Skip to main content
SpringerLink
Log in

Environmental Influences on the Manifestation of Diabetes Mellitus in Chinese Hamsters

  • Chapter
The Genetics of Diabetes Mellitus

Abstract

It is well known that external and internal environmental factors can influence the development of diabetes mellitus if the proper genotype is present. Such factors as obesity (6,19,43) and diet (12,13,65), as well as age, hormones, drugs, and liver disorders (57) can affect glucose tolerance. Even in monozygotic twins, who have identical genotypes, there is a high degree of discordance in a variety of parameters associated with diabetes (7,36–39,47,54,63,64).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Allison, R.S.: Carbohydrate tolerance In overweight and obesity. Lancet 1, 537 (1927)

    Article  Google Scholar 

  2. Bouchardat, H.: De la Glucosurie du Diabète Sucré. Paris, 1883. Cited by: Renold, A.E., Burr, I., Stauffacher, W.: On the pathogenesis of diabetes mellitus: Possible usefulness of spontaneous hyperglycemic syndromes in Animals. In: Nobel Symposium 13. Pathogenesis of Diabetes Mellitus. Cerasi, E., Luft, R. (eds.). New York-London: John Wiley, 1969

    Google Scholar 

  3. Butler, L.: The inheritance of diabetes in the Chinese hamster. Diabetologia 3, 124 (1967)

    Article  PubMed  CAS  Google Scholar 

  4. Butler, C., Gerritsen, G.C.: A comparison of the modes of inheritance of diabetes in the Chinese hamster and the KK mouse. Diabetologia 6, 163 (1970)

    Article  PubMed  CAS  Google Scholar 

  5. Carpenter, A-M., Gerritsen, G.C., Dulin, W.E., Lazarow A.: Islet and beta cell volumes in diabetic Chinese hamsters and their nondiabetic siblings. Diabetologia 3, 92 (1967)

    Article  PubMed  CAS  Google Scholar 

  6. Cerasi, E., Luft, R.: Plasma insulin response to sustained hyperglycemia induced by glucose infusion in human subjects. Lancet II, 1359 (1963)

    Article  Google Scholar 

  7. Cerasi, E., Luft, R.: Insulin response to glucose Infusion in diabetic and nondiabetic monozygotic twin pairs. Genetic control of insulin response? Acta Endocr. (Kbh) 55, 330 (1967)

    CAS  Google Scholar 

  8. Chang, A.Y.: The structure and metabolism of the pancreatic islets. Wenner-Gren Symposium No. 16. Falkurez, S., Hellman, B., Taljedal, I.B. (eds.). New York: Pergamon Press, 1970, p. 515

    Google Scholar 

  9. Chang, A.Y., Schneider, D.I.: Metabolic abnormalities in the pancreatic islets and livers of the diabetic Chinese hamster. Diabetologia 6, 180 (1970)

    Article  PubMed  CAS  Google Scholar 

  10. Chobanian, A.V., Gerritsen, G.C., Brecher, P. I., McCombs, L.: Aortic glucose metabolism in the diabetic Chinese hamster. Diabetologia 10, 589 (1974)

    Article  PubMed  CAS  Google Scholar 

  11. Chobanian, A.V., Gerritsen, G.C., Brecher, P. I., Kessler, M.: Cholesterol metabolism in the diabetic-Chinese hamster. Diabetologia 10, 595 (1974)

    Article  PubMed  CAS  Google Scholar 

  12. Cohen, A.M., Bavly, S., Poznanski, R.: Change of diet of Yemenite Jews in relation to diabetes and ischemic heart disease. Lancet II, 1399 (1961)

    Article  Google Scholar 

  13. Cohen, A.M., Bavly, S., Poznanski, R.: The prevalence of diabetes among different ethnic groups in Israel. Metabolism 10, 50 (1961 )

    PubMed  CAS  Google Scholar 

  14. Coleman, D.L., Hummel, K.P.: The influence of genetic background on the expression of the obese (ob) gene in the mouse. Diabetologia 9, 287 (1973)

    Article  PubMed  CAS  Google Scholar 

  15. Coleman, D.L., Hummel, K.P.: Hyperinsulinemia in pre-weaning diabetes (db) mice. Diabetologia 10, 607 (1974)

    Article  PubMed  CAS  Google Scholar 

  16. Coleman, D.L., Hummel, K.P.: Studies with the mutation-diabetes in the mouse. Diabetologia 3, 238 (1967)

    Article  PubMed  CAS  Google Scholar 

  17. Conforti, A.: Ultrastruttura del rene nel diabete spontaneo dell’hamster cinese (Cricetulus griseus). Acta diabet. lat. 9, 655 (1972)

