Abstract
Preparations derived from species of Rauwolfia, a plant genus belonging to the Apocynaceae family, have been used for the treatment of a great variety of diseases in the folk medicine of the regions in which they are found. The species R. serpentina is a climbing or twining shrub occurring in the Indian sub-continent and S.E. Asia. The root of this plant has been used since ancient times in both India and the Malay peninsula as an antidote to the stings and bites of insects and poisonous reptiles. It has also been used to reduce fever, as a stimulant to uterine contractions, for insomnia, and particularly for the treatment of insanity.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aceto, Harris, L.S.: Effects of various agents on reserpine-induced blepharoptosis. Toxicol. appl. Pharmacol. 7, 329–336 (1965).
Adam, H.M.: Histamine in the central nervous system and hypophysis of the dog. In: Kety, S.S., Elkes (Eds.): Regional Neurochemistry, pp. 293–306. London: Pergamon Press 1961.
Adam, H.M., Hye, H.K.A.: Concentration of histamine in different parts of brain and hypophysis of cat and its modification by drugs. Brit. J. Pharmacol. 28, 137–152 (1966).
Agarwal, S.L., Bose, D.: A study of the role of brain catecholamines in drug induced tremor. Brit. J. Pharmacol. 30, 349–353 (1967).
Alper, M.H., Schmier, J.: Modification by guanethidine of the chronotropic action of sympathomimetic amines in the heart-lung preparation of the dog pretreated with reserpine. J. Pharmacol. exp. Ther. 137, 235–241 (1962).
Alpers, H.S., Shore, P.A.: Specific binding of reserpine-association with norepinephrine depletion. Biochem. Pharmacol. 18, 1363–1372 (1969).
Ambani, Woert van M.H.: Modification of the tremorigenic activity of physostigmine. Brit. J. Pharmacol. 46, 344–347 (1972).
Amin, A.H., Crawford, T.B., Gaddum, J.H.: The distribution of substance P and 5-hydro-xytryptamine in the central nervous system of the dog. J. Physiol. (Lond.) 126, 596–618 (1954).
Andén, N.E., Fuxe, K., Hökfelt, T.: The importance of nerve impulse flow for the depletion of the monoamines from central neurones by some drugs. J. Pharm. Pharmacol. 18, 630–632 (1966).
Andén, N.E., Fuxe, K., Hökfelt, T.: Effect of some drugs on central monoamine nerve terminals lacking nerve impulse flow. Europ. J. Pharmacol. 1, 226–232 (1967).
Andén, N.E., Henning: Adrenergic nerve function, noradrenaline level and noradrenaline uptake in cat nictitating membrane after reserpine treatment. Acta physiol. scand. 67, 498–504 (1966).
Andén, N.E., Magnusson, T., Waldeck: Correlation between noradrenaline uptake and adrenergic nerve function after reserpine treatment. Life Sci. 3, 19–25 (1964).
Appel, J. B., D.X.: Chemically-induced alterations in the behavioural effects of LSD-25. Biochem. Pharmacol. 13, 861–869 (1964).
Askew, B.M.: A simple screening procedure for imipramine-like antidepressant agents. Life Sci. 10, 725–730 (1963).
Axelrod, J.: Purification and properties of phenyl-ethanolamine-N-methyl transferase. J. biol. Chem. 237, 1657–1660 (1962a).
Axelrod, J.: The enzymatic-N-methylation of serotonin and other amines. J. Pharmacol. exp. Ther. 138, 28–33 (1962b).
Axelkod, Gordon, E., Hertting, G., Kopin, Potter, L.T.: On the mechanism of tachyphylaxis to tyramine in the isolated rat heart. Brit. J. Pharmacol. 19, 56–63 (1962b).
Axelrod, J., Hertting, G., Patrick: Inhibition of H3-norepinephrine release by monoamine oxidase inhibitors. J. Pharmacol. exp. Ther. 134, 325–328 (1961a).
Axelrod, J., Hertting, G., Potter, L.: Effect of drugs on the uptake and release of 3H-norepinephrine in the rat heart. Nature (Lond.) 194, 297 (1962a).
Axelrod, J., Mueller, Thoenen, H.: Neuronal and hormonal control of tyrosine hydroxylase and phenylethanolamine N-methyltransferase activity. In: Schümann, M.J., G. (Eds.): New Aspects of Storage and Release Mechanisms of Catecholamines, pp. 212–219. Berlin-Heidelberg-New York: Springer 1970.
Axelrod, J., Whitby, L.G., Hertting, G.: Effect of psychotropic drugs on the uptake of 3H-norepinephrine by tissues. Science 133, 383–384 (1961b).
Azarnoff, D.L., Burn, J.H.: Effect of noradrenaline on the action of nicotine and tyramine on isolated atria. Brit. J. Pharmacol. 16, 335–343 (1961).
Azzaro, A.J., Wenger, Craig, C.R., Stitzel, R.E.: Reserpine-induced alterations in brain amines and their relationship to changes in the incidence of minimal electroshock seizures in mice. J. Pharmacol. exp. Ther. 180, 558–568 (1972).
Balzer, Makinose, M., W., Hasselbach, W.: The binding of calcium transport inhibitors reserpine, chlorpromazine and prenylamine to the lipid of the membranes of the sarcoplasmic reticulum. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 260, 456–473 (1968b).
Balzer, H., Makinose, M., Hasselbach, W.: The inhibition of the sarcoplasmic calcium pump by prenylamine, reserpine, chlorpromazine and imipramine. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharm. 260, 444–455 (1968a).
Banerjee, U., Burks, Feldberg, W., Goodrich, C.A.: Temperature effects of reserpine injected into the cerebral ventricles in rabbits and cats. J. Physiol. (Lond.) 197, 221–231 (1968).
Bardhan, N.R., Chatterjee, A.: Failure of ascorbic acid in the prevention of adrenal hypertrophy and ovarian inhibition in reserpinized rats. Acta anat. (Basel) 73, 278–280 (1969).
Barrai, A., Glusman, M., Rapport, M.M.: Serotonin turnover in the intact cat brain. J. Pharmacol. exp. Ther. 181, 28–35 (1972).
Barnes, C.D., Pompeiano, O.: The interaction of brain stem adrenergic systems and VIIIth nerve stimulation on the spinal cord. Neuropharmacology 10, 437–446 (1971).
Barnett, A., Benforado, J.M.: The nicotinic effects of choline esters and of nicotine in guinea pig atria. J. Pharmacol. exp. Ther. 152, 29–36 (1966).
Barraclough, C.A., Sawyer, C.H.: Blockage of the release of pituitary ovulating hormone in the rat by chlorpromazine and reserpine: possible mechanisms of action. Endocrinology 61, 341–351 (1957).
Barrett, W. E., Plummer, A. J., Earl, A.E., Rogie, B.: Effect of reserpine on gastric secretion of the dog. J. Pharmacol. exp. Ther. 113, 3 (1955).
Bartonicek, V.: Failure of imipramine to influence serotonin and catecholamine levels in specific neurons of rat brain. Med. Pharmac. Exp. 12, 395–398 (1965).
Baum, T.: Vascular reactivity of reserpine-pretreated dogs. J. Pharmacol. exp. Ther. 141, 30–35 (1963).
Beck, L., M.J.: The physiology of vasodilatation. Angiology 12, 202–222 (1961).
Beck, L., Ybarra-Falcon, L., Domino, E.F.: Hemodynamic responses to reserpine in un-anesthetized dogs immobilized with neuromuscular blocking agents. J. Pharmacol. exp. Ther. 119, 133 (1957).
Bein, H.J.: Zur Pharmakologie des Reserpin, eines neuen Alkaloids aus Rauwolfia Serpentina Benth. Experientia (Basel) 9, 107–110 (1953).
Bein, H. J.: Significance of selected central mechanisms for the analysis of the action of reserpine. Ann. N. Y. Acad. Sci. 61, 4–16 (1955).
Bein: The pharmacology of rauwolfia. Pharmacol. Rev. 8, 435–483 (1956).
Bejrablaya, D., Burn, J.H., Walker, J.M.: The action of sympathomimetic amines on heart rate in relation to the effect of reserpine. Brit. J. Pharmacol. 13, 461–466 (1958).
Bell, C.: The pharmacological nature of the response of the reserpinized guinea-pig vas deferens to postganglionic nerve stimulation. Brit. J. Pharmacol. 37, 52–56 (1969).
Ben-David, M., Khazen, K., Khazan, N., Sulman, F.G.: Correlation between depressant and mammotropic effects in fifteen reserpine analogues. Arch. int. Pharmacodyn 171, 274–284 (1968).
Benditt, E.P., R.L.: The release of enterochromaffin cell substance by reserpine. Amer. J. Path. 32, 638 (1956).
Bennett, Kendle, K.E.: The effect of reserpine upon the rate of transport in the Fallopian tube of the mouse. J. Reprod. Fertil. 13, 345–348 (1967).
Benson, G.K.: Effect of reserpine on mammary gland involution and on other organs in the rat. Proc. Soc. exp. Biol. (N. Y.) 99, 550–553 (1958).
Berkowitz, B.A., Tarver, J.H., Spector, S.: Norepinephrine in blood vessels: concentration, binding, uptake and depletion. J. Pharmacol. exp. Ther. 117, 119–126 (1971).
Berl, S., Frigyesi, T. L.: Effect of reserpine on the turnover of glutamate, glutamine, aspartate and GAB A labeled with 1–14C acetate in caudate nucleus, thalamus and sensorimotor cortex (cat). Brain Res. 14, 683–695 (1969).
Berlin, R.: Depression after methoserpidine. Lancet 1965 II, 497.
Bernardi, D., Jori, A., Morselli, P., Valzelli, L., Garattini, S.: Further effects of imipramine and its desmethyl derivative on the hypothermia induced by reserpine. J. Pharm. Pharmacol. 18, 278–282 (1966).
Bernardi, D., S., Jori, A.: Peripheral and central components in the hyperthermic effects of desipramine in reserpinized rats. J. Pharm. Pharmacol. 20, 204–209 (1968).
Berneis, K.H., A., M.: Metal dependent aggregation of biogenic amines: A possible explanation for their storage and release. Nature (Lond.) 224, 281–283 (1969).
Berneis, K.H., Pletscher, A., Da Prada, M.: Phase separation in solutions of noradrenaline and adenosine triphosphate: influence of bivalent cations and drugs. Brit. J. Pharmacol. 39, 382–389 (1970).
Berti, F., P.A.: A kinetic analysis of drugs that inhibit the adrenergic neuronal membrane amine pump. Biochem. Pharmacol. 16, 2091–2094 (1967a).
Berti, F., Shore: Interaction of reserpine and ouabain on amine concentrating mechanisms in the adrenergic neurone. Biochem. Pharmacol. 16, 2271–2274 (1967b).
Bertler, Å.: Affect of reserpine on the storage of catecholamines in brain and other tissues. Acta physiol. scand. 51, 75–83 (1961).
Bertler, Å., Carlsson, A., Rosengren, E.: Release by reserpine of catecholamines from rabbits’ hearts. Naturwissenschaften 43, 521 (1956).
Bertler, Å., Falck, B., Owman, Rosengren, E.: The localization of monoaminergic blood-brain barrier mechanisms. Pharmacol. Rev. 18, 369–385 (1966).
Bertler, Å., Rosengren, E.: Occurrence and distribution of catechol amines in brain. Acta physiol. scand. 47, 350–361 (1969).
Besson, M.J., Cheramy, A., J.: Effects of some psychotropic drugs on dopamine synthesis in the rat striatum. J. Pharmacol. exp. Ther. 177, 196–205 (1971).
Bhagat: Response of isolated guinea-pig atria to various ganglion-stimulating agents. J. Pharmacol. exp. Ther. 154, 264–270 (1966).
Bhagat, Burke, Davis, J. W.: Effect of reserpine on the activity of adrenal enzymes involved in the synthesis of adrenaline. Brit. J. Pharmacol. 43, 819–827 (1971).
Bhargava, K.P., Kar, K., Parmar, S.S.: Independent cholinergic and adrenergic mechanisms in the guinea-pig isolated vas deferens preparation. Brit. J. Pharmacol. 24, 641–650 (1965).
Bhattacharya, A.N., Marks, B.H.: Reserpine- and chlorpromazine-induced changes in hypothalamo-hypophyseal-adrenal system in rats in the presence and absence of hypothermia. J. Pharmacol. exp. Ther. 165, 108–116 (1969).
Bianchi, C., Beani, L.: Reserpine and the neuromuscular junction. J. Pharm. Pharmacol. 18, 757–758 (1966).
Bianchi, M. de, Fargier, M.C: Etude dans le temps de l’effect de la reserpine sur la médullosurrénale. C. R. Soc. Biol. (Paris) 156, 1797–1802 (1962).
Björklund, A., Falk, B.: Histochemical characterization of a tryptamine-like substance stored in cells of the mammalian adenohypophysis. Acta physiol. scand. 77, 475–489 (1969).
Black, I.B., Parker, L., Axelrod, J.: A daily rhythm in the rate of depletion of brain norepinephrine by reserpine. Biochem. Pharmacol. 18, 2688–2691 (1969).
Blackman, J.G., Campion, D.S., Fastier, F.N.: Mechanism of action of reserpine in producing gastric hemorrhage and erosion in the mouse. Brit. J. Pharmacol. 14, 112–116 (1959).
Blaschko, H., Chruściel, T.L.: The decarboxylation of amino acids related to tyrosine and the awakening action in reserpine-treated mice. J. Physiol. (Lond.) 151, 272–284 (1960).
Blinks, J.R.: Field stimulation as a means of effecting the graded release of autonomic transmitters in isolated heart muscle. J. Pharmacol. exp. Ther. 151, 221–235 (1966).
Boadle-Biber, M. C., Roth, R. H.: Effect of drugs on the synthesis of noradrenaline in guinea-pig vas deferens. Brit. J. Pharmacol. 46, 696–707 (1972).
Boakes, R.J., P.B., Candy, J.M.: Supersensitivity of central noradrenaline receptors after reserpine. Brit. J. Pharmacol. 43, 443P–444P (1971).
Boakes, P.B., Candy, J.M.: A neuronal basis for the altering action of (+)-amphetamine. Brit. J. Pharmacol. 45, 391–403 (1972).
Bogdanski, D.F., Brodle, B.B.: Role of sodium and potassium ion in storage of norepinephrine by sympathetic nerve endings. Life Sci. 5, 1563–1569 (1966).
Bogdanski, Brodle, B.B.: The effects of inorganic ions on the storage and uptake of H3-norepinephrine by rat heart slices. J. Pharmacol. exp. Ther. 165, 181–189 (1969).
Bogdanski, D.F., Sulser, F., Brodie, B.B.: Comparative action of reserpine, tetrabenazine, and chlorpromazine on central parasympathetic activity: Effects on pupillary size and lacrimation in rabbit and on salivation in dog. J. Pharmacol. exp. Ther. 132, 176–182 (1961).
Bogdanski, D.F., Tissari, A., Brodie, B.B.: The effects of inorganic ions on uptake, storage and metabolism of biogenic amines in nerve endings. Pp. 17–26. In: Psychopharmacolo-gy: A review of progress 1957–1967. Washington, Public Health Service Publication No. 1836 (1968).
Boissier, J.-R., Fichelle-Pagny, J., Simon, P.: Activité antirésèrpine chez la SQuris de l’imipramine, de l’amitriptyline et de leur dérivés monodesméthylés. Therapie 21, 109–117 (1966).
Bolton, T.B.: Intramural nerves in the ventricular myocardium of the domestic fowl and other animals. Brit. J. Pharmacol. 31, 253–268 (1967).
Bonaccorsi, A.: Studies on the hypertensive response elicited by reserpine or tetrabenazine in rats treated with amphetamine-like drugs. Europ. J. Pharmacol. 3, 97–105 (1968).
Bondarefe, W.: Submicroscopic morphology of granular vesicles in sympathetic nerves of rat pineal body. Z. Zellforsch. 67, 211–218 (1965).
Bowman, W.C., Osuide, G.: Interaction between the effects of tremorine and harmine and of other drugs in chicks. Europ. J. Pharmacol. 3, 106–111 (1968).
Boyd, H., Burnstock, G., Rogers, D.: Innervation of the large intestine of the toad (Bufo marinus). Brit. J. Pharmacol. 23, 151–163 (1964).
Brandon, K.W., Rand, M.J.: Acetylcholine and the sympathetic innervation of the spleen. J. Physiol. (Lond.) 157, 18–32 (1961).
Bray, G.A.: Studies on the interactions of thyroid hormone and catecholamines. J. clin. Invest. 43, 285–294 (1964).
Brewster, W.R., Isaacs, J.P., Osgood, P.F., King, T.L.: The hemodynamic and metabolic interrelationships in the activity of epinephrine, norepinephrine and the thyroid hormones. Circulation 13, 1–20 (1956).
Brimijoin, S., Trendelenburg, U.: Reserpine-induced release of norepinephrine from isolated spontaneously beating guinea-pig atria. J. Pharmacol. exp. Ther. 176, 149–159 (1971).
Brodie, B.B., Beavan, M.A.: Neurochemical transducer systems. Med. exp. (Basel) 8, 320–351 (1963).
Brodle, B.B., Comer, M. S., Costa, E., Dlabac, A.: The role of brain serotonin in the mechanism of a central action of reserpine. J. Pharmacol. exp. Ther. 152, 340–349 (1966).
Brodle, B.B., Costa, E.: Some current views on brain monoamines. Psychopharmacol. Bull. 2, 1–25 (1962).
Brodle, B.B., Olin, J.S., Kuntzman, R.B., Shore, P.A.: Possible interrelationship between release of brain norepinephrine and serotonin by reserpine. Science 125, 1293–1294 (1957a).
Brodle, Pletscher, A., P.A.: Evidence that serotonin has a role in brain function. Science 122, 968 (1955).
Brodie, Shore, P. A.: A concept for the role of serotonin and norepinephrine as chemical mediators in the brain. Ann. N. Y. Acad. Sci. 66, 631–642 (1957).
Brodie, Sulser, F., Costa, E.: Psychotherapeutic drugs. Ann. Rev. Med. 12, 349–368 (1961).
Brodie, B.B., Tomich, Kuntzman, R., Shore, P.A.: On the mechanism of action of reserpine: Effect of reserpine on capacity of tissues to bind serotonin. J. Pharmacol. exp. Ther. 119, 461–467 (1957b).
Brodie, D. A., Hanson, H.M.: A study of the factors involved in the production of gastric ulcers by the restraint technique. Gastroenterology 38, 353–360 (1960).
