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Effect of Androgens on Bone, Calcium, and Phosphorus Metabolism

  • H. Spencer
  • J. A. Friedland
  • I. Lewin
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 43)

Abstract

Androgens have been shown to affect skeletal growth, skeletal maturation, mineralization and collagen formation in animals.

Keywords

Bone Resorption Osteogenesis Imperfecta Urinary Calcium Anabolic Steroid Urinary Calcium Excretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Albright, F.: Cushing’s Syndrome. In: Harvey Lectures. Lancaster, Penn.: Science Press Printing Comp. 1943.Google Scholar
  2. Albright, F., Reifenstein, E.C., Jr.: The Parathyroid Glands and Metabolic Bone Disease. Baltimore, Maryland: Williams & Wilkins 1948.Google Scholar
  3. Almqvist, S., Ikkos, D., Luft, R.: Metabolic studies with methandrostenolone (17β-hydroxy-17α-methyl-androsta-l, 4-dien-3-one) in human subjects. Acta endocr. (Kbh.) 38, 413–418 (1961).Google Scholar
  4. Armstrong, W.D., Knowlton, M., Couze, M.: Influence of estradiol and testosterone propionate on skeletal atrophy from disease and on normal bones of mature rats. Endocrinology 36, 313–322(1945).Google Scholar
  5. Aschkenasy-Lelu, P., Aschkenasy, A.: Effects of androgens and oestrogens on the metabolism of proteins and the growth of tissues. In: World Review of Nutrition and Dietetics. Philadelphia: J.B. Lippincott Co. 1959.Google Scholar
  6. Barker, D.J.P., Crossley, J.N.: Effect of testosterone on estrogen-induced bone formation in mice. Nature (Lond.) 194, 1088–1089 (1962).Google Scholar
  7. Bavetta, L.A., Bekhor, I., Nimni, M.E.: Effects of hormone administration on collagen biosynthesis in the rat. Proc. Soc. exp. Biol. (N.Y.) 110, 294–297 (1962).Google Scholar
  8. Bayley, N., Gordan, G.S., Lisser, H.: Long-term experiences with methyltestosterone as a growth stimulant in short immature boys. In: Pediatric Clinics of North America. Philadelphia: W.B. Saunders Company 1957.Google Scholar
  9. Belanger, L.F., Migicovsky, B.B.: Comparative effects of vitamin D, calcium, cortisone, hydrocortisone, and norethandrolone on the epiphyseal cartilage and bone of rachitic chicks. Develop. Biol. 2, 329–342 (1960).PubMedGoogle Scholar
  10. Belanger, L.F., Migicovsky, B.B.: Radiographic and histochemical observations on the effects of norethandrolone and calcionorethandrolone on the bones of rachitic chicks. Minerva Med. 52, 2116–2118 (1961).PubMedGoogle Scholar
  11. Bergstrand, C.G.: The influence of testosterone propionate on skeletal development in the immature rabbit. Acta endocr. (Kbh.) 4, 91–101 (1950).Google Scholar
  12. Bettmann, H.K., Goldman, H. S., Abramowicz, M., Sobel, E.H.: Oxandrolone treatment of short stature: effect of predicted mature height. J. Pediat. 79, 1018–1023 (1971).PubMedGoogle Scholar
  13. Bohr, H.H., Dawids, S.G.: The effect of cortisone and anabolic steroids on the retention of radioactive calcium and strontium in rats. Acta endocr. (Kbh.) 47, 223–230 (1964).Google Scholar
  14. Brøchner-Mortensen, K., Gerup, S., Thaysen, J.H.: The metabolic effect of new anabolic 19-nor-steroids. Acta med. scand. 165, 197–205 (1959).PubMedGoogle Scholar
  15. Caldwell, R.A.: The effects of sex hormones in experimental osteoporosis in rats. Brit. J. exp. Path. 43, 103–115 (1962).PubMedGoogle Scholar
  16. Castells, S.: New approaches to treatment of osteogenesis imperfecta. Clin. Orthop. 93, 239–249(1973).PubMedGoogle Scholar
