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Chemie und Struktur menschlicher Plasma-und Lymphlipoproteine

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Fettstoffwechsel

Part of the book series: Handbuch der inneren Medizin ((INNEREN 7,volume 7 / 4))

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Zusammenfassung

Bereits im Jahre 1870 beobachtete Hoppe-Seyler, daß Lipide des Blutplasmas durch organische Lösungsmittel, wie z.B. Diäthyläther, nur unvollständig aus dem Plasma extrahiert werden können und daß Plasmalipide nicht die charakteristischen Eigenschaften einer kolloiden Fettemulsion in Wasser zeigen. Die ersten Hinweise, daß die im Plasma gelösten Lipide an Eiweiß gebunden sind, gehen auf Nerking (1901) zurück. Er entfettete mit Magnesiumchlorid gefällte lipidhaltige Fraktionen des Plasmas ausgiebig mit Äther und fand, daß nach Einwirken von proteolytischen Enzymen zusätzliche Lipide aus dem Rückstand freigesetzt werden konnten. Dies legte den Schluß nahe, daß zumindest ein Teil der im Plasma gelösten Lipide proteingebunden ist.

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Abbreviations

VLDL:

Very Low Density Lipoproteine

LDL:

Low Density Lipoproteine

HDL:

High Density Lipoproteine

VHDL:

Very High Density Lipoproteine

LpA:

Lipoprotein A, gekennzeichnet durch den Proteinanteil

LpB:

Lipoprotein, B, gekennzeichnet durch den Proteinanteil

LpC:

Lipoprotein C, gekennzeichnet durch den Proteinanteil

LpX:

Abnormes Lipoprotein bei Patienten mit Cholestase

Lp(a):

Genetische Variante von Lipoprotein B

ApoLp:

Proteinanteil von Lipoproteinen

PAGE:

Polyacrylamidgelelektrophorese

IEF:

Isoelektrische Fokussierung

SDS:

Na-Dodecylsulfat

NaPW:

Natrium-Phosphorwolframat

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Authors
  1. Gerhard M. Kostner
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Editors and Affiliations

  1. Abteilung für Klinische Chemie der Universitätskliniken, Joseph-Stelzmann-Straße 9, D-5000, Köln 41, Deutschland

    G. Assmann

  2. Klinisches Institut für Herzinfarktforschung, Medizinische Universitätsklinik, Bergheimer Straße 58, D-6900, Heidelberg, Deutschland

    J. Augustin , H. Greten , G. Middelhoff  & G. Schlierf , ,  & 

  3. Section and Laboratory of Liver Diseases, Nutrition and Alcoholism, Veterans Administration Hospital, 130 West Kingsbridge Road, Bronx, N.Y., 10468, USA

    E. Baraona  & C. S. Lieber  & 

  4. Mt. Sinai School of Medicine(CUNY), New York, N.Y., USA

    E. Baraona  & C. S. Lieber  & 

  5. Institut für Hirnforschung der Universität, Belthlestraße 15, D-7400, Tübingen, Deutschland

    H. U. Benz  & K. Harzer  & 

  6. Internistische Germeinschaftspraxis, Dialyse-Institut, Werastraße 33, D-7990, Friedrichshafen, Deutschland

    W. Brech

  7. Division of Metabolic Disease, Department of Medicine, School of Medicine, University of California, La Jolla, California, 92037, USA

    W. V. Brown

  8. Departments of Pediatrics, Genetics and Cell Biology and The Dight Institute of Human Genetics, University of Minnesota, Box 231, Mayo Memorial Building, Minneapolis, Minnesota, 55455, USA

    R. J. Desnick

  9. Department of Internal Medicine, College of Medicine, Lipid Research Clinic, University of Cincinnati Medical Center, 234 Goodman Street, Cincinnati, Ohio, 45229, USA

    W. R. Fallat

  10. Lipid Research Center, University of Cincinnati, Cincinnati, Ohio, 45229, USA

    S. Ford  & Ch. J. Glueck  & 

  11. General Clinical Research Center, University of Cincinnati, Cincinnati, Ohio, 45229, USA

    S. Ford  & Ch. J. Glueck  & 

  12. National Institutes of Health, Bethesda, Maryland, 20014, USA

    D. Fredrickson

  13. Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, 20014, USA

    P. Herbert  & R. I. Levy  & 

  14. Institut für Medizinische Biochemie der Universitä, Harrachgasse 21, A-8010, Graz, Öterreich

    G. M. Kostner

  15. Department of Pediatrics, University of Minnesota, Box 231, Mayo Memorial Building, Minneaplis, Minnesota, 55455, USA

    W. Krivit

  16. Medizinische Universitätsklinik, Bergheimer Straße 58, D-6900, Heidelberg, Deutschland

    M. Liersch , G. Schettler , E. Stange  & A. Weizel , ,  & 

  17. Courtauld Institute of Biochemistry, Middlesex Hospital Medical School, London W 1, England

    G. L. Mills

  18. Medical Research Council Lipid Metabolism Unit, Hammersmith Hospital, Ducane Road, London, W12 OHS, England

    N. B. Myant  & J. Slack  & 

  19. Departments of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, 55455, USA

    R. F. O’Dea

  20. Research Associate in the Pharmacology, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland, 20014, USA

    R. F. O’Dea

  21. Innere Abteilung, Knappschafts-Krankenhaus, Am Deimelsberg 34a, 4300, Essen-Steele, Deutschland

    J. Papenberg

  22. Neurologische Klinik und Poliklinik der Universität, v. Siebold-Straße 5, D-3400, Göttingen, Deutschland

    H. Pilz

  23. Schierghoferstraße 24a, D-8220, Traunstein/Obb, Deutschland

    H. M. Rauen

  24. Medizinische Universitätsklinik, Anich-Straße 35, A-6020, Innsbruck, Austria

    S. Sailer

  25. Abteilung für Experimentlle Zellforschung, Physiologisch-Chemisches Institute der Universität, Waldeyerstraße 15, D-4400, Münster/Westf, Deutschland

    H. Schriewer

  26. Klinisch-Chemisches Laboratorium, Medizinische Universitätsklinik, Bergheimer Straße 58, D-6900, Heidelberg, Deutschland

    D. Seidel  & H. Wieland  & 

  27. Department of Experimental Medicine and Cancer Research, Hebrew University Hadassah Medical School, Jerusalem, Israel

    O. Stein

  28. Lipid Research Laboratory, Department of Medicine B, Hadassah University Hospital, Jerusalem, Israel

    Y. Stein

  29. Division of Metabolic Disease, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, California, 92093, USA

    D. Steinberg

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© 1976 Springer-Verlag Berlin · Heidelberg

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Kostner, G.M. (1976). Chemie und Struktur menschlicher Plasma-und Lymphlipoproteine. In: Assmann, G., et al. Fettstoffwechsel. Handbuch der inneren Medizin, vol 7 / 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66302-4_4

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  • DOI: https://doi.org/10.1007/978-3-642-66302-4_4

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