 151–159 (1964)

    Article  CAS  Google Scholar 

  • Hartmann, M.: Ãœber experimentelle Unsterblichkeit von Protozoen-Individuen. Ersatz der Fortpflanzung von Amoeba proteus durch fortgesetzte Regeneration. Zool. Jahrb. Abtlg. Allg. Zool. u. Physiol. 45, 973–987 (1928)

    Google Scholar 

  • Hertwig, R.: Ãœber Kombination von Zell- und Kerngröße und ihre Bedeutung für die geschlechtliche Differenzierung und die Teilung der Zelle. Biol. Zentralbl. 23, 108–119 (1903)

    Google Scholar 

  • Klein, G., Forssberg, A.: Studies on the effect of X-rays on the biochemistry and cellular composition of ascites tumors. Exp. Cell Res. 6, 211–220 (1954)

    Article  PubMed  CAS  Google Scholar 

  • Lord, B.I., Lajtha, L.G.: Control of cell proliferation in haemopoetic tissue. Haematologia 39, 259–291 (1974)

    Google Scholar 

  • Müntzing, A.: The evolutionary significance of autopolyploidy. Hereditas 21, 263–378 (1936)

    Google Scholar 

  • Revesz, L., Norman, U.: Differential radiosensitivity in a neoplastic cell population. In: Radiation Effects in Physics, Chemistry and Biology. Ebert, M., Howard, A. (eds.). Amsterdam: North Holland, 1963, pp. 136–151

    Google Scholar 

  • Sachsenmaier, W., Dönges, K.H., Rupff, H., Czihak, G.: Advanced initiation of synchronous mitoses in Physarum polycephalum following UV-irradiation. Z. Naturforsch. 25b, 866–871 (1970)

    Google Scholar 

  • Wangenheim, K.-H. von: Zur Ursache der Abortion von Samenanlagen in Diploid-Polyploid-Kreuzungen. II. Unterschiedliche Differenzierung von Endospermen mit gleichem Genom. Z. Vererbungslehre 93, 319–334 (1962)

    Article  Google Scholar 

  • Wangenheim, K.-H. von: Entwicklungsphysiologische Untersuchungen über die Beteiligung nukleärer und extranukleärer Erbträger an der Phänogenese. Berlin Dtsch. Bot. Ges. 80, 228–236 (1967)

    Google Scholar 

  • Wangenheim, K.-H. von: Zur Bedeutung extrachromosomaler Erbträger für die Steuerung von Nucleinsäurestoffwechsel, Zelldifferenzierung und Mitosetätigkeit. Berlin Dtsch. Bot. Ges. 82, 191–199 (1969a)

    Google Scholar 

  • Wangenheim, K.-H. von: Wirkung von Röntgenbestrahlung auf Entwicklung und Ultrastruktur von Zellen des Weizenkeimlings. Radiat. Botany 9, 179–193 (1969b)

    Article  Google Scholar 

  • Wangenheim, K.-H. von: Genetische Defekte und Strahlenschädigung. Die Unterbindung der Mitose, ihre mutationsunabhängige Ursache und deren Bedeutung für Fragen der Zeilproliferation, der Strahlenresistenz und der Strahlenstimulation. Radiat. Botany 10, 469–490 (1970)

    Article  Google Scholar 

  • Wangenheim, K.-H. von: A major component of the radiation effect: Interference with endocellular control of cell proliferation and differentiation. Int. J. Radiat. Biol. 27, 7–30 (1975)

    Article  CAS  Google Scholar 

  • Wangenheim, K.-H. von: A mechanism for the endocellular control of cell differentation and cell proliferation. J. Theor. Biol. 59, 205–222 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Wangenheim, K.-H. von, Peloquin, S.J., Hougas, R.W.: Embryological investigations on the formation of haploids in the potato (Solanum tuberosum). Z. Vererbungslehre 91, 391–399 (1960)

    Article  Google Scholar 

  • Wangenheim, K.-H. von, Walther, F., Kern, H.: DNA-Synthese nach Bestrahlung mit hohen Röntgendosen und Spindelhemmung. Z. f. Pflanzenzüchtung 64, 6–19 (1970)

    Google Scholar 

  • Welsh, R.S., Vyska, K.: Properties of a new form of DNA from whole calf thymus nuclei: evidence for reactive, special sites in DNA. Arch. Biochem. Biophys. 142, 132–143 (1971)

    Article  PubMed  CAS  Google Scholar 

  • Whiting, P.W., Kayhart, M.: A wasp for study of visible mutation rates. Radiat. Res. 1, 566–567 (1954)

    Google Scholar 

  • Whiting, R.A.: Androgenesis as evidence for the nature of X-ray induced injury. Radiat. Res. 2, 71–78 (1955)

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1976 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

von Wangenheim, KH. (1976). Radiation and Endocellular Control of Cell Proliferation. In: Kiefer, J. (eds) Radiation and Cellular Control Processes. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66455-7_37

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-66455-7_37

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-66457-1

  • Online ISBN: 978-3-642-66455-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics