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Diabetes Mellitus — A Geneticist’s Nightmare

  • Chapter
The Genetics of Diabetes Mellitus

Abstract

It would be difficult to establish who first remarked on the familial nature of diabetes mellitus. With the advent of Mendelism to medicine, during the 1920s and early 1930s various investigators (e.g., Wright, Cammidge, Macklin, Lawrence, White) interpreted particular pedigrees in terms of either dominant or recessive in heritance, an approach implying major genetic heterogeneity in the disease. A standard difficulty with this approach is that when an affected individual married to a normal person produces affected and normal children, this can be interpreted ether as resulting from simple dominant in heritance or else from the “pseudodominance” seen in the marriage of a person homozygous for a recessive gene to a heterozygous, phenotypically normal carrier of that gene; half of the children of this latter marriage will be affected just as in true dominant in heritance. In a common, familial disease, individual pedigrees can be found illustrating almost any mode of inheritance.

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References

  1. Allan, W.: Heredity in diabetes. Ann. Int. Med. 6, 1272 (1933)

    Google Scholar 

  2. Barrai, I., Cann, H.M.: Segregation analysis of juvenile diabetes mellitus. J. Med. Genet. 2, 8 (1965)

    Article  PubMed  CAS  Google Scholar 

  3. Burkeholder, J.N., Pickens, J.M., Womack, W.N.: Oral glucose tolerance test in siblings of children with diabetes mellitus. Diabetes 16, 156 (1967)

    PubMed  CAS  Google Scholar 

  4. Cohen, A.M.: Effect of environmental changes on prevalence of diabetes and of artherosclerosis in various ethnic groups in Israel. In: The Genetics of Migrant and Isolate Populations, Goldschmidt, E. (ed.). Baltimore: Williams & Wilkins, 1963, p. 127

    Google Scholar 

  5. Edwards, J.H.: The simulation of Mendelism. Acta Genet. (Basel) 10 63 (1960)

    CAS  Google Scholar 

  6. Edwards, J. H.: The genetic basis of common disease. Am. J. Med. 34 627 (1963)

    Article  Google Scholar 

  7. Elston, R.C., Namboodiri, K.K., Nino, H. V., Pollitizer, W.S.: Studies on blood and urine glucose in Seminole Indians: Indications for segregation of a major gene. Am. J. Hum. Genet. 26, 13 (1974)

    PubMed  CAS  Google Scholar 

  8. Falconer, D.S.:The inheritance of liability to certain diseases, estimated from the incidence among relatives. Ann. Hum. Genet. 29, 51 (1965)

    Article  Google Scholar 

  9. Falconer, D.S.: The inheritance of liability to diseases with variableage of onset with particular reference to diabetes mellitus. Ann. Hum. Genet. 31, 1 (1967)

    PubMed  CAS  Google Scholar 

  10. Gamble, D. R., Taylor, K.W., Cumming, H.: Coxsackie virus and diabetes mellitus. Brit. Med. J. 4 260 (1973)

    Article  PubMed  CAS  Google Scholar 

  11. Gamble, D.R., Kinsley, M.L., Fitzgerald, M.G., Bolton, R., Taylor, K.W.: Viral antibodies in diabetes mellitus. Brit. Med. J. 3., 627 (1969)

    Article  PubMed  CAS  Google Scholar 

  12. Garrod, A. E.: Inborn errors of metabolism. Lecture 1. Lancet 2 1 (1908)

    Article  CAS  Google Scholar 

  13. Hansen, S.:Uber die Vererbung des Diabetes mellitus. Acta Med. Scand. 62, 85 (1925)

    Article  Google Scholar 

  14. Harris, H.: The familial distribution of diabetes mellitus : a study of the relatives of 1241 diabetic propositi.Ann. Eug. 15, 95 (1950)

    Google Scholar 

  15. Hayner, N.S., Kjelsberg, M.O., Epstein, F. H., Francis, T., Jr.: Carbohydrate tolerance and diabetes in a total community, Tecumseh, Michigan. Diabetes (1965)

    Google Scholar 

  16. Hunter, S., McKay, E.: Intravenous glucose-tolerance t e s t in parents of diabetic children. Lancet 1, 1017 (1967)

    Article  PubMed  CAS  Google Scholar 

  17. Jörgensen, G.: Zur Genetik des idiopathischen Diabetes mellitus. Deutsch. Med. J. 17., 609 (1966)

    PubMed  Google Scholar 

  18. Keen, H., Track, N.S.: Age of onset and inheritance of diabetes: importance of examining relatives.Diabetologia 4 317 (1968)

    Article  PubMed  CAS  Google Scholar 

  19. Labhart, A.: Endogene und exogene Faktoren des Diabetes: Heredität, Adipositas, Zivilisation. Helv. Med. Acta. 32, 349 (1965)

    Google Scholar 

  20. Lamy, M., Frézal, J., Rey, J.: Hérédité du diabéte sucré. J. Ann. Diabet. Hôtel Dieu 2, 5 (1961)

    CAS  Google Scholar 

  21. Lawrence, R.D.: Heredity in diabetes mellitus and renal glycosuria. Inc Chances of Morbid In heritance, Blacker, C.P. (ed.). Baltimore: Wm. Wood 1931, p.332

    Google Scholar 

  22. Lestradet, H., Battistelli, F., Ledoux, A., Combier, E.: L’hérédité du Diabete Sucré Etude Effectuée à Partir de 1000 Families d1Enfants Diabetiquès et de 1000 Families Témoins. Nouv. Presse Med. 1, 2543 (1972)

    PubMed  CAS  Google Scholar 

  23. Levit, S. G., Pessikova, L. N.: The genetics of diabetes mellitus. Trudy Med.Genet. I n s t. Gorky 3, 132 (1934)

    Google Scholar 

  24. MacCuish, A.C., Irvine, W.J., Barnes, E.W., Duncan, L.J.P.: Antibodies to Pancreatic is letcells in insulin-dependent diabetics -with coexistent autoimmune disease.Lancet 2, 1529 ( 1974)

    Article  PubMed  CAS  Google Scholar 

  25. MacDonald, M.J.: Equal incidence of adult-on set diabetes among ancestors of juvenile diabetics and non diabetics.Diabetologia 10, 767 (1974)

    Article  CAS  Google Scholar 

  26. Miyao, S.: Diabetes mellitus and in heritance.Bull. Inst. Const. Med. Kumamoto Univ. 18, 1 (1967)

    Google Scholar 

  27. Mouratoff, G.J., Scott, E.M.: Diabetes mellitusin Eskimos after a decade.J. Am. Med. Ass. 226, 1345 (1973)

    Article  CAS  Google Scholar 

  28. Neel, J.V., Fajans, S.S., Conn, J.W., Davidson, R.T.: Diabetes mellitus. In: Genetics and the Epidemiology of Chronic Diseases. Public Health Service Publication No. 1163. Neel, J.V., Shaw, M.W., Schull, W.J. (eds.). Washington: Government Printing Office, 1965, p. 105

    Google Scholar 

  29. Nerup,J.,Platz, P., Andersen, O.O., Christy, M., Lyngsøe, J., Poulsen, J.E., Ryder, L.P.,Nielsen, L.S., Thomsen, M., Svejgaard, A.: HL-A antigens and di a -betes mellitus. Lancet 2, 864 (1974)

    Article  PubMed  CAS  Google Scholar 

  30. O’Sullivan, J. E., Williams, R. F., McDonald, G.W.: The prevalence of diabetes mellitus and related variables: a population study in Sudbury, Massachusetts. J. Chron. Dis. 20, 535 (1967)

    Article  PubMed  Google Scholar 

  31. Petrie, L. M., McLaughlin, C. D., Hodgins, T. E.: Mass screening for lowered glucose tolerance. Ann. Int. Med. 40, 963 (1954)

    PubMed  CAS  Google Scholar 

  32. Pincus, G., White, P.: On the in heritance of diabtes, mellitus. I. An analysis of 675 family histories. Am. J. Med. Sci. 186, 1 (1933)

    Article  Google Scholar 

  33. Pincus, G., White, P.: On the inheritance of diabetes mellitus. II. Further analysis of family histories. Am. J. Med. Sci. 188, 159 (1934)

    Article  Google Scholar 

  34. Pincus, G., White, P.: On the inheritance of diabetes mellitus. III. The blood sugar values of the relatives of diabetics. Am. J. Med. Sci. 188, 782 (1934)

