Humoral and Cell-Mediated Mechanisms of Allograft Rejection

  • K. Theodor Brunner
  • Jean-Charles Cerottini
Part of the Handbuch der allgemeinen Pathologie book series (PATHOLOGIE, volume 6 / 8)


Allograft immunity is generally considered as a manifestation of cell-mediated immunity (CMI). This concept was introduced by Mitchison (1954) and Billingham et al. (1954), who showed that allograft immunity could be regularly transferred from immune donors to normal recipients with lymphoid cells, but not with serum. However, the actual mechanism by which transfer of immune lymphoid cells leads to graft destruction is still not entirely elucidated.


Target Cell Effector Cell Allograft Rejection Graft Rejection Plaque Form Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations used in this contribution


cell-mediated immunity


cell-mediated cytotoxicity


thymus-derived lymphocytes


bursa-derived lymphocytes


cytolytic T lymphocytes


killer cells


Fc portion of IgG molecules


mixed leukocyte culture




cytotoxic lymphocytes


plaque forming cells




concanavalin A


cytochalasin B


antibody-dependent CMC


antibody-dependent LMC


specific macrophage arming factor


ethylene-diamine tetraacetic acid


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Copyright information

© Springer-Verlag, Berlin · Heidelberg 1977

Authors and Affiliations

  • K. Theodor Brunner
  • Jean-Charles Cerottini

There are no affiliations available

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