Abstract
Transplant rejection is the result of an immune attack of the host against the implanted foreign cells. The graft-versus-host-reaction (GVHR) is the reverse process: the transplant reacts against the host, damages it and may even kill it. GVHR has gained increased attention in the past 20 years since it was first correctly described by Billingham et al. (1955), Trentin (1956), and Simonsen (1957).
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References
Abenberg, A.C., Wilkes, B., Waksman, B.H.: The production of runt disease in rats thymectomized at birth. J. exp. Med. 116, 759–772 (1962).
Allison, A.C., Denman, A.M., Barnes, R.D.: Cooperating and controlling functions of thymusderived lymphocytes in relation to autoimmunity. Lancet 1971 II, 135–140.
Van Alten, P.J., Fennell, R.A.: The effects of chorioallantoic grafts on the developing chick embryo. I. Studies on weight and histology of homologous and heterologous tissues. J. Embryol. exp. Morph. 7, 459–475 (1959).
Ambrus, C.M., Ambrus, J.L., Feltz, E.T.: Mitigation of secondary disease in mice receiving bone marrow from donors pretreated with cortisone and alkylating agents. Transplantation 4, 245–249 (1966).
Anderson, N.D., Nowell, P.C.: Fatal agranulocytosis and thrombocytopenia in F1 hybrid guinea pigs following local inoculation of parental strain lymphoid cells. Fed. Proc. 25, 660 (1966).
Aoki, T., Hämmerling, U., de Harven, E., Boyse, E.A., Old, L.J.: Antigenic structure of cell surfaces. J. exp. Med. 130, 979–1001 (1969).
Arakawa, K., Jézéquel, A.-M., Macvie, S.I., Johnston, R., Perez, Z.M., Steiner, J.W.: The liver in murine transplantation (runt) disease. Observations of the acute lesions by light and electron microscopy. Amer. J. Path. 49, 257–299 (1966).
Argyris, B.F.: The role of macrophages. Thymus- and bone marrow-derived cells in the graft-versus-host reaction. Transplantation 17, 387–391 (1974).
Armerding, D., Katz, D.H.: Activation of T and B lymphocytes in vitro. II. Biological and biochemical properties of an allogeneic effect factor (AEF) active in triggering specific B lymphocytes. J. exp. Med. 140, 19–37 (1974).
Armstrong, M.Y.K., Gleichmann, E., Gleichmann, H., Beldotti, L., Andre-Schwartz, J., Schwartz, R.S.: Chronic allogeneic disease. II. Development of lymphomas. J. exp. Med. 132, 417–439 (1970).
Armstrong, M.Y.K., Schwartz, R.S., Beldotti, L.: Neoplastic sequelae of allogeneic disease. III. Histological events following transplantation of allogeneic spleen cells. Transplantation 5, 1380–1392 (1967).
Asantila, T., Sorvari, T., Hirvonen, T., Toivanen, P.: Xenogenic reactivity of human fetal lymphocytes. J. Immunol. 111, 984–987 (1973).
Atkins, R.C., Ford, W.L.: The effect of lymphocytes and serum from tolerant rats on the graft-versus-host activity of normal lymphocytes. Transplantation 13, 442–445 (1972).
Atkins, R.C., Ford, W.L.: Early cellular events in a systemic graft-versus-host reaction. I. The migration of responding and non-responding donor lymphocytes. J. exp. Med. 141, 664–680 (1975).
Auerbach, R., Shalaby, M.R.: Graft-versus-host reaction in tissue culture. J. exp. Med. 138, 1506–1520 (1973).
Auxier, J.A.: Dosimetric considerations in criticality exposures. In: Diagnosis and Treatment of Acute Radiation Injury, p. 141–150. Geneva: World Health Organization 1961.
Bach, F.H.: The major histocompatibility complex in transplantation immunology. Transplant. Proc. 5, 23–29 (1973).
Bach, F.H., Albertini, R.J., Joo, P., Anderson, J.L., Bortin, M.M.: Bone marrow transplantation in a patient with the Wiskott-Aldrich syndrome. Lancet 1968 II, 1364–1366.
Bach, F.H., Amos, D.B.: Hu-1: Major histocompatibility locus in man. Science 156, 1506–1508 (1967).
Bain, B., Lowenstein, L.: Genetic studies on the mixed leukocyte reaction. Science 145, 1315–1316 (1964).
Bain, G.O., Alton, J.D.: Hepatomegaly in hybrid mice from parental spleen cells. Arch. Path. 78, 633–642 (1964).
Bain, G.O., Diener, E.: Liver infiltration in graft-versus-host reaction. Effect of anti-ϑ-serum. Transplantation 13, 626–627 (1972).
Bain, G.O., Fenna, D.: Lymphoid infiltration in the F1 hybrid liver as a thymus cell function. Transplantation 13, 391–399 (1972).
Balner, H., de Vries, M.J., van Bekkum, D.W.: Secondary disease in rat radiation chimeras. J. nat. Cancer Inst. 32, 419–459 (1964).
Barnes, B.A., Schad, P.B., Pinn, V.W.: Modification of the graft-versus-host reaction in F1 mice treated with 6-mercaptopurine. Transplantation 4, 154–158 (1966).
Barnes, D.W.H., Loutit, J.F., Micklem, H.S.: Secondary disease of radiation chimeras: A syndrome due to lymphoid aplasia. Ann. N.Y. Acad. Sci. 99, 374–385 (1962).
Baumann, P., Thierfelder, S.: Unterdrückung der primären und sekundären Immunantwort durch Antilymphozytenserum (ALS), gemessen an der antigen-spezifischen Proliferationsaktivität im Graft-versus-Host Modell. Blut 28, 51–55 (1974).
Becker, H., Cronkite, E.P., Fliedner, T.M., Messner, H., Stodtmeister, R.: Osteomyelofibrose in Ratten nach letaler Ganzkörperbestrahlung und Transfusion allogener Knochenmarkszellen. EURATOM Ges. f. Strahlenforschg. (GFS), Assoziation Nr. 031–64–1 BIAD, 1968.
Beer, A.E., Billingham, R.E.: Procurement of runt disease of maternal origin. Transplant. Proc. 5, 887–891 (1973).
Van Bekkum, D.W.: Factors influencing the take and the rejection of bone marrow grafts. Proc. 7th Congr. Eur. Soc. Haematol, p. 947–952. London-Basel: Karger 1959.
Van Bekkum, D.W.: Foreign bone marrow transplantation following fractionated whole-body irradiation in mice. In: Radiation Effects in Physics, Chemistry and Biology (Ed. M. Ebert, A. Howard), p. 362–371. Amsterdam: North Holland Publishing Co. 1963.
Van Bekkum, D.W., Balner, H., Dicke, K.A., van den Berg, F.G., Prinsen, G.H., Hollander, C.F.: The effect of pretreatment of allogenic bone marrow graft recipients with antilymphocytic serum on the acute graft-versus-host reaction in monkeys. Transplantation 13, 400–407 (1972).
Van Bekkum, D.W., Ledney, G.D., Balner, H., van Putten, L.M., de Vries, M.J.: Suppression of secondary disease following foreign bone marrow grafting with antilymphocyte serum. In: CIBA Foundation Symposium “Antilymphocytic Serum” (Ed. G.E.W. Wolstenholme, M.O’ Connor), p. 97. London: Churchill 1967.
Van Bekkum, D.W., de Vries, M.J.: Radiation Chimaeras. New York-London: Logos Press, Academic Press 1967.
Van Bekkum, D.W., de Vries, M.J., van der Waay, D.: Lesions characteristic of secondary disease in germfree heterologous radiation chimeras. J. nat. Cancer Inst. 38, 223–231 (1967).
Bennett, M.: Graft-versus-host reaction in mice. Transplantation 11, 158–169 (1971).
Berman, M., Puryear, K., Argyris, B.F.: In vitro recognition of alloantigens: nature of responding and stimulating cells. Cell. Immunol. 23, 126–139 (1976).
Berry, C.L.: Histopathological findings in the combined immunity deficiency syndrome. J. clin. Path. 23, 193–202 (1970).
Biggs, P.M., Payne, L.N.: Cytological identification of proliferating donor cells in chick embryos injected with adult chicken blood. Nature (London) 184, 1594 (1959).
Bildsøe, P., Ford, W.L., Pettirossi, O., Simonsen, M.: GVH analysis of organ-grafted rat which defy the normal rules for rejection. Transplantation 12, 189–193 (1971).
Billingham, R.E.: The biology of graft-versus-host reactions. Harvey Lectures 62, 21–78. New York-London: Academic Press 1968.
Billingham, R.E., Brent, L.: Acquired tolerance of foreign cells in newborn animals. Proc. roy. Soc. B. 146, 78–90 (1957).
Billingham, R.E., Brent, L. Quantitative studies on tissue transplantation immunity. IV. Induction of tolerance in newborn mice and studies on the phenomenon of runt disease. Phil. Trans. B 242, 439–477 (1959).
Billingham, R.E., Brent, L., Medawar, P.B.: Acquired tolerance of skin homografts. Ann. N.Y. Acad. Sci. 59, 409–416 (1955).
Billingham, R.E., Brown, J.B., Defendi, V., Silvers, W.K., Steinmüller, D.: Quantitative studies on the induction of tolerance of homologous tissues and on runt disease in the rat. Ann. N.Y. Acad. Sci. 87, 457–471 (1960).
Billingham, R.E., Defendi, V., Silvers, W.K., Steinmüller, D.: Quantitative studies on the induction of tolerance of skin homografts and on runt disease in neonatal rats. J. nat. Cancer Inst. 28, 365–435 (1962).
Billingham, R.E., Silvers, W.: The immunobiology of transplantation. In: Foundations of Immunology (Ed. A. Osler, L. Weiss), Englewood Cliffs/N.Y.: Prentice-Hall Inc. 1971.
Billingham, R.E., Silvers, W.K.: Some factors that determine the ability of cellular inocula to induce tolerance of tissue homografts. J. cell. comp. Physiol. 60 (Suppl. 1), 183–200 (1962).
Binet, J.L., Mathé, G.: Etude en microscopie optique et électronique des «cellules immunologiquement compétentes» au cours des réactions de greffe. C. R. Acad. Sci. (Paris) 253, 1852–1853 (1961).
Binet, J.L., Mathé, G.: Optical and electron microscope studies of the immunologically competent cells during the reaction of graft against the host. Ann. N.Y. Acad. Sci. 99, 426–431 (1962).
Biozzi, G., Howard, J.G., Mouton, D., Stiffel, C.: Modifications of graft-versus-host reaction induced by pretreatment of the host with M. tuberculosis and C. parvum. Transplantation 3, 170–177 (1965).
Blaese, R.M., Martinez, C., Good, R.A.: Immunologic incompetence of immunologically runted animals. J. exp. Med. 119, 211–224 (1964).
Blanden, R.V.: Increased antibacterial resistance and immunodepression during graft-versus-host reactions in mice. Transplantation 7, 484–497 (1969).
Blomgren, H., Andersson, B.: Inhibition of erythroid cell growth in irradiated mice by allogeneic lymphoid cells: a quantitative method for graft-versus-host reactivity of lymphoid cells. Cell. Immunol. 3, 318–325 (1972).
Blomgren, H., Andersson, B.: Cross-reactivity patterns of mouse lymphocytes sensitized against the major histocompatibility complex using a graft-versus-host assay. Cell. Immunol. 11, 122–129 (1974).
Blomgren, H., Jacobsson, H.: Inhibition of erythroid cell growth by allogeneic murine lymphocytes. Evidence for a synergism between lymph node cells and thymocytes. Cell. Immunol. 13, 288–303 (1974).
Boggs, S.S., Boggs, D.R., Neil, G.L., Sartiano, G.: Cycling characteristics of endogenous spleen colony-forming cells as measured with cytosine arabinoside and methotrexate. J. Lab. clin. Med. 82, 727–739 (1973).
Bomford, R., Shand, F.L., Christie, G.H.: Observations on the mechanism of antitumor resistance induced by the graft-versus host reaction. Transplantation 20, 433–435 (1975).
