Zusammenfassung
Gangliosidosen sind durch genetischen Enzymdefekt bedingte seltene Lipidstoffwech-selstörungen, bei denen Ganglioside, also spezielle Glykosphingolipide (s. Abschnitt E) pathologisch angehäuft werden. Der fatale Speicherprozeß läuft vor allem im zentralen Nervensystem ab; der Tod tritt im allgemeinen im frühen oder späteren Kindesalter ein.
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Literatur
Adachi, M., Schneck, L., Volk, B.W.: Ultrastructural studies of eight cases of fetal Tay-Sachs disease. Lab. Invest. 30, 102 (1974).
Adachi, M., Torii, J., Karvounis, P.C., Volk, B.W.: Alteration of astrocytic organelles in various lipidoses and allied diseases. Acta neuropath. (Berl.) 18, 74 (1971).
Adachi, M., Torii, J., Schneck, L., Volk, B.W.: The fine structure of fetal Tay-Sachs disease. Arch. Path. 91, 48 (1971).
Aronson, S.M., Lewitan, A., Rabiner, A.M., Epstein, N., Volk, B.W.: The megalencephalic phase of infantile amaurotic familial idiocy. Arch. Neurol. Psychiat. (Chic.) 79, 151 (1958).
Attal, C., Farkas-Bargeton, E., Edgar, G.W.F., Pham-Huu-Trung, Girard, F., Mozziconazzi, P.: Idiotie amaurotique infantile familiale avec surcharge viscerale. Ann. Pédiat. 14, 1725 (1967).
Bernheimer, H., Seitelberger, F.: Über das Verhalten der Ganglioside im Gehirn bei zwei Fällen von spätinfantiler amaurotischer Idiotie. Wien. klin. Wschr. 80, 163 (1968).
Bernsohn, J., Grossman, H.J. (Eds.): Lipid storage diseases. Enzymatic defects and clinical implications. New York-London: Academic Press 1971.
Blieden, L.C., Desnick, R.J., Carter, J.B., Krivitt, W., Moller, J.H., Sharp, H.L.: Cardiac involvement in Sandhoff’s disease. Inborn error of glycosphingolipid metabolism. Amer. J. Cardiol. 34, 83 (1974).
Brett, E.M., Ellis, R.B., Haas, L., Ikonne, J.U., Lake, B.D., Patrick, A.D., Stephens, R.: Late onset GM2-gangliosidosis. Clinical, pathological, and biochemical studies on eight patients. Arch. Dis. Childh. 48, 775 (1973).
Brunngraber, E.G., Witting, L.A., Haberland, C., Brown, B.: Glycoproteins in Tay-Sachs disease: Isolation and carbohydrate composition of glycopeptides. Brain Res. 38, 151 (1972).
Buxton, P., Cumings, J.N., Ellis, R.B., Lake, B.D., Mair, W.G.P., Roberts, J.R., Young, E.P.: A case of GM2 gangliosidosis of late onset. J. Neurol. Neurosurg. Psychiat. 35, 685 (1972).
Callahan, J.W., Wolfe, L.S.: Isolation and characterization of keratan sulfates from the liver of a patient with GM1 gangliosidosis type I. Biochim. biophys. Acta (Amst.) 215, 527 (1970).
Cantz, M., Kresse, H.: Sandhoff disease: Defective glycosaminoglycan catabolism in cultured fibroblasts and its correction by β-N-acetylhexosaminidase. Eur. J. Biochem. 47, 581 (1974).
Cohen, M., Dixon, G.S.: Report of a case of amaurotic family idiocy: with histologic report on the eyes. J. Amer. med. Ass. 48, 1751 (1970).
Cotlier, E.: Tay-Sachs disease: abbreviated hexosaminidase A test from finger tip samples. Clin. chim. Acta 38, 233 (1972).
Dacremont, G., Kint, J.A.: GM1 ganglioside accumulation and β-galactosidase deficiency in a case of GM1 gangliosidosis (Landing disease). Clin. chim. Acta 21, 421 (1968).
Derry, D.M., Fawcett, J.S., Andermann, F., Wolfe, L.S.: Late infantile systemic lipidosis. Major monosialogangliosidosis. Delineation of two types. Neurology (Minneap.) 18, 340 (1968).
Desnick, R.J., Snyder, P.D., Desnick, S.J., Krivit, W., Sharp, H.L.: Sandhoff’s disease: Ultrastructural and biochemical studies. In: Advanc. exp. Med. Biol., Vol. 19: Sphingolipids, Sphingolipidoses and Allied Disorders (S.M. Aranson, B.W. Volk, Eds.), p. 351–371. New York-London: Plenum Press 1972.
Diezel, P.B.: Histochemische Untersuchungen in primären Lipidosen: Amaurotische Idiotie, Gargoylismus, Niemann-Picksche Krankheit, Gauchersche Krankheit mit besonderer Berücksichtigung des Zentralnervensystems. Virchows Arch. path. Anat. 326, 89 (1954).
Diezel, P.B.: Die Stoffwechselstörungen der Sphingolipide. Eine histochemische Studie an den primären Lipidosen und den Entmarkungskrankheiten des Nervensystems. Berlin-Göttingen-Heidelberg: Springer 1957.
Dreyfus, J.-C., Poenaru, L., Svennerholm, L.: Absence of hexosaminidase A and B in a normal adult. New Engl. J. Med. 292, 61 (1975).
Eeg-Olofsson, L., Kristensson, K., Sourander, P., Svennerholm, L.: Tay-Sachs disease: a generalized metabolic disorder. Acta paediat. scand. 55, 546 (1966).
Fluharty, A.L., Lassila, E.L., Porter, M.T., Kihara, H.: The electrophoretic separation of human β-galactosidase on cellulose acetate. Biochem. Med. 5, 158 (1971).
Fontaine, G., Résibois, A., Tondeur, M., Jonniaux, G., Farriaux, J.P., Voet, W., Maillard, E., Loeb, H.: Gangliosidosis with total hexosaminidase deficiency: Clinical, biochemical and ultrastructural studies and comparison with conventional cases of Tay-Sachs disease. Acta neuropath. (Berl.) 23, 118 (1973).
Franceschetti, A., Wildi, E., Klein, D.: Examen anatomoclinique d’un cas d’idiotie amaurotique infantile (Tay-Sachs). Acta genet. (Basel) 5, 343 (1955).
Friedland, J., Schneck, L., Saifer, A., Pourfar, M., Volk, B.W.: Identification of Tay-Sachs disease carriers by acrylamide gel electrophoresis. Clin. chim. Acta 28, 397 (1970).
Galjaard, H., Hoogeveen, A., de Wit-Verbeek, H.A., Reuser, A.J.J., Keijzer, W., Wester veld, A., Bootsma, D.: Tay-Sachs and Sandhoff’s disease: Intergenic complementation after somatic cell hybridization. Exp. Cell Res. 87, 444 (1974).
Gilbert, F., Kucherlapati, R., Creagan, R.P., Murnane, M.J., Darlington, G.J., Ruddle, F.H.: Tay-Sachs’ and Sandhoff’s diseases: The assignment of genes for Hexosaminidase A and B to individual human chromosomes. Proc. nat. Acad. Sci. (Wash.) 72, 263 (1975).
Gonatas, N.K., Baird, H.W., Evangelista, J.: The fine structure of neocortical synapses in infantile amaurotic idiocy. J. Neuropath. exp. Neurol. 27, 39 (1968).
Gonatas, N.K., Gonatas, J.: Ultrastructural and biochemical observations on a case of infantile lipidosis and its relationship to Tay-Sachs’ disease and gargoylism. J. Neuropath. exp. Neurol. 24, 318 (1965).
Greenfield, J.G.: The retina in cerebrospinal lipidosis. Proc. roy. Soc. Med. 44, 686 (1951).
Haberland, C., Brunngraber, E., Witting, L., Brown, B.: The white matter in GM2 gangliosidosis. A comparative histopathological and biochemical study. Acta neuropath. (Berl.) 24, 43 (1973).
Harcourt, R.B., Dobbs, R.H.: Ultrastructure of the retina in Tay-Sachs disease. Brit. J. Ophthal. 52, 898 (1968).
Harzer, K.: Analytische isoelektrische Fraktionierung der N-Acetyl-β-D-hexosaminidasen. Z. anal. Chem. 252, 170 (1970).
Harzer, K.: Inheritance of the enzyme deficiency in three neurolipidoses: Variant O of Tay-Sachs disease (Sandhoff’s disease), classic Tay Sachs disease, and metachromatic leukodystrophy. Identification of the heterozygous carriers. Hum.-Genet. 20, 9 (1973).
Harzer, K., Sandhoff, K., Schall, H., Kollmann, F.: Enzymatische Untersuchungen im Blut von Überträgern einer Variante der Tay-Sachs’schen Erkrankung (Variante O) Klin. Wschr. 49, 1189 (1971).
Harzer, K., Stengel-Rutkowski, S., Gley, E.-O., Albert, A., Murken, J.-D., Zahn, V., Henkel, K.P.: Pränatale Diagnose der GM2-Gangliosidose Typ 2 („Sandhoff-Jatzkewitz-Krankheit“). Dtsch. med. Wschr. 100, 106 (1975).
Heyne, K., Kemmer, C., Simon, C., Trübsbach, A.: Generalisierte GM1-Gangliosidose: Feinstruktur und differential-diagnostische Bedeutung speichernder Lymphozyten u. Knochenmarkszellen. Pädiat. Pädol. 8, 272 (1973).
Heyne, K., von der Linde, J., Trübsbach, A.: Die Lungenerkrankung bei generalisierter GM1-Gangliosidose. Helv. paediat. Acta 27, 591 (1972).
Ho, M.W., O’Brien, J.S.: Differential effect of chloride ions on β-galactosidase isoenzymes: a method for separate assay. Clin. chim. Acta 32, 443 (1971).
Hooft, C., Senesael, L., Delbeke, M.J., Kint, J., Dacremont, G.: The GM1 gangliosidosis (Landing disease). Europ. Neurol. 2, 225 (1969).
Hofft, C., Vlietinck, R.F., Dacremont, G., Kint, J.A.: GM1 gangliosidosis Type II. Europ. Neurol. 4, 1 (1970).
Hultberg, B.: N-Acetylhexosaminidase activities in Tay-Sachs disease. Lancet 1969 II, 1195.
Jörgensen, L., Blackstad, T.W., Harmark, W., Steen, J.A.: Niemann-Pick’s disease. Report of a case with histochemical evidence of neuronal storage of acid glycolipids. Acta neuropath. (Berl.) 4, 75 (1964).
Jungalwala, F.B., Robins, E.: Glycosidases in the nervous system. III. Separation, purification and substrate specifities of β-galactosidases and β-glucuronidase from brain. J. biol. Chem. 243, 4258 (1968).
Kaback, M.M., Sloan, H.R., Sonneborn, M., Herndon, R.M.: GM1-gangliosidosis type I: In utero detection and fetal manifestations. J. Pediat. 82, 1037 (1973).
Kaback, M.M., Zeiger, R.S.: Heterozygote detection in Tay-Sachs disease. A prototype community screening program for the prevention of recessive genetic disorders. In: Advanc. exp. Med. Biol., Vol. 19: Sphingolipids, Sphingolipidoses and Allied Disorders (S.M. Aronson, B.W. Volk, Eds.), p. 613–632. New York-London: Plenum Press 1972.
Kamoshita, S., Landing, B.H.: Distribution of lesions in myenteric plexus and gastrointestinal mucosa in lipidoses and other neurologic disorders of children. Amer. J. clin. Path. 49, 312 (1968).
Kanfer, J.N., Spielvogel, C.: Hexosaminidase activity of cultured human skin fibroblasts. Biochim. biophys. Acta (Amst.) 193, 203 (1973).
Klenk, E.: Beiträge zur Chemie der Lipidosen. Niemann-Picksche Krankheit und amaurotische Idiotie. Hoppe-Seylers Z. physiol. Chem. 262, 128 (1939–40).
Klenk, E.: Über die Ganglioside des Gehirns bei der infantilen amaurotischen Idiotie vom Typus Tay Sachs. Ber. dtsch. Chem. Ges. 75, 1632 (1942).
Kolodny, E.H.: Sandhoffs disease: Studies on the enzyme defect in homozygotes and detection of heterozygotes. In: Advanc. exp. Med. Biol., Vol. 19: Sphingolipids, Sphingolipidoses and Allied Disorders (S.M. Aronson, B.W. Volk, Eds.), p. 321–341. New York-London: Plenum Press 1972.
