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Humoral and Cell-Mediated Mechanisms of Allograft Rejection

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Transplantation

Part of the book series: Handbuch der allgemeinen Pathologie ((1712,volume 6 / 8))

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Abstract

Allograft immunity is generally considered as a manifestation of cell-mediated immunity (CMI). This concept was introduced by Mitchison (1954) and Billingham et al. (1954), who showed that allograft immunity could be regularly transferred from immune donors to normal recipients with lymphoid cells, but not with serum. However, the actual mechanism by which transfer of immune lymphoid cells leads to graft destruction is still not entirely elucidated.

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Abbreviations

CMI :

cell-mediated immunity

CMC :

cell-mediated cytotoxicity

T-cells :

thymus-derived lymphocytes

B-cells :

bursa-derived lymphocytes

CTL :

cytolytic T lymphocytes

K-cells :

killer cells

Fc :

Fc portion of IgG molecules

MLC :

mixed leukocyte culture

PHA :

phytohemagglutinin

CL :

cytotoxic lymphocytes

PFC :

plaque forming cells

GVH :

graft-versus-host

ConA :

concanavalin A

CB :

cytochalasin B

AD-CMC :

antibody-dependent CMC

AD-LMC :

antibody-dependent LMC

SMAF :

specific macrophage arming factor

EDTA :

ethylene-diamine tetraacetic acid

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Authors
  1. K. Theodor Brunner
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  2. Jean-Charles Cerottini
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Johann Wilhelm Masshoff

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Brunner, K.T., Cerottini, JC. (1977). Humoral and Cell-Mediated Mechanisms of Allograft Rejection. In: Masshoff, J.W. (eds) Transplantation. Handbuch der allgemeinen Pathologie, vol 6 / 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66392-5_6

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  • DOI: https://doi.org/10.1007/978-3-642-66392-5_6

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  • Print ISBN: 978-3-642-66394-9

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