Brodie, D.A., H.M., Sines, J.O., Ader, R.: A symposium on current research on gastric ulcers. J. Neuropsychiat. 4, 388–408 (1963).
Brogden, R.N., Speight, T.M., Avery, G.S.: Levodopa: A review of its pharmacological properties and therapeutic uses with particular reference to parkinsonism. Drugs 2, 262–400 (1971).
Brooks, D.C., Gershon, M.D.: An analysis of the effect of reserpine upon ponto-geniculo-occipital wave activity in the cat. Neuropharmacology 11, 499–510 (1972).
Brooks, D.C., Gershon, M.D., Simon, R.P.: Brain stem serotonin depletion and ponto-geniculo-occipital wave activity in the cat treated with reserpine. Neuropharmacology 11, 511–520 (1972).
Brown, G.L.: The release and fate of the transmitter liberated by adrenergic nerves. Proc. roy. Soc. B 162, 1–19 (1965).
Brown, P.S.: The effect of reserpine, 5-hydroxytryptamine and other drugs on induced ovulation in immature mice. J. Endocr. 35, 161–168 (1966).
Brown, P.S.: Pituitary follicle-stimulating hormone in immature female rats treated with drugs that inhibit the synthesis or antagonise the actions of catecholamines and 5-hydroxy-tryptamine. Neuroendocrinology 7, 183–192 (1971).
Buckley, N.M.: Role of endogenous norepinephrine in cardiac inotropic effects of nucleosides Arch. int. Pharmacodyn 188, 92–104 (1970).
Bülbring, E.: The action of adrenaline on transmission in the superior cervical ganglion. J. Physiol. (Lond.) 103, 55–67 (1944).
Burger, A., Philippu, A., Schümann, H.J.: Untersuchungen zur Bedeutung einer ATPase aus Milznervengranula. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 260, 101–102 (1968).
Burger, A., A., Schümann, H.J.: ATP-Spaltung und Aminaufnahme durch Milznervengranula. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 262, 208–220 (1969).
Burn, J.H., R.: A test for tranquillizing drugs. Arch. int. Pharmacodyn. 113, 290–295 (1958).
Burn, J.H., Leach, Rand, M.J., Thompson, J.W.: Peripheral effects of nicotine and acetylcholine resembling those of sympathetic stimulation. J. Physiol. (Lond.) 148, 332–352 (1959).
Burn, J.H., Rand, M.J.: Reserpine and noradrenaline in artery walls. Lancet 1957 II, 1097.
Burn, J.H., Rand, M.J.: Action of nicotine on the heart. Brit. med. J. 1958a I, 137–139.
Burn, J.H., Rand, M.J.: Noradrenaline in artery walls and its dispersal by reserpine. Brit. med. J. 1958b I, 903–908.
Burn, J.H., Rand, M.J.: Excitatory action of the vagus in the isolated atria in relation to adrenaline. J. Physiol. (Lond.) 142, 173–186 (1958c).
Burn, J.H., Rand, M.J.: The action of sympathomimetic amines in animals treated with reserpine. J. Physiol. (Lond.) 144, 314–336 (1958d).
Burn, J. H., Rand, M. J.: Fall of blood pressure after a noradrenaline infusion and its treatment by pressor agents. Brit. med. J. 1959a I, 394–397.
Burn, J. H., Rand, M.J.: The cause of the supersensitivity of smooth muscle to noradrenaline. J. Physiol. (Lond.) 147, 135–143 (1959b).
Burn, J.H., Rand, M.J.: Sympathetic postganglionic mechanism. Nature (Lond.) 184, 163–165 (1959 c).
Burn, J. H., Rand, M.J.: The effect of precursors of noradrenaline on the response to tyramine and sympathetic stimulation. Brit. J. Pharmacol. 15, 47–55 (1960a).
Burn, J.H., Rand, M.J.: Sympathetic postganglionic cholinergic fibres. Brit. J. Pharmacol. 15, 56–66 (1960b).
Burn, J.H., Rand, M. J.: A new interpretation of the adrenergic nerve fibres. Advanc. Pharmacol. 1, 1–30 (1962).
Burn, J.H., Rand, M.J.: Acetylcholine in adrenergic transmission. Ann. Rev. Pharmacol. 5, 163–182 (1965).
Burnstock, G., Gannon, B., Iwayama, T.: Sympathetic innervation of vascular smooth muscle in normal and hypertensive animals. Circulat. Res. 27, Suppl. 2, 5–23 (1970).
Burnstock, G., Holman, M.E.: Effect of denervation and of reserpine treatment on transmission at sympathetic nerve endings. J. Physiol. (Lond.) 160, 461–469 (1962).
Butcher, L.L., Rhodes, D.L., Yuwiler, A.: Behavioural and biochemical effects of preferentially protecting monoamines in the brain against the action of reserpine. Europ. J. Pharmacol. 18, 204–212 (1972).
Butterbaugh, G.G., Spratt, J.L.: The possible role of brain monoamines in the acute toxicity of digitoxigenin. (Protective effects of Serpasil, Singoserp, and tetrabenazine.) J. Pharmacol. exp. Ther. 175, 121–130 (1970).
Cairoli, V.J., Crout, J.R.: Role of the autonomic nervous system in the resting tachycardia of experimental hyperthyroidism. J. Pharmacol. exp. Ther. 158, 55–65 (1967).
Cairoli, V. J., Reilly, J.F., Roberts, J.: Effect of reserpine pretreatment on the response of isolated papillary muscle to ephedrine. Brit. J. Pharmacol. 18, 588–594 (1962).
Callingham, B. A., Mann, M.: Adrenaline and noradrenaline, replacement of, in the innervated and denervated adrenal gland of the rat, following depletion with reserpine. Nature (Lond.) 182, 1020–1021 (1958).
Callingham, B. A., Mann, M.: Depletion and replacement of the adrenaline and noradrenaline contents of the rat adrenal gland, following treatment with reserpine. Brit. J. Pharmacol. 18, 138–149 (1962).
Calne, D.B.: Parkinsonism: Physiology, pharmacology and treatment. London: Arnold 1970.
Calvert, D.N., Brody, T.M.: Role of the sympathetic nervous system in CC14 hepatotoxicity. Amer. J. Physiol. 198, 669–676 (1960).
Campbell, A., Robertson, E.: Treatment of severe hypertension with hexamethonium bromide. Brit. med. J. 1950 II, 804–806.
Carlsson, A.: Brain monoamines and psychotropic drugs. Neuropsychopharmacol. 2, 417–421 (1961).
Carlsson, A.: Pharmacological depletion of catecholamine stores. Pharmacol. Rev. 18, 541–549 (1965a).
Carlsson, A.: Drugs which block the storage of 5-hydroxytryptamine and related amines. In: Erspamer, V. (Ed.): Handbuch der Exp. Pharmakol., Vol. 19, pp. 529–592. Berlin-Heidelberg-New York: Springer 1965b.
Carlsson, A.: Physiological and pharmacological release of monoamines in the central nervous system. In: von Euler, U.S., Rosell, S., Uvnäs, B. (Eds.): Mechanisms of Release of Biogenic Amines, pp. 331–346. Oxford: Pergamon Press 1966.
Carlsson, A., Dahlström, A., Fuxe, K., Hillarp, N.-Å.: Failure of reserpine to deplete noradrenaline neurons of α-methylnoradrenaline formed from α-methyldopa. Acta Pharmacol. (Kbh.) 22, 270–276 (1965).
Carlsson, A., Hillarp, N.-Å.: Release of adenosine triphosphate along with adrenaline and noradrenaline following stimulation of adrenal medulla. Acta physiol. scand. 37, 235–239 (1956).
Carlsson, A., Hillarp, N.-Å., Waldeck, B.: A Mg++-ATP dependent storage mechanism in the amine granules of the adrenal medulla. Med. exp. (Basel) 6, 47–53 (1962).
Carlsson, A., Hillarp, N.-Å., Waldeck, B.: Analysis of the Mg++-ATP dependent storage mechanisms in the amine granules of the adrenal medulla. Acta physiol. scand. 59, Suppl. 215, 1–38 (1963)b.
Carlsson, A., Jonasson, J., Rosengren, E.: Time correlation between the effects of reserpine on behaviour and storage mechanism for arylalkyamines. Acta physiol. scand. 59, 474–477 (1963a).
Carlsson, A., Lindqvist, M.: The interference of tetrabenazine, benzquinamide and prenyla-mine with the action of reserpine. Acta pharmacol. (Kbh.) 24, 112–120 (1966).
Carlsson, A., Lindqvist, M.: Metatyrosine as a tool for selective protection of catecholamine stores against reserpine. Europ. J. Pharmacol. 2, 187–192 (1967).
Carlsson, A., Lindqvist, M.: Central and peripheral monoaminergic membrane-pump blockade by some addictive analgesics and antihistamines. J. Pharm. Pharmacol. 21, 460–464 (1969).
Carlsson, A., Lindqvist, M., Magnusson, T.: 3,4-Dihydroxy-phenylalanine and 5-hydro-xytryptophan as reserpine antagonists. Nature (Lond.) 180, 1200 (1957 b).
Carlsson, A., Rosengren, E., Bertler, A., Nilsson, J.: Effect of reserpine on the metabolism of catecholamines. In: Garattini, S., Ghetti, V. (Eds.): Psychotropic Drugs, Vol. 6, pp. 363–372. Amsterdam: Elsevier 1957a.
Carlsson, A., Waldeck, B.: Rapid release of H3-metaraminol induced by combined treatment with protriptyline and reserpine. J. Pharm. Pharmacol. 17, 327–328 (1965a).
Carlsson, A., Waldeck, B.: Mechanism of amine transport in the cell membranes of the adrenergic nerves. Acta pharmacol. (Kbh.) 22, 293–300 (1965b).
Carlsson, A., Waldeck, B.: The accumulation of H3-noradrenaline in the adrenergic nerve fibers of reserpine-treated mice. J. Pharm. Pharmacol. 19, 182–190 (1967).
Carlsson, A., Waldeck, B.: Different mechanisms of drug-induced release of noradrenaline and its congeners a-methylnoradrenaline and metarminol. Europ. J. Pharmacol. 4, 165–168 (1968).
Carrier, G.O., Pegram, B.L., Carrier, O., Jr.: Antagonistic effects of reserpine on d-tubo-curarine action on motor function of rabbits. Europ. J. Pharmacol. 6, 125–128 (1969).
Carrier, O., Jr., Clower, B.R., Whittington, P.J.: Inhibition of cholesterol-induced vascular lesions by dietary reserpine. J. Atheroscler. Res. 8, 229–236 (1968).
Carrier, O., Jr., Douglas, B.H., Garrett, L., Whittington, P. J.: The effect of reserpine on vascular tissue sodium and potassium content. J. Pharmacol. exp. Ther. 158, 494–503 (1967).
Carrier, O., Jr., Holland, W.C.: Supersensitivity in perfused isolated arteries after reserpine. J. Pharmacol. exp. Ther. 149, 212–218 (1965).
Carrier, O., Jr., Jurevics, H.A.: The role of calcium in “nonspecific” supersensitivity of vascular muscle. J. Pharmacol. exp. Ther. 184, 81–94 (1973).
Carriere, O., Jr., Shibata, S.: A possible role for tissue calcium in reserpine supersensitivity. J. Pharmacol. exp. Ther. 155, 42–49 (1967).
Carrier, O., Jr., Whittington-Coleman, P.J., Matheny, J., Shibata, S.: Tissue calcium losses following reserpine administration in rabbits. Arch. int. Pharmacodyn. 187, 97–105 (1970).
Cashin, C.H.: Effect of sympathomimetic drugs in eliciting hypertensive response to reserpine in the rat, after pretreatment with monoamineoxidase inhibitors. Brit. J. Pharmacol. 44, 203–209(1972).
Cervoni, P., Kirpekar, S.M., Schwab, A.: The effect of drugs on uptake and release of catecholamines in the isolated left atrium of the guinea pig. J. Pharmacol. exp. Ther. 151, 196–206 (1966).
Cervoni, P., Reit, E., McCullough, J.: Studies on the decentralized nictitating membrane of the cat. II. Uptake and retention of norepinephrine and epinephrine. J. Pharmacol. exp. Ther. 175, 649–663 (1970).
Chang, P., Rand, M.J.: Temperature dependence of catecholamine depletion by reserpine in the heart of the toad (Bufo marinus). Brit. J. Pharmacol. 42, 371–374 (1971).
Chatterjee, A.: Effect of reserpine on adrenal cortical activity in rats. Endokrinologie 48, 265–268 (1965).
Chen, G., Bohner, B.: The anti-reserpine effects of certain centrally-acting agents. J. Pharmacol. exp. Ther. 131, 179–184 (1961).
Chen, G., Ensor, C.R., Bohner, B.: A facilitation of reserpine on the central nervous system. Proc. Soc. exp. Biol. (N.Y.) 86, 507–510 (1954).
Chen, G., Ensor, C.R., Bohner, B.: Studies of drug effects on electrically induced extensor seizures and clinical implications. Arch. int. Pharmacodyn. 172, 183–218 (1968).
Chessin, M., Kramer, E.R., Scott, C.C.: Modification of the pharmacology of reserpine and serotonin by iproniazid. J. Pharmacol. exp. Ther. 119, 453–460 (1957).
Chidsey, C.A., Braunwald, E. Morrow, A.G., Mason, D. T.: Myocardial norepinephrine concentration in man. New Engl. J. Med. 269, 653–658 (1963).
Choi, S.J., Roberts, J., Kelliher, G.J.: Modification of the action of propranolol and quini-dine on Na22- and K42-exchange by reserpine. Europ. J. Pharmacol. 20, 22–33 (1972).
Clarke, D. E.: The effect of differing reserpine pretreatments on the cardiovascular response to tyramine. J. Pharm. Pharmacol. 19, 474–475 (1967).
Clarke, D.E., Adams, H.R., Buckley, J.P.: Chronic reserpine treatment on adrenergic neuronal and receptor function in the isolated perfused mesenteric blood vessels of the dog. Europ. J. Pharmacol. 12, 378–381 (1970).
Clementi, F., Mantegazza, P., Botturi, M.: Pharmacologic and morphologic study on the nature of the dense-core granules present in the presynaptic endings of sympathetic ganglia. Int. J. Neuropharmacol. 5, 281–285 (1966).
Glower, B.R., Carrier, O., Jr., Ball, C.R.: The protective action of reserpine against diet-induced atrial thrombosis. Europ. J. Pharmacol. 2, 131–135 (1967).
Clower, B.R., Douglas, B.H., Carrier, O., Jr.: Protection by reserpine of carbon tetra-chloride-induced hepatic necrosis. Europ. J. Pharmacol. 2, 276–280 (1968).
Cole, J., Glees, P.: Reserpine and its antagonists methyl-phenidate (Ritalin) and amphetamine in monkeys. 2nd Intern. Cong. Psychiat. Zürich, 1957, 2, 398–403 (1957).
Cook, L., Catania, A.C.: Effects of drugs on avoidance and escape behaviour. Fed. Proc. 23, 818–835 (1964).
Cooper, K.E., Cranston, W.I., Honour, A.J.: Effects of intraventricular and intrahypo-thalamic injection of noradrenaline and 5-HT on body temperature in conscious rabbits. J. Physiol. (Lond.) 181, 852–864 (1965).
Cooper, K.E., Cranston, W.I., Honour, A. J.: Observations on the site and mode of action of pyrogens in the rabbit brain. J. Physiol. (Lond.) 191, 325–337 (1967).
Coppola, J.A., Leonardi, R.G., Lippman, W., Perrine, J.W., Ringler, I.: Induction of pseudopregnancy in rats by depletors of endogenous catecholamines. Endocrinology 77, 485–490 (1965).
Corrodi, H., Masuoka, D.T., Clark, W.G.: Effect of 6-hydroxydopamine on rat heart noradrenaline. Europ. J. Pharmacol. 15, 160–163 (1971).
Costa, E., Garattini, S., Valzelli, L.: Interactions between reserpine, chlorpromazine, and imipramine. Experientia (Basel) 16, 461–463 (1960).
Costa, E., Revzin, A.M., Kuntzman, R., Spector, S., Brodle, B.B.: Role for ganglionic norepinephrine in sympathetic synaptic transmission. Science 133, 1822–1823 (1961).
Cotillo, P., Bonaccorsi, A.: Observations on the interactions between desipramine and reserpine on adrenergic transmission in the rat. J. Pharm. Pharmacol. 24, 103–107 (1972).
Cotzias, G.C., Papavasiliou, P.S., Gellene, R.: Modifications of Parkinsonism-chronic treatment with l-dopa. New Engl. J. Med. 280, 337–345 (1969).
Coupland, R.E.: Strain sensitivity of albino rats to reserpine. Nature (Lond.) 181, 930–931 (1958).
Coupland, R.E.: The catecholamine content of the adrenal medulla of the rat following reserpine-induced depletion. J. Endocr. 18, 154–161 (1959).
Cranston, E.M.: Effect of tranquilizers and other agents on sexual cycle of mice. Proc. Soc. exp. Biol. (N.Y.) 98, 320–322 (1958).
Crout, J.R., Muskus, A.J., Trendelenburg, U.: Effect of tyramine on isolated guinea pig atria in relation to their noradrenaline stores. Brit. J. Pharmacol. 18, 660–611 (1962).
Dahlström, A.: The effect of reserpine and tetrabenazine on the accumulation of noradrenaline in the rat sciatic nerve after ligation. Acta physiol. scand. 69, 167–179 (1967).
Dahlström, A.: The effects of drugs on axonal transport of amine storage granules. In: Schümann, H.J., Kroneberg, G. (Eds.): New Aspects of Storage and Release of Catecholamines, pp. 20–36. Bayer Symposium II. Berlin-Heidelberg-New York: Springer 1970.
Dahlström, A., Fuxe, K.: Evidence for the existence of monoamine neurons in the central nervous system. II. Experimentally induced changes in the intraneuronal amine levels of bulb-spinal neuron systems. Acta physiol. scand. 64, Suppl. 247, 1–36 (1965).
Dahlström, A., Fuxe, K., Hillarp, N.-Å.: The site of action of reserpine. Acta pharmacol. (Kbh.) 22, 277–292 (1965).
Dahlström, A., Häggendal, J.: Studies on the transport and lifespan of amine storage granules in a peripheral adrenergic neurone system. Acta physiol. scand. 67, 278–288 (1966a).
Dahlström, A., Häggendal, J.: Recovery of noradrenaline levels after reserpine compared with the life span of amine storage granules in rat and rabbit. J. Pharm. Pharmacol. 18, 750–752 (1966b).