Kolodny, E.H., Brady, R.O., Volk, B.W.: Demonstration of an alteration of ganglioside metabolism in Tay-Sachs disease. Biochem. biophys. Res. Commun. 37, 526 (1969).
Krivit, W., Desnick, R.J., Lee, J., Moller, J., Wright, F., Sweeley, C.C., Snyder, P.D., Sharp, H.L.: Generalized accumulation of neutral glycosphingolipids with GM2 ganglioside accumulation in the brain. Sandhoffs disease (variant of Tay-Sachs disease). Amer. J. Med. 52, 763 (1972).
Labre, F., Chazalette, J.P., Guibaud, P., Richard, P., Pernoud, N., Vanier, M.T.: La gangliosidose à GM1 (forme infantile) à propos de cinq observations. Lyon Méd. 229, 335 (1973).
Landing, B.H., Freiman, D.G.: Histochemical studies on the cerebral lipidoses and other cellular metabolic disorders. Amer. J. Path. 33, 1 (1957).
Landing, B.H., Silverman, F.N., Craig, J.M., Jacoby, M.D., Lahey, M.E., Chadwick, D.L.: Familial neurovisceral lipidosis. Amer. J. Dis. Child. 108, 503 (1964).
Lazarus, S.S., Wallace, B.J., Volk, B.W.: Neuronal enzyme alteration in Tay-Sachs disease. Amer. J. Path. 41, 579 (1962).
Ledeen, R., Salsman, K.: Structure of Tay-Sachs ganglioside. Biochemistry 4, 2225 (1965).
Ledeen, R., Salsman, K., Gonatas, J., Taghavy, A.: Structure comparison of the major monosialogang-liosides from brains of normal human, gargoylism, and late infantile systemic lipidosis. Part I. J. Neuropath. exp. Neurol. 24, 341 (1965).
Lowden, J.A., Callahan, J.W., Norman, M.G., Thain, M., Prichard, J.S.: Juvenile GM1-gangliosidosis. Occurrence with absence of two β-galactosidase components. Arch. Neurol. (Chic.) 31, 200, 1974.
Lowden, J.A., Cutz, E., Conen, P.E., Rudd, N., Doran, T.A.: Prenatal diagnosis of GM1-gangliosidosis. New Engl. J. Med. 288, 225 (1973).
Lowden, J.A., La Ramée, M.-A.: Problems in prenatal diagnosis using sphingolipid hydrolase assays. In: Advanc. exp. Med. Biol., Vol. 19: Sphingolipids, Sphingolipidoses and Allied Disorders (S.M. Aronson, B.W. Volk, Eds.), p. 257–267. New York-London: Plenum Press 1972.
MacBrinn, M., Okada, S., Ho, M.W., Hu, C.C., O’Brien, J.S.: Generalized gangliosidosis: impaired cleavage of galactose from a mucopolysaccharide and a glycoprotein. Science 163, 946 (1969).
Makita, A., Yamakawa, T.: The glycolipids of the brain of Tay-Sachs disease. The chemical structures of a globoside and main ganglioside. Jap. J. exp. Med. 33, 361 (1963).
Martin-Sneessens, L.: La mégalencéphalie dans l’idiotie amaurotique. A propos d’une observation clinique. Acta neurol. belg. 61, 515 (1961).
Max, S.R., MaClaren, N.K., Brady, R.O., Bradley, R.M., Rennels, M.B., Tanaka, J., Garcia, J.H., Cornblath, M.: GM3 (hematoside) sphingolipodystrophy. New Engl. J. Med. 291, 929 (1974).
Menkes, J.H., O’Brien, J.S., Okada, S., Grippo, J., Andrews, J.M., Cancilla, P.A.: Juvenile GM2-gangliosidosis. Biochemical and ultrastructural studies on a new variant of Tay-Sachs disease. Arch. Neurol. (Chic.) 25, 14 (1971).
Mossakowski, M.J., Zelman, J., Majdecki, T., Baranowicz, B.: GM1-generalized gangliosidosis with unusual involvement of the white matter. Neuropat. Pol. 9, 23 (1971).
Myers, G.J., Hedley-Whyte, E.T., Fagan, M.E.: Reevaluation of role of rectal biopsy in diagnosis of pediatric neurologic disorders. Neurology (Minneap.) 23, 27 (1973).
Nakai, H., Landing, B.H.: Suggested use of rectal biopsy in the diagnosis of neural lipidoses. Pediatrics 26, 225 (1960).