    Article  CAS  Google Scholar 

  18. Cornblath, M., Joassen, G., Weisskopf, B., Swiatek, K.R.: Hypoglycemia in the newborn. Pediat. Clin. N. Amer. 13, 905 (1966)

    CAS  Google Scholar 

  19. Ditschuneit, H.: Diabetes. Proceedings of the XVII. Cong. Inter. Diabetes Fed. Rodriguez, R.R., Vallance-Owen, J. (eds.). Amsterdam: Excerpta Medica, 1971, p. 526

    Google Scholar 

  20. Dulin, W.E., Chang, A.Y. and Gerritsen, G.C.: Spontaneous diabetes in the Chinese -hamster. In: Les Mutants Pathologiques Chez L’Animal, leur intérêt dans la recherche bio-médicale. Sabourdy, M. (ed.). Paris: Centre National de la Recherche Scientifique, 1970, p. 133

    Google Scholar 

  21. Dulin, W.E., Gerritsen, G.C.: Interaction of genetics and environment on diabetes in the Chinese hamster as. compared with human and other diabetic animal species. Acta diabet. lat. (Suppl.1) 9, 48 (1972)

    Google Scholar 

  22. Dulin, W.E., Gerritsen, G.C.: Experimental models for investigation of diabetic therapeutic problems. In: Metabolic Regulation, Insulin Metabolism and Diabetes. Academic Press. In press.

    Google Scholar 

  23. Falconer, D.S.: The UFAW Handbook on the Care and Management of Laboratory Animals. 3rd ed. Lane-Petter, W., Worden, A.N., Hill, B.F., Patterson, J.S., Ververs, H.G. (eds.). Kent: The Courier Printing and Publishing Co., Ltd., 1966, p. 72

    Google Scholar 

  24. Falconer, D.S.: Introduction to Quantitative Genetics. New York: Ronald Press, 1960, p. 129

    Google Scholar 

  25. Farquhar, J.W.: The significance of hypoglycemia in the newborn infant of the diabetic woman. Arch. Dis. Childh. 31, 203 (1956)

    Article  PubMed  CAS  Google Scholar 

  26. Federman, J. L., Gerritsen, G.C.: The retinal vasculature of the Chinese hamster: A preliminary study. Diabetologia 6, 186 (1970)

    Article  PubMed  CAS  Google Scholar 

  27. Frankel, B. J., Gerich, J. E., Hagura, R., Fanska, R.E., Gerritsen, G.C., Grodsky, G.M.: Abnormal secretion of insulin and glucagon by the in vitro perfused pancreas of the genetically diabetic Chinese hamster. J. Clin. Invest. 53, 1637 (1974)

    Article  PubMed  CAS  Google Scholar 

  28. Gerritsen, G.C., Dulin, W.E.: Serum proteins of Chinese hamsters and response of diabetics to tolbutamide and insulin. Diabetes 15, 331 (1966)

    PubMed  CAS  Google Scholar 

  29. Gerritsen, G.C., Dulin, W.E.: Characterization of diabetes in the Chinese hamster. Diabetologia 3, (1967)

    Google Scholar 

  30. Gerritsen, G.C., Needham, L.B., Schmidt, F.L., Dulin, W.E.: Studies on the prediction and development of diabetes in offspring of diabetic Chinese hamsters. Diabetologia 6, 158 (1970)

    Article  PubMed  CAS  Google Scholar 

  31. Gerritsen, G.C., Blanks, M.C.: Preliminary studies on food and -water consumption of prediabetic Chinese hamsters. Diabetologia 6, 177 (1970)

    Article  PubMed  CAS  Google Scholar 

  32. Gerritsen, G.C., Dulin, W.E.: Effect of diet restriction on onset of development of diabetes in prediabetic Chinese hamsters. Acta diabet. lat. (Suppl. 1) 9, 597 (1972)

    Google Scholar 

  33. Gerritsen, G.C., Blanks, M.C.: Characterization of Chinese hamsters by metabolic balance, glucose tolerance and insulin secretion. Diabetologia 10, 493 (1974)