  17. Castells, S., Inamdar, S., Baker, R.K., Wallach, S.: Effects of porcine calcitonin in osteogenesis imperfecta tarda. J. Pediat. 80, 757–762 (1972).PubMedGoogle Scholar
  18. Cattell, H.S., Clayton, B.: Failure of anabolic steroids in the therapy of osteogenesis imperfecta. J. Bone Jt. Surg. 50A, 123–141 (1968).Google Scholar
  19. Clein, L.J., Kowalewski, K.: Some effects of cortisone and an anabolic steroid on healing of experimental fractures. Canad. J. Surg. 5, 108–117 (1962).PubMedGoogle Scholar
  20. Cooke, A. M.: Osteoporosis. Lancet 268, 877–882, (1955)1.PubMedGoogle Scholar
  21. 929–937 (1955).Google Scholar
  22. Dankowski, T.S., Lee, R. A., Cohn, R.E., D’Ambrosia, R.D., Limaye, N.R.: Oxandrolone therapy of growth retardation. Amer. J. Dis. Child. 109, 526–532 (1965).Google Scholar
  23. Dymling, J.F., Isaksson, B., Sjorgren, B.: Anabolic steroids in the treatment of osteopenia. In: Protein Metabolism. Berlin-Heidelberg-New York: Springer 1962.Google Scholar
  24. Eisenberg, E.: Effects of androgens, estrogens and corticoids on strontium kinetics in man. J. clin. Endocr. 26, 566–572 (1966).PubMedGoogle Scholar
  25. Ershoff, B.H., Alfin-Slater, R.B., Bernick, S.: Osteoporosis in dystrophic mice. Arch. Path. 72, 599–601 (1961).PubMedGoogle Scholar
  26. Fischer, F., Hastrup, B.: Cortisone and calcium balance (effect of calcium, vitamin D and methylandrostenediol). Acta endocr. (Kbh.) 16, 141–148 (1954).Google Scholar
  27. Gardner, W.U.: Influence of sex and sex hormones on the breaking strength of bones of mice. Endocrinology 32, 149–160 (1943).Google Scholar
  28. Gordan, G.S., Eisenberg, E.: The effect of estrogens, androgens and corticoids on skeletal kinetics in man. Proc. roy. Soc. Med. 56, 1027–1029 (1963).PubMedGoogle Scholar
  29. Griboff, S.L., Herrmann, J.B., Smellin, A., Moss, J.: Hypercalcemia secondary to bone metastases from carcinoma of the breast. J. clin. Endocr. 14, 378–388 (1954).PubMedGoogle Scholar
  30. Heaney, R.P.: Radiocalcium metabolism in disuse osteoporosis in man. Amer. J. Med. 33, 188–200(1962).PubMedGoogle Scholar
  31. Henneman, P.H., Irwin, J.W., Wang, D.M.K., Burrage, W.S.: The effect of estrogen and androgen on calcium metabolism during cortisone administration. J. clin. Endocr. 15, 858 (1955).Google Scholar
  32. Henneman, P.H., Wallach, S.: A review of prolonged use of estrogens and androgens in postmenopausal and senile osteoporosis. Arch. ntern. Med. 100, 715–723 (1957).Google Scholar
  33. Hernberg, C. A.: Treatment of postmenopausal osteoporosis with oestrogens and androgens. Acta endocr. (Kbh.) 34, 51–59 (1960).Google Scholar
  34. Herrmann, J. B., Kirsten, E., Krakauer, J.S.: Hypercalcemic syndrome associated with androgenic and estrogenic therapy. J. clin. Endocr. 9, 1–12 (1949).PubMedGoogle Scholar
  35. Hollo, I.: Postmenopausal osteoporosis. Pathogenesis and the mode of action of hormone therapy. Ther. hung. 20, 123–126 (1972).PubMedGoogle Scholar
  36. Howard, E.: Steroids and bone maturation in infant mice: relative activities of dehydroepi-androsterone and testosterone. Endocrinology 70, 131–141 (1962).PubMedGoogle Scholar
  37. Howard, R.P., Furman, R.H.: Metabolic and serum lipid effects of methylandrostane and meth-ylandrostane pyrazoles. J. clin. Endocr. 22, 43–51 (1962).PubMedGoogle Scholar
  38. Joss, E.E., Zuppinger, K. A., Sobel, E.H.: Effect of testosterone propionate and methyl testosterone on growth and skeletal maturation in rats. Endocrinology 72, 123–130 (1963).Google Scholar
