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The λ Repressor and its Action

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Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitätsforschung

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Abstract

Repressors are a class of proteins which regulate the expression of specific sets of genes by inhibiting their transcription. This concept of genetic regulation was proposed by Jacob and Monod (1961) and was based on genetic experiments on the expression of the lactose genes of Escherichia coli and the regulation of the lytic functions of the coliphage λ. The general principle of negative regulation in its present form is as follows: an operon consists of a set of adjacent genes which are coordinately transcribed or repressed. The operon is transcribed by RNA polymerase which recognizes a transcription initiation site called the promoter. A repressor protein turns off the transcription of the operon by binding specifically to a DNA site called the operator which precedes the genes of the operon, and interfering with either the binding of RNA polymerase to the promoter or the initiation of transcription. In response to a specific chemical or physical stimulus, the cell produces a specific inducer substance which inactivates the repressor and allows induction or derepression of the operon.

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  1. Abteilung Mikrobiologie, Biozentrum der Universität Basel, Klingelbergstrasse 70, CH-4056, Basel, Switzerland

    Vincenzo Pirrotta

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Pirrotta, V. (1976). The λ Repressor and its Action. In: Arber, W., et al. Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitätsforschung. Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitätsforschung, vol 74. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66336-9_2

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  • DOI: https://doi.org/10.1007/978-3-642-66336-9_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-66338-3

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