Cell Membrane Antigens Associated with Human Adult Acute Leukemia
Cell membrane antigens associated with the blast phase of human acute leukemia are separable from inhibitory proteins and from histocompatibility antigens also present in the membranes. Since these antigens are not detectable in remission or normal white blood cells, they provide a useful marker for identification of cells undergoing carcinomatous changes. Blast antigens from acute lymphatic leukemia (ALL) are also present on early human fetal thymus cells; antigens from both sources produce cell-mediated immune (CMI) responses and are structurally similar. Blast antigens from acute myelocytic leukemia (AML) are not associated with fetal antigens and do not cross react with ALL antigens. ALL cells possess a larger quantity of CMI inhibitory protein than AML cells. The isolation, purification and identification of these blast antigens is a step toward their use in studying cultured and cloned subpopulations of cells thought to be associated with pre-leukemia.
Key WordsCell membrane antigens Leukemias
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- 1.HOLLINSHEAD, A.C., HERBERMAN, R.B.: Separation of the major histocompatibility antigens from other antigens present on human leukemic and white blood cell membranes. In: Unifying Concepts of Leukemia. Bibl. haemat., No. 39, R.M. DUTCHER, L. CHIECO-BIANCHI (eds.), pp. 828–837 (Karger, Basel) 1973 Google Scholar
- 2.HOLLINSHEAD, A.C., HERBERMAN, R.B.: Identification and characterization: Cell membrane antigens associated with the blast phase of human adult leukemia. Comparative leukemia Research 1973. In: Leukemogenesis, ITO, R.M. DUTCHER eds., Univ. of Tokyo Press, Tokyo/Karger, Basel, pp. 339–348, 1975 Google Scholar
- 5.HOLLINSHEAD, A.C.: Suppression of the immune response to tumor-associated antigens of acute leukemia. Ninth Leukocyte Culture Conference, Dec 1974 Google Scholar