Abstract
There is considerable evidence that 3′,5′-cyclic nucleotides modulate contractile properties of smooth muscle cells (1, 4, 5, 17, 19). It has been suggested that adenosine 3′,5′ monophosphate (cAMP), and guanosine 3′,5′ monophosphate (cGMP) may influence the level of intracellular free Ca++ ions responsible for smooth muscle contraction, in opposite directions (1, 10, 16). However, liberation of Ca++ ions triggering and controlling contraction may in turn regulate CAMP and (or) cGMP contents, since, within physiologic limits, variations of Ca++ activity influence the enzymatic reactions involved in the synthesis and degradation of both cyclic nucleotides (2, 13, 14, 18). Contradictions between the relevant observations suggest that the role of calcium in the regulation of cyclic nucleotide metabolism may vary from one tissue to the other.
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Stoclet, JC., Michon, T., Scheftel, JM., Demesy-Waeldele, F. (1976). Calcium and Regulation of Cyclic Nucleotides in Rat Aorta. In: Betz, E. (eds) Ionic Actions on Vascular Smooth Muscle. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66427-4_7
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DOI: https://doi.org/10.1007/978-3-642-66427-4_7
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