Bonavida, B., Kedar, B.: Transplantation of allogeneic lymphoid cells specifically depleted of graft-versus-host reactive cells. Nature (London) 249, 658–659 (1974).
Boranic, M.: Treatment of secondary disease in leukaemic mice with host-type and third-party haemopoietic cells and blood. Rev. europ. Et. clin. Biol. 15, 309–314 (1970).
Boranic, M.: Time pattern of antileukemic effect of graft-versus-host reaction in mice. Transplant. Proc. 3, 394–396 (1971).
Bortin, M.M.: A compendium of reported human bone marrow transplants. Transplantation 9, 571–587 (1970).
Bortin, M.M., Rimm, A.A., Rose, W.C., Saltzstein, E.C.: Graft-versus-host leukemia. V. Absence of antileukemic effect using allogeneic H-2-identical immunocompetent cells. Transplantation 18, 280–283 (1974).
Bortin, M.M., Saltzstein, E.C.: Graft-versus-host inhibition: fetal liver and thymus cells to minimize secondary disease. Science 164, 316–318 (1969).
Borysenko, M., Tulipan, P.: The graft-versus-host reaction in the snapping turtle Chelydra serpentina. Transplantation 16, 496–504 (1973).
Boyer, G.S.: Chorioallantoic membrane lesions produced by inoculation of adult fowl leucocytes. Nature (London) 185, 327–328 (1960).
Boyse, E.A.: Fate of mouse spleen cells transplanted into homologous and F1 hybrid hosts. Immunology 2, 170–182 (1959).
Brent, L., Medawar, P.B.: Quantitative studies on tissue transplantation immunity. VII. The normal lymphocyte transfer reaction. Proc. roy. Soc. B 165, 281–307 (1966a).
Brent, L., Medawar, P.B.: Quantitative studies on tissue transplantation immunity. VIII. The effect of irradiation. Proc. roy. Soc. B 165, 413–423 (1966b).
Bretscher, P.: Hypothesis: A model for generalised autoimmunity. Cell. Immunol. 6, 1–11 (1973).
Britton, S.: When allogeneic mouse spleen cells are mixed in vitro the T cells secrete a product which guides the maturation of B cells. Scand. J. Immunol. 1, 89–98 (1972).
Brune, K.: Graft-versus-Host Reaktionen: Modelle, Beeinflußbarkeit und klinische Analogien. Schweiz, med. Wschr. 100, 49–58 (1970).
Buckley, R.H., Amos, B., Kremer, W.P., Stickel, D.L.: Incompatible bone marrow transplantation in lymphopenic immunologic deficiency. Circumvention of fatal graft-versus-host disease by immunologic enhancement. New Engl. J. Med. 285, 1035–1042 (1971).
Buja, L.M., Ferrans, V.J., Graw jr., R.G.: Cardiac pathologic findings in patients treated with bone marrow transplantation. Hum Path. 7, 17–45 (1976).
Burkhardt, R., Bartl, R., Beil, E., Demmler, K., Hoffmann, E., Kronseder, A., Irrgang, U., Ulrich, M., Wiemann, H., Langenecker, H., Saar, U.: Myelofibrosis-Osteosclerosis Syndrome-Review of literature and histomorphology. Advanc. Biosci. 16, 11–56 (1974).
Burnet, F.M.: Cellular Immunology. Melbourne: Melbourne University Press 1969.
Burnet, F.M., Boyer, G.: Loss of specificity on passage of immunologically competent cells in the chick embryo. Nature (London) 186, 175–176 (1960).
Burnet, F.M., Boyer, G.: The chorioallantoic lesion in the Simonsen phenomenon. J. Path. Bact. 81, 141–150 (1961).
Burnet, M., Burnet, D.: Graft-versus-host reactions on the chorioallantoic membrane of the chick embryo. Nature (London) 188, 376–379 (1960).
Caldwell, I.W., Montgomery, P.R., Peachey, R.D.G.: Toxic epidermal necrolysis and malignant lymphoma. Brit. J. Derm. 79, 287–292 (1967).
Cantor, H.: The effects of the anti-theta antiserum upon graft-versus-host activity of spleen and lymph node cells. Cell. Immunol. 3, 461–469 (1972).
Cantor, H., Asofsky, R.: Synergy among lymphoid cells mediating the graft-versus-host response. II. Synergy in graft-versus-host reactions produced by BALB/c lymphoid cells of differing anatomic origin. J. exp. Med. 131, 235–246 (1970).
Cantor, H., Asofsky, R.: Synergy among lymphoid cells mediating the graft-versus-host response. III. Evidence for interaction between two types of thymus-derived cells. J. exp. Med. 135, 764–779 (1972).
Cantor, H., Asofsky, R., Talal, N.: Synergy among lymphoid cells mediating the graft-versus-host response. I. Synergy in graft-versus-host reactions produced by cells from NZB/B1 mice. J. exp. Med. 131, 223–234 (1970a).
Cantor, H., Mandel, M.A., Asofsky, R.: Studies of thoracic duct lymphocytes of mice. II. A quantitative comparison of the capacity of thoracic duct lymphocytes and other lymphoid cells to induce graft-versus-host reactions. J. Immunol. 104, 409–413 (1970b).
Cantor, H., Mosier, D.E.: Maturation of reactivity to histocompatibility antigens. Transplant. Proc. 4, 159–163 (1972).
Cantrell, J.L., Hildemann, W.H.: Characteristics of histocompatibility barriers in congenic mice. Transplant. Proc. 5, 271–274 (1973).
Carnaud, C., Markowicz, O., Trainin, N.: The influence of a graft-versus-host reaction on the incidence of metastases after tumor transplantation. Cell. Immunol. 14, 87–97 (1974).
Carrel, A. (1908), cit. Schabel (1975).
Cepellini, R., Bonnard, G.D., Coppo, F., Miggiano, B.C., Pospisil, M., Curtoni, E.S., Pelle-grino, M.: Mixed leukocyte cultures and HL-A antigens. II. Inhibition by anti-HL-A sera. Transplant. Proc. 3, 63–70 (1971).
Cheers, Ch., Sprent, J., Miller, J.F.A.P.: Interaction of thymus lymphocytes with histoincompatible cells. IV. Mixed lymphocyte reactions of activated thymus lymphocytes. Cell. Immunol. 10, 57–67 (1974).
Chomette, G., Mathé, G., Auriol, M., Brocherious, C., Pinaudeau, Y.: Le syndrome secondaire chez l’homme: Etude anatomique de six cas de leucémie traités par greffe allogénique de moelle osseuse après irradiation totale. Virchows Arch. Path. Anat. A 349, 98–114 (1970).
Claman, H.N., Chaperone, E.A., Hayes, L.L.: Thymus marrow immunocompetence. Transplantation 7, 87–98 (1969).
Clancy, J., Adams, B.J., Elkins, W.L.: Fate of deoxyribonucleic acid-synthesizing cells and their progeny in a local graft-versus-host reaction. Transplantation 15, 52–58 (1973).
Clancy jr. , J., Tønder, O., Boettcher, C.E.: The effect of neonatal rat graft-versus-host disease (GVHD) in Fc receptor lymphocytes. J. Immunol. 116, 210–217 (1976).
Cline, M.J., Gale, R.P., Stiehmer, E.R., Opelz, G., Young, L.S., Feig, S.A., Fahey, J.L.: Bone marrow transplantation in man. Ann. intern. Med. 83, 691–708 (1975).
Cock, A.G., Simonsen, M.: Immunological attack on newborn chickens by injected adult cells. Immunology 2, 103–110 (1958).
Cohen, I.R., Wekerle, H.: Regulation of autosensitization. J. exp. Med. 137, 224–238 (1973).
Cohen, J.A., Vos, O., van Bekkum, D.W.: The present status of radiation protection by chemical and biological agent in mammals. In: Advances in Radiobiology (Ed. G.C. de Hevesy, A.G. Forssberg, J.D. Abbatt), p. 134–144. Edinburgh: Oliver & Boyd 1957.
Congdon, C.C.: Cooperative group on bone marrow transplantation in man. Transplant. Proc. 2, 342–360 (1970).
Congdon, C.C., Urso, L.S.: Homologous bone marrow in the treatment of radiation injury in mice. Amer. J. Path. 33, 749–767 (1957).
Coppleson, L.W., Michie, D.: Comparison of the chorioallantoic membrane and splenomegaly systems of graft-versus-host assay in the chick embryo. Nature (London) 208, 53–54 (1965).
Cornelius, E.A.: Clinical hematological and pathologic changes following parabiosis of syngeneic tolerant and nontolerant mice. Lab. Invest. 19, 282–289 (1968).
Cornelius, E.A., Aponte, L.J.: Sex-linked abrogation of graft-versus-host reaction. Transplantation 17, 128–131 (1974).
Cornelius, E.A., Martinez, C., Yunis, E.J., Good, R.A.: Hematological and pathological changes induced in tolerant mice by the injection of syngeneic lymphoid cells. Transplantation 6, 33–44 (1968).
Cornelius, E.A., Yunis, E.J., Martinez, M.: Depression of erythrocyte maturation as a result of the graft-versus-host reaction. Proc. Soc. exp. Biol. (N.Y.) 132, 564–567 (1969).
Daguillard, F., Garneau, R., Deschenes, L., Chouinard, C., Fudenberg, H.H., Schanfield, M.: Hyperactive production of antibody of a boy with thymic dysplasia undergoing graft-versus-host reaction. Clin. Immunol. Immunopath. 2, 52–61 (1973).
David, L.A., Ruth, R.F., Law, G.R.J.: Specific detection of cellular transplantation antigen by fluorescent isoantibody. Ann. N.Y. Acad. Sci. 129, 46–75 (1966).
Davies, A.J.S., Doak, S.M.A.: Fate of homologous adult spleen cells injected into newborn mice. Nature (London) 187, 610–611 (1960).
Davies, D.A.L.: The presence of non-H-2 histocompatibility specificities in preparations of mouse H-2 antigens. Transplantation 1, 562–568 (1963).
De Hart, R.L., Cosgrove, G.E., Upton, A.C.: Modification of the foreign spleen reaction: Amelioration of blood and tissue changes. Lab. Invest. 10, 872–882 (1961).
De Koning, J., Dooren, L.J., van Bekkum, D.W., van Rood, J.J., Dicke, K.A., Radl, J.: Transplantation of bone marrow cells and fetal thymus in an infant with lymphopenic immunological deficiency. Lancet 1969 I, 223–227.
Dempster, W.J.: Kidney homotransplantation. Brit. J. Surg. 40, 447–465 (1953).
Denko, J.D.: The histopathology of the irradiation syndrome after homologous injections in mice. Radiat. Res. 5, 607+ (1956).
Dicke, K.A., van Hooft, J.I., van Bekkum, D.W.: Selective elimination of immunologically competent cells from bone marrow and lymphatic cell mixtures. II. Mouse spleen cell fractionation on a discontinuous albumin gradient. Transplantation 6, 562–570 (1968).
Dicke, K.A., Lina, P.H., van Bekkum, D.W.: Adaptation of albumin density gradient centrifugation to human bone marrow fractionation. Rev. europ. Etud. clin. Biol. 15, 305–309 (1970).
Di George, A.M.: Congenital absence of the thymus and its immunological consequences, concurrence with congenital hypoparathyreoidism. In: (ed.) R.A. Good: Immunologic Deficiency Diseases in Man. Birth Defects (Orig. Art. Series) 4, 116–121 (1968).
Dooren, L.J., de Vries, M.J., van Bekkum, D.W., Cleton, F., de Koning, J.: Sex-linked thymic epithelial hypoplasia in two siblings. J. Pediat. 72, 51–62 (1968).
Dorsch, S.E., Roser, B.: A quantitative lymph node weight assay for allogeneic interactions in the rat. Aust. J. exp. Biol. med. Sci. 52, 253–264 (1974).
Douglas, S.D., Fudenberg, H.H.: Graft-versus-host reaction in Wiskott-Aldrich syndrome: Ante-mortem diagnosis of human GvH in an immunological deficiency disease. Vox Sang. (Basel) 16, 172–178 (1968).