  39. Kaplan, J. G., Moshang, T., Jr., Bernstein, R., Parks, J. S., Bongiovanni, A.M.: Constitutional delay of growth and development. Effects of treatment with androgens. J. Pediat. 82, 38–44 (1973).PubMedGoogle Scholar
  40. Keele, D.K., Vose, G.P.: A study of bone density. Amer. J. Dis. Child. 118, 759–764 (1969).PubMedGoogle Scholar
  41. Kochakian, C.D., Murlin, J.R.: The relationship of the synthetic male hormone, androsten-dion, to the protein and energy metabolism of castrate dogs, and the protein metabolism of a normal dog. Amer. J. Physiol. 117, 642–657 (1936).Google Scholar
  42. Kowalewski, K.: Comparison of the effects of cortisone and certain anabolic-androgenic steroids on the uptake of radiosulfur in a healing fractured bone. Endocrinology 62, 493–497 (1958a).PubMedGoogle Scholar
  43. Kowalewski, K.: Uptake of radiosulphur in growing bones of cockerels treated with cortisone and 17-ethyl-19-nortestosterone. Proc. Soc. exp. Biol. (N.Y.) 97, 432–434 (1958b).Google Scholar
  44. Kowalewski, K.: Uptake of radiosulfate in growing bones of cockerels treated with cortisone and certain anabolic-androgenic steroids. Endocrinology 63, 759–764 (1958c).PubMedGoogle Scholar
  45. Kowalewski, K.: Effect of steroids on bone formation. In: Protein Metabolism. Berlin-Heidelberg-New York: Springer 1962.Google Scholar
  46. Lafferty, F.W., Spencer, G.E., Pearson, O. H.: Effects of androgens, estrogens and high calcium intakes on bone formation and resorption in osteoporosis. Amer. J. Med. 36, 514–528 (1964).PubMedGoogle Scholar
  47. Landau, R.L., Kappas, A.: Anabolic hormones in hyperparathyroidism. Ann. intern. Med. 62, 1223–1233 (1965).PubMedGoogle Scholar
  48. Laron, Z.: Effectiveness of fluoxymesterone on linear growth and weight in children with growth retardation and underweight. Acta endocr. (Kbh.) 36, 541–548 (1961).Google Scholar
  49. Laron, Z.: Use of fluoxymesterone in the treatment of growth retardation. Acta Paediat. 52, 465–472 (1963).Google Scholar
  50. Laron, Z., Boss, J.H.: Failure of 19-norandrostenolonephenylpropionate (Durabolin) to prevent the alterations produced by cortisone on the growing bone in rats. Endocrinology 69, 608–612(1961).PubMedGoogle Scholar
  51. Laron, Z., Kowadlo, A., Arie, B.Z., Kalish, L, Kende, S.: Interaction between 19 nor-andros-tenolone phenylpropionate (Durabolin) and 6-methyl-prednisolone (Medrol) on the bones of rats fed a low calcium diet. Israel J. exp. Med. 11, 41–47 (1963).Google Scholar
  52. Laszlo, D., Schilling, A., Bellin, J., Gottesman, E.D., Schulman, C.A.: Effect of testosterone on patients with bone metastases. J. Amer. med. Ass. 148, 1502–1507 (1952).Google Scholar
  53. Laszlo, D., Spencer, H.: Newer techniques in the study of calcium metabolism in man and effects of hormones thereon. In: Hormones and the Aging Process. New York City: Academic Press 1956.Google Scholar
  54. Lederer, J.: Etude clinique d’un nouval anabolisant des proteines. Schweiz. med. Wschr. 90, 1379–1383(1960).PubMedGoogle Scholar
  55. Levin, S.M., Simkin, A., Naor, E., Robin, G.C., Goldenberg, A., Dorfman, H.: A comparison of assay technics in experimental disuse osteoporosis: the effect of nandrolone phenylpropionate. Clin. Orthopaed. Related Res. 82, 246–252 (1972).Google Scholar
  56. Lewin, I.: Metabolic effects of structurally related steroid hormones. Fed. Proc. 24, 638 (1965).Google Scholar
  57. Little, K.: Interaction between catabolic and anabolic steroids. Curr. Ther. Res. 12 (10), 658–676(1970).PubMedGoogle Scholar
  58. Llaurado, J.G., Trunnell, J.B., Claus, J.L.: Some effects of simultaneous administration of norethandrolone and cortisone in the rat. Acta endocr. (Kbh.) 32, 536–544 (1959).Google Scholar
