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Chemistry of Anti-H1 Histamine Antagonists

  • Chapter
Histamine II and Anti-Histaminics

Abstract

In this Chapter a survey and discussion of the chemistry of compounds which antagonize the effects of histamine at H1 receptors are presented. Ellis (1969) has compiled an extensive list of reviews on histamine, 5-hydroxytryptamine, and their antagonists, several of which include some account of the chemical aspects of antihistaminics. Here, attention is drawn in particular to the reviews of Witiak (1970), Doerge (1971), and Melville (1973); an extensive review of earlier work is available in Czech (Protiva, 1955). Developments in the field are presented periodically in Annual Reports in Medicinal Chemistry sponsored by the Division of Medicinal Chemistry of the American Chemical Society, e.g. Tozzi (1972).

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  1. Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14.100, Ribeirão Preto, S.P., Brazil

    Mauricio Rocha e Silva

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Casy, A.F. (1978). Chemistry of Anti-H1 Histamine Antagonists. In: Rocha e Silva, M. (eds) Histamine II and Anti-Histaminics. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 18 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66445-8_4

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