Dupont, B.: Bone marrow transplantation in severe combined immunodeficiency with an unrelated MLC compatible donor. Int. Soc. exp. Hematology, III. Ann. Meeting, Houston 1974, p. 44.
Dyminski, J.W., Argyris, B.F.: In vitro sensitization to transplantation antigens. VII. Enhanced graft-versus-host activity of in vitro allosensitized lymphoid cells. Cell. Immunol. 7, 205–212 (1973).
Ebert, J.D.: Report on the Department of Embryology. Year Book of the Carnegie Institution (Washington) 58, 361–362, (1959).
Ebert, J.D.: Report on the Department of Embryology. Year Book of the Carnegie Institution (Washington) 58, 402–403, (1959).
Ebert, J.D.: The effects of chorioallantoic transplants of adult chicken tissues on homologous tissues of the host chick embryo. Proc. nat. Acad. Sci. (Wash.) 40, 337–347 (1954).
Eijsvoogel, V.P.: The cellular recognition in vitro of antigens related to human histocompatibility. Semin. Hematol. 11, 305–324 (1974).
Eikman, E.A., Bowser, R.T.: Alteration in graft-versus-host reactivity and in hematopoietic stem cells of spleen cell inocula from donor mice pretreated with pertussis antigen. J. Immunol. 108, 253–260 (1972).
Elkins, W.L.: Invasion and destruction of homologous kidney by locally inoculated lymphoid cells. J. exp. Med. 120, 329–347 (1964).
Elkins, W.L.: The interaction of donor and host lymphoid cells in the pathogenesis of renal cortical destruction induced by a local graft-versus-host reaction. J. exp. Med. 123, 103–118 (1966).
Elkins, W.L.: Specific and non-specific lymphoid cell proliferation in the pathogenesis of graft-versus-host reactions. Transplantation 9, 273–301 (1970).
Elkins, W.L.: Cellular immunology and the pathogenesis of graft-versus host reactions. Progr. Allergy 15, 78–187 (1971).
Elkins, W.L., Guttmann, R.D.: Pathogenesis of a local graft-versus-host reaction: Immunogenicity of circulating host leukocytes. Science 159, 1250–1251 (1968).
Elkins, W.L., Kavathas, P., Bach, F.H.: Activation of T cells by H-2-factors in the graft-versus-host reaction. Transplant. Proc. 5, 1759–1762 (1973).
Elves, M.W.: The impairment of graft-versus-host reaction by immunisation of F1 hybrids with low doses of parental cells. Transplantation 16, 403–407 (1973).
Fahey, J.L., Mann, D.L., Asofsky, R., Rogentine, G.N.: Recent progress in human transplantation immunology. Ann. intern. Med. 71, 1177–1196 (1969).
Falk, R.E., Collste, L., Möller, G.: Release of migration inhibitory factors from immune rat lymphocytes confronted with histocompatibility antigens. Nature (London) 224, 1206–1207 (1969).
Fass, L., Ochs, H.D., Thomas, E.D., Mickelson, E., Storb, R., Fefer, A.: Studies of immunological reactivity following syngeneic or allogeneic marrow grafts in man. Transplantation 16, 630–640 (1973).
Fefer, A., Buckner, C.D., Clift, R.A., Fass, L., Lerner, K.G., Mickelson, E.M., Neiman, P., Rudolph, R., Storb, R., Thomas, E.D.: Marrow grafting in identical twins with hematologic malignancies. Transplant. Proc. 5, 927–931 (1973).
Field, E.O., Cauchi, N.M., Gibbs, J.E.: The transfer of refractoriness to GVH disease in F1 hybrid rats. Transplantation 5, 241–247 (1967).
Field, E.O., Gibbs, J.E.: Effects of thymectomy and irradiation on graft-versus-host disease. Transplantation 3, 634–638 (1965).
Field, E.O., Gibbs, J.E.: Reduced sensitivity of F1 hybrid rats to re-challenge with parental strain spleen cells. Clin. exp. Immunol. 1, 195–205 (1966).
Field, E.O., Gibbs, J.E., Tucker, D.F., Hellmann, K.: Effect of thalidomide on the graft-versus-host reaction. Nature (London) 211, 1308–1310 (1966).
Finerty, J.C.: Parabiosis in physiological studies. Physiol. Rev. 32, 277–289 (1952).
Fink, M.P., Cloud, C.L.: Graft-versus-host disease in rats after donor treatment with cyclophosphamide and spleen cells of host origin. Transplantation 17, 508–512 (1974).
Floersheim, G.L., Seiler, K.: Differential effects of immunosuppressive drugs on a cutaneous graft-versus-host reaction in chickens. Transplantation 5, 1355–1370 (1967).
Ford, W.L.: A local graft-versus-host reaction following intradermal injection of lymphocytes in the rat. Brit. J. exp. Path. 48, 335–345 (1967).
Ford, W.L., Atkins, R.C.: Specific unresponsiveness of recirculating lymphocytes after exposure to histocompatibility antigen in F1 hybrid rats. Nature New Biology (London) 234, 178–180 (1971).
Ford, W.L., Burr, W., Simonsen, M.: A lymph node weight assay for the graft-versus-host activity of rat lymphoid cells. Transplantation 10, 258–266 (1970).
Ford, W.L., Simmonds, S.J., Atkins, R.C.: Early cellular events in a systemic graft-versus-host reaction. II. Autoradiographic estimates of the frequency of donor lymphocytes which respond to each Ag-B-determined antigenic complex. J. exp. Med. 141, 681–696 (1975).
Fox, M.: Cytological estimation of proliferating donor cells during graft-versus-host disease in F1 hybrid mice injected with parental spleen cells. Immunology 5, 489–495 (1962).
Fox, M.: The significance of lymphoid repopulation in the graft-versus-host reaction. Ann. N.Y. Acad. Sci. 129, 297–309 (1966).
Fox, M., Howard, J.G.: An acquired type of refractoriness to graft-versus-host reaction in adult F1 hybrid mice. Transplantation 1, 2–14 (1963).
Frizzera, G., Moran, E.M., Rappaport, H.: Angio-immunoblastic lymphadenopathy with dysproteinaemia. Lancet 1974 I, 1070–1073.
Fudenberg, H., Solomon, A.: “Acquired Agammaglobulinemia” with autoimmune hemolytic disease: Graft-versus-host reaction? Vox. Sang. (Basel) 6, 68–79 (1961).
Gallagher, M.T., Richie, E.R., Heim, L.R., Judd, K.P., Trentin, J.J.: Inhibition of the graft-versus-host reaction. I. Reduction of the GVH potential of mouse spleen cells (with a sparing of stem cells) by treatment with antilymphocyte globulin-derived Fab fragments. Transplantation 14, 597–602 (1972).
Gale, R.P., Opelz, G., Sparkes, R.: Bone marrow transplantation between mixed lymphocyte culture-reactive individuals. Transplantation 20, 194–198 (1975).
Garcia-Giralt, E., Morales, V.H., Lasalvia, E., Mathé, G.: Suppression of graft-versus-host reaction by a spleen extract. J. Immunol. 109, 878–881 (1972).
Gatti, R.A., Good, R.A.: Macrophage function in severe combined immunodeficiency disease. J. Pediat. 80, 285–298 (1972).
Gatti, R.A., Kersey, J.H., Yunis, E.J., Good, R.A.: Graft-versus-host disease. Progr. clin. Path. 5, 1–18 (1973).
Gatti, R.A., Meuwissen, H.J., Allen, H.D., Hong, R., Good, R.A.: Immunological reconstitution of sex-linked lymphopenic immunological deficiency. Lancet 1968 II, 1366–1369.
Gatti, R.A., Meuwissen, H.J., Terasaki, P.I., Good, R.A.: Recombination within the HL-A locus. Tissue Antigens (Copenhagen) 1, 239–241 (1971).
Gelfand, E.W., Phillips, R.A., Miller, R.G., McCulloch, E.A., Rosen, F.S.: The use of cell separation techniques and isoantibody to host antigens in the treatment of severe combined immunodeficiency disease with HL-A-incompatible maternal marrow. Exp. Hematol. 2, 122–130 (1974).
Gengozian, N., Edwards, C.L., Vodopick, H.A., Hübner, K.F.: Bone marrow transplantation in a leukemic patient following immunosuppression with antithymocyte globulin and total body irradiation. Transplantation 15, 446–454 (1973).
Gershon, R.K., Cohen, P., Hencin, R., Liebhaber, S.A.: Suppressor T cells. J. Immunol. 108, 586–590 (1972).
Gesner, B.M., Woodruff, J.J.: Cellular Recognition (Ed. R.I. Smith, R.A. Good). New York: Appleton 1969.
Githens, J.H., Hathaway, W.E., Cox, S.M., Suvatte, V., Metzgar, A.: Serial study of the bone marrow changes in runt disease. Transplantation 6, 619–623 (1968).
Githens, J.H., Muschenheim, F., Fulginiti, V.A., Robinson, A., Kay, H.E.M.: Thymic alymphoplasia with XX/XY lymphoid chimerism secondary to probable maternal-fetal transfusion. J. Pediat. 75, 87–94 (1969).
Gittes, R.F., Russell, P.S.: Male histocompatibility antigens in mouse endocrine tissues: Functional and histologic evidence. J. nat. Cancer Inst. 26, 283–303 (1961).
Gleichmann, E., Gleichmann, H.: Graft-versus-host reaction: a pathogenetic principle for the development of drug allergy, autoimmunity, and malignant lymphoma in non-chimeric individuals. Hypothesis. Z. Krebsforsch. 85, 91–109 (1976).
Gleichmann, E., Gleichmann, H., Schwartz, R.S., Weinblatt, A., Armstrong, M.Y.K.: Immunologic induction of malignant lymphoma. Identification of donor and host tumors in the graft-versus-host model. J. nat. Cancer Inst. 54, 107–116 (1975).
Gleichmann, E., Gleichmann, H. Wilke, W.D.: Autoimmunization and lymphomagenesis in parent — F1 combinations differing at the major histocompatibility complex: Model for spontaneous disease caused by altered selfantigens? Transplant. Rev. 31, 156–224 (1976).
Gleichmann, H., Gleichmann, E., André-Schwartz, J., Schwartz, R.S.: Chronic allogeneic disease. III. Genetic requirements for the induction of glomerulonephritis. J. exp. Med. 135, 516–532 (1972).
Gleichmann, H., Gleichmann, E., Peters, K.: Induction of immune complex glomerulonephritis in F1 hybrid mice: Superiority of cortisone-resistent parental thymocytes over spleen cells. Cell. Immunol. 14, 123–127 (1974).
Globerson, A., Auerbach, R.: Primary immune reactions in organ cultures. Science 149, 991–993 (1965).
Glucksberg, H., Storb, R., Fefer, A., Buckner, C.D., Neiman, P.E., Clift, R.A., Lerner, K.G., Thomas, E.D.: Clinical manifestations of graft versus-host disease in human recipients of marrow from HL-A-matched sibling donors. Transplantation 18, 295–304 (1974).
Golstein, P., Blomgren, H.: Further evidence for autonomy of T cells mediating specific in vitro cytotoxicity: Efficiency of very small amounts of highly purified T cells. Cell. Immunol. 9, 127–141 (1973).
Good, R.A.: Communication given at the annual meeting of the Int. Soc. exp. Hematol. (1973), cit. Speck (1975).
Good, R.A., Dalmasso, A.P., Martinez, C., Archer, O.K., Pierce, J.C., Papermaster, B.W.: The role of the thymus in development of immunologic capacity in rabbits and mice. J. exp. Med. 116, 773–796 (1962).
Goodman, J.W., Basford, N.L., Shinpock, S.G.: Marrow stem cell-thymocyte interaction in hemopoiesis. XIV. Internat. Congr. Hematology, Sao Paulo 1972 Abstract No. 95.
Gotjamanos, T.: A comparison of the changes produced in reticuloendothelial organs of mice during host-versus-graft and graft-versus-host reaction. Aust. J. exp. Biol. med. Sci. 48, 567–581 (1970).
