Skip to main content
SpringerLink
Log in
Book cover

Ionic Actions on Vascular Smooth Muscle pp 124–131Cite as

Effect of Phosphodiesterase-Inhibition on Smooth Muscle Tone

  • Chapter

Abstract

In most smooth muscles stimulation of β-adrenergic receptors results in an increase in cyclic AMP (cAMP) levels that precedes relaxation. There is a large body of evidence suggesting that cAMP mediates the relaxant effects produced by these drugs (1, 3).

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. ANDERSSON, R.G.G.: Cyclic AMP and calcium ions in mechanical and metabolic responses of smooth muscles; influence of some hormones and drugs. Acta physiol. scand. 382, Suppl. 1–59 (1972).

    CAS  Google Scholar 

  2. ANDERSSON, R.G.G., NILSSON, K.: Cyclic AMP and calcium in relaxation in intestinal smooth muscle. Nature (Lond.) 238, 119–120 (1972).

    Article  CAS  Google Scholar 

  3. BäR, H.-P.: Cyclic nucleotides and smooth muscle. Adv. cycl. Nucl. Res. 4, 195–237 (1974).

    Google Scholar 

  4. BUEDING, E., BüLBRING, E.: The inhibitory action of adrenaline. Biochemic and biophysic observations. In: Pharmacology of Smooth Muscle. Bülbring, E. (Ed.) Pergamon Press 1964, pp. 37–54.

    Google Scholar 

  5. BüLBRING, E., TOMITA, T.: Effect of calcium, barium and magnesium on the action of adrenaline in the smooth muscle of guinea-pig taenia coli. Proc. roy. Soc. B 172, 103–111 (1969).

    Article  Google Scholar 

  6. FLECKENSTEIN, A.: Specific inhibitors and promoters of calcium action in the excitation-contraction coupling of heart muscle and their role in the prevention of production of myocardial lesions. In: Calcium and the Heart. Harris, P., Opie, L. (Eds.) London-New York: Academic Press 1971.

    Google Scholar 

  7. FRANKENHäUSER, B., HODGKIN, A.L.: The action of calcium on the electrical properties of squid axons. J. Physiol. (Lond.) 137, 218–244 (1957).

    Google Scholar 

  8. GILMAN, A.G.: A protein binding assay for adenosine 3′,5′-cyclic monophosphate. Proc. nat. Acad. Sci. (Wash.) 67, 305–312 (1970).

    Article  CAS  Google Scholar 

  9. HARPER, J.F., BROOKER, G.: Femtomole sensitive radioimmunoassay for cyclic AMP and cyclic GMP after 2′O acetylation by acetic anhydride in aqueous solution. J. cycl. Nucl. Res. 1, 207–218 (1975).

    CAS  Google Scholar 

  10. KATZ, A.M., TADA, M., KIRCHBERGER, M.A.: Control of calcium transport in the myocardium by the cyclic AMP-protein kinase system. Adv. cycl. Nucl. Res. 5, 453–472 (1975).

    CAS  Google Scholar 

  11. KUKOVETZ, W.R., JUAN, H., PöCH, G.: Zum Mechanismus der Papaverinwirkung auf isolierte Koronargefäße. Naunyn-Schmiedeberg’s Arch. Pharmacol. 264, 262 (1969a).

    Article  CAS  Google Scholar 

  12. KUKOVETZ, W.R., PöCH, G., JUAN, H.: The role of phosphodiesterase inhibition in the mechanism of coronary dilatation by drugs. Abstr. 4th Int. Congr. Pharmacol. Basel, Switzerland: Schwabe (1969b).

    Google Scholar 

  13. KUKOVETZ, W.R., PöCH, G.: Inhibition of cyclic 3′,5′-nucleotide-phosphodiesterase as a possible mode of action of papaverine and similarly acting drugs. Naunyn-Schmiedeberg’s Arch. Pharmacol. 267, 189–194 (1970).

    Article  CAS  Google Scholar 

  14. KUKOVETZ, W.R., PöCH, G., HOLZMANN, S., PAIETTA, E.: Zum Wirkungs-mechanismus von Bencyclan an der glatten Muskulatur. Arzneim.-Forsch (Drug Res.) 25, 722–726 (1975).

    CAS  Google Scholar 

  15. MARSHALL, J.M., KROEGER, E.A.: Adrenergic influences on uterine smooth muscle. Phil. Trans. B 265, 135–148 (1973).

    Article  CAS  Google Scholar 

  16. PöCH, G.: Assay of phosphodiesterase with radioactively labelled cyclic 3′,5′-AMP as substrate. Naunyn-Schmiedeberg’s Arch. Pharmacol. 268, 272–294 (1971).

    Article  Google Scholar 

  17. PöCH, G., KUKOVETZ, W.R.: Role of cyclic AMP in drug-induced coronary vasodilatation. Adv. cycl. Nucl. Res. 1, 195–211 (1972).

    Google Scholar 

  18. PöCH, G., UMFAHRER, W.: Differentiation of intestinal smooth muscle relaxation caused by drugs that inhibit phosphodiesterase. In print: Naunyn-Schmiedeberg’s Arch. Pharmacol. 1976.

    Google Scholar 

  19. TAKAGI, K., TAKAYANAGI, I., TOMIYAMA, A.: Actions of dibutyryl cyclic adenosine monophosphate, papaverine and isoprenaline on the intestinal smooth muscle. Jap. J. Pharmacol. 21, 477–483 (1971).

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. W. R. Kukovetz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Pöch
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Wurm
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. Holzmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. E. Paietta
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Physiologisches Institut, Lehrstuhl I, Gmelinstr. 5, 7400, Tübingen, Germany

    Eberhard Betz

Rights and permissions

Reprints and permissions

Copyright information

© 1976 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Kukovetz, W.R., Pöch, G., Wurm, A., Holzmann, S., Paietta, E. (1976). Effect of Phosphodiesterase-Inhibition on Smooth Muscle Tone. In: Betz, E. (eds) Ionic Actions on Vascular Smooth Muscle. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66427-4_25

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-66427-4_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-07836-4

  • Online ISBN: 978-3-642-66427-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation