Abstract
The bone marrow erythrocytic precursors of 12 patients with refractory anemia (preleukemia) or myelomonocytic leukemia were studied by transmission electron microscopy. The results were tabulated in a semiquantitative manner and a comparison was established between the two main diagnostic groups. The following results are reported. 1. Similar nuclear and cytoplasmic abnormalities of the normoblasts were observed in preleukemia and leukemia. 2. A nuclear lesion consisting of nuclear clefts and blebs was demonstrated in at least some of the normoblasts in all of the patients. Although not specific, this finding appears to be a new contribution in the field of preleukemia and myelomonocytic leukemia. 3. Iron overload, including the presence of pathologic sideroblasts, is common to both preleukemia and leukemia.
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Maldonado, J.E., Maigne, J., Lecoq, D. (1977). Comparative Electron-Microscopic Study of the Erythrocytic Line in Refractory Anemia (Preleukemia) and Myelomonocytic Leukemia. In: Bessis, M., Brecher, G. (eds) Hemopoietic Dysplasias (Preleukemic States). Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66312-3_12
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DOI: https://doi.org/10.1007/978-3-642-66312-3_12
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