Gowans, J.L.: The fate of parental strain small lymphocytes in F1 hybrid rats. Ann. N.Y. Acad. Sci. 99, 432–455 (1962).
Gowans, J.L., Gesner, B.M., McGregor, D.D.: The immunological activity of lymphocytes. In: Biological Activity of the Leucocyte. CIBA Foundation Study Group No. 10, (Ed. G.E.W. Wolstenholme, M. O’Connor). p. 32–40. London: Churchill 1961.
Gorer, P.A., Boyse, E.A.: Pathological changes in F1 hybrid mice following transplantation of spleen cells from donors of the parental strain. Immunology 2, 182–193 (1959).
Granger, G., Kolb, W.: Lymphocyte in vitro cytotoxicity: Mechanisms of immune and nonimmune small lymphocyte-mediated target L cell destruction. J. Immunol. 101, 111–120 (1968).
Graw, R.G., Buckner, C.D., Whang-Peng, J., Leventhal, B.G., Krüger, G., Berard, C., Henderson, E.S.: Complication of bone marrow transplantation: Graft-versus-host disease resulting from chronic-myelogenous-leukemia leucocyte transfusions. Lancet 1970II, 338–341.
Graw jr., R.G., Leventhal, B.G., Yankee, R.A., Rogentine, G.N., Whang-Peng, J., Ginnif, M.H., Herzig, G.P., Halterman, R.H., Henderson, E.S.: HL-A and mixed leukocyte culture matched allogeneic bone marrow transplantation in patients with acute leukemia. Transplant. Proc. 3, 405–408 (1971).
Grebe, S.C., Streilein, J.W.: (1975a) cit. Grebe, S.C., Streilein, J.W. (1976)
Grebe, S.C., Streilein, J.W.: (1975b) cit. Grebe, S.C., Streilein, J.W. (1976).
Grebe, S.C., Streilein, J.W.: Graft-versus-host reactions: A review. Advanc. Immunol. 22, 119–221 (1976).
Groff, P., Torhorst, J., Speck, B., Nissen, C., Weber, W., Cornu, P., Rossier, J., Biland, L.: Die Graft-versus-Host Krankheit eine wenig bekannte Komplikation der Bluttransfusion. Schweiz. med. Wschr. 106, 634–639 (1976).
Grogan, T.M., Broughton, D.D., Doyle, W.F.: Graft-versus-host reaction Arch. Path. 99, 330–334 (1975).
Grundmann, E.: Die Bildung von Lymphocyten und Plasmazellen im lymphatischen Gewebe der Ratte. Beitr. path. Anat. 119, 217–262 (1958).
Grundmann, E.: Experimentelle Untersuchungen über die zelluläre Speicherung des Polyvinylpyridin-N-oxids. Fortschr. Staublungenforsch. 2, 223–228 (1967).
Grundmann, E.: Die Rolle der Lymphocyten bei der Wahrung der individuellen Integrität. Verh. dtsch. Ges. inn. Med. 79, 118–129 (1973).
Grundmann, E., Hobik, H.P.: Lymphoretikuläre Sarkome bei immunologisch geschädigten Mäusen. Z. Krebsforsch. 79, 298–303 (1973a).
Grundmann, E., Hobik, H.P.: Graft-versus-Host Reaktion — Allogenkrankheiten — Lymphome. Beitr. path. Anat. 150, 323–329 (1973b).
Grundmann, E., Hobik, H.P.: Studien zur Graft-versus-Host Reaktion. Nova Acta Leopoldina (Halle) 41, 449–461 (1975).
Guttermann, J.U., Hersh, E.M., Rodriguez, V., McCredie, K.B., Mavligit, G., Reed, R., Burgess, M.A., Smith, T., Gehan, E., Bodey, G.P., Freireich, E.J.: Chemoimmunotherapy of adult acute leukemia. Prolongation of remission in myeloblasts leukemia with BCG. Lancet 1974 II, 1405–1409.
Haferkamp, O., Schachenmayr, W., Kleeberg, U.R., Wildfeuer, A., Borowski, K., Meister, H., Konietzko, N., Engels, J., Schrewe, K.H.: Schnell verlaufende Auszehrungskrankheit mit generalisierter Lymphadenopathie, Hautbeteiligung und interstitieller Lungeninfiltration. Dtsch. med. Wschr. 100, 335–342 (1975).
Hall, J.G., Parry, D.M., Smith, M.E.: The distribution and differentiation of lymph-born immuno-blasts after intravenous injection into syngeneic recipients. Cell Tiss. Kinet. 5, 269–281 (1972).
Halle-Pannenko, O., Martyre, M.C., Mathé, G.: Prevention of graft-versus-host reaction by donor pretreatment with soluble H-2 antigens. Transplantation 11, 414–417 (1971).
Harriss, E., Currie, C., Kriss, J.P., Kaplan, H.S.: Studies on anemia in F1 hybrid mice injected with parental strain lymphoid cells. J. exp. Med. 113, 1095 (1961).
Harriss, E., Currie, C., Kriss, J.P., Kaplan, H.S.: Studies on anemia in F1 hybrid mice injected with parental strain lymphoid cells. J. exp. Med. 113, 1112–1113 (1961).
Hašková, V., Gansova, E., Hajná, J.: Immunocompetence in regional graft-versus-host reaction of blood cells from skin allografted or ALS-treated rats. Folia biol. (Praha) 19, 261–266 (1973a).
Hšsková, V., Korčáková, L., Bednarik, T.: Dissociation of lymphocyte activation and graft-versus-host competence of blood cells after skin grafting in rats treated with antithymocyte and normal pig serum. Transplantation 16, 325–330 (1973b).
Hathaway, W.E., Brangle, R.W., Nelson, T.L., Rockel, I.E.: Aplastic anemia and alymphocytosis in an infant with hypogammaglobulinemia: Graft-versus-host reaction? J. Pediat. 68, 713–722 (1966).
Hathaway, W.E., Fulginiti, V.A., Pierce, C.W., Githens, J.H., Pearlman, D.S., Muschenheim, F., Kempe, H.: Graft-versus-host reaction following a single blood transfusion. J. Amer. med. Ass. 201, 1015–1020 (1967).
Hathaway, W.E., Githens, J.H., Blackburn, W.R., Fulginiti, V., Kempe, H.: Aplastic anemia, histiocytosis and erythrodermia in immunologically deficient children: probable human runt disease. New Engl. J. Med. 273, 953–958 (1965).
Hays, E.F.: Graft-versus-host reaction and the viral induction of mouse lymphoma. Cancer Res. 32, 270–275 (1972a).
Hays, E.F.: Development of neoplasia and karyotype analysis in mice with graft-versus-host reaction. Cancer Res. 32, 276–279 (1972b).
Hellström, I., Hellström, K.E.: Lymphocyte-mediated cytotoxic reactions and blocking serum factors in tumor-bearing individuals and in rats tolerant to skin allografts; similarities and possible differences. In: Progress in Immunology II, vol. 5, (Ed. L. Brent, J. Holborrow), p. 147–157. New York: American Elsevier Publ. Co. 1974.
Heron, J.: Is transplantation tolerance in the rat serum-mediated? Transplantation 15, 534–539 (1973).
Herrlich, A., Ehrengut, W., Schleussing, H.: Der Impfschaden. In: Handbuch der Schutzimpfungen, S. 237–239. Berlin-Heidelberg-New York: Springer 1965.
Heslop, B.F., Hardy, B.E.: The distribution of 51-Cr-labeled syngeneic and allogeneic lymph node cells in the rat. Transplantation 11, 128–134 (1971).
Hildemann, W.H., Gallagher, B.A., Walford, R.L.: Pathologic changes in lymphoid tissues in early transplantation (runt) disease in mice. Amer. J. Path. 45, 481–493 (1964).
Hilgard, H., Burnet, D., Burnet, F.M.: Tolerance as shown by the Simonsen reaction on the chorioallantoic membrane. Aust. J. exp. Biol. med. Sci. 40, 232–240 (1962).
Hirata, A.A., Schechtman, A.M.: Studies on immunological depression in chickens. J. Immunol. 85, 230–239 (1960).
Hitzig, W.H.: Konnatale Defektzustände des lymphatischen Systems. In: Lymphozyt und klinische Immunologie. Hrsg. H. Theml, H. Begemann. S. 112–123. Berlin-Heidelberg-New York: Springer 1975.
Hobik, H.P.: Die Hemmung der Graft-versus-Host Reaktion in Maus und Ratte durch L-Asparaginase. Verh. dtsch. Ges. Path. 53, 525–528 (1969a).
Hobik, H.P.: Der Einfluß immunosuppressiver Agenden auf die Graft-versus-Host Reaktion in der Maus. In: Organtransplantation, Immunologie und Klinik. (Hrsg. A. Heymer, D. Ricken), S. 269–274. Stuttgart-New York: Schattauer 1969b.
Hobik, H.P.: Effect of L-Asparaginase and other immunosuppressive agents on the course of graft-versus-host disease in rats and mice. Exp. Hematol. 20, 18–20 (1970).
Hobik, H.P.: Osteomyelosclerosis in experimental graft-versus-host disease. V. Congr. Europ. Soc. Pathology, Vienna 1975 Abstract no. 110, p. 62.
Hobik, H.P., Sawada, S.: Zur Morphologie der Milzfollikel von Mäusen der Stämme NZB/NZW und C 57/B1/6. Verh. dtsch. Ges. Path. 54, 235–237 (1970).
Hong, R., Kay, H.E.M., Cooper, M.D., Meuwissen, H., Allan, M.J.G., Good, R.A.: Immunological reconstitution in lymphopenic immunological deficiency syndrome. Lancet 1968 I, 503–506.
Howard, J.C., Hunt, S.V., Gowans, J.L.: Identification of marrow-derived and thymus-derived small lymphocytes in the lymphoid tissue and thoracic duct lymph of normal rats. J. exp. Med. 135, 200–219 (1972).
Howard, J.G.: Changes in the activity of the reticulo-endothelial system (RES) following the injection of parental spleen cells into F1 hybrid mice. Brit. J. exp. Path. 42, 72–82 (1961).
Howard, J.G.: The use of reticuloendothelial function for studying graft-versus-host reaction in the presence of potential host-versus-graft reaction. J. reticuloendoth. Soc. 1, 29–39 (1964).
Howard, J.G., Christie, G.H., Boak, J.L., Kinsky, R.G.: Peritoneal and alveolar macrophages derived from lymphocyte populations during graft-versus-host reaction. Brit. J. exp. Path. 50, 448–455 (1969).
Howard, J.G., Woodruff, M.F.A.: Effect of the graft-versus-host reaction on the immunological responsiveness of the mouse. Proc. roy. Soc. B 154, 532–539 (1961).
Huber, B., Peña-Martinez, J., Festenstein, H.: Spleen cell transplantation in mice: Influence of non-H2M-locus on graft-versus-host and host-versus-graft reactions. Transplant. Proc. 5, 1373–1375 (1973).
Isacson, P.: Cellular transfer of antibody production from adult to embryo in domestic fowls. Yale J. Biol. Med. 32, 209–228 (1959).
Jackson, R.H., Oo, M.: Nephrotic syndrome with Hodgkin’s disease. Lancet 1971II, 821–822.
Jammet, H., Mathé, G., Pendic, B., Duplan, J.F., Maupin, B., Latarjet, R., Kalic, D., Schwarzenberg, L., Djukic, Z., Vigne, J.: Etude de six cas d’irradiation totale aiguë accidentelle. Rev. franc. Et. clin. Biol. 4, 210–225 (1959).
Jeannet, M., Wonham, V.A., Winn, H.J., Russell, P.S.: Donor selection for kidney transplantation, based on leukocyte pheno- and genotyping and mixed lymphocyte culture. Transplant. Proc. 1, 382–384 (1969).
Joller, P.W.: Graft-versus-host reactivity of lymphoid cells inhibited by anti-recognition structure serum. Nature New Biology (London) 240, 214–215 (1972).
Kadowaki, J., Zuelzer, W.W., Brough, A.J., Thompson, R.I., Woolley jr., P.V., Gruber, D.: XX/XY lymphoid chimaerism in congenital immunological deficiency syndrome with thymic alymphoplasia. Lancet 1965II, 1152–1155.