  59. MacGillivray, M.H., Kolotkin, M., Munschauer, R.W.: Enhanced linear growth responses in hypopituitary dwarfs treated with growth hormone plus androgen versus growth hormone alone. Pediat. Res. 8, 103–108 (1974).PubMedGoogle Scholar
  60. Martin, L.G., Clark, J.W., Connor, T.B.: Growth hormone secretion enhanced by androgens. J. clin. Endocr. 28, 425–428 (1968).PubMedGoogle Scholar
  61. McCullagh, E.P., Rossmiller, H.R.: Methyl testosterone. III. Effect upon body weight and growth. J. clin. Endocr. 1, 507–510 (1941).Google Scholar
  62. McSwiney, R.R., Prunty, F.T.O.: Metabolic effects of three testosterone derivatives including 17α-ethyl-19-nortestosterone. J. Endocr. 16, 28–40 (1957).PubMedGoogle Scholar
  63. Mellman, W.J., Bongiovanni, A.M., Garrison, M., Steikar, D.D.: Comparison of fluoxymes-terone and methyltestosterone as growth stimulants. Pediatrics 28, 525–530 (1961).PubMedGoogle Scholar
  64. Muldowney, F.P., O’Donovan, D.K., Gallagher, J.E., Cantwell, D.F., Abrahamson, M., Freaney, R.: Bone formation in osteogenesis imperfecta: The effect of anabolic steroid therapy. J. Irish med. Ass. 54, 132–135 (1964).Google Scholar
  65. Owen, M., Triffitt, J.T., Melick, R.A.: Albumin in bone. In: Hard Tissue Growth, Repair and Remineralization. Ciba Foundation Symposium 11. London: Ass. Sci. Pub. 1973.Google Scholar
  66. Plum, F., Dunning, M.F.: Amelioration of hypercalciuria following poliomyelitis by 17-ethyl-19-nortestosterone (Nilevar). J. clin. Endocr. 18, 860–871 (1958).PubMedGoogle Scholar
  67. Puche, R.C., Romano, M.C.: Effect of dehydroepiandrosterone sulfate on the mineral accretion of chick embryo frontal bones cultivated in vitro. Calc. Tis. Res. 4, 39–47 (1969).Google Scholar
  68. Puche, R.C., Romano, M.G: The effect of androgens on the carbohydrate metabolism of bone. Calc. Tis. Res. 6(2), 133–142 (1970).Google Scholar
  69. Raisz, L.G.: Physiologic and pharmacologic regulation of bone resorption. New Engl. J. Med. 282, 909–916(1970).PubMedGoogle Scholar
  70. Ray, C.G., Kirschvink, J.F., Waxman, S.H., Kelley, V.G: Studies of anabolic steroids. III. The effect of oxandrolone on height and skeletal maturation in mongoloid children. Amer. J. Dis. Child. 110, 618–623(1965).PubMedGoogle Scholar
  71. Reifenstein, E.G, Jr.: Control of corticoid-induced protein depletion and osteoporosis by anabolic steroid therapy. Metabolism 7, 78–89 (1958).PubMedGoogle Scholar
  72. Reifenstein, E.C., Jr., Albright, F.: The metabolic effects of steroid hormones in osteoporosis. J. clin. Invest. 26, 24–56 (1947).Google Scholar
  73. Reilly, W.A., Gordan, G.S.: Dissociation of growth-stimulating and skeleton-maturing actions of the synthetic androgen, fluoxymesterone. J. Pediat. 59, 188–193 (1961).PubMedGoogle Scholar
  74. Riggs, B.L., Jowsey, J., Kelly, P. J., Jones, J. D., Maher, F.T.: Effect of sex hormones on bone in primary osteoporosis. J. clin. Invest. 48, 1065–1072 (1969).PubMedGoogle Scholar
  75. Riggs, B.L., Ryan, R.J., Wahner, H.W., Jiang, N.-S., Mattox, V.R.: Serum concentrations of estrogen, testosterone and gonadotropins in osteoporotic and nonosteoporotic postmenopausal women. J. clin. Endocr. 36, 1097–1099 (1973).PubMedGoogle Scholar
  76. Robison, R.: Possible significance of hexosephosphoric esters in ossification. Biochem. J. 17, 286–293 (1923).PubMedGoogle Scholar
  77. Rodin, A.E., Kowalewski, K.: Histological and histochemical effects of cortisone and an anabolic androgen on long bones of young cockerels and rats. Canad. J. Surg. 6, 229–236 (1963).PubMedGoogle Scholar
