Abstract
In 11 healthy test subjects and 8 patients with chronic arterial occlusive diseases, the blood flow properties were determined before and 15, 30 and 45 min. after the intravenous injection of 750 mg essential phospholipids (LIPOSTABIL, NATTERMANN). LIPOSTABIL did not change the “macro-rheological” parameters, such as hematocrit, blood viscosity and plasma viscosity. However, a statistically significant increase of the passage of erythrocytes did occur through a capillary filter (with capillaries of 8 um in diameter), which simulates the conditions prevailing in the microcirculation. In the patients with peripheral arterial occlusive diseases, an increase of the capillary filtrate could similarly be found, but these differences were just below the borderline of statistical significance. The present findings indicate that, in some way, the flow properties of the erythrocytes, and thus their deformability, are influenced in a manner such that their passage through narrow capillaries is facilitated, and the capillary flow-rate is thereby increased.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bartels, U.: Über den Einfluß der Cholinphosphatide auf die Aggregation der Erythrozyten und die Viskosität des Blutes. M.D. Thesis, Med. Univ. Klinik, Frankfurt (1971).
Ehrly, A.M.: EPL and blood viscosity. In: Phospholipids. Ed. by G. Schettler, Thieme, Stuttgart 1972, S. 97
Ehrly, A.M.: Desaggregation von Erythrozytenaggregaten durch “essentielle” Phospholipide. In: Gefäßwand und Blutplasma IV. Ed. R. Emmrich, VEB Gustav Fischer Verlag, Jena, 1974, S. 165
Ehrly, A.M.: Influence of phospholipids on blood viscosity. — First International Symposium of Chemistry, Metabolism, Function and Pharmacology of Phospholipids Scecin Sept. 1972. Ed. by L. Samochowiec and J. Wojcicki 1973, p. 45
Ehrly, A.M.: Reduction in blood viscosity at low rates of shear by surface active substances: A new hemorheologic phenomenon. — Biorheology 5, 209 (1968)
Eikermann, H.: Sonderstellung und Therapie der Atherosklerose und arteriosklerotischen Krankheitsgeschehen. — Fortschr. Med. 74, 381 (1956)
Ehrly, A.M.: Hämorheologische Probleme bei Venenerkrankungen. — Zentralbl. Phlebologie 6, 338 (1967)
Köhler, S.: Untersuchungen über den Einfluß von Diuretika auf die Fließeigenschaften des Blutes. — Statistischer Anhang S. 85. M.D. Thesis, Med. Univ. Klinik, Frankfurt (1973)
Wells, R.E., et.al.: Measurement of viscosity of biologic fluids by cone plate viscosimeter. — J. Lab, Clin. Med. 57, 646 (1961)
Ehrly, A.M. and Rossbach P.: The detection of changes in erythrocyte shape by a filtration method using 8 µm filters.–II. International Symposium on metabolism and membrane permeability of erythrocytes, thrombocytes and leucocytes, Wien 1972. In: Erythrocytes, Thrombocytes and Leucocytes. Ed. by Gerlach, Moser, Deutsch, Wilmans, Thieme, Stuttgart (1973), S. 52
Ehrly, A.M. and Rossbach P.: Studies with an 8 µm filter system, — VII. Europ. Soc. Microcirculation, Aberdeen 1972, Pt. I. Bibl. anat. 11, 55 (1973)
Ehrly, A.M.: Untersuchungen über die Senkung der Strukturviskosität menschlichen Blutes im Hinblick auf die Therapie angiologischer Erkrankungen unter besonderer Berücksichtigung der Blutlipide. — Habilitationsschrift Med. Univ. Klinik, Frankfurt, 1969
Ehrly, A.M.: Increased blood flow by improvement of the flow properties of blood: A new concept in the treatment of vascular diseases. — VIII. Intern. Congr. of Angiology, Rio de Janeiro 1972. In: Progress on Angiology: Prodeedings VIII. Intern. Congress of Angiology 1972. Ed.: G.C. de Lemos Cordeiro and R.C. Mayall. Vol. III, 987 (1974)
Ehrly, A.M.: Verbesserung der Fließeigenschaften des Blutes: Ein neues Prinzip zur medikamentösen Therapie chronischer peripherer arterieller Durchblutungsstörunqen. — VASA 2, Suppl. 1 (1973)
Ehrly, A.M. and Jung G.: Circadian rhythm of human blood viscosity. — I. Internat. Kongr. liber Biorheologie Lyon 1972, Biorheologie 10, 577 (1973)
Warstat, T.H.: Untersuchungen. über den Einfluß von niedermolekularem Dextran auf die Filtrabilität des Blutes in 8 um Filtern. — M.D. Thesis, Med. Univ. Klinik, Frankfurt (1974)
Ehrly, A.M., Köhler H.-J., Schroeder W. und Müller R.: Sauerstoffdruckwerte im ischämischen Muskelgewebe von Patienten mit chronischen peripheren arteriellen Verschlußkrankheiten. Klin. Wschr. 53, 687 (1975)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1976 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Ehrly, A.M., Blendin, R. (1976). Influence of Essential Phospholipids on the Flow Properties of the Blood. In: Peeters, H. (eds) Phosphatidylcholine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66424-3_17
Download citation
DOI: https://doi.org/10.1007/978-3-642-66424-3_17
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-66426-7
Online ISBN: 978-3-642-66424-3
eBook Packages: Springer Book Archive