Kano, K., Beldotti, L., Milgrom, F., Schwartz, R.S.: Glomerulonephritis in the graft-versus-host reaction: Serologic demonstration of antihost antibodies. J. Immunol. 112, 410–412 (1974).
Kaplan, H.J., Stevens, T.R., Streilein, J.W.: Transplantation immunology of the anterior chamber of the eye. I. An intra-ocular graft-versus-host reaction (immunogenic anterior uveitis). J. Immunol. 115, 800–804 (1975a).
Kaplan, H.J., Streilein, J.W., Stevens, T.R.: Transplantation immunology of the anterior chamber of the eye. II. Immune response to allogeneic cells. J. Immunol. 115, 805–810 (1975b).
Kaplan, H.S., Rosston, B.H.: Studies on a wasting disease induced in F1 hybrid mice injected with parental strain lymphoid cells. Stanf. med. Bull. 17, 77–92 (1959).
Katz, D.H.: The allogeneic effect on immune responses: Model for regulatory influences of T lymphocytes on the immune system. Transplant. Rev. 12, 141–179 (1972).
Katz, D.H., Hamaoka, T., Dorf, M.E., Benacerraf, B.: Cell interactions between histoincompatible T and B lymphocytes. V. Failure of histoincompatible T cells to interfere with physiologic cooperation between syngeneic T and B lymphocytes. J. Immunol. 112, 855–857 (1974).
Katz, D.H., Paul, W.E., Benacerraf, B.: Carrier function in antihapten antibody responses. V. Analysis of cellular events in the enhancement of antibody responses by the “allogeneic effect” in DNP-DVA-primed guinea pigs challenged with a heterologous DNP-conjugate. J. Immunol. 107, 1319–1328 (1971).
Keast, D.: Runting syndromes, autoimmunity, and neoplasia. Advanc. Cancer Res. 11, 43–71 (1968a).
Keast, D.: A simple index for the measurement of the runting syndrome and its use in the study of the influence of the gut flora in its production. Immunology 15, 237–245 (1968b).
Keast, D.: The murine runting syndrome and neoplasia. Immunology 16, 693–697 (1969).
Keast, D., Walters, M.N.J.: The pathology of murine runting and its modification by neomycin sulphate gavages. Immunology 15, 247–262 (1968).
Kersey, J.H., Meuwissen, H.J., Good, R.A.: Graft-versus-host reactions following transplantation of allogeneic hematopoietic cells. Hum. Path. 2, 389–402 (1971).
Kettmann, J., Skarvall, H.: The allogeneic effect: Bystander effect in the primary immune response in vitro. Europ. J. Immunol. 4, 641–645 (1974).
Kiger, N., Florentin, I., Mathé, G.: Inhibition of graft-versus-host reaction by preincubation of the graft with a thymic extract (lymphocyte chalone). Transplantation 16, 393–397 (1973).
Killby, V.A.A., Lafferty, K.J., Ryan, M.: Interaction of embryonic chicken spleen cells and adult allogeneic leucocytes. Aust. J. exp. Biol. med. Sci. 50, 309–321 (1972).
Kisken, W.A., Swenson, N.A.: Unresponsiveness of mixed leucocyte cultures from thymectomized adult dogs. Nature (London) 224, 76–77 (1969).
Klein, J.: The H-2 system: Past and present. Transplant. Proc. 5, 11–21 (1973).
Klein, J., Egorov, I.K.: Graft-versus-host reaction with an H-2 mutant. J. Immunol. Ill, 976–979 (1973).
Klein, J., Park, J.M.: Graft-versus-host reaction across different regions of the H-2 complex of the mouse. J. exp. Med. 137, 1213–1225 (1973).
Koch, C., Henriksen, K., Juhl, F., Wiik, A., Faber, V., Andersen, V., Dupont, B., Sønderstrup-Hansen, G., Svejgaard, A., Thomsen, M., Ernst, P., Killmann, S.-A., Good, R.A., Jensen, K., Muller-Berat, N.: Bone-marrow transplantation from an HL-A non-identical but mixed-lymphocyte-culture identical donor. Lancet 1973 I, 1146–1150.
Kolb, H.J., Storb, R., Graham, T.C., Kolb, H., Thomas, E.D.: Antithymocyte serum and methotrexate for control of graft-versus-host disease in dogs. Transplantation 16, 17–23 (1973).
Koltay, M., Kinsky, R.G., Arnason, B.G., Schaffner, J.B.: Immunoglobulins and antibody formation in mice during the graft-versus-host reaction. Immunology 9, 581–590 (1965).
Koszinowski, U., Ertl, H.: Lysis mediated by T cells and restricted by H-2 antigen of target cells infected with vaccinia virus. Nature (London) 255, 552–554 (1975).
Kramer, A.K., van der Velden, N.A.: Vererbungslehre und Zucht. In: Versuchstiere und Versuchstiertechnik Vol. II, S. 193–223. Veröff. Gesellsch. f. Versuchstierkunde, Basel 1975.
Krěn, V., Braun, A., Štark, O., Kraus, P., Frenzl, B., Brdička, R.: Runting syndrome in rats and its inhibition by homologous sera. Folia biol. (Praha) 8, 341–350 (1962).
Krën, V., Vesely, P., Frenzel, B., Štark, O.: Inhibition of the runting syndrome in rats. Folia biol. (Praha) 6, 333–341 (1960).
Kretschmer, R., Jeannet, M., Mereu, T.R., Kretschmer, K., Winn, H., Rosen, F.S.: Hereditary thymic dysplasia: A graft-versus-host reaction induced by bone marrow cells with a partial 4a series histoincompatibility. Pediat. Res. 3, 34–40 (1969).
Krueger, G.R.F.: Zur Pathogenese von Tumoren des lymphoretikulären Gewebes bei Transplantationsempfängern. Verh. dtsch. Ges. Path. 54, 175–181 (1970).
Krueger, G.R.F.: The significance of immunosuppression and antigenic stimulation for the development of malignant lymphomas. (With special reference to cancer chemotherapy). Rec. Res. Cancer Res. 52, 88–95 (1975).
Krueger, G.R.F., Berard, C.W., Delellis, R.A., Graw, R.G., Yankee, R.A., Leventhal, B.G., Rogentine, G.N., Herzig, G.P., Halterman, R.H., Henderson, E.S.: Graft-versus-host diseas: Morphologic variation and differential diagnosis in 8 cases of Hl-A-matched bone marrow transplantation. Amer. J. Path. 63, 179–196 (1971b).
Krueger, G.R.F., Berard, C.W., Elias, P.M., Graw, R.G.: Morphology of graft-versus-host reaction in Hl-A-matched bone marrow transplantation and its differential diagnosis Exp. Hema-tol. 21, 4–6 (1971a).
Krueger, G.R.F., Graw, R.G., Rogentine, G.N., Darrow, C.C., Neefe, J.R., Luetzeler, J.: Pathology of modified graft-versus-host disease in bone marrow allografted monkeys treated with antilymphocyte serum. Blut 30, 19–30 (1975).
Krueger, G.R.F., Malmgren, R.A., Berard, C.W.: Malignant lymphomas and plasmocytosis in mice under prolonged immunosuppression and persistent antigenic stimulation. Transplantation 11, 138–144 (1971c).
Krumlovsky, F.A., del Greco, F., Herdson, P.B., Lazar, P.: Renal disease associated with toxic epidermal necrolysis (Lyell’s disease). Amer. J. Med. 57, 817–825 (1974).
Lapp, W.S., Möller, G.: Prolonged survival of H-2 incompatible skin allografts on F1 animals treated with parental lymphoid cells. Immunology 17, 339–344 (1969).
Lawrence, W.L., Simonsen, M.: The property of “strength” of histocompatibility antigens, and their ability to produce antigenic competition. Transplantation 5, 1304–1322 (1967).
Lennert, K., Nagai, K., Schwarze, E.W.: Patho-anatomical features of the bone marrow. Clin. Hematol. 4, 331–351 (1975).
Levin, D.M., Rosenstreich, D., Reynolds, H.Y.: Demonstration of graft-versus-host, mixed leucocyte reaction and monocyte chemotactic factor production in guinea pig Peyer’s patch cells. Fed. Proc. 33, 803+ (1974).
Levine, S.: Graft-versus-host disease. Liver involvement in splenectomized rats. Transplantation 6, 294–295 (1968a).
Levine, S.: Local and regional forms of graft-versus-host disease in lymph nodes. Transplantation 6, 799–801 (1968b).
Levine, S., Iwahara, M.: Graft-versus-host disease produced with whole blood. Transplantation 8, 462–465 (1969).
Lewis, R.M., Armstrong, M.Y.K., Andrè-Schwartz, J., Muftuoglu, A., Beldotti, L., Schwartz, R.S.: Chronic allogeneic disease I. Development of glomerulonephritis. J. exp. Med. 128, 653–667 (1968).
Liacopoulos, P., Merchant, B., Harrell, B.E.: Inhibition of the graft-versus-host reaction by pretreatment of donors with various antigens. Transplantation 5, 1423–1435 (1967a).
Liacopoulos, P., Merchant, B., Harrell, B.E.: Effect of donor immunization with somatic polysaccharides on the graft-versus-host reactivity of transferred donor splenocytes. Proc. Soc. exp. Biol. (N.Y.) 125, 958–962 (1967b).
Lonai, P., Clark, W.R., Feldman, M.: Participation of θ-bearing cell in an in vitro assay of transplantation immunity. Nature (London) 229, 566–567 (1971).
Longenecker, B.M., Pazderka, F., Law, G.R.J., Ruth, R.F.: The graft-versus-host reaction to minor alloantigens. Cell. Immunol. 8, 1–11 (1973).
Longmire, R.L., McMillan, R., Yelenosky, R., Armstrong, S., Lang, J.E., Craddock, C.G.: In vitro splenic IgG synthesis in Hodgkin’s disease. New Engl. J. Med. 289, 763–767 (1973).
Lukes, R.J., Tindle, B.H.: Immunoblastic lymphadenopathy: A hyperimmune entity resembling Hodgkin’s disease. New Engl. J. Med. 292, 1–8 (1975).
Lydyard, P.M., Ivanyi, J.: The role of opsonization in antithymocyte globulin-indiced suppression of graft-versus-host reaction in chick embryos. Transplantation 17, 400–404 (1974).
Martin, J., Binder, T.: Une complication rare de la vaccination jennerienne: La nécrolyse épidermique toxique (Lyell). Schweiz. med. Wschr. 101, 1446–1448 (1971).
Mathé, G., Amiel, J.L., Bernard, J.: Traitement de souris AkR à Tage de six mois par irradiation totale suivie de transfusion de cellules hématopoiétiques allogéniques. Incidences respectives de la leucémie et du syndrome secondaire. Bull. Cancer 47, 331–340 (1960).
Mathé, G., Amiel, J.L., Niemetz, J.: Recherche d’un test d’histocompatibilité pour les essais de greffes allogéniques. I Etude chez la souris. Rev. franc. Et. clin. Biol. 6, 684–687 (1961).
Mathé, G., Amiel, J.L., Matsukura, M., Méry, A.M.: Restauration hématopoïétique de souris irradiées par greffe de moelle osseuse allogénique de plusieurs donneurs de diverses lignées. C.R. Acad. Sci. (Paris) 255, 3480–3482 (1962).
Mathé, G., Amiel, J.L., Schwarzenberg, L., Cattan, A., Schneider, M., de Vries, M.J., Tubiana, M., Lalanne, C., Binet, J.L., Papiernik, M., Seman, G., Matsukura, M., Mèry, A.M., Schwarzman, V., Flaisler, A.: Successful allogenic bone marrow transplantation in man: Chimerism, induced specific tolerance and possible antileukemic effects. Blood 25, 179–196 (1965).
Mathé, G., Amiel, J.L., Schwarzenberg, L., Choay, J., Trolard, P., Schneider, M., Hayat, M., Schlumberger, J.R., Jasmin, C.: Bone marrow graft in man after conditioning by antilymphocytic serum. Brit. med. J. 1970 II, 131–136.