    Article  PubMed  CAS  Google Scholar 

  34. Gerritsen, G.C., Johnson, M.A., Soret, M.G., Schultz, J. R.: Epidemiology of Chinese hamsters and preliminary evidence for genetic heterogeneity of diabetes. Diabetologia 10, 581 (1974)

    Article  PubMed  Google Scholar 

  35. Gerritsen, G.C., Blanks, M.C., Miller, R.L., Dulin, W.E.: Effect of diet limitation on the development of diabetes in prediabetic Chinese hamsters. Diabetologia 10, 559 (1974)

    Article  PubMed  CAS  Google Scholar 

  36. Gottlieb, M.S., Root, H.F.: Diabetes mellitus in twins. Diabetes 17, 693 (1968)

    PubMed  CAS  Google Scholar 

  37. Grodsky, G.M., Frankel, B. J., Gerich, J. E., Gerritsen, G.C.: The diabetic Chinese hamster: In vitro insulin and glucagon release; the “Chemical Diabetic”; and the effect of diet on ketonuria. Diabetologia 10, 521 (1974)

    Article  PubMed  CAS  Google Scholar 

  38. Harvald, B.: Genetic prespectives in diabetes mellitus. Acta Med. Scand. (Suppl. 476) 17, (1967)

    Google Scholar 

  39. Harvald, B., Hauge, M.: Hereditary factors elucidated by twin studies. Genetics and epidemiology of chronic disease. U.S. Pub. Health Services Publ. 1163, 1 (1965)

    Google Scholar 

  40. Holcomb, G.N., Klemm, L.A., Dulin, W.E.: The polyol pathway for glucose metabolism in tissues from normal, diabetic and ketotic Chinese hamsters. Diabetologia 10, 549 (1974)

    Article  PubMed  CAS  Google Scholar 

  41. Hummel, K.P., Coleman, D.L., Lane, P.W.: The influence of genetic background on expression at the diabetes locus in the mouse. I. C57BL/KsJ and C57BL/6J strains. Biochem. Genet. 7, 1 (1972)

    Article  CAS  Google Scholar 

  42. Joslin, E.P., Dublin, L.T., Marks, H.H.: Studies in diabetes mellitus. IV. Etiology. Amer. J. Med. Sci. 192, 9 (1936)

    Article  Google Scholar 

  43. Karam, J.H., Grodsky, G.M., Forsham, P.H.: Excessive insulin response to glucose In obese subjects as measured by immunochemical assay. Diabetes 12, 197 (1973)

    Google Scholar 

  44. Krauer, F., Joyce, J., Young, M.: The influence of high maternal plasma glucose levels and maternal blood flow on the placental transfer of glucose in the guinea pig. Diabetologia 9, 453 (1973)

    Article  PubMed  CAS  Google Scholar 

  45. Luse, S.A., Caramia, F., Gerritsen, G.C., Dulin, W.E.: Spontaneous diabetes mellitus in the Chinese hamster: an electron microscopic study of the islets of Langerhans. Diabetologia 3, 97 (1967)

    Article  PubMed  CAS  Google Scholar 

  46. Luse, S.A., Gerritsen, G.C., Dulin, W.E.: Cerebral abnormalities in diabetes mellitus an ultrastructural study of the brain in early onset diabetes mellitus in the Chinese hamster. Diabetologia 6, 192 (1970)

    Article  Google Scholar 

  47. Malins, J.M., Cassar, J., Pyke, D.A.: Diabetes in a pair of identical twins. Diabetes 19, 878 (1970)

    PubMed  CAS  Google Scholar 

  48. May, K.K., Beaton, J. R.: Hyperphagia in the insulin-treated rat. Proc. Soc. Exp. Biol. (N.Y.) 127, 1201 (1968)

    CAS  Google Scholar 

  49. McCombs, L., Gerritsen, G.C., Dulin, W.E., Chobanian, A.V.: Morphologic changes in the aorta of the diabetic Chinese hamster. Diabetologia 10, 607 (1974)

    Article  Google Scholar 

  50. Nakamura, M., Yamada, K.: Studies on a diabetic KK strain of mouse. Diabetologia 3, 212 (1967)

    Article  PubMed  CAS  Google Scholar 

  51. Neel, J. Y., Fajans, S. S., Conn, J.W., Davidson, R.T.: Genetics and the epidemiology of chronic diseases. Neel, J.V., Shaw, M., Schull, W. (eds.). U.S. Pub. Health Service Publ. 1163, 1965, p. 105

