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Untersuchungen zur Metabolisierung von Halothan und Ēthrane am Menschen mit und ohne Vorbehandlung von Phenobarbital

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Inhalationsanaesthesie mit Ēthrane

Zusammenfassung

Bis 1964 wurden die gebräuchlichen Inhalationsnarkotika mit Ausnahme von Trichloräthylen (Barett u. Johnston, 1939) durchwegs für biochemisch inert gehalten. In jenem Jahr veröffentlichte Van Dyke, daß Abbauprodukte für die Toxizität verschiedener flüchtiger Anästhetika möglicherweise verantwortlich seien, und in nachfolgenden Arbeiten wurde das unspezifische mischfunktionelle Enzymsystem P 450, das im endoplasmatischen Retikulum lokalisiert ist, als entscheidend für die Metabolisierung der Inhalationsanästhetika erkannt (van Dyke et al. , 1964, 1965).

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Authors
  1. B. Grothe
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  2. A. Doenicke
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  3. G. Hauck
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  4. D. Lindström
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  5. T. Bauer
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  6. J. Kugler
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Editor information

Editors and Affiliations

  1. Institut für Anaesthesiologie, Klinikum Charlottenburg, der Freien Universität Berlin, Spandauer Damm 130, 1000, Berlin 19, Deutschland

    J. B. Brückner

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© 1976 Springer-Verlag Berlin Heidelberg

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Grothe, B., Doenicke, A., Hauck, G., Lindström, D., Bauer, T., Kugler, J. (1976). Untersuchungen zur Metabolisierung von Halothan und Ēthrane am Menschen mit und ohne Vorbehandlung von Phenobarbital. In: Brückner, J.B. (eds) Inhalationsanaesthesie mit Ēthrane. Anaesthesiology and Resuscitaton/Anaestesiologie und Wiederbelelung/Anaesthésiologie et Réanimation, vol 99. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66406-9_4

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  • DOI: https://doi.org/10.1007/978-3-642-66406-9_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-07766-4

  • Online ISBN: 978-3-642-66406-9

  • eBook Packages: Springer Book Archive

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