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  • Chapter
Histamine II and Anti-Histaminics

Abstract

During the past eight decades, histamine has, from time to time, been both invoked and challenged as a physiologic regulator of the cardiovascular system (Lewis, 1927; Dale, 1929a, b; Best and McHenry, 1931; Burn, 1950; Schayer, 1968; Altura and Zweifach, 1965 a, b; Rocha e Silva, 1966; Kahlson and Rosengren, 1968, 1971; Altura and Altura, 1974a; Levi et al., 1976; Powell and Brody, 1976). Although certain aspects of the actions of histamine on some parts of the cardiovascular system have been reviewed previously (Rocha e Silva, 1966; Beck, 1965; Somlyo and Somlyo, 1970; Altura, 1971, 1976, 1977; Altura and Altura, 1974a; Shepherd and VanHoutte, 1975, 1977), none of these has analyzed the complex, multifaceted effects this biogenic amine exerts on the systemic, cardiac and regional vasculatures, including those on the microcirculation and vascular smooth muscle. Moreover, species differences among mammals with respect to some of these actions have not been critically evaluated in the past.

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Authors
  1. B. Mauricio Altura
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  2. S. Halevy
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  3. L. R. Johnson
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Editors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14.100, Ribeirão Preto, S.P., Brazil

    Mauricio Rocha e Silva

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Altura, B.M., Halevy, S., Johnson, L.R. (1978). Pharmacological Actions. In: Rocha e Silva, M. (eds) Histamine II and Anti-Histaminics. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 18 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66445-8_1

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  • DOI: https://doi.org/10.1007/978-3-642-66445-8_1

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