  78. Running, O., Makinen, E., Lahtinen, K., Faijola, E.: Effect of nandrolone phenylpropionate on the bone of young rats. Endocrinology 75, 477–484 (1964).Google Scholar
  79. Ropes, M.W., Rossmeisl, E.C., Bauer, W.: The effect of estrin in osteogenesis imperfecta. J. clin. Invest. 25, 932–933(1946).Google Scholar
  80. Rubinstein, H.S., Solomon, M.L.: The growth depressing effect of large doses of testosterone propionate in the castrate albino rat. Endocrinology 28, 112–114 (1941).Google Scholar
  81. Scharer, V.K., Habich, H., Prader, A.: Wachstumsförderung mit neuen anabolen Steroiden. Helv. med. Acta 27, 530–534 (1960).PubMedGoogle Scholar
  82. Schilling, A., Laszlo, D.: Rate of urinary calcium excretion following intravenous administration as an indicator of bone metabolism. Proc. Soc. exp. Biol. (N.Y.) 78, 286–289 (1951).Google Scholar
  83. Silberberg, M., Silberberg, R.: Response of cartilage and bone of growing mice to testosterone propionate. Arch. Path. 32, 85–95 (1941).Google Scholar
  84. Silberberg, M., Silberberg, R.: Steroid hormones and bone. In: The Biochemistry and Physiology of Bone. New York City: Academic Press 1956.Google Scholar
  85. Simpson, M.E., Marx, W., Becks, H., Evans, H.M.: Effect of testosterone propionate on the body weight and skeletal system of hypophysectomized rats. Synergism with pituitary growth hormone. Endocrinology 35, 309–316 (1944).Google Scholar
  86. Skoog, W. A., Adams, W. S.: Metabolic balance studies of a patient with multiple myeloma given combined ACTH-androgen therapy: Comparisons of three androgens administered in varying dosage on exchanges of calcium, phosphorus and nitrogen. Metabolism 2, 614–625 (1962).Google Scholar
  87. Smith, Q. T., Allison, D.J.: Cutaneous collagen and hexosamine and femur collagen of testosterone propionate-treated rats of various ages. Biochem. Pharmacol. 14, 709–720 (1965).PubMedGoogle Scholar
  88. Sobel, H., Bonorris, G.: Effect of hormones on femurs and carcass nitrogen of animals treated with antianabolic agents. Metabolism 12, 246–251 (1963).PubMedGoogle Scholar
  89. Sobel, E.H., Raymond, S., Quinn, K.V., Talbot, N.B.: The use of methyltestosterone to stimulate growth: Relative influence on skeletal maturation and linear growth. J. clin. Endocr. 16, 241–248 (1956).PubMedGoogle Scholar
  90. Solomons, C.C., Styner, J.: Osteogenesis imperfecta: Effect of magnesium administration on pyrophosphate metabolism. Calc. Tis. Res. 3, 318–326 (1969).Google Scholar
  91. Spencer, H.: unpublished data.Google Scholar
  92. Spencer, H., Berger, E., Charles, M. L., Gottesman, E.D., Laszlo, D.: Metabolic effects of 17-ethyl-19-nortestosterone in man. J. clin. Endocr. 17, 975–984 (1957).PubMedGoogle Scholar
  93. Spencer, H., Hausinger, A., Laszlo, D.: The calcium tolerance test in senile osteoporosis. J. Amer. Geriat. 2, 19–25 (1954).Google Scholar
  94. Spencer, H., Lewin, I.: Derangements of calcium metabolism in patients with neoplastic bone involvement. J. chron. Dis. 16, 713–726 (1963).PubMedGoogle Scholar
  95. Spencer, H., Lewin, L, Friedland, J.A.: Changes in calcium metabolism in metastatic bone disease. Israel J. med. Sci. 3, 643–656 (1967).Google Scholar
  96. Spencer, H., Menczel, J., Lewin, I.: Metabolie and radioisotope studies in osteoporosis. Clin. Orthopaed. 35, 202–219 (1964a).Google Scholar
  97. Spencer, H., Menczel J., Lewin, I., Samachson, J.: Absorption of calcium in osteoporosis. Amer. J. Med. 37, 223–234 (1964 b).PubMedGoogle Scholar