Dahlström, A., Häggendal, J.: Recovery of noradrenaline in adrenergic axons of rat sciatic nerves after reserpine treatment. J. Pharm. Pharmacol. 21, 633–638 (1969).
Dandiya, P.C., Johnson, G., Sellers, E.A.: Influence of variation in environmental temperature on the acute toxicity of reserpine and chlorpromazine in mice. Canad. J. Biochem. 38, 591–596 (1960).
Davis, W. G.: The effects of beta adrenoceptor blocking agents on the membrane potential and spike generation in the smooth muscle of guinea-pig taenia coli. Brit. J. Pharmacol. 38, 12–19 (1970).
Day, M., Green, J.P.: The uptake of amino acids and the synthesis of amines by neoplastic mast cells in culture. J. Physiol. (Lond.) 164, 210–226 (1962).
Day, M.D., Rand, M.J.: A hypothesis for the mode of action of α-methyldopa in relieving hypertension. J. Pharm. Pharmacol. 15, 221–224 (1963a).
Day, M.D., Rand, M.J.: Awakening from reserpine sedation by α-methyl dopa. J. Pharm. Pharmacol. 15, 631–632 (1963b).
Day, M.D., Rand, M. J.: A possible mechanism of action for a-methyldopa (Aldomet). Int. J. Neuropharmacol. 3, 173–175 (1964).
Degkwitz, R., Frowein, R., Kulenkampff, C., Mohs, U.: Über die Wirkungen des l-Dopa beim Menschen und deren Beeinflussung durch Reserpin, Chlorpromazin, iproniazid and Vitamin B6. Klin. Wschr. 38, 120–123 (1960).
Deming, Q.B.: Experimental atherosclerosis and hypertension. In: Gross, F. (Ed.): Antihypertensive therapy: Principles and practice, pp. 111–124. Berlin-Heidelberg-New York: Springer 1966.
Dengler, H.J., Michaelson, I.A., Spiegel, H.E., Titus, E.: The uptake of labeled norepinephrine by isolated brain and other tissues of the cat. Int. J. Neuropharmacol. 1, 23–38 (1962).
Dengler, H.J., Spiegel, H.E., Titus, E.O.: Effects of drugs on uptake of isotopic norepinephrine by cat tissues. Nature (Lond.) 191, 816–817 (1961).
Dews, P.B., Morse, W.H.: Behavioural pharmacology. Ann. Rev. Pharmacol. 1, 145–174 (1961).
Dingell, J.V., Owens, M.L., Norvich, M.R., Sulser, F.: On the role of norepinephrine biosynthesis in the central action of amphetamine. Life Sci. 6, 1155–1162 (1967).
Domenjoz, R., Theobald, W.: Zur Pharmakologie de Tofranil (N-(3-dimethylaminopropyl)-iminodibenzyl-bydrochlorid). Arch. int. Pharmacodyn. 120, 450–489 (1959).
Domino, E.F., Rech, R.H.: Observations on the initial hypertensive response to reserpine. J. Pharmacol. exp. Ther. 121, 171–182 (1957).
Donald, D.E., Shepherd, J.T.: Initial cardiovascular adjustment to exercise in dogs with chronic cardiac denervation. Amer. J. Physiol. 207, 1325–1329 (1964).
Dontas, A.S.: The hypotensive property of hydralazine and reserpine. J. Pharmacol. exp. Ther. 116, 17 (1956).
Dorris, R.L., Shore, P.A.: Amine uptake and storage mechanisms in the corpus striatum of rat and rabbit. J. Pharmacol. exp. Ther. 179, 15–19 (1971).
Doyle, A.E., McQueen, E.G., Smirk, E.H.: Treatment of hypertension with reserpine, with reserpine in combination with pentapyrrolidinium, and with reserpine in combination with veratrum alkaloids. Circulation 11, 170–181 (1955).
Draskóczy, P.R., Burack, W.R., Weiner, N.: Catecholamine release from adrenal slices and rate of respiration. J. Pharmacol. exp. Ther. 141, 58–64 (1963).
Duvoisin, R.C.: Neurological reactions to psychotropic drugs. Pp. 561–573 In: Psychophar-macology. A review of progress: 1957–1967. Washington: Public Health Service Publication No. 1836 (1968).
Ehringer, H., Hornykiewicz, O.: Verteilung von Noradrenalin und Dopamin (3-hydro-xytyramin) im Gehirn des Menschen und ihr Verhalten bei Erkrankungen des extrapyramidalen Systems. Klin. Wschr. 38, 1236–1239 (1960).
Emâs, S.: On the mechanism for the stimulating action of reserpine on acid secretion in gastric fistula cats. Acta physiol. scand. 64, 224–237 (1965).
Emmelin, N.: Supersensitivity following “pharmacological denervation”. Pharmacol. Rev. 13, 17–37 (1961).
Engberg, I., Lundberg, A., Ryall, R. W.: The effect of reserpine on transmission in the spinal cord. Acta physiol. scand. 72, 115–122 (1968).
Eränkö, O., Hopsu, V.: Effect of reserpine on the histochemistry and content of adrenaline and noradrenaline in the adrenal medulla of the rat and the mouse. Endocrinology 62, 15–23 (1958).
Erspamer, V.: Observations on the 5-hydroxytryptamine (Enteramine) release caused by reserpine in the rat. Experientia (Basel) 12, 63–64 (1956).
Euler, U.S. von: The presence of the adrenergic neurotransmitter in intraaxonal structures. Acta physiol. scand. 43, 155–166 (1958).
Euler, U.S. Von: Catecholamines in nerve and organ granules. In: von Euler, U.S., Rosell, S., Uvnäs, B. (Eds.): Mechanisms of Release of Biogenic Amines, pp. 211–222. Oxford: Pergamon Press 1966.
Euler, U.S. von: Acute neuromuscular transmission failure in vas deferens after reserpine. Acta physiol. scand. 76, 255–256 (1969).
Euler, U. S. von: Effect of some metabolic factors and drugs on uptake and release of catecholamines in vitro and in vivo. In: Schümann, H. J., Kroneberg, G. (Eds.): New Aspects of Storage and Release Mechanisms of Catecholamines, pp. 144–158. Berlin-Heidelberg-New York: Springer 1970.
Euler, U.S. von, Lishajko, F.: Noradrenaline release from isolated nerve granules. Acta physiol. scand. 51, 193–203 (1961a).
Euler, U.S. von, Lishajko, F.: Effect of reserpine on the release of catecholamines from isolated nerve and chromaffin cell granules. Acta physiol. scand. 52, 137–145 (1961b).
Euler, U. S. von, Lishajko, F.: Effect of reserpine on the uptake of catecholamines in isolated nerve storage granules. Int. J. Neuropharmacol. 2, 127–134 (1963).
Euler, U.S. von, Lishajko, F.: Effects of drugs on the storage granules of adrenergic nerves. Proc. 2nd. int. Pharmac. Meeting, Prague, August 1963, Vol. 3, 245–259. Oxford: Pergamon Press 1965.
Euler, U.S. von, Lishajko, F.: Inhibitory action of adrenergic blocking agents on catecholamine release and uptake in isolated nerve granules. Acta physiol. scand. 68, 257–262 (1966).
Euler, U.S. von, Lishajko, F.: Mechanism of drug-induced catecholamine release from adrenergic nerve granules. Circulat. Res. 21, Suppl. 3, 63–69 (1967).
Euler, U.S. von, Lishajko, F.: Inhibitory action of adrenergic blocking agents on re-uptake and net uptake of noradrenaline in nerve granules. Acta physiol. scand. 74, 501–506 (1968).
Euler, U.S. von, Persson, N.-Å.: Potentiation of adrenergic cardiovascular effects of two quaternary nicotine analogues by reserpine. Acta physiol. scand. 78, 459–464 (1970).
Euler, U. S. von, Stjärne, L., Lishajko, F.: Effect of reserpine, segontin and phenoxybenzamine on the catecholamines and ATP of isolated nerve and adrenomedullary storage granules. Life Sci. 3, 35–40 (1964).
Evans, W., Loughnan, O.: The drug treatment of hyperpiesia. Brit. Heart J. 1939 I, 199–228.
Everett, G.M., Toman, J.E.P.: Mode of action of Rauwolfia alkaloids and motor activity. Recent Advanc. Biol. Psychiat. 1, 75–81 (1959).
Faith, M.E., Young, L.D., Grabarits, F., Harvey, J.A.: Differences in the duration of reserpine action in the rat depending on the measure employed. Int. J. Neuropharmacol. 7, 575–585 (1968).
Feldberg, W., Myers, R.D.: A new concept of temperature by amines in the hypothalamus. Nature (Lond.) 200, 1325 (1963).
Feldberg, W., Myers, R.D.: Effects of temperature of amines injected into the cerebral ventricles. A new concept of temperature regulation. J. Physiol. (Lond.) 173, 226–237 (1964).
Feldberg, W., Myers, R.D.: Changes in temperature produced by microinjections of amines into the anterior hypothalamus of cats. J. Physiol. (Lond.) 177, 239–245 (1965).
Ferguson, R.S.: Reserpine and Rauwolfia in psychoneuroses. Brit. med. J. 1955 II, 1563.
Fibiger, H.C., Trimbach, C., Campell, B. A.: Enhanced stimulant properties of (+)-amphetamine after chronic reserpine treatment in the rat: Mediation by hypophagia and weight loss. Neuropharmacology 11, 57–67 (1972).
Fink, M.: EEG classification of psychoactive compounds in man: a review and theory of behavioural associations. Pp. 497–507 In: Psychopharmacology. A Review of Progress: 1957–1967. Washington, Public Health Service Publication No. 1836 (1968).
Finnerty, F. A.: Reserpine and the newborn infant. J. Amer. med. Ass. 160, 997 (1956).
Fleming, W.W., Trendelenburg, U.: The development of supersensitivity to norepinephrine after pretreatment with reserpine. J. Pharmacol. exp. Ther. 133, 41–51 (1961).
Flückiger, E.: Pharmakologie der Antihypertonika. In: Sarre, H. (Ed.): Hypertonie: Pathogenese, Klinik and Therapie, pp. 235–249. Stuttgart: Schattauer 1969.
Foster, M.N., Gayle, R.F.: Dangers in combining reserpine (Serpasil) with electroconvulsive therapy. J. Amer. med. Ass. 159, 1520–1522 (1955).
France, E.S.: Reversal by pargyline of reserpine block of induced ovulation — direct ovarian effects. Neuroendocrinology 6, 77–89 (1970).
Freedman, D. X.: Effect of LSD-25 on brain serotonin. J. Pharmacol. exp. Ther. 134, 160–166 (1961).
Freedman, D.X.: Psychotomimetic drugs and brain biogenic amines. Amer. J. Psychiat. 119, 843–850 (1963).
Freedman, D.X., Giarman, N.J.: LSD-25 and the status and level of brain serotonin. Ann. N.Y. Acad. Sci. 96, 98–106 (1962).
Freis, E.D.: Effectiveness of drug therapy in hypertention: present status. Circulat. Res. 28, Suppl. 2, 70–75 (1971).
Freis, E.D., Wanko, A., Wilson, I.M., Parrish, A.E.: Treatment of essential hypertension with chlorothiazide (diuril); its use alone and combined with other antihypertensive agents. J. Amer. med. Ass. 166, 137–140 (1958).
Friedman, A.H., Walker, C.A.: Circadian rhythms in rat mid-brain and caudate nucleus biogenic amine levels. J. Physiol. (Lond.) 197, 77–85 (1968).
Frohlich, E.D., Freis, E.D.: Clinical trial of guanethidine, a new type of antihypertensive agent. Med. Ann. D.C. 28, 419–422 (1959).
Furchgott, R.F., Garcia, P.S.: Effects of inhibition of monoamine oxidase in the actions and interactions of norepinephrine, tyramine and other drugs on guinea-pig left atrium. J. Pharmacol. exp. Ther. 163, 98–122 (1968).
Furchgott, R.F., Gubareff, T. de, Grossman, A.: Release of autonomic mediators in cardiac tissue by suprathreshold stimulation. Science 129, 328–329 (1959).
Furchgott, R.F., Kirpekar, S.M., Rieker, M., Schwab, A.: Actions and interactions of norepinephrine, tyramine and cocaine on aortic strips of rabbit and left atria of guinea pig and cat. J. Pharmacol. exp. Ther. 142, 39–58 (1963).
Fuxe, K.: Evidence for the existence of monoamine neurons in the central nervous system. IV. The distribution of monoamine nerve terminals in the central nervous system. Acta physiol. scand. 64, Suppl. 247, 37–85 (1965).
Fuxe, K., Hillarp, N.-Å.: Uptake of l-dopa and noradrenaline by central catecholamine neurons. Life Sci. 3, 1403–1406 (1964).
Gaffney, T.E., Chidsey, C.A., Braunwald, E.: Study of the relationship between the neurotransmitter store and adrenergic nerve block induced by reserpine and guanethidine. Circulat. Res. 12, 264–269 (1963).
Gaffney, T.E., Morrow, D.H., Chidsey, C.A.: The role of myocardial catecholamines in the response to tyramine. J. Pharmacol. exp. Ther. 137, 301–305 (1962).
Gaitonde, B.B., Satoskar, R.S., Mandrekar, S. S.: The effect of reserpine on acid gastric secretion in anaesthetized cat. Arch. int. Pharmacodyn. 127, 118–127 (1960).
Gantt, W.H.: Cardiovascular component of the conditional reflex to pain, food and other stimuli. Physiol. Rev. Suppl. 40, 266–291 (1960).
Garattini, S., Fresia, P., Mortari, A., Palma, V.: The pressor effect of reserpine after monoamine-oxidase inhibitors. Med. exp. (Basel) 2, 252–259 (1960b).
Garattini, S., Giachetti, A., Jori, A., Pieri, L., Valzelli, L.: Effect of imipramine, amitriptyline and their monomethyl derivatives on reserpine activity. J. Pharm. Pharmacol. 14, 509–514 (1962).
Garattini, S., Jori, A.: Interactions between imipramine-like drugs and reserpine on body temperature. In: Garattini, S., Dukes, N.M.G. (Eds.): First Intern. Symp. on Antidepressant Drugs, p. 179–193. Amsterdam: Exerpta Medica Foundation 1967.
Garattini, S., Kato, R., Valzelli, L.: Effect of reserpine analogues on tissue serotonin. Experientia (Basel) 16, 120 (1960a).
Garcia, A.G., Kirpekar, S.M.: Release of noradrenaline from the cat spleen by sodium deprivation. Brit. J. Pharmacol. 47, 729–747 (1973).
Gardier, R.W., James, E.A., Johnson, P.C., Richards, A.B., Roesch, R.P.: Vasodepression induced by acetylcholine in the atropinized dog. Brit. J. Pharmacol. 20, 579–585 (1963).
Garrett, R.L., Carrier, O., Jr.: Alteration of extracellular calcium dependence in vascular tissue by reserpine. Europ. J. Pharmacol. 13, 306–311 (1971).
Garrett, R.L., Carrier, O., Jr.: Douglas, B.H.: Effects of reserpine on blood pressure and vascular electrolytes in hypertension. Europ. J. Pharmacol. 2, 236–238 (1967).
Gaunt, R., Renzi, A.A., Antonchak, N., Miller, G. J., Gilman, M.: Endocrine aspects of the pharmacology of reserpine. Ann. N. Y. Acad. Sci. 59, 22–35 (1954).
Geffen, L.B., Ostberg, A.: Distribution of granular vesicles in normal and constricted sympathetic neurons. J. Physiol. (Lond.) 204, 583–592 (1969).
Gessa, G.L., Krishna, G., Forn, J., Tagliamonte, A., Brodie, B.B.: Behavioural and vegetative effects produced by dibutyryl cyclic AMP injected into different areas of the brain. In: Greengard, P., Costa, E. (Eds.): Role of cyclic AMP in cell function. Advances in biochemical psychopharmacology, Vol. 3, pp. 371–381. New York: Raven Press 1970.
Gey, K. F., Pletscher, A.: Effects of chlorpromazine on the metabolism of dl-2-C14-dopa in the rat. J. Pharmacol. exp. Ther. 145, 337–343 (1964).
Giachetti, A., Shore, P.A.: Studies in vitro of amine-uptake mechanisms in heart. Biochem. Pharmacol. 15, 607–614 (1966).
Giarman, N. J., Pepeu, G.: Drug-induced changes in brain acetylcholine. Brit. J. Pharmacol. 19, 226–234 (1962).
Gielen, W.Z.: Über die Funktion von Gangliosiden. Ein Serotonin- und Ca+2-Receptor. Z. Naturforsch. 21, 1007–1008 (1966).
Gilgen, A., Maichel, R.P., Nikodijevic, O., Brodie, B.B.: Essential role of catecholamines in the mobilization of free fatty acids and glucose after exposure to cold. Life Sci. 1, 709–715 (1962).
Gillespie, E., Levine, R.J., Malawista, S.E.: Histamine release from rat peritoneal mast cells: Inhibition by colchicine and potentiation by deuterium oxide. J. Pharmacol. exp. Ther. 164, 158–165 (1968).
Gillespie, J.S.: Tissue binding of noradrenaline. Proc. roy. Soc. B 116, 1–10 (1966).
Gillespie, J.S., Hamilton, D.N.H., Hosie, R.J.A.: The extraneuronal uptake and localization of noradrenaline in the cat spleen and the effect on this of some drugs, of cold and of denervation. J. Physiol. (Lond.) 206, 563–590 (1970).
Gillespie, J.S., MacKenna, B.R.: The inhibitory action of the sympathetic nerves on the smooth muscle of the rabbit gut, its reversal by reserpine and restoration by catecholamines and by dopa. J. Physiol. (Lond.) 156, 17–34 (1961).
Gillette, J.R., Dingell, J.-V., Sulser, F., Kuntzman, R., Brodie, B.B.: Isolation from rat brain of a metabolite product, desmethylimipramine, that mediates the antidepressant activity of imipramine. Experientia (Basel) 17, 417–418 (1961).
Gillis, C.N., Paton, D.M.: Cation dependence of sympathetic transmitter retention by slices of rat ventricle. Brit. J. Pharmacol. 29, 309–318 (1967).
Glover, A.B., McCulloch, M.W.: Interactions between reserpine and desmethylimipramine. Europ. J. Pharmacol. 11, 163–168 (1970).
Glowinski, J., Axelrod, J.: Effect of drugs on the uptake, release and metabolism of H3-norepinephrine in the rat brain. J. Pharmacol. exp. Ther. 149, 43–49 (1965).
