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Metabolism and Excretion of Histamine

  • Chapter
Histamine II and Anti-Histaminics

Abstract

The formation of histamine in mammals is, to our knowledge, a unique process. The reaction is catalyzed by histidine decarboxylase, an enzyme which may undergo changes in activity as part of the adaptation of animals to variations of internal or external environment. The inducible type of histidine decarboxylase has been detected in all tissues of commonly studied species, and in tested tissues of other species. From the distribution and inducible characteristics of histidine decarboxylase, physiologic roles for histamine have been proposed in microcirculatory control, some cases of rapid growth, and as a neurotransmitter in brain.

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Authors
  1. R. W. Schayer
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  2. H. Wetterqvist
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  3. Mauricio A. Beaven
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  4. Z. Horakova
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Editors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14.100, Ribeirão Preto, S.P., Brazil

    Mauricio Rocha e Silva

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Schayer, R.W., Wetterqvist, H., Beaven, M.A., Horakova, Z. (1978). Metabolism and Excretion of Histamine. In: Rocha e Silva, M. (eds) Histamine II and Anti-Histaminics. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 18 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66445-8_3

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  • DOI: https://doi.org/10.1007/978-3-642-66445-8_3

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