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Ontogenetic Aspects

  • Chapter
Transplantation

Part of the book series: Handbuch der allgemeinen Pathologie ((1712,volume 6 / 8))

Abstract

This chapter is a description of the ontogenic aspects of transplantation immunity. “Ontogeny” is defined in Webster’s Dictionary as “the… course of development of an individual organism”. In the context of this chapter we will analyze the course of development of an individual function (i.e., the capacity to reject foreign transplants) in some selected species, including man. This analysis will be done by discussing two interrelated aspects: (1) the development of the ability to reject foreign tissues as a function of age and (2) the development of the probable effector cells responsible for cell-mediated immunity, such as graft rejection, as well as other functions related to competent lymphocytes of the thymus-dependent lineage. Since the exact mechanisms by which foreign tissue grafts are destroyed are still not properly defined, we will describe the ontogenic events mainly as “all-or-none” phenomena. However, we are including descriptions of developmental events of the thymus-dependent cell-mediated immune responses, since the vast bulk of evidence indicates that a major component of graft rejection is mediated by thymus-dependent responses (see Wilson and Billingham, 1967 or Najarian and Foker, 1969 for review). Although humoral antibodies can, under special circumstances, mediate the destruction of allografts (see for example Baldamus et al., 1973) and hyperacute organ rejections are the results of humoral mechanisms (Najarian and Foker, 1969), it is accepted that the main effector mechanism is related to thymus-dependent cell-mediated responses.

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Authors
  1. Osias Stutman
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  2. Catherine E. Calkins
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Johann Wilhelm Masshoff

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Stutman, O., Calkins, C.E. (1977). Ontogenetic Aspects. In: Masshoff, J.W. (eds) Transplantation. Handbuch der allgemeinen Pathologie, vol 6 / 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66392-5_5

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  • DOI: https://doi.org/10.1007/978-3-642-66392-5_5

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