Mathé, G., Amiel, J.L., Schwarzenberg, L., Schneider, M., Cattan, A., Schlumberger, J.R., Nouza, K., Hrask, Y.: Bone marrow transplantation in man. Transplant. Proc. 1, 16–24 (1969).
Mathé, G., Bernard, J.: Essai de traitement, par l’irradiation X suivie de l’administration de cellules myéloïdes homologues, de souris AK atteintes de leucémie spontanée très avancée. Bull. Cancer 45, 289–300 (1958).
Mathé, G., Bernard, J.: Essais de traitement de la léucémie greffée 1210 par l’irradiation X suivie de transfusion de cellules hématopoïétiques normales (isologues ou homologuesm myéloïdes ou lymphoïdes, adultes ou embryonnaires). Rev. franc. Et. clin. Biol. 4, 442–446 (1959).
Mathé, G., Jammet, H., Pendič, B., Schwarzenberg, L., Duplan, J.F., Maupin, B., Latarjet, R., Larrieu, M.J., Kalič, D., Djukič, Z.: Transfusions et greffes de moelle osseuse homologue chez des humains irradiés a haute dose accidentellement. Rev. franc. Et. clin. Biol. 4, 226–238 (1959).
Mathé, G., Hartmann, L., Loverdo, A., Bernard, J.: Essai de protection par l’injection de cellules médulaires isologues ou homologues contre la mortalité produite par l’or radioactif. Rev. franc. Et. clin. Biol. 3, 1086–1087 (1958).
Mazurenko, N.P.: Induction of leucoses in mice with infectious viruses and the significance of the latter in the etiology of disease. Probl. Oncol. (N.Y.) 6, 873–882 (1960).
McBride, R.A.: Graft-versus-host reaction in lymphoid proliferation. Cancer Res. 26, 1135–1151 (1966).
McCullagh, P.J.: The abrogation of immunological tolerance by means of allogeneic confrontation. Transplant. Rev. 12, 180–197 (1972).
McGregor, D.D.: Bone marrow origin of immunologically competent lymphocytes in the rat. J. exp. Med. 127, 953–966 (1968).
Medawar, P.B.: In: Ciba Foundation Study Group 16. (1963).
Medzihradsky, J.: Modification of tumor homograft immunity during the graft-versus-host reaction. Neoplasma (Bratisl.) 13, 223–226 (1966).
Medzihradsky, J.: Suppression of the tumor transplannation immunity by the local graft-versus-host reaction. Neoplasma (Bratisl.) 14, 369–375 (1967).
Merritt, C.B., Darrow, C.C. II, Vaal, L., Rogentine, G.N. jr.: Bone marrow transplantation in rhesus monkeys following irradiation. Transplantation 14, 9–20 (1972).
Meuwissen, H.J., Good, R.A.: Suppression of graft-versus-host reaction by mitomycin C. Nature (London) 215, 634–635 (1967).
Meuwissen, H.J., Kersey, J., Pabst, H., Gatti, R., Chilgren, R., Good, R.A.: Graft-versus-host reactions in bone marrow transplantation. Transplant. Proc. 3, 414–417 (1971).
Meyer, H., Heron, I.: Regional lymph node response in rats to injection of semiallogeneic lymphocytes. Acta path. microbiol. scand. B 81, 724–730 (1973).
Michie, D., Woodruff, M.F.A., Zeiss, J.M.: An investigation of immunological tolerance based on chimaera analysis. Immunology 4, 413–424 (1961).
Miller, J., Pierce, J.C., Martinez, C., Good, R.A.: An assay of graft-host interactions across strong and weak histocompatibility barriers in mice. J. exp. Med. 117, 863–877 (1963).
Miller, J.F.A.P., Howard, J.G.: Some dissimilarities between the neonatal thymectomy syndrome and graft-versus-host disease. J. reticuloendoth. Soc. 1, 369–392 (1964).
Miller, J.F.A.P., Mitchell, G.F.: The thymus and the precursors of antigen reactive cells. Nature (London) 216, 659–663 (1967).
Miller, M.E.: Thymic dysplasia (Swiss agammaglobulinemia). I. Graft-versus-host reaction following bone marrow transfusion. J. Pediat. 70, 730–736 (1967).
Miller, M.E., Hummeler, K.: Thymic dysplasia (Swiss agammaglobulinemia) II. Morphologic and functional observations. J. Pediat. 70, 737–744 (1967).
Möller, G.: Suppressive effect of graft-versus-host reaction on the immune response to heterologous red cells. Immunology 20, 597–609 (1971).
Monié, H.J., Everett, N.B.: The popliteal node assay for graft-versus-host interaction in mice. I. Location and proliferation of donor and host cells within the popliteal node. Anat. Rec. 179, 19–25 (1974).
Morse, H.C., Asofsky, R.: In vivo effects of antithymocyte serum on the homing pattern and graft-versus-host reactivity of murine splenic lymphocytes. Cell. Immunol. 11, 19–29 (1974).
Mun, A.M., Kosin, J.L., Sato, J.: Enhancement of growth of chick host spleens following chorioallantoic graft of homologous tissues. J. Embryol. exp. Morph. 7, 512–521 (1959).
Murphy, J.B.: The effect of adult chicken organ grafts on the chick embryo. J. exp. Med. 24, 1–5 (1916).
Naiman, J.L., Punnett, H.H., Lischner, H.W., Destine, M.L., Arey, J.B.: Possible graft versus-host reaction after intrauterine transfusion for Rh erythroblastosis fetalis. New Engl. J. Med. 281, 697–701 (1969).
Nakic, B., Kastelan, A.: Quantitative analysis of chimaeric state in mice. I. Pattern of distribution of donor cells in lymphoid organs of hosts neonatally inoculated with isologous spleen cells. Immunology 12, 609–614 (1967).
Nakic, B., Kastelan, J., Mikuska, J., Bunarevic, A.: Quantitative analysis if the chimaeric state in mice. II. Cytological examination of the proportion of proliferating donor and host cells in runt disease in mice. Immunology 12, 615–627 (1967).
Nakič, B., Teplitz, R.L., Ohno, S.: Cytological analysis of parabiotic disease in mice. Transplantation 4, 22–31 (1966).
Neefe, J.R. jr., Merrit, C.B., Darrow, C.C., II, Rogentine, G.N. jr.: Beneficial influence of limites histocompatibility of bone marrow grafted to unrelated rhesus monkeys preconditioned with X ray and ALS. Transplant. Proc. 6, 125–128 (1974).
Nielsen, H.E.: Reactivity of lymphocytes from germfree rats in mixed leukocyte culture and in graft-versus-host reaction. J. exp. Med. 136, 417–426 (1972).
Nisbet, N.W., Simonsen, M.: Primary immune response in grafted cells dissociation between proliferation of activity and proliferation of cells. J. exp. Med. 125, 967–981 (1967).
Nowell, P.C., Cole, L.J.: Pathologic changes in old non-irradiated F1 hybrid mice injected with parental strain spleen cells. Transplant. Bull. 6, 435–437 (1959).
Nowell, P.C., Defendi, V.: Distribution of proliferating donor cells in runt disease in rats. Transplantation 2, 375–382 (1964).
Okumura, K., Tada, T.: Regulation of homocytotropic antibody formation in the rat. IX. Further characterization of the antigen-specific inhibitory T cell factor in hapten-specific homocytotropic antibody response. J. Immunol. 112, 783–791 (1974).
Oliner, H., Schwartz, R., Dameshek, W.: Studies in experimental autoimmune disorders. I. Clinical and laboratory features of autoimmunization (runt disease) in the mouse. Blood 17, 20–44 (1961).
Ono, K., de Witt, C.W., Wallace, J.H., Lindsey, E.S.: Immunosuppressive activity of allogeneic antilymphocyte serum in the rat. Transplantation 7, 122–131 (1969).
Oppltová, L., Démant, P.: Genetic determinants for the graft-versus-host reaction in the H-2 complex. Transplant. Proc. 5, 1367–1371 (1973).
Ordal, J.C., Grumet, F.C.: Genetic control of the immune response. The effect of graft-versus-host reaction on the antibody response to Poly-L (Tyr, Glu)-Poly-D, L-Ala-Poly-L-Lys in non-responder mice. J. exp. Med. 136, 1195–1206 (1972).
Ornellas, E.P., Sanfilippo, F., Scott, D.W.: Cellular events in tolerance. IV. The effect of a graft-versus-host reaction and endotoxin on hapten- and carrier-specific tolerance. Europ. J. Immunol. 4, 587–591 (1974).
Osborne, D.P. jr., Katz, D.H.: The allogeneic effect in inbred mice. III. Unique antigenic structural requirements in the expression of the phenomenon on unprimed cell populations in vivo. J. exp. Med. 137, 991–1008 (1973a).
Osborne, D.P. jr., Katz, D.H.: The allogeneic effect in inbred mice. IV. Regulatory influences of graft-versus-host reactions on host T lymphocyte functions. J. exp. Med. 138, 825–838 (1973b).
Owen, J.J.T., Moore, M.A.S., Harrison, G.A.: Chromosome marker studies in the graft-versus-host reaction in the chick embryo. Nature (London) 207, 313–315 (1965).
Owens, A.H. jr., Santos, G.W.: The effect of cytotoxic drugs on graft-versus-host disease in mice. Transplantation 11, 378–382 (1971).
Papadimitriou, J.M., Keast, D.: The electron microscopy of livers of mice runted as a result of the graft-versus-host reaction and bacterial endotoxin. Brit. J. exp. Path. 50, 574–577 (1969).
Park, B.H., Good, R.A., Gate, J., Burke, R.: Fatel graft-versus-host reaction following transfusion of allogeneic blood and plasma in infants with combined immunodeficiency disease. Transplant. Proc. 6, 385–387 (1974).
Parkman, R., Mosier, D., Umansky, I., Cochran, W., Carpenter, W., Rosen, F.S.: Graft-versus-host disease after intrauterine transfusion and exchange transfusions for hemolysis in newborns. New Engl. J. Med. 290, 359–362 (1974).
Pick, E., Turk, J.L.: The biological activities of soluble lymphocyte products. Clin. exp. Immunol. 10, 1–23 (1972).
Pinkett, M.O., Cowdrey, C.R., Nowell, P.C.: Mixed hematopoietic pulmonary origin of “alveolar macrophages” as demonstrated by chromosome markers. Amer. J. Path. 48, 859–867 (1966).
Pirofsky, B., Davies, G.H., Ramirez-Mateos, J.C., Newton, B.W.: Cellular immune competence in the human fetus. Cell. Immunol. 6, 324–328 (1973).
Pollard, M.: Spontaneous “secondary” disease in germfree AKR mice. Nature (London) 222, 92–94 (1969).
Porter, K.A.: Use of foetal haematopoietic tissue to prevent late deaths in rabbit radiation chimaeras. Brit. J. exp. Pathol. 40, 273–280 (1959).
Porter, K.A.: Graft-versus-host reactions in the rabbit. Brit. J. Cancer 14, 66–76 (1960).
Potworowski, E.F., Zavallone, J.D., Gilker, J.C., Lamoureux, G.: Inhibition of the graft-versus-host reaction by thymus-specific antibodies. Rev. Eur. Et. clin. Biol. 16, 155–157 (1971).
Radaszkiewicz, T., Lennert, K.: Lymphogranulomatosis X. Dtsch. med. Wschr. 100, 1157–1162 (1975).
Ramseier, H., Billingham, R.E.: Studies on delayed cutaneous inflammatory reactions elicited by inoculation of homologous cells into hamsters’ skins. J. exp. Med. 123, 629–656 (1966).
Ramseier, H., Streilein, J.W.: Homograft sensitivity reactions in irradiated hamsters. Lancet 1965 I, 622–624.
Rao, V.S., Bonavida, B., Zighelboim, J., Fahey, J.L.: Preferential induction of serum blocking activity and enhancement of skin allograft by soluble alloantigen. Transplantation 17, 568–575 (1974).