    Google Scholar 

  52. Oakley, N.W., Beard, R.W., Turner, R.C.: Effect of sustained maternal hyperglycaemia on the fetus in normal and diabetic pregnancies. Brit. Med. J.1, 466 (1972)

    Article  PubMed  CAS  Google Scholar 

  53. Pyke, D.A.: Clinical diabetes and its biochemical basis. Oakley, W.G., Pyke, D.A., Taylor, K.W. (eds.). London: Blackwell, 1968, p. 245

    Google Scholar 

  54. Pyke, D.A., Tattersall, R.B.: Diabetic retinopathy in identical twins. Diabetes 22, 613 (1973)

    PubMed  CAS  Google Scholar 

  55. Schlaepfer, W.W., Gerritsen, G.C., Dulin, W.E.: Segmental demyelination in the distal peripheral nerves of chronically diabetic Chinese hamsters. Diabetologia 10, 541 (1974)

    Article  PubMed  Google Scholar 

  56. Schmidt, F.L., Leslie, L.G., Schultz, J. R., Gerritsen, G.C.: Epidemiological studies of the Chinese hamster. Diabetologia 6, 154 (1970)

    Article  PubMed  CAS  Google Scholar 

  57. 56a. Schmidt, F.L., Miller, R.L., Peterson, T., Soret, M.G.: A microsurgical technique for orthotopic ovarian transplantation in the Chinese hamster. Surgery. (In press)

    Google Scholar 

  58. Seltzer, H.S.: Diabetes Mellitus: theory and practice. (Ellenberg, M., Rifkin, H. (eds.). New York: McGraw Hill, 1970, p. 453

    Google Scholar 

  59. Shirai, T., Welsh, G.W., 3rd, Sims, S.A.H.: Diabetes mellitus in the Chinese hamster. II. The evolution of renal glomerulopathy. Diabetologia 3, 266 (1967)

    Article  PubMed  CAS  Google Scholar 

  60. Simpson, N.E.: Multifactorial Inheritacne. A possible hypothesis for diabetes. Diabetes 13, 462 (1964)

    PubMed  CAS  Google Scholar 

  61. Soret, M.G., Dulin, W.E., Gerritsen, G.C.: Early Diabetes, Advances in Metabolic Disorders, Supplement 2. Camerini-Davalos, R., Cole, H.S. (eds.). New York: Academic Press, 1973, p. 291

    Google Scholar 

  62. Soret, M.G., Dulin, W.E., Mathews, J., Gerritsen, G.C.: Morphologic abnormalities observed in retina, pancreas and kidney of diabetic Chinese hamsters. Diabetologia 10, 567 (1974)

    Article  PubMed  CAS  Google Scholar 

  63. Stein, S. P., Charles, E.: Emotional factors in juvenile diabetes mellitus: a study of early life experience of adolescen: diabetics. Amer. J. Psychiat. 128, 700 (1971)

    PubMed  CAS  Google Scholar 

  64. Tattersall, R.B., Pyke, D.A.: Diabetes in identical twins. Lancet 2, 1120 (1972)

    Article  PubMed  CAS  Google Scholar 

  65. ThenBerg, H.: The genetic aspect of diabetes mellitus. J. Amer. Med. Assoc. 112, 1091 (1939)

    Article  Google Scholar 

  66. Wall, J. R., Pyke, D.A., Oakley, W.G.: Effect of carbohydrate restriction in obese diabetics: relationship of control to weight loss. Brit. Med. J. 1, 577 (1973)

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. G. C. Gerritsen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. C. Blanks
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F. L. Schmidt
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. W. E. Dulin
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Medizinische Klinik und Poliklinik der Universität, Humboldtallee, 1, D-3400, Göttingen, Germany

    Werner Creutzfeldt  & Johannes Köbberling  & 

  2. Department of Human Genetics, 1137 E Catherine Street, Ann Arbor, MI, 48104, USA

    James V. Neel

Rights and permissions

Reprints and permissions

Copyright information

© 1976 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Gerritsen, G.C., Blanks, M.C., Schmidt, F.L., Dulin, W.E. (1976). Environmental Influences on the Manifestation of Diabetes Mellitus in Chinese Hamsters. In: Creutzfeldt, W., Köbberling, J., Neel, J.V. (eds) The Genetics of Diabetes Mellitus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66332-1_18

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-66332-1_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-07651-3

  • Online ISBN: 978-3-642-66332-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation