Halide Ions in Biological Systems
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Biochemical applications of Cl, Br and I NMR made to date have involved studies of the relaxation of aqueous ions taking part in chemical exchange with a protein, another macromolecule or some other molecule of biological interest. The efficiency of the quadrupolar relaxation mechanism for liganded halogen nuclei in a non-symmetric environment (cf. Chapter 2) results in clearly observable changes in the transverse and longitudinal relaxation times even when only a very small fraction of the ions become liganded. This effect, which has been termed “chemical amplification”, forms the basis of studies of biological problems through Cl, Br and I NMR.
KeywordsLine Width Relaxation Rate Correlation Time Rotational Correlation Time Quadrupole Coupling Constant
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