    Article  Google Scholar 

  35. Rimoin, D. L.: Inheritance of diabetes mellitus. Med. Clin. N. A. 55., 807 (1971)

    CAS  Google Scholar 

  36. Rimoin, D. L., Schimke, R.N.: Genetic Disorders of the Endocrine Glands. St. Louis: C.V. Mosby, 1971

    Google Scholar 

  37. Rush, T., Tupper, C. J.: Two-hour postprandial glucose determinations in a periodic health appraisal program. Geriatrics 15., 630 (1960)

    PubMed  CAS  Google Scholar 

  38. Rushfort, N. B., Bennett, P. H., Steinberg, A. G., Burch, T. A., Miller, M.: Diabetes in the Pima Indians. Diabetes 20, 756 (1971)

    Google Scholar 

  39. Simpson, N. E.: The genetics of diabetes: A study of 233 families of juvenile diabetics. Ann. Hum. Getnet. 26, 1 (1962)

    Article  CAS  Google Scholar 

  40. Simpson, N. E.: Multifactorial inheritance: a possible hypothesis for diabetes. Diabetes 13, 462 (1964)

    PubMed  CAS  Google Scholar 

  41. Simpson, N. E.: Heritabilities of liability to diabetes when sex and age at onset are considered. Ann. Hum. Genet. 32., 283 (1969)

    Article  PubMed  CAS  Google Scholar 

  42. Sisk, C.W.: Application of one-hour glucose tolerance test to genetic studies of diabetes in children. Lancet 1, 262 (1968)

    Article  Google Scholar 

  43. Smith, C.: Discrimination between different modes of in heritance in genetic disease. Clin. Genet. 2, 303 (1971)

    Article  PubMed  CAS  Google Scholar 

  44. Smith, C., Falconer, D. S., Duncan, L. J. P.: A statistical and genetical study of diabtes. II. Heritability of liability. Ann. Hum. Genet. 35, 281 (1972)

    Article  PubMed  CAS  Google Scholar 

  45. Steinberg, A. G., Wilder, R.M.: A study of the genetics of diabetes mellitus. Am. J. Hum. Genet. 4, 113 (1952)

    PubMed  CAS  Google Scholar 

  46. Steinberg, A. G., Rushfort, N.B., Bennett, P. H., Burch, T. A., Miller, M.: Nobel Symposium 13: The Pathogenesis of Diabetes Mellitus. Cerasi, E., Luft, R. (eds.). New York: John Wiley & Sons 1970, p. 237

    Google Scholar 

  47. Tattersall, R. B., Fajans, S. S.: A difference between the inheritance of class icaljuvenile - onset and maturity-onset type diabetes of young people. Diabetes 24, 44 (1975)

    Article  PubMed  CAS  Google Scholar 

  48. Thompson, M.W., Watson, E.M.: Inheritance of diabetes mellitus : analysis of family histories of 1,631 diabetics. Diabetes 1, 268 (1952)

    PubMed  CAS  Google Scholar 

  49. Thompson, G.S.:Genetic factors in diabetes mellitus studied by the oral glucose tolerance test. J. Med. Genet. 2, 221 (1965)

    Article  PubMed  CAS  Google Scholar 

  50. Wilkerson, H. L. C., Krall, L. P.:Diabetes in a New England town. J. Am. Med. Ass. 135, 209 (1947)

    Article  CAS  Google Scholar 

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Authors
  1. J. V. Neel
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Editors and Affiliations

  1. Medizinische Klinik und Poliklinik der Universität, Humboldtallee, 1, D-3400, Göttingen, Germany

    Werner Creutzfeldt  & Johannes Köbberling  & 

  2. Department of Human Genetics, 1137 E Catherine Street, Ann Arbor, MI, 48104, USA

    James V. Neel

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Neel, J.V. (1976). Diabetes Mellitus — A Geneticist’s Nightmare. In: Creutzfeldt, W., Köbberling, J., Neel, J.V. (eds) The Genetics of Diabetes Mellitus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66332-1_1

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  • DOI: https://doi.org/10.1007/978-3-642-66332-1_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-07651-3

  • Online ISBN: 978-3-642-66332-1

  • eBook Packages: Springer Book Archive

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