Effect of Sodium Nitroprusside, Temperature, and Calcium Withdrawal on the Relaxation Speed of Vascular Smooth Muscle

  • V. A. W. Kreye
  • J. B. Lüth


Sodium nitroprusside (NP; Nipruss, Nipride) is a powerful inhibitor of excitation-contraction coupling in vascular smooth muscle. Our older findings on its cellular mode of action were published elsewhere (5). Recently, we have begun to study the relaxation process of slowly relaxing arterial strips by measuring the effect of NP and other measures on the speed of relaxation. This is a first and preliminary report from current work, and some of the findings and conclusions in this presentation might be liable to alterations with advancing work.


Vascular Smooth Muscle Sodium Nitroprusside Caffeine Contraction Arterial Strip Norepinephrine Induce Contraction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    DOST, F.H.: Grundlagen der Pharmakokinetik. Stuttgart: Thieme 1968, 2nd ed.Google Scholar
  2. 2.
    FABIATO, A., FABIATO, F.: Relaxing and inotropic effects of cyclic AMP on skinned cardiac cells. Nature (Lond.) 253, 556–558 (1975).CrossRefGoogle Scholar
  3. 3.
    JONES, A.W., SOMLYO, A.P., SOMLYO, A.V.: Potassium accumulation in smooth muscle and associated ultra-structural changes. J. Physiol. (Lond.) 232, 247–273 (1973).Google Scholar
  4. 4.
    KATZ, A.M., TADA, M., KIRCHBERGER, M.A.: Control of calcium transport in the myocardium by the cyclic AMP-protein kinase system. Advanc. Cycl. Nucl. Res. 5, 453–472 (1975).Google Scholar
  5. 5.
    KREYE, V.A.W., BARON, G.D., LüTH, J.B., Schmidt-Gayk, H.: Mode of action of sodium nitroprusside on vascular smooth muscle. Naunyn-Schmiedeberg’s Arch. Pharmacol. 288, 381–402 (1975).CrossRefGoogle Scholar
  6. 6.
    KREYE, V.A.W., WEISSAUER, R.: Calculation of the optimal angle to cut helical strips from small arteries. To be published.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1976

Authors and Affiliations

  • V. A. W. Kreye
  • J. B. Lüth

There are no affiliations available

Personalised recommendations