Glowinski, J., Iversen, L.L., Axelrod, J.: Storage and synthesis of norepinephrine in the reserpine-treated rat brain. J. Pharmacol. exp. Ther. 151, 385–399 (1966).
Goldin, A., Burton, R.M., Humphreys, S.R., Vendetti, J.M.: Antileukemic action of reserpine. Science 125, 156–157 (1957).
Gonzalez, J.R., Imahara, J.K.: Electroshock therapy with the phenothiazines and reserpines — a survey and report. Amer. J. Psychiat. 121, 253–256 (1964).
Graeff, F.G., Leme, J.G., Rocha e Silva, M.: Role played by catechol and indoleamines in the central actions of reserpine after monoaminoxidase inhibition. Int. J. Neuropharmacol. 4, 17–26 (1965).
Gray, W.D., Rauh, C.E.: The anticonvulsant action of inhibitors of carbonic anhydrase: Site and mode of action in rats and mice. J. Pharmacol. exp. Ther. 156, 383–396 (1967).
Gray, W.D., Rauh, C.E., Shanahan, R.W.: The mechanism of the antagonistic action of reserpine on the anticonvulsant effect of inhibitors of carbonic anhydrase. J. Pharmacol. exp. Ther. 139, 350–360 (1963).
Green,A.P.: Antihypertensive drugs. Advanc. Pharmacol. 1, 161–225 (1962).
Green, H., Erickson, R.W.: Further studies with tranylcypromine (monoamine oxidase inhibitor) and its interaction with reserpine in rat brain. Arch. int. Pharmacodyn. 135, 407–425 (1962).
Green, J.P.: Histamine. In: Lijthe, A. (Ed.): Handbook of Neurochemistry. Vol. 4, pp. 221–250. New York: Plenum Publ. Corp. 1970.
Green, R.D., Fleming, W.W.: Agonist-antagonist interactions in the normal and supersensitive nictitating membrane of the spinal cat. J. Pharmacol. exp. Ther. 156, 207–214 (1967).
Green, R.D., Fleming, W. W.: Analysis of supersensitivity in the isolated spleen of the cat. J. Pharmacol. exp. Ther. 162, 254–262 (1968).
Grillo, M.A.: Electron microscopy of sympathetic tissues. Pharmacol. Rev. 18, 387–399 (1966).
Guyton, A.C.: Textbook of Medical Physiology, pp. 301–304. 4th Edition. Philadelphia: Saunders 1971.
Häggendal, J.: The presence of 3-O-methylated noradrenaline (normetanephrine) in normal brain tissue. Acta physiol. scand. 59, 261–268 (1963).
Häggendal, J., Dahlström, A.: Uptake and retention of 3H-noradrenaline in adrenergic nerve terminals after reserpine and axotomy. Europ. J. Pharmacol. 10, 411–415 (1970).
Häggendal, J., Dahlström, A.: The recovery of noradrenaline in adrenergic nerve terminals of the rat after reserpine treatment. J. Pharm. Pharmacol. 23, 81–89 (1971).
Häggendal, J., Dahlström, A.: The recovery of the capacity for uptake-retention of 3H-noradrenaline in rat adrenergic nerves after reserpine. J. Pharm. Pharmacol. 24, 565–574 (1972).
Häggendal, J., Hamberger, B.: Quantitative in vitro studies on noradrenaline uptake and its inhibition by amphetamine, desipramine and chlorpromazine. Acta physiol. scand. 70, 277–280 (1967).
Häggendal, J., Lindqvist, M.: Disclosure of labile monoamine fractions in brain and their correlation to behaviour. Acta physiol. scand. 60, 351–357 (1964).
Häggendal, J., Malmfors, T.: Evidence of dopamine-containing neurons in the retina of rabbits. Acta physiol. scand. 59, 295–296 (1963).
Hagen, R., Barrnett, R., Lee, F.: Biochemical and electron microscopic study of particles isolated from mastocytoma cells. J. Pharmacol. exp. Ther. 126, 91–97 (1959).
Halliwell, G., Quinton, R.M., Williams, F.E., A comparison of imipramine, chlorpromazine and related drugs in various tests involving autonomic function and antagonism of reserpine. Brit. J. Pharmacol. 23, 330–350 (1964).
Hamberger,B.: Reserpine-resistant uptake of catecholamines in isolated tissues of the rat: a histochemical study. Acta physiol. scand. 71, Suppl. 295, 1–56 (1967).
Hamberger, B., Malmfors, T., Norberg, K.-A., Sachs, C.: Uptake and accumulation of catecholamines in peripheral adrenergic neurons of reserpinized animals, studied with a histochemical method. Biochem. Pharmacol. 13, 841–844 (1964).
Hamberger, B., Masuka, D.: Localization of catecholamine uptake in rat brain slices. Acta Pharmacol. (Kbh.) 22, 363–368 (1965).
Hanson, L.C.F.: The disruption of the conditioned avoidance response following selective depletion of brain catecholamines. Psychopharmacologia (Berl.) 6, 100–110 (1965).
Hanson, L.C.F.: Evidence that the central action of amphetamine is mediated via catecholamines. Psychopharmacologia (Berl.) 9, 79–80 (1966).
Hanson, L.C.F.: Evidence that the central action of (+)-amphetamine is mediated via catecholamines. Psychopharmacologia (Berl.) 10, 289–297 (1967).
Hardistry, R.M., Ingram, G.I.C., Stacey, R.S.: Reserpine and human platelet 5-hydro-xytryptamine. Experientia (Basel) 12, 42 (1956).
Harrison, T.S.: Some factors influencing thyrotropin release in the rabbit. Endocrinology 68, 466–478 (1961).
Harrison, T. S.: Adrenal medullary and thyroid relationships. Physiol. Rev. 44, 161–185 (1964).
Hartmann, E.: Reserpine: its effect on the sleep-dream cycle in man. Psychopharmacologia (Berl.) 9, 242–247 (1966).
Hassler, R., Bak, I.J.: Submikroskopische Catecholaminspeicher als Angriffspunkte der Psychopharmaka Reserpin und Monoaminohemmer. Nervenarzt 37, 493–498 (1966).
Haverback, B. J., Stevenson, T.D., Sjoerdsma, A., Terry, L.L.: The effects of reserpine and chlorpromazine on gastric secretion. Amer. J. med. Sci. 230, 601–604 (1955).
Haverback, B.J., Wirtschafter, S.K.: The gastrointestinal tract and naturally occurring pharmacologically active amines. Advanc. Pharmacol. 1, 309–347 (1962).
Heimans, R.L., Rand, M.J., Fennessy, M.R.: Effects of amantadine on uptake and release of dopamine by a particulate fraction of rat basal ganglia. J. Pharm. Pharmacol. 24, 875–879 (1972).
Herman, E.H., Barnes, C.D.: Drug modification of the Schiff-Sherrington phenomenon. J. Pharmacol. exp. Ther. 516, 48–54 (1967).
Herr, B., Costa, E.: Normal rate of 3H-norepinephrine uptake by isolated iris of rabbits injected with reserpine and pargyline. Int. J. Neuropharmacol. 8, 463–469 (1969).
Hertting, G., Axelrod, J., Whitby, L.G.: Effect of drugs on the uptake and metabolism of H3-norepinephrine. J. Pharmacol. exp. Ther. 134, 146–153 (1961).
Herz, A.: Drugs and conditioned avoidance response. Int. Rev. Neurobiol. 2, 229–277 (1960).
Hess, S.M.., Redfield, B.G., Udenfriend, S.: The effect of monoamine oxidase inhibitors and tryptophan on the tryptamine content of animal tissues and urine. J. Pharmacol. exp. Ther. 127, 178–181 (1959).
Hess, S.M., Shore, P.A., Brodie, B.B.: Persistence of reserpine action after the disappearance of drug from brain. J. Pharmacol. exp. Ther. 118, 84–90 (1956)
Hillarp, N.-Å.: Adenosinephosphate and inorganic phosphate in the adrenaline and noradrenaline containing granules of the adrenal medulla. Acta physiol. scand. 42, 321–332 (1958a).
Hillarp, N.-Å.: The release of catecholamines from the amine containing granules of the adrenal medulla. Acta physiol. scand. 43, 292–302 (1958b).
Hillarp, N.-Å.: Further observations on the state of the catecholamines stored in the adrenal medullary granules. Acta physiol. scand. 47, 271–279 (1959).
Hökfelt, T.: The effect of reserpine on the intraneuronal vesicles of the rat vas deferens. Experientia (Basel) 22, 56 (1966).
Hökfelt, T.: Ultrastructural studies on the uptake and accumulation of monoamines in peripheral and central neurones, p. 70. In: Abstracts of the Fourth International Congress on Pharmacology, Basel (1969).
Hoffmann, F., Hoffmann, E.J., Talesnik, J.: Influence of the thyroid hormone on the effector systems of the mammalian heart. Amer. J. Physiol. 148, 689–699 (1947).
Hoffman, R.A.: Effect of and interaction between tranquilizers, serotonin and lysergic acid diethylamide on the body temperature of pigeons. Amer. J. Physiol. 195, 751–754 (1958a).
Hoffman, R.A.: Temperature response of the rat to action and interaction of chlorpromazine, reserpine and serotonin. Amer. J. Physiol. 195, 755–758 (1958b).
Hollander, W., Welkins, R.W.: Chlorothiazide: New type of drug for the treatment of hypertension. Boston med. Quart. 8, 69–75 (1957).
Holton, P., Rand, M.J.: Sympathetic vasodilatation in the rabbit ear. Brit. J. Pharmacol. 19, 513–526 (1962).
Holtz, P., Balzer, H., Westermann, E., Wezler, E.: Beeinflussung der Evipannarkose durch Reserpin, Iproniazid und biogene Amine. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 231, 333–348 (1957).
Holzbauer, M., Vogt, M.: Depression by reserpine of the noradrenaline concentration in the hypothalamus of the cat. J. Neurochem. 1, 8–11 (1956).
Honda, F., Immura, H.: Inhibition of cyclic 3′, 5′ nucleotide phosphodiesterase by phenthiazine and reserpine derivatives. Biochim. biophys. Acta (Amst.) 161, 267–269 (1968).
Hong, E., Mendoza, P. A., Pardo, E. G.: Influence of previous reserpine administration on the ganglionic action of selected sympathomimetic amines. Life Sci. 4, 2383–2392 (1965).
Hopkins, T.F., Pincus, G.: Effects of reserpine on gonadotropin-induced ovulation in immature rats. Endocrinology 73, 775–780 (1963).
Hornykiewicz, O.: Dopamine (3-hydroxytyramine) and brain function. Pharmacol. Rev. 18, 925–964 (1966).
Horst, W.D., Pool, W.R., Spiegel, H.E.: Correlation between brain dopamine levels and l-dopa activity in anti-parkinson tests. Europ. J. Pharmacol. 21, 337–342 (1973).
Howland, R.D., Spector, S.: Disposition of histamine in mammalian blood vessels. J. Pharmacol. exp. Ther. 182, 239–245 (1972).
Hudgins, P.M., Fleming, W. W.: A relatively nonspecific supersensitivity in aortic strips resulting from pretreatment with reserpine. J. Pharmacol. exp. Ther. 153, 70–80 (1966).
Hudgins, P.M., Harris, T.M.: Further studies on the effects of reserpine pretreatment on rabbit aortas: Calcium and histologic studies. J. Pharmacol. exp. Ther. 175, 609–618 (1970).
Hughes, J., Vane, J.R.: An analysis of the responses of the isolated portal vein of the rabbit to electrical stimulation and to drugs. Brit. J. Pharmacol. 30, 46–66 (1967).
Huković, S.: Isolated rabbit atria with sympathetic nerve supply. Brit. J. Pharmacol. 14, 372–376 (1959a).
Huković, S.: The action of sympathetic blocking agents on isolated and innervated atria and vessels. Brit. J. Pharmacol. 15, 117–121 (1959b).
Huković, S.: Responses of the isolated sympathetic nerve-ductus deferens preparation of the guinea pig. Brit. J. Pharmacol. 16, 188–194 (1961).
Hussar, E., Bruno, E.: Acute duodenal ulcer associated with reserpine therapy. Gastroenterology 31, 500–504 (1956).
Hutchins, D.A., Rogers, K.J.: Physiological and drug-induced changes in the glycogen content of mouse brain. Brit. J. Pharmacol. 39, 9–25 (1970).
Iggo, A., Mum, A. R.: The structure and function of a slowly adapting touch corpuscle in hairy skin. J. Physiol. (Lond.) 200, 763–796 (1969).
Iggo, A., Vogt, M.: Preganglionic sympathetic activity in normal and reserpine-treated cats. J. Physiol. (Lond.) 150, 114–133 (1960).
Innes, I.R., Krayer, O.: Studies on veratrum alkaloids. XXVII. The negative chronotropic action of veratramine and reserpine in the heart depleted of catechol amines. J. Pharmacol. exp. Ther. 124, 245–251 (1958).
Innes, I.R., Krayer, O., Waud, D.R.: The action of Rauwolfia alkaloids on the heart rate and on the functional refractory period of atrio-ventricular transmission in the heart-lung preparation of the dog. J. Pharmacol. exp. Ther. 124, 324–332 (1958).
Isaac, L., Goth, A.: Interaction of antihistaminics with norepinephrine uptake: a cocainelike effect. Life Sci. 4, 1899–1904 (1965).
Isbell, H., Logan, C.R.: Studies on the diethylamide of lysergic acid (LSD-25). II. Effects of chlorpromazine, azacyclonal and reserpine on the intensity of the LSD reaction. Arch. Neurol. Psychiat. (Chic.) 77, 350–358 (1957).
Iversen, L.L., Glowinsky, J., Axelrod, J.: Uptake and storage of H3-norepinephrine in the reserpine-pretreated rat heart. J. Pharmacol. exp. Ther. 150, 173–183 (1965).
Iversen, L.L., Kravitz, E.A.: Sodium dependence of transmitter uptake at adrenergic nerve terminals. Molec. Pharmacol. 2, 360–362 (1966).
Iwayama, T., Fleming, W. W., Burnstock, G.: Ultrastructure of mitochondria in atrial muscle associated with depression and supersensitivity produced by reserpine. J. Pharmacol. exp. Ther. 184, 95–105 (1973).
Izumi, F., Oka, M., Yoshida, H., Imaizumi, R.: Effect of reserpine on monoamine oxidase activity in guinea pig heart. Life Sci. 6, 2333–2343 (1967).
Izumi, F., Oka, M., Yoshida, H., Imaizumi, R.: Stimulatory effects of reserpine on monoamine oxidase in guinea pig heart. Biochem. Pharmacol. 18, 1739–1748 (1969).
Jepson, J.B., Zaltzman, P., Udenfriend, S.: Microsomal hydroxylation of tryptamine, indole-acetic acid and related compounds to 6-hydroxyderivatives. Biochim. biophys. Acta (Amst.) 62, 91–102 (1962).
Jobe, P.C., Picchioni, A.L., Chin, L.: Role of brain norepinephrine in audiogenic seizure in the rat. J. Pharmacol. exp. Ther. 184, 1–10 (1973).
Johnson, H. L.: Nonmast-cell histamine kinetics. III. Uptake, metabolism and decline of H3-histamine in the female rat and effects of endogenous histamine release. J. Pharmacol. exp. Ther. 171, 88–97 (1970).
Jonason, J.: Effects of reserpine on the noradrenaline content of atrophied rat salivary glands. Acta physiol. scand. 75, 73–77 (1969).
Jongh, D.K. de, van Proosdij-Hartzema, E.G.: Investigations into experimental hypertension. IV. The acute effects of Rauwolfia alkaloids on the blood pressure of rats with experimental renal hypertension. Acta physiol. pharmacol. neerl. 4, 175–179 (1955).
Jongh, D.K. de, van Proosdij-Hartzema, E. G.: Augmentation of blood pressure in rabbits by reserpine. Acta physiol. pharmacol. neerl. 7, 364–365 (1958).
Jonvet, M.: Neuropharmacology of sleep, pp. 523–540. In: Psychopharmacology. A review of progress: 1957–1967. Washington, Public Health Service Publication, No. 1836 (1968).
Jori, A., Garattini, S.: Interaction between imipramini-like agents and catecholamine-induced hyperthermia. J. Pharm. Pharmacol. 17, 480–488 (1965).
Jori, A., Paglialunga, S., Garattini, S.: Adrenergic mediation in the antagonism between desipramine and reserpine. J. Pharm. Pharmacol. 18, 326–327 (1966).
Junod, A.F.: Uptake, metabolism and efflux of 14C-5-hydroxytryptamine in isolated perfused rat lungs. J. Pharmacol. exp. Ther. 183, 341–355 (1972).
Juorio, A.V., Vogt, M.: Monoamines and their metabolites in the avian brain. J. Physiol. (Lond.) 189, 489–518 (1967).
Jurevics, H.A., Carrier, O., Jr.: The influence of reserpine on the calcium-induced responses of spontaneously beating isolated rabbit atria. J. Pharmacol. exp. Ther. 184, 189–197 (1973).
Jurna, I., Grossmann, W., Nell, T.: Depression by amantadine of drug-induced rigidity in the rat. Neuropharmacology 11, 559–564 (1972).
Kärki, N.T., Paasonen, M.K.: Selective depletion of noradrenaline and 5-hydroxytryptamine from rat brain and intestine by Rauwolfia alkaloids. J. Neurochem. 3, 352–357 (1959).
Kalsner, S., Nickerson, M.: Effects of reserpine on the disposition of sympathomimetic amines in vascular tissue. Brit. J. Pharmacol. 35, 394–405 (1969).
Kanematsu, S., Hilliard, J., Sawyer, C.H.: Effect of reserpine on pituitary prolactin content and its hypothalamic site of action in the rabbit. Acta endocr. (Kbh.) 44, 467–474 (1963).
Kanematsu, S., Sawyer, C.H.: Effects of intrahypothalamic implants of reserpine on lactation and pituitary prolactin content in the rabbit. Proc. Soc. exp. Biol. (N. Y.) 113, 967–970 (1963).
Key, B.J., Bradley, P.B.: The effect of drugs on conditioning and habituation to arousal stimuli in animals. Psychopharmacologia (Berl.) 1, 450–462 (1960).
Khan, A.U., Forney, R.B., Hughes, F.W.: Plasma free fatty acids in rats after shock as modified by centrally acting drugs. Arch. int. Pharmacodyn 151, 466–474 (1964).
Khazan, N., Sulman, F., Winnik, H.: Effect of reserpine on pituitary-gonadal axis. Proc. Soc. exp. Biol. (N.Y.) 105, 201–204 (1960).
Killam, E.K.: Drug action on the brain stem reticular formation. Pharmacol. Rev. 14, 175–223 (1962).
Killam, E.K.: Pharmacology of the reticular formation, pp. 411–445. In: Psychopharmacology. A review of progress: 1957–1967. Washington, Public Health Service Publication No. 1836 (1968).
Killam, K.F., Killam, E.K.: Rhinencephalic activity during acquisition and performance of conditional behaviour and its modification by pharmacological agents. Progr. Brain Res. 27, 388–399 (1967).
Kim, K.S., Shore, P.A.: Mechanism of action of reserpine and insulin on gastric amines and gastric acid secretion, and the effect of monoamine oxidase inhibition. J. Pharmacol. exp. Ther. 141, 321–325 (1963).
Kirpekar, S.M., Goodlad, S. A. J., Lewis, J. J.: Reserpine depletion of adenosine triphosphate from the rat suprarenal medulla. Biochem. Pharmacol. 1, 232–233 (1958).
Kirpekar, S.M., Lewis, J. J.: Effects of reserpine and hydrallazine on isolated strips of carotid arteries. J. Pharm. Pharmacol. 10, 255–259 (1958).
Kirshner, N.: Uptake of catecholamines by a particulate fraction of the adrenal medulla. J. biol. Chem. 237, 2311–2317 (1962).
Kirshner, N., Rorie, M., Kamin, D.L.: Inhibition of dopamine uptake in vitro by reserpine administered in vivo. J. Pharmacol. exp. Ther. 141, 285–289 (1963).
Kitay, J.L, Holub, D.A., Jailer, J.W.: “Inhibition” of pituitary ACTH release after administration of reserpine or epinephrine. Endocrinology 65, 548–554 (1959).
Klawans, H. L.: Pharmacology of parkinsonism: a review. Dis. nerv. Syst. 29, 805–816 (1968).
Klein, F.: Hypotensive drugs. In: Meyler, L., Herxheimer, A. (Eds.): Side Effects of Drugs, pp. 202–211. Amsterdam: Exerpta Medica Foundation 1968.
Kline, N.S.: The use of Eauwolfia serpentia Benth. in neuropsychiatric conditions. Ann. N.Y. Acad. Sci. 59, 107–132 (1954).
Kobinger, W.: Reversibility of a facilitatory action of reserpine on the central nervous system by methylamphetamine. Experientia (Basel) 14, 337–338 (1958).
Koch-Weser, J.: Role of norepinephrine release in the interval-strength relationship of heart muscle. J. Pharmacol. exp. Ther. 150, 184–189 (1965).
Koe, B.K., Weissman, A.: p-Chlorophenylalanine: A specific depletor of brain serotonin. J. Pharmacol. exp. Ther. 154, 499–516 (1966).
Kopin, I. J., Gordon, E.K.: Metabolism of norepinephrine-H3 released by tyramine and reserpine. J. Pharmacol. exp. Ther. 138, 351–359 (1962).
Kopin, I. J., Gordon, E.K.: Metabolism of administered and drug-released norepinephrine-H3 in the rat. J. Pharmacol. exp. Ther. 140, 207–216 (1963).
Kopin, I. J., Hertting, G., Gordon, E.K.: Fate of norepinephrine-H3 in the isolated perfused rat heart. J. Pharmacol. exp. Ther. 138, 34–40 (1962).
Koslow, S.H., Roth, L.J.: Reserpine and acetazolamide in maximum electroshock seizure in the rat. J. Pharmacol. exp. Ther. 176, 711–717 (1971).
Krayer, O., Alper, M.H., Paasonen, M.K.: Action of guanethidine and reserpine upon the isolated mammalian heart. J. Pharmacol. exp. Ther. 135, 164–173 (1962).
Krayer, O., Fuentes, T.: Changes of heart rate caused by direct cardiac action of reserpine. J. Pharmacol. exp. Ther. 123, 145–152 (1958).
Krell, R.D., Patil, P.N.: Steric aspects of adrenergic drugs. XIX. Influence of various factors on the stereoselectivity of pre-and postjunctional sites to norepinephrine isomers in isolated rat vasa deferentia. J. Pharmacol. exp. Ther. 182, 101–115 (1972).
Krista, L.M., Burger, R.E., Waibel, P.E.: The influence of various drugs on the growth and beta-aminopropionitrile-induced dissecting aneurysm of turkeys. Poultry Sci. 42, 522–526 (1963).
Kroneberg, G., Schümann, H.J.: Der Einfluß der Rauwolfia-Alkeloide Reserpin, Rescinnamin und Canescin auf den Katecholamin-Gehalt des Nebennierenmarks. Arzneimittel-Forsch. 7, 279–280 (1957a).
Kroneberg, G., Schümann, H.J.: Die Wirkung des Reserpins auf den Hormongehalt des Nebennierenmarks. Naunyn-Schmiedeberg Arch. exp. Path. Pharmak. 231, 349–360 (1957b).
Kroneberg, G., Schümann, H.J.: Adrenalinsekretion und Adrenalin Verarmung der Kaninchennebennieren nach Reserpin. Naunyn-Schmiedeberg Arch. exp. Path. Pharmak. 234, 133–146 (1958).
Kroneberg, G., Stoepel, K.: Der Einfluß von α-methyl-dopa auf die Tyraminwirkung an mit Reserpin vorbehandelten Katzen. Experientia (Basel) 19, 252–253 (1963).
Krüger, J.S., Randrup, A.: Pharmacological evidence for a cholinergic mechanism in brain involved in a special stereotyped behaviour of reserpinized rats. Brit. J. Pharmacol. 34, 217P–218P (1968).
Kruger, S., Robinson, G.A., Schueler, F. W.: A study of the antileukemic activity of Rauwolfia alkaloids. Arch. int. Pharmacodyn. 129, 125–130 (1960a).
Kruger, S., Standeffer, W.C., Schueler, F.W.: Some effects of reserpine on normal and leukemic mice. Arch. int. Pharmacodyn. 129, 395–400 (1960b).
Kubo, T., Nishio, H., Misu, Y.: The acute partial failure of neuromuscular transmission by reserpine in the isolated perfused rabbit’s heart. Jap. J. Pharmacol. 20, 442–445 (1970).
Kulkarni, A.S., Shideman, F.E.: Sensitivities of the brains of infant and adult rats to the catecholamine-depleting actions of reserpine and tetrabenazine. J. Pharmacol. exp. Ther. 153, 428–433 (1966).
Kuntzman, R., Jacobson, M.M.: On the mechanism of heart norepinephrine depletion by tyramine, guanethidine and reserpine. J. Pharmacol. exp. Ther. 144, 399–404 (1964).
Kuschke, H. J., Frantz, J.: Über eine hyperglykamische Wirkung von Reserpin. Naunyn-Schmiedeberg Arch. exp. Path. Pharmak. 224, 269–274 (1955).
Lage, G.L., Spratt, J.L.: Antagonism of intravenous digitoxigenin lethality by reserpine pretreatment in the mouse. Proc. Soc. exp. Biol. (N. Y.) 125, 580–583 (1967).
Langendorff, M., Melching, H.-J., Langendorff, H., Koch, R., Jaques, R.: Untersuchungen über einen biologischen Strahlenschutz XXI. Mitteilung: Weitere Untersuchungen zur Wirkung zentral-erregender und-dämpfender Pharmaka auf die Strahlenempfindlichkeit des Tieres. Strahlentherapie 104, No. 3, 1–8 (1957).
Larochelle, L., Bédard, P., Poirier, L. J., Sourkes, T. L.: Correlative neuroanatomical and neuropharmacological study of tremor and catatonia in the monkey. Neuropharmacology 10, 273–288 (1971).
Lasagna, L., McCann, W.P.: Effect of tranquilizing drugs on amphetamine toxicity in aggregated mice. Science 125, 1241–1242 (1957).
Ledda, F., Baldi, V.: The effect of reserpine on mammalian neuro-muscular transmission. Life Sci. 4, 955–957 (1965).
Lee, F.L.: The relation between norepinephrine content and response to sympathetic nerve stimulation of various organs of cats pretreated with reserpine. J. Pharmacol. exp. Ther. 156, 137–141 (1967).
Lee, W.C., Shideman, F. E.: Role of myocardial catecholamines in cardiac contractility. Science 129, 967–968 (1959a).
Lee, W.C., Shideman, F.E.: Mechanism of the positive inotropic response to certain ganglionic stimulants. J. Pharmacol. exp. Ther. 126, 239–249 (1959b).
Lemberger, L., Axelrod, J., Kopin, I. J.: The disposition and metabolism of tryptamine and the in vivo formation of 6-hydroxy-tryptamine in the rabbit. J. Pharmacol. exp. Ther. 177, 169–176 (1971).
Lettati, H.F., Sellers, E.A., Schönbaum, E.: Modification of drug-induced hypothermia. Canad. J. Physiol. Pharmacol. 42, 745–755 (1964).
Levill, B., Roberts,J.: The capacity of different digitalis materials to induce ventricular rhythm disturbances in the reserpine-pretreated cat. J. Pharmacol. exp. Ther. 156, 159–161 (1967).
Levin, E.Y., Levenberg, B., Kaufman, S.: Enzymic conversion of 3, 4-dihydroxyphenyl-ethylamine to norepinephrine. J. biol. Chem. 235, 2080–2086 (1960).
Levison, P.K., Freedman, D.X.: Recovery of a discriminated leverpress avoidance performance from the effects of reserpine, chlorpromazine and tetrabenazine. Arch. int. Pharmacodyn. 170, 31–38 (1967).
Levitt, M., Spector, S., Sjoerdsma, A., Udenfriend, S.: Elucidation of the rate-limiting step in norepinephrine biosynthesis in the perfused guinea-pig heart. J. Pharmacol. exp. Ther. 148, 1–8 (1965).
Lewis,J.J.: Rauwolfia Derivatives. In: Root, W.S., Hofmann, F.G. (Eds.): Physiological Pharmacology, pp. 479–536. Vol. I, London: Academic Press 1963.
Liebman, J.: Modification of the chronotropic action of sympathomimetic amines by reserpine in the heart-lung preparation of the dog. J. Pharmacol. exp. Ther. 133, 63–69 (1961).
Liebman, J., Muskus, A. J., Waud, D.R.: The depletion of norepinephrine stores in the heart of the dog by reserpine-type alkaloids. J. Pharmacol. exp. Ther. 136, 75–79 (1962).
Lindmar, R.: Die Wirkung von l, l-Dimethyl-4-Phenyl-Piperazinium-Jodid am isolierten Vorhof im Vergleich zur Tyramin- und Nicotinwirkung. Naunyn-Schmiedeberg Arch. exp. Path. Pharmak. 242, 458–466 (1962).
Lindmar, R., Muscholl, E.: Die Wirkung von Pharmaka auf die Elimination von Noradrenalin aus der Perfusionsflüssigkeit und die Noradrenalinaufnahme in das isolierte Herz. Naunyn-Schmiedeberg Arch. exp. Path. Pharmak. 247, 469–492 (1964).
Livett, B.G., Geffen, L.B., Austin, L.: Proximo-distal transport of (14C) noradrenaline and protein in sympathetic nerves. J. Neurochem. 15, 931–939 (1968).
Louis, W. J., Doyle, A.E.: The pressor response to noradrenaline and tyramine during angiotensin tachyphylaxis in the dog. Clin. Sci. 31, 247–254 (1966).
Lovenberg, W., Weissbach, H., Udenfriend, S.: Aromatic 1-amino acid decarboxylase. J. biol. Chem. 237, 89–93 (1962).
Luby,E.: Reserpine-like drugs — Clinical efficacy, pp. 1077–1082. In: Psychopharmacology: A review of progress, 1957–1967. Washington, Public Health Service Publication No. 1836 (1968).
Lucas, R. A.: The chemistry and pharmacology of the Rauwolfia alkaloids. Progr. Med. Chem. 3, 146–186 (1963).
Lundborg,P.: Storage function and amine levels of the adrenal medullary granules at various intervals after reserpine treatment. Experientia (Basel) 19, 479–480 (1963).
Lundborg, P., Stitzel, R.: Uptake of biogenic amines by two different mechanisms present in adrenergic granules. Brit. J. Pharmacol. 29, 342–349 (1967a).
Lundborg, P., Stitzel, R.: Effect of reserpine and protriptyline on the subcellular distribution of H3-metaraminol in the mouse heart. Brit. J. Pharmacol. 30, 379–384 (1967b).
Maanen, J.H. van, Smelik, P.G.: Induction of pseudopregnancy in rats following local depletion of monoamines in the median eminence of the hypothalamus. Neuroendocrinology 3, 177–186 (1968).
Macmillan, W.H., Rand, M.J.: The effects in rabbits of thyroidectomy and treatment with triiodothyronine on the sensitivity to noradrenaline and the content of noradrenaline in aorta and spleen. J. Pharm. Pharmacol. 14, 257–267 (1962).
Macmillan, W.H., Smith, D.J., Jacobson, J.H.: Responses of normal, denervated and reserpine-treated arteries to sympathomimetic amines and nicotine in dogs. Brit. J. Pharmacol. 18, 39–48 (1962).
Maggiolo, C., Haley, T.J.: Brain concentration of reserpine-H3 and its metabolites in the mouse. Proc. Soc. exp. Biol. (N.Y.) 115, 149–151 (1964).
Magus, R.D., Krause, F.W., Riedel, B.E.: Dissociation of reserpine-induced depression of spontaneous motor activity and release of brain serotonin in rats. Biochem. Pharmacol. 13, 943–947 (1964).
Mahfouz, M., Ezz, E. A.: The effect of reserpine and chlorpromazine on the response of the rat to acute stress. J. Pharmacol. exp. Ther. 123, 39–42 (1958).
Maickel, R.P., Westermann, E.O., Brodie, B.B.: Effects of reserpine and cold-exposure on pituitary-adrenocortical function in rats. J. Pharmacol. exp. Ther. 134, 167–175 (1961).
Malhotra, C.L., Das, P.K.: Effect of reserpine on the acetylcholine content of the heart, the ileum and the hypothalamus of the dog. Brit. J. Pharmacol. 18, 190–193 (1962).
Malhotra, C.L., Mehta, V.L.: The effect of reserpine on the acetylcholine release of the cerebral cortex of dog under different anaesthetics. Brit. J. Pharmacol. 27, 131–134 (1966).
Malhotra, C.L., Prasad, S.: Effect of some drugs on the acetylcholine release from the cerebral cortex of cat. Indian J. Physiol. Pharmacol. 12, 103–106 (1968).
Malhotra, C.L., Pundlik, P.G.: The effect of reserpine on the acetylcholine content of different areas of the central nervous system of the dog. Brit. J. Pharmacol. 14, 46–47 (1959).
Maling, H.M., Fleisch, J.H., Saul, W.F.: Species differences in aortic responses to vasoactive amines: The effects of compound 48/80, cocaine, reserpine and 6-hydroxydopamine. J. Pharmacol. exp. Ther. 170, 672–683 (1971).
Malmfors, T.: Evidence of adrenergic neurons with synaptic terminals in the retina of rats demonstrated with fluorescence and electron microscopy. Acta physiol. scand. 58, 99–100 (1963).
Malmfors, T.: Studies on adrenergic nerves. The use of rat and mouse iris for direct observations on their physiology and pharmacology at cellular and subcellular levels. Acta physiol. scand. 64, Suppl. 248, 1–95 (1965).
Malmfors, T.: Fluorescent histochemical studies on the uptake, storage, and release of catecholamines. Circula. Res. 21, Suppl. 3, 25–42 (1967).
Malpica, J.F., Jurupe, H., Campos, H.A.: Actions of reserpine and tyramine on the acetylcholine content of brain stem, heart and blood of the rat. Arch. int. Pharmacodyn. 185, 13–19 (1970).
Manara, L., Garattini, S.: Time course of 3H-reserpine levels in brains of normal and tetra-benazine-pretreated rats. Europ. J. Pharmacol. 2, 139–141 (1967).
Manara, L., Mennini, T., Carminati, P.: Reduced binding of 3H-reserpine to the hearts of 6-hydroxydopamine-pretreated rats. Europ. J. Pharmacol. 17, 183–185 (1972).
Manara, L., Sestini, M.G., Algeri, S., Garattini, S.: On the ability of desipramine to interfere with reserpine-induced noradrenaline release. J. Pharm. Pharmacol. 18, 194–195 (1966).
Mandell, A.J., Knapp, S.: The effects of chronic administration of some cholinergic and adrenergic drugs on the activity of choline acetyltransferase in the optic lobes of the chick brain. Neuropharmacology 10, 513–516 (1971).
Mannaioni, P.F., Ledda, F., Baldi, V., Catini, C.: Differential release of histamine by 5-hydroxytryptamine, noradrenaline and reserpine from neoplastic mast cells in vitro: biological and fluorescence microscope observations. Europ. J. Pharmacol. 3, 203–211 (1968).
Marcus, F.I., Pavlovich, J., Cuccia, C.: Inhibition of myocardial uptake of tritiated digoxin by reserpine pretreatment in the dog. Circulation 34, Suppl. 3, 162–163 (1966).
Margules, D.L.: Noradrenergic rather than serotonergic basis of reward in the dorsal tegmentum. J. comp, physiol. Psychol. 67, 32–35 (1969).
Marrazzi, A.S.: Electrical studies on the pharmacology of autonomic synapses. II. The action of a sympathomimetic drug (epinephrine) on sympathetic ganglia. J. Pharmacol. exp. Ther. 65, 395–404 (1939).
Marsden, G.A., Broch, O.J. Jr., Guldberg, H.C.: Catechol-O-Methyl transferase and monoamine oxidase activities of rat submaxillary glands: Effects of ligation, sympathectomy and some drugs. Europ. J. Pharmacol. 15, 335–342 (1971).
Mason, D.T., Braunwald, E.: Effects of guanethidine, reserpine, and methyldopa on reflex venous and arterial constriction in man. J. Clin. Invest. 43, 1449–1463 (1964).
Matthews, R.J.: The effects of epinephrine, levarterenol, and dl-isoproterenol on transmission in the superior cervical ganglion. J. Pharmacol. exp. Ther. 116, 433–443 (1956).
Maxwell, D.H., Palmer, H.T.: Demonstration of antidepressant or stimulant properties of imipramine in experimental animals. Nature (Lond.) 191, 84–85 (1961).
Maxwell, R.A., Keenan, P.D., Chaplin, E., Roth, B., Eckhardt, S.B.: Molecular features affecting the potency of tricyclic antidepressants and structurally related compounds as inhibitors of the uptake of tritiated norepinephrine by rabbit aortic strips. J. Pharmacol. exp. Ther. 166, 320–329 (1969).
Maxwell, R. A., Plummer, A. J., Osborne, M. W., Ross, S.D.: Evidence for a peripheral action of reserpine. J. Pharmacol. exp. Ther. 116, 42 (1956).
Maxwell, R.A., Povalski, H., Plummer, A.J.: A differential effect of reserpine on pressor amine activity and its relationship to other agents producing this effect. J. Pharmacol. exp. Ther. 125, 178–183 (1959).
Maxwell, R.A., Ross, S.D., Plummer, A.J., Sigg, E.B.: A peripheral action of reserpine. J. Pharmacol. exp. Ther. 119, 69–77 (1957).
Mayer, G., Meunier, J.M., Thevenot-Duluc, A. J.: Prolongation de la grossesse par retards de nidation obtenus chez la ratte par administration de reserpine. Ann. Endocr. (Paris) 21, 1–13 (1960).
Mayor, D., Kapeller, K.: Fluorescence microscopy and electron microscopy of adrenergic nerves after constriction at two points. J. roy. micr. Soc. 87, 277–294 (1967).
McCubbin, J.W., Page, I.H.: Do ganglion-blocking agents and reserpine affect central vasomotor activity? Circulat. Res. 6, 816–824 (1958).
McCulloch, M. W., Proctor, C., Rand, M.J.: Evidence for an adrenergic homeostatic broncho-dilator reflex mechanism. Europ. J. Pharmacol. 2, 214–223 (1967).
McGeer, P.L., Boulding, J.E., Gibson, W. C., Foulkes, R. G.: Drug-induced extrapyramidal reactions. J. Amer. med. Ass. 177, 665–670 (1961).
McGeer, P.L., McGeer, E.G., Wada, J.A.: Central aromatic amine levels in behaviour. II. Serotonin and catecholamine levels in various cat brain areas following administration of psychoactive drugs or amine precursors. Arch. Neurol. (Chic.) 9, 81–89 (1963).
Mcneill, J.H.: Reserpine supersensitivity to catecholamine-induced cardiac Phosphorylase activation. Canad. J. Physiol. Pharmacol. 47, 515–519 (1969).
McQueen, E.G.: The effect of control of blood pressure on vascular reactivity in experimental renal hypertension. Clin. Sci. 21, 133–140 (1961).
McQueen, E. G., Doyle, A. E., SmlrK, F.H.: The circulatory effects of reserpine. Circulation 11, 161–169 (1955).
McQueen, E.G., Hodge, J. V.: Modification of secondary lesions in renal hypertensive rats by control of the blood pressure with reserpine. Quart. J. Med. 30, 213–230 (1961).
Medina, M.A., Landez, J.H., Forster, L.L.: Inhibition of tissue histamine formation by decaborane. J. Pharmacol. exp. Ther. 169, 132–137 (1969).
Meites, J., Nicoll, C. S., Taiwalkeb, P. K.: Effects of reserpine and serotonin on milk secretion and mammary growth in the rat. Proc. Soc. exp. Biol. (N. Y.) 101, 563–565 (1959).
Melville, K.I., Johnson, M.C.: Cerebrospinal fluid electrolyte changes during lateral ventricular perfusion with noradrenaline and associated cardiovascular responses. Neuropharmacology 9, 79–95 (1970).
Meter, W. van, Karczmar, A.G.: Effect of catecholamine depletion on anticholinesterase activity in the central nervous system. Fed. Proc. 26, 651 (1967).
Meter, W. van, Karczmar, A.G.: An effect of physostigmine on the central nervous system of rabbits related to brain levels of norepinephrine. Neuropharmacology 10, 379–390 (1971).
Mirkin, B. L.: Catechol amine depletion in the rat’s denervated adrenal gland following chronic administration of reserpine. Nature (Lond.) 182, 113–114 (1958).
Mirkin, B.L., Cervoni, P.: The adrenergic nature of neurohumoral transmission in the cat nictitating membrane following treatment with reserpine. J. Pharmacol. exp. Ther. 138, 301–308 (1962).
Misu, Y., Tanaka, C., Takaori, S.: Effects of dichloroisoproterenol and phenoxybenzamine on the transmembrane potentials of the isolated rabbits’ heart. Jap. J. Pharmacol. 15, 176–186 (1965).
Mohammed, S., Gaffney, T.E., Yard, A.C., Gomez, H.: Effects of methyldopa, reserpine and guanethidine on hindleg vascular resistance. J. Pharmacol. exp. Ther. 160, 300–307 (1968).
Molinoff, P.B., Brimijoin, S., Axelrod, J.: Induction of dopamines-hydroxylase and tyrosine hydroxylase in rat hearts and sympathetic ganglia. J. Pharmacol. exp. Ther. 182, 116–129 (1972).
Monnier, M., Graber, S.: Classification electrophysiologique des substances psycholeptiques. (Position du chlordiazepoxide “Librium”.) Arch. int. Pharmacodyn. 140, 206–216 (1962).
Montanari, R., Stockham, M. A.: The effect of imipramine on the reserpine toxicity in adrenal-ectomized rats. J. Pharm. Pharmacol. 14, 126–127 (1962a).
Montanari, R., Stockham, M.A.: Effects of single and repeated doses of reserpine on the secretion of adrenocorticotrophic hormone. Brit. J. Pharmacol. 18, 337–345 (1962b).
Moran, N.C., Westerholm, B.: The influence of reserpine on 5-hydroxyptamine and histamine content of rat mast cells and of some rat tissues. Acta physiol. scand. 58, 20–29 (1963).
Morgan, M., Mandell, A. J.: Indole (ethyl) amine-N-methyl transferase in the brain. Science 165, 492–493 (1969).
Morpurgo, C., Theobald, W.: Behavioural reactions to amphetamine in reserpinized rats. Int. J. Neuropharmacol. 5, 375–377 (1966).
Mueller, P.S., McDonald, R.K.: Observations on hypothermia induced by reserpine and chlorpromazine. Proc. Soc. exp. Biol. (N.Y.) 128, 826–830 (1968).
Mueller, R.A., Shideman, F.E.: Restoration of cardiac responsiveness to tyramine after reserpine. J. Pharmacol. exp. Ther. 160, 53–60 (1968a).
Mueller,R.A., Shideman, F.E.: A comparison of the absorption, distribution and metabolism of reserpine in infant and adult rats. J. Pharmacol. exp. Ther. 163, 91–97 (1968b).
Mueller, R.A., Shideman, F.E.: The prolongation of reserpine-induced cardiac norepinephrine depletion by metabolic inhibitors. Biochem. Pharmacol. 17, 451–467 (1968c).
Mueller, R.A., Thoenen, H., Axelrod, J.: Compensatory increase in adrenal tyrosine hydroxylase activity after chemical sympathectomy. Science 163, 468–469 (1969 a).
Mueller, R.A., Thoenen, H., Axelrod, J.: Increase in tyrosine hydroxylase activity after reserpine administration. J. Pharmacol. exp. Ther. 169, 74–79 (1969b).
Muggenberg, A., Kowalczyk, T., Hoekstra, G., Grummer, R.H.: Experimental production of gastric ulcers in swine by reserpine. Amer. J. vet. Res. 27, 1663–1669 (1966).
Murad, J.E., Shore, P.A.: Association between biochemical and behavioural actions of tricyclic antidepressants. Int. J. Neuropharmacol. 5, 299–304 (1966).
Murnaghan, M.F.: Restoration of the chronotropic effect of tyramine on rat atria after reserpine. Brit. J. Pharmacol. 34, 88–98 (1968).
Musacchio, J.M., Bhagat, B., Jackson, D.J., Kopin, I.J.: The effect of disulfiram on the restoration of the response to tyramine by dopamine and α-methyldopa in the reserpinetreated cat. J. Pharmacol. exp. Ther. 152, 293–297 (1966).
Muscholl,E.: Die Konzentration von Noradrenalin und Adrenalin in den einzelnen Abschnitten des Herzens. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 237, 350–364 (1959).
Muscholl,E.: Die Hemmung der Noradrenaline-Aufnahme des Herzens durch Reserpin und die Wirkung von Tyramin. Naunyn-Schmiedeberg Arch. exp. Path. Pharmak. 240, 234–241 (1960).
Muscholl, E.: Indirectly acting sympathomimetic amines. Pharmacol. Rev. 18, 551–559 (1966).
Muscholl, E., Vogt, M.: The concentration of adrenaline in the plasma of rabbits treated with reserpine. Brit. J. Pharmacol. 12, 532–535 (1957).
Muscholl, E., Vogt, M.: The action of reserpine on the peripheral sympathetic system. J. Physiol. (Lond.) 141, 132–155 (1958).
Muskus, A. J.: Effect of pretreatment with reserpine and reserpine analogs on the response of isolated guinea-pig atria to tyramine. J. Pharmacol. exp. Ther. 133, 296–300 (1962).
Nagatsu, T., Levitt, M., Udenfriend, S.: Tyrosine hydroxylase: The initial step in norepinephrine synthesis. J. biol. Chem. 239, 2910–2917 (1964).
Nasmyth, P.A.: An investigation of the action of tyramine and its interrelationship with the effects of other sympathomimetic amines. Brit. J. Pharmacol. 18, 65–75 (1962).
Nayler, W. G.: A direct effect of reserpine on ventricular contractility. J. Pharmacol. exp. Ther. 139, 222–229 (1963).
Neff,N.H., Costa, E.: Effect of tricyclic antidepressants and chlorpromazine on brain catecholamine synthesis, pp. 28–34. In: Antidepressant drugs. Proceedings of 1st Int. Symposium. Int. Congress Series No. 122. Excerpta Medica, Foundation. Amsterdam, New York, London (1967).
Norberg, K.-A.: Drug-induced changes in monoamine levels in the sympathetic adrenergic ganglion cells and terminals: a histochemical study. Acta physiol. scand. 65, 221–234 (1965).
Norn, S., Shore, P. A.: Further studies on the nature of persistent reserpine binding: evidence for reversible and irreversible binding (in heart, spleen, adrenals and small intestine of rats). Biochem. Pharmacol. 20, 1291–1295 (1971).
Oka, M., Ohuchi, T., Yoshida, H., Imaizumi, R.: Selective release of noradrenaline and adrenaline from isolated adrenal medullary granules. Life Sci. 5, 433–438 (1966).
Orlans,F.B.H., Finger, K.F., Brodie, B.B.: Pharmacological consequences of the selective release of peripheral norepinephrine by syrosingopine (SU 3118). J. Pharmacol. exp. Ther. 128, 131–139 (1960).
Paasonen, M.K., Dews, P. B.: Effects of raunescine and isoraunescine on behaviour and on the 5-hydroxytryptamine and noradrenaline contents of brain. Brit. J. Pharmacol. 13, 84–88 (1958).
Paasonen, M.K., Krayer, O.: Effect of reserpine upon the mammalian heart. Fed. Proc. 16, 326–327 (1957).
Paasonen, M.K., Krayer, O.: The release of norepinephrine from the mammalian heart by reserpine. J. Pharmacol. exp. Ther. 123, 153–160 (1958).
Palm, D., Grobecker, H., Bak, I.J.: Membrane effects of catecholamine releasing drugs. In: Schumann, H. J., Kroneberg, G. (Eds.): New Aspects of Storage and Release Mechanisms of Catecholamines, pp. 188–198. Berlin-Heidelberg-New York: Springer 1970.
Parratt, J. R., West, G. B.: Release of 5-hydroxytryptamine and histamine from tissues of the rat. J. Physiol. (Lond.) 137, 179–192 (1957).
Pasteels, J. L.: Comparaison entre l’action des androgénes et de la réserpine sur l’hypophyse et la glande mammaire chez le rat. Ann. endocr. (Paris) 22, 257–268 (1961).
Paton, D.M.: Effects of Na+ and K+ on the uptake of metaraminol by rabbit ventricular slices. Brit. J. Pharmacol. 41, 65–75 (1971).
Pegram, B.L., Carrier, O., Jr.: Change in calcium dependence of isolated arteries after reserpine. Amer. J. Physiol. 217, 1736–1741 (1969).
Pellegrino de Iraldi, A., de Robertis, E.: Action of reserpine, iproniazid and pyrogallol on nerve endings of the pineal gland. Int. J. Neuropharmacol. 2, 231–239 (1963).
Penefsky, Z.J., Kahn, M.: Inotropic effects of dexamethasone in mammalian heart muscle. Europ. J. Pharmacol. 15, 259–266 (1971).
Penna, M., Linares, F., Caceres, L.: Mechanism for cardiac stimulation during hypoxia. Amer. J. Physiol. 208, 1237–1242 (1965).
Pennefather, J.N., Rand, M.J.: Increase in noradrenaline content of tissues after infusion of noradrenaline, dopamine and l-dopa. J. Physiol. (Lond.) 154, 277–287 (1960).
Perera, G. A.: Edema and congestive failure related to administration of Rauwolfia serpentina. J. Amer. med. Ass. 159, 439–440 (1955).
Philippu, A., Becke, H., Burger, A.: Effect of drugs on the uptake of noradrenaline by isolated hypothalamic vesicles. Europ. J. Pharmacol. 6, 96–101 (1969).
Philippu, A., Burkat, U., Becke, H.: Uptake of norepinephrine by the isolated hypothalamic vesicles. Life Sci. 7, 1009–1017 (1968).
Philippu, A., Palm, D., Schümann, H. J.: Effect of segontin and reserpine on isolated medullary granules. Nature (Lond.) 205, 183 (1965).
Philippu, A., Pfeiffer, R., Schümann, H.J., Lickfeld, K.: Eigenschaften der Noradrenalin speichernden Granula des sympathischen Ganglion stellatum. Naunyn-Schmiedeberg Arch. exp. Path. Pharmak. 258, 251–265 (1967).
Pinter, E. J., Pattee, C.J.: Fat-mobilizing action of amphetamine. J. clin. Invest. 47, 394–402 (1968).
Pirch, J.H., Rech, R.H., Moobe, K.E.: Depression and recovery of the electrocorticogram, behaviour and brain amines in rats treated with reserpine. Int. J. Neuropharmacol. 6, 375–385 (1967).
Pletscher, A., Burkard, W.F., Tranzer, I.P., Gey, K.F.: Two sites of 5-hydroxytryptamine uptake in blood platelets. Life Sci. 6, 273–288 (1967).
Pletscher, A., Gey, K.F.: Action of imipramine and amitriptyline on cerebral monoamines as compared with chlorpromazine. Med. exp. (Basel) 6, 165–168 (1962).
Pletscher, A. Shore, P.A., Brodie, B.B.: Serotonin release as a possible mechanism of reserpine action. Science 122, 374–375 (1955).
Pletscher, A., Shore, P.A., Brodie, B.B.: Serotonin as a mediator of reserpine action in brain. J. Pharmacol. exp. Ther. 116, 84–89 (1956).
Plummer, A.J., Earl, A., Schneider, J.A., Trapold, J., Barret, W.: Pharmacology of Rauwolfia alkaloids, including reserpine. Ann. N. Y. Acad. Sci. 59, 8–21 (1954).
Pöldinger, W.: Combined administration of desipramine and reserpine or tetrabenazine in depressive patients. Psychopharmacologia (Berl.) 4, 308–310 (1963).
Pollock, D., Muir, T.C., Macdonald, A., Henderson, G.: Morphine-induced changes in the sensitivity of the isolated colon and vas deferens of the rat. Europ. J. Pharmacol. 20, 321–328 (1972).
Potter, L.T.: Storage of norepinephrine in sympathetic nerves. Pharmacol. Rev. 18, 439–451 (1966).
Potter, L.T.: Role of intraneuronal vesicles in the synthesis, storage and release of noradrenaline. Circulat. Res. 21, Suppl. 3, 13–24 (1967).
Potter, L.T., Axelrod, J.: Studies on the storage of noradrenaline and the effect of drugs. J. Pharmacol. exp. Ther. 140, 199–206 (1963).
Potter, L.T., Cooper, T., Willman, V.L., Wolfe, D.E.: Synthesis, binding, release and metabolism of norepinephrine in normal and transplanted dog hearts. Circulat. Res. 16, 468–481 (1965).
Pradhan, S.N., Bowling, C.: Effects of nicotine on self-stimulation in rats. J. Pharmacol. exp. Ther. 176, 229–243 (1971).
Purshottam, N.: Effects of tranquilizers on induced ovulation in mice. Amer. J. Obstet. Gynec. 83, 1405–1409 (1962).
Quetsch, R.M., Achor, R.W.P., Litin, E.M., Faucett, R.L.: Depressive reactions in hypertensive patients: a comparison of those treated with rauwolfia and those receiving no specific antihypertensive treatment. Circulation 19, 366–375 (1959).
Quinn, G.P., Shore, P.A., Brodie, B.B.: Biochemical and pharmacological studies of Ro I-9569 (tetrabenazine), a non-indole tranquilizing agent with reserpine-like effects. J. Pharmacol. exp. Ther. 127, 103–109 (1959).
Raab, W., Marchet, H., Herrlich, H.C.: Effect of reserpine and syrosingopine on the rate of contractility of the human heart. Amer. J. Cardiol. 7, 404–411 (1961).
Radouco-Thomas, S., Tessier, L., Lajiunessey, N., Garcin, F.: Role of calcium in the reser-pine-induced cerebral monoamines depletion. Int. Z. klin. Pharmakol. Ther. Toxikol. 5, 5–11 (1971).
Rand, M.J., Trinker, F.R.: Pharmacological agents affecting the activity and release of catecholamines. Brit. J. Anaesth. 38, 666–689 (1966).
Randrup, A., Munkvad, I., Udsen, P.: Adrenergic mechanisms and amphetamine induced abnormal behaviour. Acta pharmacol. (Kbh.) 20, 145–157 (1963).
Raper, C., Wale, J.: Propranolol, M.J. 1999 and Ciba 39089-Ba in ouabain and adrenaline induced cardiac arrhythmias. Europ. J. Pharmacol. 4, 1–12 (1968).
Ratner, A., Talwalker, P.K., Meites, J.: Effect of reserpine on prolaction-inhibiting activity of rat hypothalamus. Endocrinology 77, 315–319 (1965).
Rech,R.H.: Antagonism of reserpine behavioural depression by d-amphetamine. J. Pharmacol. exp. Ther. 146, 369–376 (1964).
Reilly, J.F., Ahlstrom, A.P., Watts, J.S., Cassidy, P., Lusky, L.M.: Influence of age, sex and cold exposure on susceptibility to reserpine-induced gastric lesions. Toxicol, appl. Pharmacol. 15, 97–105 (1969).
Reinert, H.: Role and origin of noradrenaline in the superior cervical ganglion. J. Physiol. (Lond.) 167, 18–29 (1963).
Reis, D.J., Moorhead, D.T., Merlino, N.: Dopa-induced excitement in the cat. Its relationship to brain norepinephrine concentrations. Arch. Neurol. (Chic.) 22, 31–39 (1970).
Reis, D. J., Weinbren, M., Corvelli, A.: A circadian rhythm of norepinephrine regionally in cat brain: its relationship to environmental lighting and to regional diurnal variations in brain serotonin. J. Pharmacol. exp. Ther. 164, 135–145 (1968).
Resnick, O., Krus, D.M., Raskin, M.: Accentuation of the psychological effects of LSD-25 in normal subjects treated with reserpine. Life Sci. 4, 1433–1437 (1965).
Restall, P.A., Smirk, F.H.: Treatment of high blood pressure with hexamethonium iodide. N. Z. med. J. 49, 206–209 (1950).
Rewerski, W., Jori, A.: Effect of desipramine injected intracerebrally in normal or reser-pinized rats. J. Pharm. Pharmacol. 20, 293–296 (1968).
Richardson, K.C.: Fine structure of autonomic nerve endings in smooth muscle of the rat vas deferens. J. Anat. (Lond.) 96, 427–442 (1962).
Richardson, K.C: Fine structure of the albino rat iris with special reference to identification of adrenergic and cholinergic nerves and nerve endings in its intrinsic muscles. Amer. J. Anat. 114, 173–206 (1964).
Ringer,R.K.: The influence of reserpine on early growth, blood pressure and dissecting aneurysms in. turkeys, pp. 21–28. In: Proceedings of the conference on the use of the tranquilizing and antihypertensive agent serpasil in animal and poultry production. New Brunswick, N.J.: Rutgers University 1959.
Ringer,R.K.: Aortic rupture, plasma cholesterol and arteriosclerosis following serpasil administration to turkeys, pp. 32–39. In: The second conference on the use of reserpine in poultry production. Summut, N.J.: University of Minnesota, St. Paul, Minn., sponsored by Ciba Pharmaceutical Products, Inc. 1960.
Robertis, E.D.P. de: Histophysiology of synapses and neurosecretion. London: Pergamon Press 1964.
Roberts, J., Ito, R., Reilly, J., Cairoli, V. J.: Influence of reserpine and TM 10 on digitalis-induced ventricular arrhythmia. Circulat. Res. 13, 149–158 (1963).
Roos, B.-E., Steg, G.: The effect of L-3, 4-dihydroxyphenylalanine and DL-5-hydroxytrypto-phan on rigidity and tremor induced by reserpine, chlorpromazine, and phenoxybenzamine. Life Sci. 3, 351–360 (1964).
Rosengren, E.: On the role of monoamine oxidase for the inactivation of dopamine in brain. Acta physiol. scand. 49, 370–375 (1960).
Rosengren, E., Svensson, S.E.: Histamine formation in rat gastric mucosa and lung after injecting reserpine or adrenaline. Brit. J. Pharmacol. 37, 659–665 (1969).
Rossum, J.M. van, Schoot, J.B. van der, Hurkmans, J.A.Th.M.: Mechanism of action of cocaine and amphetamine in the brain. Experientia (Basel) 18, 229–231 (1962).
Roth, R. A., Stone,C. A.: The action of reserpine on noradrenaline biosynthesis in sympathetic nerve tissue. Biochem. Pharmacol. 17, 1581–1590 (1968).
Rubin, B., Malone,M.H., Waugh, M.H., Burke, J.C.: Bioassay of rauwolfia roots and alkaloids. J. Pharmacol. exp. Ther. 120, 125–136 (1957).
Rutledge, C.O., Weiner, N.: The effect of reserpine upon the synthesis of norepinephrine in isolated rabbit heart. J. Pharmacol. exp. Ther. 157, 290–302 (1967).
Ryan, M. J., Brody, M. J.: Distribution of histamine in the canine autonomic nervous system. J. Pharmacol. exp. Ther. 174, 123–132 (1970).
Sabelli, H. C.: Influence on the effect of vasoconstrictor amines by pretreatment with reserpine. Nature (Lond.) 187, 784–785 (1960).
Saferan, M., Vogt, M.: Depletion of pituitary cortiocotrophin by reserpine and by a nitrogen mustard. Brit. J. Pharmacol. 15, 165–169 (1960).
Salmotraghi, G.C., Sollero, L., Page, I.H.: Blockade by Brom-Lysergic-acid-Diethylamide (BOL) of the potentiating action of serotonin and reserpine on hexobarbital hypnosis. J. Pharmacol. exp. Ther. 117, 166–168 (1956).
Sanyal, R. K., West, G. B.: The relationship of histamine and 5-hydroxytryptamine to anaphylactic shock in different species. J. Physiol. (Lond.) 144, 525–531 (1958).
Sartorelli, A.C., Magus, R.D.: Interaction of reserpine with polynucleotides. Pharmacologist 7, 171 (1965).
Schaepdryver, A.F. de: Hypertensive responses in reserpinized dogs. Arch. int. Pharma-codyn. 124, 45–52 (1960).
Schaepdryver, A.F. de, Preziosi, P.: Pharmacological depletion of adrenaline and noradrenaline in various organs of mice. Arch. int. Pharmacodyn. 121, 177–221 (1959).
Schanberg, S.M., Giarman, N.J.: Drug-induced alterations in the sub-cellular distribution of 5-hydroxytryptamine in rat’s brain. Biochem. Pharmacol. 11, 187–194 (1962).
Schayer, R.W.: Formation and binding of histamine in rat tissues in vitro. Amer. J. Physiol. 187, 63–65 (1956).
Schlittler, E.: Rauwolfia alkaloids with special reference to the chemistry of reserpine. In: The Alkaloids, Vol. 8. New York: Academic Press 1965.
Schlittler, E., Bein, H.J.: Rauwolfia Alkaloids, In: Schlittler, E. (Ed.): Antihypertensive Agents, pp. 191–221. New York: Academic Press (1967).
Schmidt, G., Küsel, H. J., Dalri sis>, H.: Über die Wirkung von Reserpin auf die sympathischmotorische Innervation des Auges. Naunyn-Schmiedeberg Arch. exp. Path. Pharmak. 261, 75–88 (1968).
Schmitt, H., Schmitt, H.: Interaction de la réserpine et de quelques amines sympathi-comiméthiques. C. R. Soc. Biol. (Paris) 151, 2030–2032 (1957).
Schmitt, H., Schmitt, H.: Sur les effets hypertenseurs de la reserpine apres certains sympathi-comimetiques. Arch. int. Pharmacodyn. 120, 251–262 (1959).
Schmitt, H., Schmitt, H.: Modifications des effets des amines sympathicomimétiques sur la pression artérielle et la membrane nictitante par la réserpine. Arch. int. Pharmacodyn. 125, 30–47(1960).
Schmitt, H., Schmitt, H.: Inhibition de l’hypertension réserpinique postamphétaminique par les substances anti-dépressives du groupe de l’imipramine. C. R. Soc. Biol. (Paris) 160, 303–306 (1966).
Schmitt, H., Schmitt, H., Depodlly, F.: Potentiation of the effects of indirect sympathomimetic amines by reserpine and bretylium. Nature (Lond.) 196, 73 (1962).
Schneider, J. A., Rinehart, R. K.: Pharmacological interactions of serotonin and réserpine in dogs. J. Pharmacol. exp. Ther. 116, 51 (1956).
Schümann, H. J.: Die Wirkung von Insulin und Reserpin auf den Adrenalin- und ATP-Gehalt der chromaffinen Granula des Nebennierenmarks. Naunyn-Schmiedeberg Arch. exp. Path. Pharmak. 233, 237–249 (1958).
Schümann, H.J.: Medullary particles. Pharmacol. Rev. 18, 433–438 (1966).
Schwartz, A., Lee, K.S.: Effect of reserpine on heart mitochondria. Nature (Lond.) 188, 948–949 (1960).
Seiden, L.S., Peterson, D.D.: Reversal of the reserpine-induced suppression of the conditioned avoidance response by L-dopa: correlation of behavioural and biochemical effects in two strains of mice. J. Pharmacol. exp. Ther. 159, 422–428 (1968).
Shaskan, E.G., Snyder, S.H.: Kinetics of serotonin accumulation into slices of rat brain: relationship to catecholamine uptake. J. Pharmacol. exp. Ther. 175, 404–418 (1970).
Shellenberger, M.K., Elder, J.T.: Changes in rabbit core temperature accompanying alterations in brainstem monoamine concentrations. J. Pharmacol. exp. Ther. 158, 219–226 (1967).
Sheppard, H., Lucus, R.C., Tsien, W.H.: The metabolism of reserpine-C14. Arch. int. Pharmacodyn. 103, 256–269 (1955).
Sheppard, H., Tsien, W.H.: Metabolism of reserpine-C14. II. Species differences as studied in vitro. Proc. Soc. exp. Biol. (N.Y.) 90, 437–446 (1955).
Sheppard, H., Tsien, W.H., Plummer, A. J., Peets, E.A., Giletti, B.U., Shulert, A.R.: Brain reserpine levels following large and small doses of reserpine-H3. Proc. Soc. exp. Biol. (N.Y.) 97, 717–721 (1958).
Sheppard, H., Tsien, W.H., Sigg, E.B., Lucas, R.H., Plummer, A.J.: The metabolism of reserpine-C14. III. C14-concentration vs. time in the brains and other tissues of rats and guinea pigs. Arch. int. Pharmacodyn. 113, 160–168 (1957).
Shimazu, T., Amakawa, A.: Regulation of glycogen metabolism in liver by the autonomic nervous system. III. Differential effects of sympathetic stimulation and of catecholamines on liver Phosphorylase. Biochim. biophys. Acta (Amst.) 165, 349–356 (1968).
Shiørring, E., Randrup, A.: “Paradoxical” stereotyped activity of reserpinized rats. Int. J. Neuropharmacol. 7, 71–73 (1968).
Shore, P. A.: Release of serotonin and catecholamines by drugs. Pharmacol. Rev. 14, 531–550 (1962).
Shore, P.A., Brodie, B.B.: LSD-like effects elicited by reserpine in rabbits pretreated with iproniazid. Proc. Soc. exp. Biol. (N.Y.) 94, 433–435 (1957a).
Shore, P.A., Brodie, B.B.: Influence of various drugs on serotonin and norepinephrine in the brain. In: Garattini, S., Ghetti, V. (Eds.): Psychotropic Drugs, pp. 423–427. London: Elsevier 1957 b.
Shore, P.A., Busfield, D.: The effect of desmethylimipramine on reserpine-induced release of gastric histamine and adrenal catecholamines. Life Sci. 3, 361–366 (1964).
Shore, P.A., Silver, S.L., Brodie, B.B.: Interaction of reserpine, serotonin and lysergic acid diethylamide in brain. Science 122, 284–285 (1955).
Sigg, E.B.: Autonomic side-effects induced by psychotherapeutic agents, pp. 581–588. In: Psychopharmacology. A review of progress: 1957–1967. Washington, Public Health Service Publication No. 1836 (1968).
Sigg, E.B., Gyermek, L., Hell, R.: Antagonism to reserpine-induced depression by imipramine, related psychoactive drugs and some autonomic agents. Psychopharmacologia (Berl.) 7, 144–149 (1965).
Sjöstrand, N.O.: Effect of reserpine and hypogastric denervation on the noradrenaline content of the vas deferens and the seminal vesicle of the guinea-pig. Acta physiol. scand. 56, 376–380 (1962).
Skou, J.C.: Enzymatic basis for active transport of Na+ and K+ across cell membrane. Physiol. Rev. 45, 596–617 (1965).
Smirk, F.H., Alstad, K.S.: Treatment of arterial hypertension by penta- and hexamethonium salts, based on 150 tests on hypertension of various aetiology and 53 patients treated for periods of two to fourteen months. Brit. med. J. 1951 I, 1217–1228.
Smirk, F.H., Doyle, A.E.: Hypotensive action of reserpine. Lancet 1954 I, 1096–1097.
Smirk, F.H., Doyle, A.E., McQueen, E.G.: Control of blood pressure by combined action of reserpine and pentapyrrolidinium. Lancet 1954 II, 159–161.
Smith, A.A., Karmin, M., Gavitt, J.A.: Interaction of catecholamines with levorphanol and morphine in the mouse eye. J. Pharmacol. exp. Ther. 151, 103–109 (1966).
Smith, A.D.: Biochemistry of adrenal chromaffin granules. In: Campbell, P.N. (Ed.): The Interaction of Drugs and Subcellular Components on Animal Cells, pp. 239–292. London: Churchill 1968.
Smith, C.B.: Enhancement by reserpine and a-methyl dopa of the effects of d-amphetamine upon the locomotor activity of mice. J. Pharmacol. exp. Ther. 142, 343–350 (1963).
Smith, T.H.F., Rossi, G.V.: The effect of reserpine and mecamylamine on experimental atheromatosis in the normotensive and hypertensive rat. J. Pharmacol. exp. Ther. 135, 367–373 (1962).
Snyder, S.H., Axelrod, J.: Circadian rhythm in pineal serotonin: Effect of monoamine oxidase inhibition and reserpine. Science 149, 542–544 (1965).
Snyder, S.H., Glowinski, J., Axelrod, J.: The physiological disposition of H3-histamine in the rat brain. J. Pharmacol. exp. Ther. 153, 8–14 (1966).
Somlyo, A.V., Vinall, P., Somlyo, A.P.: Excitation-contraction coupling and electrical events in two types of vascular smooth muscle. Microvasc. Res. 1, 354–373 (1969).
Spann, J.F. Jr., Sonnenblick, E.H., Cooper, T., Chidsey, C. A., Willman, V.L., Braunwald, E.: Cardiac norepinephrine stores and the contractile state of heart muscle. Circulat. Res. 19, 317–325 (1966).
Spector, S., Hirsch, C.W., Brodle, B.B.: Association of behavioural effects of parygyline, a non-hydrazide MAO inhibitor with increase in brain norepinephrine. Int. J. Neuropharmacol. 2, 81–93 (1963).
Spector, S., Shore, P.A., Brodle, B.B.: Biochemical and pharmacological effects of the monoamine oxidase inhibitors iproniazid, l-phenyl-2-hydrazinopropane (JB 516) and 1-phenyl-3-hydrazinobutane (JB 835). J. Pharmacol. exp. Ther. 128, 15–21 (1960).
Spilker, B., Cervoni, P.: Electrical membrane activity and frequency force relations in normal, denervated and reserpine pretreated cat heart muscle. J. Pharmacol. exp. Ther. 168, 60–69 (1969).
Srimal, R.C., Jaju, B.P., Sinha, J.N., Dixit, K.S., Bhargava, K.P.: Analysis of the central vasomotor effects of choline. Europ. J. Pharmacol. 5, 239–244 (1969).
Stark, P., Boyd, E.S., Fuller, R.W.: A possible role of serotonin in hypothalamic self-stimulation in dogs. J. Pharmacol. exp. Ther. 146, 147–153 (1964).
Steg, G.: α-Rigidity in reserpinized rats. Experientia (Basel) 20, 79–80 (1964).
Stein, L.: Self-stimulation of the brain and the central stimulant action of amphetamine. Fed. Proc. 23, 836–850 (1964).
Stein, L., Ray, O.S.: Accelerated recovery from reserpine depression by monoamine oxidase inhibitors. Nature (Lond.) 188, 1199–1200 (1960).
Stille, G., Lauener, H., Eichenburger, E.: Ein pharmakologischer Vergleich klinisch gebräuchlicher Antidepressiva unter besonderer Berücksichtigung von Noveril (HF-1927 Wander). Schweiz, med. Wschr. 95, 366–372 (1965).
Stitzel, R.E., Campos, H.A., Shideman, F.E.: Effect of hemicholinium on the catecholamine depleting actions of reserpine, morphine and insulin in rabbit tissues. J. Pharmacol. exp. Ther. 149, 193–198 (1965).
Stitzel, R.E., Lundborg, P.: Effect of reserpine and monoamine oxidase inhibition on the uptake and subcellular distribution of H3-noradrenaline. Brit. J. Pharmacol. 29, 99–104 (1967).
Stitzel, R.E., Wagner, L.A., Stawarz, R.J.: Studies on the microsomal metabolism of 3H-reserpine. J. Pharmacol. exp. Ther. 182, 500–506 (1972).
Stjärne, L.: Studies of catecholamine uptake storage and release mechanisms. Acta physiol. scand. 62, Suppl. 228, 1–97 (1964).
Stjärne, L.: Storage particles in noradrenergic tissues. Pharmacol. Rev. 18, 425–432 (1966).
Stjärne, L., Lagercrantz, H., Hedqvist, P.: Subcellular distribution of reserpine in sympathetic nerves and in the adrenal medulla. Abstracts, 4th Int. Congr. Pharmac, Basel, p. 495 (1969).
Stjärne, L., Lishajko, F.: Drug induced inhibition of noradrenaline synthesis in vitro in bovine splenic nerve tissue. Brit. J. Pharmacol. 27, 398–404 (1966).
Stjärne, L., Roth, R.H., Lishajko, F.: Noradrenaline formation from dopamine in isolated subcellular particles from bovine splenic nerve. Biochem. Pharmacol. 16, 1729–1739 (1967).
Stjärne, L., Schapiro, S.: Effect of reserpine on secretion from the denervated adrenal medulla. Nature (Lond.) 184, 2023–2024 (1959).
Sugrue, M.F., Shore, P.A.: The mode of sodium dependency of the adrenergic neuron amine carrier. Evidence for a second, sodium-dependent, optically specific and reserpine-sensitive system. J. Pharmacol. exp. Ther. 170, 239–245 (1969).
Sugrue, M.F., Shore, P.A.: Further evidence for a sodium-dependent, optically specific and reserpine-sensitive amine carrier mechanism at the adrenergic neuron. J. Pharmacol. exp. Ther. 177, 389–397 (1971).
Sulser, F., Bass, A.D.: Pharmacodynamic and biochemical considerations on the mode of action of reserpine-like drugs, pp. 1065–1075. In: Psychopharmacology: A review of progress: 1957–1967. Washington, Public Health Service Publication No. 1836 (1968).
Sulser, F., Bickel, M.H., Brodie, B.B.: The action of desmethylimipramine in counteracting sedation and cholinergic effects of reserpine-like drugs. J. Pharmacol. exp. Ther. 144, 321–330 (1964).