  98. Stern, P.H.: Inhibition by steroids of parathyroid hormone-induced Ca45 release from embryonic rat bone in vitro. J. Pharmacol. exp. Ther. 168, 211–217 (1969).PubMedGoogle Scholar
  99. Swyer, A.J., Berger, J.S., Gordon, H.M., Laszlo, D.: Hypercalcemia in osteolytic metastatic cancer of the breast. Amer. J. Med. 8, 724–732 (1950).PubMedGoogle Scholar
  100. Tanabe, Y., Wilcox, F.H.: Endocrine control of serum alkaline phosphatase activity in the chicken. Poultry Sci. 49, 411–416 (1961).Google Scholar
  101. Tyslowitz, R.F.: Trans. 4th Josiah Macy, Jr. Conf. on Metabolic Aspects Convalescence, p. 123, 1943.Google Scholar
  102. Urist, M.R., Budy, A.M., McLean, F.C.: Endosteal-bone formation in estrogen-treated mice. Amer. J. Bone Jt. Surg. 32, 143–162 (1950).Google Scholar
  103. Van Wayjen, R.G.A.: Long term balance studies on certain anabolic agents. Symposium on Anabolic Therapy, Michigan and Wayne County Academies of General Practice, Detroit, Michigan, March 21, 1962.Google Scholar
  104. Van Wayjen, R.G.A., Buyze, G.: Clinical-pharmacological evaluation of certain anabolic steroids. Acta endocr. (Kbh.) (Suppl. 63) 39, 18–36 (1961).Google Scholar
  105. Vittek, J., Altman, K., Gordon, G.G., Southren, A.L.: The metabolism of 7α-3H-testosterone by rat mandibular bone. Endocrinology 94, 325–329 (1974).PubMedGoogle Scholar
  106. Vose, G. P., Keele, D. K.: Bone growth in nonambulatory children on oxymetholone and fluoride therapies. Growth 37, 213–221 (1973).PubMedGoogle Scholar
  107. Watkin, D.M.: The assessment of protein nutrition in aged man. Ann. N.Y. Acad. Sci. 69, 902–913(1958).PubMedGoogle Scholar
  108. Watkin, D.M., Parsons, J.M., Yiengst, M.J., Shock, N.W.: Metabolism in the aged: The effect of stanolone on the retention of nitrogen, potassium, phosphorus, and calcium and on the urinary excretion of 17-keto, 11-oxy, and 17-hydroxy steroids in eight elderly men on high and low protein diets. J. Gerontol. 10, 268–287 (1955).PubMedGoogle Scholar
  109. Wentworth, J.H., Smith, P.K., Gardner, W.U.: The composition of bones of mice receiving estrogens and androgens. Endocrinology 26, 61–67 (1940).Google Scholar
  110. Whedon, G.D., Shorr, E.: Metabolic studies in paralytic acute anterior poliomyelitis. J. clin. Invest. 36, 941–1033(1957).PubMedGoogle Scholar
  111. Wiancko, K.B., Kowalewski, K.: Strength of callus in fractured humerus of rat treated with anti-anabolic and anabolic compounds. Acta Endocr. (Kbh.) 36, 310–318 (1961).Google Scholar
  112. Wilkins, L.: Disturbances in growth. Bull. N.Y. Acad. Med. 29, 280–294 (1953).PubMedGoogle Scholar
  113. Woodard, H.Q.: Changes in blood chemistry associated with carcinoma metastatic to bone. Cancer 6, 1219–1227(1953).PubMedGoogle Scholar
  114. Woodard, H.Q., Escher, G.C., Farrow, J.H.: Changes in the blood chemistry of patients with disseminated carcinoma of the breast during endocrine therapy. Cancer 7, 744–757 (1954).PubMedGoogle Scholar
  115. Zachmann, M., Prader, A.: Anabolic and androgenic effect of testosterone in sexually immature boys and its dependency on growth hormone. J. clin. Endocr. 30, 85–95 (1970).PubMedGoogle Scholar
  116. Zanganah, F., Steiner, M.M.: Oxandrolone therapy in growth retardation of children. Amer. J. Dis. Child. 113, 233–241 (1967).Google Scholar

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© Springer-Verlag Berlin · Heidelberg 1976

Authors and Affiliations

  • H. Spencer
  • J. A. Friedland
  • I. Lewin

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