Reilly, R.W., Kirsner, J.B.: Runt intestinal disease. Lab. Invest. 14, 102–107 (1965).
Rich, S.S., Rich, R.R.: Regulatory mechanism in cell-mediated immune responses. I. Regulation of mixed lymphocyte reactions by alloantigen-activated thymus-derived lymphocytes. J. exp. Med. 140, 1588–1603 (1974).
Richie, E.R., Gallagher, T.M., Trentin, J.J.: Prevention of graft-versus-host disease by Fab fragments derived from ALG. Transplant. Proc. 5, 873–876 (1973a).
Richie, E.R., Gallagher, M.T., Trentin, J.J.: Inhibition of the graft-versus-host reaction. II. Prevention of acute graft-versus-host mortality by Fab fragments of antilymphocyte globulin. Transplantation 15, 486–491 (1973b).
Richie, E.R., Monié, H.J., Trentin, J.J., Taub, R.N.: Inhibition of the graft-versus-host reaction. III. Altered in vivo distribution of spleen cells pretreated with FAB fragments of antithymocyte globulin. Transplantation 19, 115–121 (1975).
Rieke, W.O.: Lymphocytes from thymectomized rats: Immunologic, proliferative, and metabolic properties. Science 152, 535–538 (1966).
Riethmüller, G., Rieber, E.P., Seeger, I.: Suppression of graft-versus-host reaction by univalent antiimmunoglobulin antibody. Nature New Biology (London) 230, 248–250 (1971).
Rolstad, B., Ford, W.L.: Immune responses of rats deficient in thymus-derived lymphocytes to strong transplantation antigens (Ag-B). Transplantation 17, 405–415 (1974).
Rouse, B.T., Warner, N.L.: Suppression of graft-versus-host reactions in chickens by pretreatment of leukocytes with anti-light chain sera. Cell. Immunol. 3, 470–477 (1972).
Rubinstein, J.R., Cottier, H., Rossi, E., Gugler, E.: Unusual combined immunodeficiency syndrome exhibiting kappa-IgD paraproteinemia, residual gut immunity and graft-versus-host reaction after plasma infusion. Acta paediat. scand. 62, 365–372 (1973).
Rudolph, R.H., Fefer, A., Thomas, E.D., Buckner, C.D., Clift, R.A., Storb, R.: Isogeneic marrow grafts for hematologic malignancy in man. Arch, intern. Med. 132, 285–297 (1973).
Russel, P.S.: The weight-gain assay for runt disease in mice. Ann. N.Y. Acad. Sci. 87, 445–456 (1960).
Russel, P.S.: In: Ciba Foundation Symposium on Transplantation. London: Churchill 1962.
Safford, J.W., Tokuda, S.: Suppression of the graft-versus-host reaction by passive immunization of donor against recipient antigens. Proc. Soc. exp. Biol. Med. 133, 651–654 (1970).
Salaman, M.H., Wedderburn, N., Festenstein, H., Huber, B.: Detection of a graft-versus-host reaction between mice compatible at the H-2 locus. Transplantation 16, 29–31 (1973).
Salmon, S.E., Smith, B.A., Lehrer, R.I., Mogerman, S.N., Shinefield, H.R., Perkins, H.A.: Modification of donor lymphocytes for transplantation in lymphopenic immunological deficiency. Lancet 1970 II, 149–150.
Santos, G.W., Sensenbrenner, L.L., Burke, P.J., Colvin, M., Owens, A.H. jr., Bias, W.B., Slavin, R.E.: Marrow transplantation in man following cyclophosphamide. Transplant. Proc. 3, 400–404 (1971).
Saurat, J.H., Didier-Jean, L., Gluckman, E., Bussel, A.: Graft-versus-host reaction and lichen planus-like eruption in man. Brit. J. Derm. 92, 591–592 (1975).
Schabel, S.I.: Graft-versus-host atherosclerosis. Lancet 1975I, 396.
Schäfer, K.H.: Nierenerkrankungen nach Erstimpfung gegen Pocken. Mschr. Kinderheilk. 111, 361–368 (1963).
Schlipköter, H.W., Brockhaus, A.: Die Hemmung der experimentellen Silikose durch subcutane Verabreichung von Polyvinylpyridin-N-Oxyd. Klin. Wschr. 39, 1182–1189 (1961).
Schröder, J., de la Chapelle, A.: Fetal lymphocytes in the maternal blood. Blood 39, 153–162 (1972).
Schwartz, R.S., Andrè-Schwartz, J., Armstrong, M.Y.K., Beldotti, L.: Neoplastic sequelae of allogenic disease. I. Theoretical considerations and experimental design. Ann. N.Y. Acad. Sci. 129, 804–821 (1966).
Schwartz, R.S., Beldotti, L.: The treatment of chronic murine homologous disease: A comparative study of four “immunosuppressive agents”. Transplantation 3, 79–97 (1965a).
Schwartz, R.S., Beldotti, L.: Malignant lymphomas following allogenic disease: Transition from am immunological to a neoplastic disorder. Science 149, 1511–1514 (1965b).
Schwarz, J.A.: Die Entwicklung des Immunsystems. Klin. Wschr. 52, 857–870 (1974).
Scott, D.W., Ornellas, E.P.: Allogeneic interactions in the immune response and tolerance. II. Mechanism of stimulation of TNP plaque-forming cells in normal rats. Cell. Immunol. 11, 116–121 (1974).
Shapiro, M.: Familial autohemolytic anemia and runting syndrome with Rh-0-specific autoantibody. Transfusion 7, 281–296 (1967).
Shortman, K., Brunner, K.T., Cerottini, J.C.: Separation of stages in the development of the “T” cells involved in cell-mediated immunity. J. exp. Med. 135, 1375–1391 (1972).
Sidky, Y.A., Auerbach, R.: Lymphocyte-induced angiogenesis: A quantitative and sensitive assay of the graft-versus-host reaction. J. exp. Med. 141, 1084–1100 (1975).
Sieber, O., Fulginiti, V., Durie, B., Salmon, S.: Successful immunological reconstitution in severe combined immunodeficiency disease with transplantation from a non-compatible donor. Clin. Res. 22, 230 (1974).
Silobrcic, V., Trentin, J.J.: On the mechanism of “homologous disease” in sublethally irradiated mice. Transplantation 4, 719–731 (1966).
Simonsen, M.: Biological incompatibility in kidney transplantation in dogs. Acta path. microbiol. scand. 32, 1–35 (1953).
Simonsen, M.: The impact on the developing embryo and animal of adult homologous cells. Acta path. microbiol. scand. 40, 480–500 (1957).
Simonsen, M.: Graft-versus-host reactions. Their natural history, and applicability as tools of research. Progr. Allergy 6, 349–467 (1962).
Simonsen, M., Engelbreth-Holm, J., Jensen, E., Poulsen, H.: A study of the graft-versus-host reaction in transplantation to embryos, F1 hybrids, and irradiated animals. Ann. N.Y. Acad. Sci. 73, 834–841 (1958).
Simonsen, M., Jensen, E.: The graft-versus-host assay in transplantation chimaeras. In: Biological Problems of Grafting, p. 214–238. Oxford: Blackwell 1959.
Singh, J.N., Sabbadini, E., Sehon, A.H.: Cytotoxicity in graft-versus-host reaction. I. Role of donor and host spleen cells. J. exp. Med. 136, 39–48 (1972).
Singh, J.N., Sabbadini, E., Sehon, A.H.: Detection of nonspecific cytotoxicity in graft-versus-host reaction as a function of target cell type. Cell. Immunol. 8, 280–289 (1973).
Siskind, G., Leonard, L., Thomas, L.: The runting syndrome. Ann. N.Y. Acad. Sci. 87, 452–456 (1960).
Siskind, G.W., Thomas, L.: Studies on the runting syndrome in newborn mice. In: Biological Problems of Grafting, p. 176–192. Oxford: Blackwell 1959.
Slavin, R.E., Santos, G.W.: The graft-versus-host reaction in man after bone marrow transplantation: Pathology, pathogenesis, clinical features, and implication. Clin. Immunol. Immunopath. 1, 472–498 (1973).
Smitananda, N., Nelson, D.S., McRae, J.: Erythropoiesis in mice with graft-versus-host reactions: Effects of cells from various tissues on erythropoiesis and other measures of graft-versus-host reaction. Pathology (Sydney) 4, 35–46 (1972).
Solomon, J.B., Tucker, D.F.: Influence of age of the chick embryo host on the splenomegaly syndrome in the graft-versus-host reaction. Exp. Cell. Res. 25, 460–462 (1962).
Speck, B.: Bone marrow transplantation—clinical results and problems. Blut 27, 297–302 (1973).
Speck, B.: Knochenmarkstransplantation bei Leukämie: Möglichkeiten, Probleme. Schweiz. med. Wschr. 105, 1286–1289 (1975).
Speck, B., Dooren, L.J., de Koning, J., van Bekkum, D.W., Eernisse, J.G., Elkerbout, F., Vossen, J.M., van Rood, J.J.: Clinical experience with bone marrow transplantation: Failure and success. Transplant. Proc. 3, 409–413 (1971).
Speck, B., Zwann, F.E., van Rood, J.J., Eernisse, J.G.: Allogeneic bone marrow transplantation in a patient with aplastic anemia using a phenotypically HL-A-identical unrelated donor. Transplantation 16, 24–28 (1973).
Sprent, J.: Circulating T and B lymphocytes of the mouse. I. Migratory properties. Cell. Immunol. 7, 10–39 (1973).
Sprent, J., Basten, A.: Circulating T and B lymphocytes of the mouse. II Lifespan. Cell. Immunol. 7, 40–59 (1973).
Sprent, J., Miller, J.F.A.P.: Interaction of thymus lymphocytes with histoincompatible cell. I. Quantitation of the proliferative response of thymus cells. Cell. Immunol. 3, 361–384 (1972a).
Sprent, J., Miller, J.F.A.P.: Interaction of thymus lymphocytes with histoincompatible cells. II. Recirculating lymphocytes derived from antigen-activated thymus cells. Cell. Immunol. 3, 385–404 (1972b).
Stastny, P., Stembridge, V.A., Vischer, T., Ziff, M.: Homologous disease in the adult rat, a model for autoimmune disease. II. Findings in the joints, heart and other tissues. J. exp. Med. 122, 681–692 (1965).
Stastny, P., Stembridge, V.A., Ziff, M.: Homologous disease in the adult rat, a model for autoimmune disease. I. General features and cutaneous lesions. J. exp. Med. 118, 635–648 (1963).
Storb, R., Evans, R.S., Thomas, E.D., Buckner, C.D., Clift, R.A., Fefer, A., Neiman, P., Wright, S.E.: Paroxysmal nocturnal haemoglobinuria and refractory marrow failure treated by marrow transplantation. Brit. J. Haemat. 24, 743–750 (1973a).
Storb, R., Gluckman, E., Thomas, E.D., Buckner, C.D., Clift, R.A., Fefer, A., Glucksberg, H., Graham, T.C., Johnson, F.L., Lerner, K.G., Neiman, P., Ochs, H.: Treatment of established human graft-versus-host disease by antithymocyte globulin. Blood. 44, 57–76 (1974b).
Storb, R., Kolb, H.J., Graham, T.C., Kolb, H., Weiden, P.L., Thomas, E.D.: Treatment of established graft-versus-host disease in dogs by antithymocyte serum or Prednisone. Blood 42, 601–609 (1973b).
Storb, R., Thomas, E.D., Buckner, C.D., Clift, R.A., Johnson, F.L., Fefer, A., Glucksberg, E.R., Giblett, E.R., Lerner, K.G., Neiman, P.: Allogeneic marrow grafting for treatment of aplastic anemia. Blood 43, 157–180 (1974a).
Streilein, J.W.: A common pathogenesis for the lesions of graft-versus-host disease. Transplant. Proc. 3, 418–421 (1971a).
Streilein, J.W.: In: Immunology and the Skin (Ed. W. Montagna, R.E. Billingham). New York: Appleton 1971b.
Streilein, J.W.: Analysis of graft-versus-host disease in Syrian hamsters. IV. The refractory state and immunologic competence. J. exp. Med. 135, 567–587 (1972a).