Sulser, F., Owens, M.L., Norvich, M.R., Dingel, J.V.: The relative role of storage and synthesis of brain norepinephrine in the psychomotor stimulation evoked by amphetamine or by desipramine and tetrabenazine. Psychopharmacologia (Berl.) 12, 322–332 (1968).
Sulser, F., Owens, M.L., Strada, S.J., Dingell, J.V.: Modification by desipramine (DMI) of the availability of norepinephrine released by reserpine in the hypothalamus of the rat in vivo. J. Pharmacol. exp. Ther. 168, 272–282 (1969).
Sulser, F., Watts, J., Brodie, B.B.: On the mechanism of antidepressant action of imipramine-like drugs. Ann. N. Y. Acad. Sci. 96, 279–288 (1961).
Sun, S.C., Sohal, R.S., Colcolough, H.J., Burch, G.E.: Histochemical and electron microscopic studies of the effects of reserpine on the heart muscle of mice. J. Pharmacol. exp. Ther. 161, 210–221 (1968).
Szara, S.: Dimethytryptamine: Its metabolism in man; the relation of its psychotic effect to the serotonin metabolism. Experientia (Basel) 12, 441–442 (1956).
Tafuri, W.L.: Ultrastructure of the vesicular component in the intraneural nervous system of the guinea-pig’s intestines. Z. Naturforsch. (B) 19, 622–625 (1964).
Tagliamonte, A., Tagliamonte, P., Perez-Cruet, J., Stern, S., Gessa, G.L.: Effect of psychotropic drugs on tryptophan concentration in the rat brain. J. Pharmacol. exp. Ther. 177, 475–480 (1971).
Takagi, M., Zanerttini, D., Khalil, E.: Tolerance of reserpinized dogs to digitalis. Amer. J. Cardiol. 15, 203–205 (1965).
Takenaka, F.: Response of vascular strip preparations to noradrenaline and tyramine. Jap. J. Pharmacol. 13, 274–281 (1963).
Taketomo, Y., Shore, P.A., Tomich, E.G., Kuntzman, R., Brodie, B.B.: Studies on the mechanism of reserpine-induced epinephrine release and hyperglycaemia. J. Pharmacol. exp. Ther. 119, 188 (1957).
Tanz, R.D.: Possible relationship between ouabain-induced augmentation and endogenous cardiac catecholamine release. In: Tanz, R.D., Kavaler, F., Roberts, J. (Eds.): Factors influencing myocardial contractility, pp. 563–577. New York: Academic Press 1967.
Tanz, R.D., Coram, W.M., Brining, C., Cavaliere, T.: The inotropic action of ouabain in relation to ventricular norepinephrine content. Arch. int. Pharmacodyn. 173, 294–305 (1968).
Tanz, R.D., Marcus, S.M.: Influence of endogenous cardiac catecholamine depletion on the force and rate of isolated heart preparation and their response to ouabain. J. Pharmacol. exp. Ther. 151, 38–45 (1966).
Taugner, G., Hasselbach, W.: Über den Mechanismus der Catecholamin-Speicherung in den “chromaffinen Granula” des Nebennierenmarks. Naunyn-Schmiedeberg’s Arch. exp. Path. 255, 266–286 (1966).
Taylor, A. W.: Free fatty acid levels in exercised and nonexercised reserpinized rats. Amer. J. Physiol. 223, 319–322 (1972).
Taylor, J., Green, R.D.: Analysis of reserpine-induced supersensitivity in aortic strips of rabbits. J. Pharmacol. exp. Ther. 177, 127–135 (1971).
Taylor, R.E., Jr., Fregly, M.J.: Effect of reserpine on body temperature regulation of the rat. J. Pharmacol. exp. Ther. 138, 200–207 (1962).
Tedeschi, D.H., Fowler, P. J., Fugita, T., Miller, R.B.: Mechanisms underlying reserpine-induced ptosis and blepharospasm: Evidence that reserpine decreases central sympathetic outflow in rats. Life Sci. 6, 515–523 (1967).
Ten Eick, R.E., Wyte, S.R., Ross, S.M., Hoffman, B.F.: Post-countershock arrhythmias in untreated and digitalized dogs. Circulat. Res. 21, 375–389 (1967).
Thoa, N.B., Eccleston, D., Axelrod, J.: The accumulation of C14-serotonin in the guinea-pig vas deferens. J. Pharmacol. exp. Ther. 169, 68–73 (1969).
Thoenen, H., Mueller, R.A., Axelrod, J.: Transynaptic induction pf adrenal tyrosine hydroxylase. J. Pharmacol. exp. Ther. 169, 249–254 (1969a).
Thoenen, H., Mueller, R.A., Axelrod, J.: Increased tyrosine hydroxylase activity after drug-induced alteration of sympathetic transmission. Nature (Lond.) 221, 1264 (1969b).
Thompson,J.H.: Serotonin and the alimentary tract. Res. Communications in Chem. Pathol. and Pharmacol. 2, 687–781 (1971).
Thompson, J. H., Campbell, L.B.: The effect of reserpine upon gastrointestinal serotonin in the Sprague-Dawley rat. Experientia (Basel) 23, 826–827 (1967).
Thorp, A.: Histamine and mast cells in nerves. Med. exp. (Basel) 4, 180–182 (1961).
Toda, N.: Effects of adrenaline, noradrenaline and reserpine on the transmembrane potentials in both pacemaker and non-pacemaker fibers of the rabbit atrium. Jap. J. Pharmacol. 10, 78–91 (1960).
Toda, N., Yamasaki, Y., Fujiwara, M.: Response to sympathetic nerve stimulation and noradrenaline in atria treated with reserpine and in atria from rabbits pretreated with reserpine. Jap. J. Pharmacol. 20, 517–529 (1970).
Tozer, T.N., Neff, N.M., Brodie, B.B.: Application of steady state kinetics to the synthesis rate and turnover time of serotonin in the brain of normal and reserpine-treated rats. J. Pharmacol. exp. Ther. 153, 177–182 (1966).
Trendelenburg, U.: The action of histamine and 5-hydroxytryptamine on isolated mammalian atria. J. Pharmacol. exp. Ther. 130, 450–460 (1960).
Trendelenburg, U.: Modification of the effect of tyramine by various agents and procedure. J. Pharmacol. exp. Ther. 134, 8–17 (1961).
Trendelenburg, U.: Supersensitivity and subsensitivity to sympathomimetic amines. Pharmacol. Rev. 15, 225–276 (1963).
Trendelenburg, U.: The effect of sympathetic nerve stimulation on isolated atria of guinea pigs and rabbits pretreated with reserpine. J. Pharmacol. exp. Ther. 147, 313–318 (1965).
Trendelenburg, U.: Mechanisms of supersensitivity and subsensitivity to sympathomimetic amines. Pharmacol. Rev. 18, 629–640 (1966).
Trendelenburg, U., Draskóczy, P.R.: The effect of intraneuronal inactivation on the transmembranal uptake of l- and d-norepinephrine. J. Pharmacol. exp. Ther. 175, 521–522 (1970).
Trendelenburg, U., Gravenstein, J.S.: Effect of reserpine pretreatment on stimulation of the accelerans nerve of the dog. Science. 128, 901–903 (1958).
Trendelenburg, U., Muskus, A., Fleming, W.W., Sierra, B.G.A. de la: Modification by reserpine of the action of sympathomimetic amines in spinal rats; a classification of sympathomimetic amines. J. Pharmacol. exp. Ther. 138, 170–180 (1962).
Trendelenburg, U., Pfeffer, R.I.: Effect of infusion of sympathomimetic amines on the response of spinal cats to tyramine and to sympathetic stimulation. Naunyn-Schmiede-berg Arch. exp. Path. Pharmak. 248, 39–53 (1964).
Trendelenburg, U., Sierra, B.G.A. de la, Muskus, A.: Modification by reserpine of the response of the atrial pacemaker to sympathomimetic amines. J. Pharmacol. exp. Ther. 141, 301–309 (1963).
Trendelenburg, U., Weiner, N.: Sensitivity of the nictitating membrane after various procedures and agents. J. Pharmacol. exp. Ther. 136, 152–161 (1962).
Tripod, J., Meier, R.: Wirkung von Serpasil (Reserpin, ein neues Alkaloid von Rauwolfia serpentina B.) auf isolierte Kreislauf organe. Arch. int. Pharmacodyn. 97, 251–266 (1954a).
Tripod, J., Meier, R.: Détermination et classification pharmacodynamique de l’action vasculaire périphérique de l’aprésoline, du néprésol et du serpasil. Arch. int. Pharmacodyn. 99, 104–125 (1954b).
Tripod, J., Studer, A., Wirz, E., Meier, R.: Modifications de la réactivité vasculaire périphérique “in vivo” par quelques hypotenseurs, entre autres la réserpine et l’hydralazine. Arch. int. Pharmacodyn. 126, 126–139 (1960).
Troquet, J., Calinet-Lagneaux, D., Hermann-Gedang, I.: Influence of reserpine on myocardial content of potassium in the rat. Arch. int. Pharmacodyn. 163, 232–234 (1966).
Tsai, T.H., Denham, S., McGrath, W.R.: Sensitivity of the isolated nictitating membrane of the cat to norepinephrine and acetylcholine after various procedures and agents. J. Pharmacol. exp. Ther. 164, 146–157 (1968).
Vakil, R.J.: Clinical trial of Rauwolfia serpentina in essential hypertension. Brit. Heart. J. 11, 350–355 (1949).
Vakil, R. J.: Rauwolfia serpentina in the treatment of high blood pressure. Circulation 12, 220–229 (1955).
Van Orden, L.S., Bensch, K.G., Giarman, N.J.: Histochemical and functional relationships of catecholamines in adrenergic nerve endings. II. Extravesicular norepinephrine. J. Pharmacol. exp. Ther. 155, 428–439 (1967).
Van Orden, L.S., Bloom, F. E., Barrnett, R. J., Giarman, N. J.: Hictochemical and functional relationships of catecholamines in adrenergic nerve endings. I. Participation of granular vesicles. J. Pharmacol. exp. Ther. 154, 185–199 (1966).
Van Orden, L.S., Burke, J.P., Geyer, M., Lodoen, F.V.: Localization of depletion-sensitive and depletion-resistant norepinephrine storage sites in autonomic ganglia. J. Pharmacol. exp. Ther. 174, 56–71 (1970).
Viveros, O.H., Arqueros, L., Kirshner, N.: Mechanism of secretion from the adrenal medulla. V. Retention of storage vesicle membranes following release of adrenaline. Molec. Pharmacol. 5, 342–349 (1969).
Vogt, M.: Concentration of sympathin in different parts of central nervous system under normal conditions and after administration of drugs. J. Physiol. (London) 123, 451–481 (1954).
Volle, R. L.: Modification by drugs of synaptic mechanisms in autonomic ganglia. Pharmacol. Rev. 18, 839–869 (1966).
Votava, Z., Glisson, S.M., Himwich, H.E.: Behavioural reaction of rats pretreated with reserpine to LSD-25. Int. J. Neuropharmacol. 6, 543–547 (1967).
Wada, J.A., Wrinch, J., Hill, D., McGeer, P.L., McGeer, E.G.: Central aromatic amine levels and behaviour. Arch. Neurol. (Chic.) 9, 69–80 (1963).
Wagner, L.A., Stitzel, R.E.: Studies on the subcellular distribution of H3-reserpine. J. Pharm-Pharmacol. 21, 875–876 (1969).
Wagner, L.A., Stitzel, R.E.: The relation between the subcellular distribution of 3H-reserpine and its proposed site of action. J. Pharm. Pharmacol. 24, 396–402 (1972).
Wakade, A.R., Krusz, J.: Effect of reserpine, phenoxybenzamine, and cocaine on neuromuscular transmission in the vas deferens of the guinea-pig. J. Pharmacol. exp. Ther. 181, 310–317 (1972).
Walker, C.A., Speciale, S.G., Friedman, A.H.: The influence of drug treatment on norepinephrine levels and ultrastructure of the rat hypothalamus and caudate nucleus during a programmed light-dark cycle. Neuropharmacology 10, 325–334 (1971).
Waud, D.R.: The influence of reserpine upon the changes in femoral blood flow produced by stimulation of the lumbar sympathetic chain. Experientia (Basel) 17, 234 (1961).
Waud, D.R., Kottegoda, S.R., Krayer, O.: Threshold dose and time course of norepinephrine depletion of mammalian heart by reserpine. J. Pharmacol. exp. Ther. 124, 340–346 (1958).
Weil-Malherbe, H., Posner, H.: The effect of drugs on the release of epinephrine from adreno-medullary particles in vitro. J. Pharmacol. exp. Ther. 140, 93–102 (1963).
Weiner, N., Jardetzky, O.: Study of catecholamine nucleotide complexes by nuclear magnetic resonance spectroscopy. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 248, 308–318 (1964).
Weiner, N., Rutledge, C.O.: The actions of reserpine on the biosynthesis and storage of catecholamines. In: von Eitler, U.S., Rosell, U.S., Uvnäs, B. (Eds.): Mechanisms of Release of Biogenic Amines, pp. 307–318. Oxford: Pergamon Press 1966.
Weiner, N., Trendelenburg, U.: The effect of cocaine and of pretreatment with reserpine on the uptake of tyramine-2-C14 and dl-epinephrine-2-C14 into heart and spleen. J. Pharmacol. exp. Ther. 137, 56–61 (1962).
Weiner, R.I., Ganong, W.F.: Effect of the depletion of brain catecholamines on puberty and the estrous cycle in the rat. Neuroendocrinology 8, 125–135 (1971).
Weir, M.C.L., McLennan, H.: The action of catecholamines in sympathetic ganglia. Canad. J. Biochem. 41, 2627–2636 (1963).
Weiss, B., Costa, E.: Adenyl cyclase activity in rat pineal gland: effects of chronic denervation and norepinephrine. Science 156, 1750–1752 (1967).
Weiss, J.L., Chase, T.N.: Levodopa in Parkinsonism. Drugs 2, 257–261 (1971).
Weissbach, H., King, W., Sjoerdsma, A., Udenfriend, S.: Formation of indole-3-acetic acid and tryptamine in animals. J. biol. Chem. 234, 81–86 (1959).
Weissman, A., Koe, B.K., Tenen, S.S.: Antiamphetamine effects following inhibition of tyrosine hydroxylase. J. Pharmacol. exp. Ther. 151, 339–352 (1966).
Wells, H., Briggs, F.N., Munson, P.L.: The inhibitory effect of reserpine on ACTH secretion in response to stressful stimuli. Endocrinology 59, 571–579 (1956).
Westermann, E.O., Maickel, R.P., Brodle, B.B.: On the mechanism of pituitary-adrenal stimulation by reserpine. J. Pharmacol. exp. Ther. 138, 208–217 (1962).
Westfall, D.P.: Nonspecific supersensitivity of the guinea-pig vas deferens produced by decentralization and reserpine treatment. Brit. J. Pharmacol. 39, 110–120 (1970a).
Westfall, D.P.: The effect of reserpine treatment and decentralization on the ion distribution in the vas deferens of the guinea pig. Brit. J. Pharmacol. 39, 121–127 (1970b).
Westfall, D.P., Fleming, W.W.: Sensitivity changes in the dog heart to norepinephrine, calcium and aminophylline resulting from pretreatment with reserpine. J. Pharmacol. exp. Ther. 159, 98–106 (1968a).
Westfall, D.P., Fleming, W.W.: The sensitivity of the guinea-pig pacemaker to norepinephrine and calcium after pretreatment with reserpine. J. Pharmacol. exp. Ther. 164, 259–269 (1968a).
Wheat, M., Jr., Palmer, R.F., Bartley, T.D., Sellman, R.C.: Treatment of dissecting aneurysms of the aorta without surgery. J. thorac. cardiovasc. Surg. 50, 364–373 (1965).
Whelan, R.F., Skinner, S. L.: Autonomic transmitter mechanisms. Brit. med. Bull. 19, 120–124 (1963).
Whitrington, P., Zaimis, E.: The reserpine-treated cat. Brit. J. Pharmacol. 17, 380–391 (1961).
Whittington-Coleman, P.J., Carrier, O., Jr., Clower, B.R.: The effects of reserpine on vasopressin-cholesterol-induced atheromatous lesions. J. Pharmacol. exp. Ther. 160, 32–39 (1968).
Wilcken, D.E.L., Brender, D., Shorey, C.D., MacDonald, G.J.: Reserpine: Effect on structure of heart muscle. Science 157, 1332 (1967).
Wilkins, R.W., Judson, W.E.: The use of Rauwolfia serpentina in hypotensive agents. New Engl. J. Med. 248, 48–53 (1953).
Winter, C.H., Flataker, L.: Effects of lysergic acid diethylamide upon performance of trained rats. Proc. Soc. exp. Biol. (N. Y.) 92, 285–289 (1956).
Wofford, J.J., Cummins, A. J.: Hemorrhage from duodenal ulcer during the administration of reserpine. New Engl. J. Med. 255, 1193–1194 (1956).
Wolfe, D., Potter, L.T., Richardson, K.C., Axelrod, J.: Localizing tritiated norepinephrine in sympathetic axons by electron microscopic autoradiography. Science 138, 440–442 (1962).
Woodson, R.E., Youngken, H.W., Schlittler, E., Schneider, J.A.: Rauwolfia: Botany, Pharmacognosy, Chemistry and Pharmacology. Boston: Little, Brown 1957.
Youdin, M.B.H., Sandler, M.: Activation of monoamine oxidase by reserpine. Europ. J. Pharmacol. 4, 105–108 (1968).
Youngken, H. W.: Rauwolfia serpentina. Herbalist 23, 35–43 (1957).
Zaimis, E.: Reserpine induced circulatory failure. Nature (Lond.) 192, 521–523 (1961).
Zbinden G.: Reserpine antagonists and their effects on reserpine induced catecholamine depletion of the adrenal medulla. Int. J. Neuropharmacol. 1, 435–445 (1962).
Zetler, G.: Der Harmin-tremor und seine Antagonisten. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 231, 34–54 (1957).
Zwieten, P.A. van, Bernsheimer, H., Hornykievicz, O.: Zentrale Wirkung des Reserpins auf die Kreislaufreflexe des Carotissinus. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 253, 310–326 (1966).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1977 Springer-Verlag Berlin · Heidelberg
About this chapter
Cite this chapter
Rand, M.J., Jurevics, H. (1977). The Pharmacology of Rauwolfia Alkaloids. In: Gross, F. (eds) Antihypertensive Agents. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 39. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66309-3_4
Download citation
DOI: https://doi.org/10.1007/978-3-642-66309-3_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-66311-6
Online ISBN: 978-3-642-66309-3
eBook Packages: Springer Book Archive