Abstract
Techniques for grafting skin were developed in the mid-sixteenth century. Three surgical principles were considered essential: preparation of the graft bed, adequate nutrition of the graft, and good hemostasis to permit graft contact with the host bed. These were rapidly abandoned, however, as crushing gunshot wounds that often necessitated amputation replaced sword slashes as the major form of injury. With the scientific renaissance of biologic sciences in the mid-nineteenth century and the success with use of aseptic free skin grafts permitted by the discovery of antiseptics, experimental and clinical skin grafting were revived. However, physicians did not recognize the biologic fact that grafting from one individual to another almost uniformly produced graft failure (Converse and Casson, 1968). Losses continued to be attributed to poor surgical technique resulting in inadequate graft nutrition (Thiersch, 1886).
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Lucas, Z.J. (1977). Skin Grafts in Animals and Man. In: Masshoff, J.W. (eds) Transplantation. Handbuch der allgemeinen Pathologie, vol 6 / 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66392-5_10
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