Streilein, J.W.: In: Cancer Chemotherapy II, the 22nd Hahnemann Symposium (Eds. I. Brodsky, S.B. Kahn, J.H. Mover). New York: Grune & Stratton 1972b.
Streilein, J.W.: Pathologic lesions of graft-versus-host disease in hamsters: Antigenic target versus “innocent bystander”. Progr. exp. Tumor Res. (Basel) 16, 396–408 (1972c).
Streilein, J.W., Billingham, R.E.: Cutaneous hypersensitivity reactions to cellular isoantigens in rats. J. exp. Med. 126, 455–473 (1967).
Streilein, J.W., Billingham, R.E.: An analysis of graft-versus-host disease in syrian hamsters. I. The epidermolytic syndrome: Description and studies on its procurement. J. exp. Med. 132, 163–180 (1970a).
Streilein, J.W., Billingham, R.E.: An analysis of graft-versus-host disease in syrian hamsters. II. The epidermolytic syndrome: Studies on its pathogenesis. J. exp. Med. 132, 181–197 (1970b).
Streilein, J.W., Streilein, J.: An analysis of graft-versus-host disease in Syrian hamsters. III. Hematological manifestations: Description and studies in pathogenesis. Transplantation 13, 378–390 (1972).
Streilein, J.W., Stone, M.J.: Graft-versus-host disease: Unmasking of forbidden clones. Transplant. Proc. 5, 861–865 (1973).
Swingle, K.F., Grant, T.J., Valle, P.M.: Effect of immunosuppressive drugs on a localized graft-versus-host reaction in the rat. Proc. Soc. exp. Biol. (N.Y.) 142, 1329–1331 (1973).
Szenberg, A., Warner, N.L.: Large lymphocytes and the Simonsen phenomenon. Nature (London) 191, 920 (1961).
Szenberg, A., Warner, N.L.: Quantitative aspects of the Simonsen phenomenon. I. The role of the large lymphocyte. Brit. J. exp. Path. 43, 123–128 (1962).
Terasaki, P.I.: Identification of the type of blood-cell responsible for the graft-versus-host reaction in chicks. J. Embryol. exp. Morph. 7, 394–408 (1959).
Thomas, E.D.: In: Clinical Immunobiology (Ed. F.H. Bach, R.A. Good), Vol. 2. New York: Academic Press 1974.
Thomas, E.D., Ashley, C.A., Lochte, H.L., Jaretzki, A., Sahler, O.D., Ferrebee, J.W.: Homo-grafts of bone marrow in dogs after lethal total-body irradiation. Blood 14, 720–736 (1959).
Thomas, E.D., Epstein, R.B.: Bone marrow transplantation in acute leukemia. Cancer Res. 25, 1521–1524 (1965).
Thomas, E.D., Rudolph, R.H., Fefer, A., Storb, R., Slichter, S., Buckner, C.D.: Isogeneic marrow grafting in man. Exp. Hematol. 21, 16–18 (1971).
Thomas, E.D., Storb, R., Clift, R.A., Fefer, A., Johnson, L., Neiman, P.E., Lerner, K.G., Gluckberg, H., Buckner, C.D.: Bone marrow transplantation II. New Engl. J. Med. 292, 895–902 (1975).
Thompson, J.S., Simmons, E.L., Hofstra, D.: Studies on the immunologic unresponsiveness during the secondary disease period of lethally irradiated mice protected by homologous bone marrow. J. Immunol. 89, 62–71 (1962).
Tigelaar, R.E., Asofsky, R.: Graft-versus-host reactivity of mouse thymocytes: Effect of cortisone pretreatment of donors. J. Immunol. 110, 567–574 (1973).
Tigelaar, R.E., Gershon, R.K., Asofsky, R.: Graft-versus-host reactivity of mouse thymocytes: Effect of in vitro treatment with anti-TL serum. Cell. Immunol. 19, 58–64 (1975).
Tittor, W., Gerbase-Delima, M., Walford, R.L.: Synergy among responding lymphoid cells in the one-way mixed lymphocyte reaction. J. exp. Med. 139, 1488–1498 (1974).
Tittor, W., Walford, R.L.: Synergistic response between thymus and lymph node cells in the mixed lymphocyte culture. Nature (London) 247, 371–375 (1974).
Treiber, W., Lapp, W.S.: Graft-versus-host-induced immunosuppression. Transplantation 16, 211–216 (1973).
Trenkner, E.: The use of allogeneic T lymphocytes and bacterial lipopolysaccharide to induce immune responses to monovalent haptens in vitro. J. Immunol. 113, 918–924 (1974).
Trentin, J.J.: Mortality and skin transplantability in X-irradiated mice receiving isologous, homologous or heterologous bone marrow. Proc. Soc. exp. Biol. (N.Y.) 92, 688–693 (1956).
Trentin, J.J., Judd, K.P.: Prevention of acute graft-versus-host (GVH) mortality with spleen-absorbed antithymocyte globulin (ATG). Transplant. Proc. 5, 865–869 (1973).
Twist, V.W., Barnes, R.D.: Popliteal lymph node weight gain assay for graft-versus-host reactivity in mice. Transplantation 15, 182–185 (1973).
Tyan, M.: Modification of severe GVH disease with antisera to the 6 antigen or to whole serum. Transplantation 15, 601–604 (1973).
Tyan, M.L.: Graft-versus-host disease, modification with concanavalin A. Transplantation 18, 305–312 (1974).
Tyan, M.L.: Modification of graft-versus-host disease with Con A and preimmunization. Proc. Soc. exp. Biol. (N.Y.) 150, 628–629 (1975).
Uphoff, D.E.: Alteration of homograft reaction by A-methopterin in lethally irradiated mice treated with homologous marrow. Proc. Soc. exp. Biol. (N.Y.) 99, 651–653 (1958).
Uphoff, D.E.: Immunologic competence of bone marrow of different genotypes. J. nat. Cancer Inst. 43, 1055–1066 (1969).
Uphoff, D.E., Law, L.W.: Genetic factors influencing irradiation protection by bone marrow. II. The histocompatibility 1 (H-2) locus. J. nat. Cancer Inst. 20, 617–624 (1958).
Virolainen, M.: Hematopoietic origin of macrophages as studied by chromosome markers in mice. J. exp. Med. 127, 943–952 (1968).
Voisin, G.A., Kinsky, R., Maillard, J.: Protection against homologous disease in hybrid mice by passive and active immunological enhancement facilitation. Transplantation 6, 187–202 (1968).
Volkman, A.: The host cell response in the local graft-versus-host reaction induced in the kidneys of F1 rats by parental thoracic duct lymphocytes. J. exp. Med. 136, 21–38 (1972).
Vos, O., de Vries, M.J., Collenreur, J.C., van Bekkum, D.W.: Transplantation of homologous and heterologous lymphoid cells in X-irradiated and non-irradiated mice. J. nat. Cancer Inst. 23, 59–73 (1959).
De Vries, M.J., Crouch, B.D., van Putten, L.M., van Bekkum, D.W.: Pathologic changes in irradiated monkeys treated with bone marrow. J. nat. Cancer Inst. 27, 67–97 (1961).
De Vries, M.J., Vos, O.: Treatment of mouse lymphosarcoma by total-body X-irradiation and by injection of bone marrow and lymph node cells. J. nat. Cancer Inst. 21, 1117–1129 (1958).
De Vries, M.J., Vos, O.: Delayed mortality of radiation chimaeras. A pathological and hematological study. J. nat. Cancer Inst. 23, 1403–1439 (1959).
Vrubel, J.: Survival of cutaneous homografts after transplantation of lymph nodes immunized against the host. Nature (London) 189, 853–854 (1961).
Wagner, H., Rollinghoff, M., Shortman, K.: In: Proc. IInd Internat. Congr. of Immunology, (Ed. L. Brent, J. Hobrow). Vol. 3. Amsterdam: North-Holland Publ. 1974.
Walker, K.Z., Schoefl, G.I., Lafferty, K.J.: The pathogenesis of the graft-versus-host reaction in chicken embryos. Pathological changes in the yolk sac, thymus, bone marrow and bursa of Fabricius. Aust. J. exp. Biol. med. Sci. 50, 675–689 (1972).
Walker, K.Z., Lafferty, K.J., Schoefl, G.I.: Pathogenesis in the graft-versus-host reaction in chicken embryos. Requirement of yolk sac-derived stem cells for the development of proliferative lesions. Aust. J. exp. Biol. med. Sci. 51, 347–355 (1973a).
Walker, K.Z., Schoefl, G.I., Lafferty, K.J., Adams, E.P.: Pathogenesis of the graft-versus-host reaction in chicken embryos. The development of hemorrhagic lesions. Aust. J. exp. Biol. med. Sci. 51, 93–107 (1973b).
Walters, M.N.I.: Pancreatitis induced by the graft-versus-host reaction. J. Path. Bact. 91, 65–69 (1966).
Warner, N.L., Szenberg, A.: Quantitative aspects of the Simonsen phenomenon. IV. Effect of immunisation to minor antigenic determinants. Aust. J. exp. Biol. med. Sci. 42, 100–108 (1964).
Weiss, L., Aisenberg, A.C.: An electron microscope study of lymphatic tissue in runt disease. J. Cell Biol. 25, 149–177 (1965).
Wilson, D.B., Billingham, R.E.: Lymphocytes and transplantation immunity. Advanc. Immunol. 7, 189–273 (1967).
Wilson, D.B., Fox, D.H.: Quantitative studies on the mixed lymphocyte interaction in rats. VI. Reactivity of lymphocytes from conventional and germfree rats to allogenetic and xenogenetic cell surface antigens. J. exp. Med. 134, 857–870 (1971).
Wilson, D.B., Nowell, P.C.: Quantitative studies on the mixed lymphocyte interaction in rats. IV. Immunologic potentiality of the responding cells. J. exp. Med. 131, 391–407 (1970).
Wilson, D.B., Nowell, P.C.: Quantitative studies on the mixed lymphocyte interaction in rats. V. Tempo and specificity of the proliferative response and the number of reactive cells from immunized donors. J. exp. Med. 133, 442–453 (1971).
Wilson, D.B., Silvers, W.K., Nowell, P.C.: Quantitative studies on the mixed lymphocyte interaction in rats. II. Relationship of the proliferative response to the immunologic status of the donors. J. exp. Med. 126, 655–665 (1967).
Witting, C., Detlefsen, W.: Zur Korrelation von Splenomegalie und Blutbildveränderungen bei der Graft-versus-Host Reaktion der Maus. Blut 31, 229–238 (1975).
Woodruff, J.J.: Role of lymphocyte surface determinants in lymph node homing. Cell. Immunol. 13, 378–384 (1974).
Woodruff, J.M., Butcher, W.I., Hellerstein, L.J.: Early secondary disease in the Rhesus monkey. II. Electron microscopy of changes in mucous membranes and external epithelia as demonstrated in the tongue and lip. Lab. Invest. 27, 85–98 (1972).
Woodruff, J.M., Eltringham, R.J., Casey, H.W.: Early secondary disease in the Rhesus monkey. I. A comparative histopathologic study. Lab. Invest. 20, 499–511 (1969).
Zakarian, S., Billingham, R.E.: Studies on normal and immune lymphocyte transfer reactions in guinea pigs, with special reference to the cellular contribution of the host. J. exp. Med. 136, 1545–1563 (1972).
Zaleski, M.: Effect of graft-versus-host reaction on the immune response to alloantigens and growth of a syngeneic tumor. Exp. Hematol. 3, 12–21 (1975).
Zaleski, M., Milgrom, F.: Immunosuppressive effect of graft-versus-host reaction. Cell. Immunol. 7, 268–274 (1973).
Zeiss, J.M., Fox, M.: Donor and host contribution to splenomegaly in homologous mouse chimaeras. Nature (London) 197, 673–675 (1963).
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Hobik, H.P. (1977). Graft-Versus-Host-Reactions. In: Masshoff, J.W. (eds) Transplantation. Handbuch der allgemeinen Pathologie, vol 6 / 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66392-5_18
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