Navon, R., Padeh, B.: Urinary test for identification of Tay-Sachs genotypes. J. Pediat. 80, 1026 (1972).
Navon, R., Padeh, B., Adam, A.: Apparent deficiency of hexosaminidase A in healthy members of a family with Tay-Sachs disease. Amer. J. hum. Gen. 25, 287 (1973).
Norden, G.W., O’Brien, J.S.: An electrophoretic variant of β-galactosidase with altered catalytic properties in a patient with GM1-gangliosidosis. Proc. nat. Acad. Sci. (Wash.) 72, 240 (1975).
Norman, R.M., Urich, H., Tingey, A.H., Goodbody, R.A.: Tay-Sachs disease with visceral involvement and its relationship to Niemann-Pick’s disease. J. Path. Bact. 78, 409 (1959).
O’Brien, J.S., Stern, M.B., Landing, B.H., O’Brien, J.K., Donnell, G.N.: Generalized gangliosidosis. Amer. J. Dis. Child. 109, 338 (1965).
O’Brien, J.S.: Generalized gangliosidosis. J. Pediat. 75, 167 (1969a).
O’Brien, J.S.: Five gangliosidoses. Lancet 1969IIb, 805.
O’Brien, J.S.: Tay-Sachs disease: from enzyme to prevention. Fed. Proc. 32, 191 (1973).
O’Brien, J.S., Ho, M.W., Veath, M.L., Wilson, J.F., Myers, G., Opitz, J.M., Zurhein, G.M., Spranger, J.W., Hartmann, H.A., Haneberg, B., Grosse, F.R.: Juvenile GM1 gangliosidosis: Clinical, pathological, chemical, and enzymatic studies. Clin. genet. 3, 411 (1972).
O’Brien, J.S., Okada, S., Chen, A., Fillerup, D.L.: Tay-Sachs disease. Detection of heterozygotes and homozygotes by serum hexosaminidase assay. New Engl. J. Med. 283, 15 (1970).
O’Brien, J.S., Okada, S., Fillerup, D.L., Veath, M.L., Adornato, B., Brenner, P.H., Leroy, J.G.: Tay-Sachs disease: prenatal diagnosis. Science 172, 61 (1971a).
O’Brien, J.S., Okada, S., Ho, M.W., Fillerup, D.L., Veath, M.L., Adams, K.: Ganglioside storage disease. In: Bernson, J.G., Grossman, H.J. (Eds.): Lipid storage diseases. Enzymatic defects and clinical implications, p. 173–225. New York-London: Academic Press 1971b.
O’Brien, J.S., Okada, S., Ho, M.W., Fillerup, D.L., Veath, M.L., Adams, K.: Ganglioside storage disease. Fed. Proc. 30, 956 (1971c).
Okada, S., McCrea, M., O’Brien, J.S.: Sandhoff’s disease (GM2-gangliosidosis type 2): Clinical, chemical, and enzyme studies in five patients. Pediat. Res. 6, 606 (1972).
Okada, S., O’Brien, J.S.: Generalized gangliosidosis, β -galactosidase deficiency. Science 160, 1002 (1968).
Okada, S., O’Brien, J.S.: Tay-Sachs disease: generalized absence of a β-D-N-acetylhexosominidase component. Science 165, 698 (1969).
Okada, S., Veath, M.L., O’Brien, J.S.: Juvenile GM2-gangliosidosis: Partial deficiency of hexosaminidase A. J. Pediat. 77, 1063 (1970).
Padeh, B., Navon, R.: Diagnosis of Tay-Sachs disease by hexosaminidase activity in leukocytes and amniotic fluid cells. Israel J. med. Sci. 7, 259 (1971).
Patel, V., Goebel, H.H., Watanabe, I., Zeman, W.: Studies on GM1-gangliosidosis, Type II. Acta neuropath. (Bed.) 30, 155 (1974).
Petrelli, M., Blair, J.D.: The liver in GM1 gangliosidosis types 1 and 2. Arch. Path. 99, 111 (1975).
Pilz, H., Müller, D., Sandhoff, K., ter Meulen, V.: Tay-Sachssche Krankheit mit Hexosaminidase-De-fekt. Klinische, morphologische und biochemische Befunde bei einem Fall mit visceraler Speicherung von Nierenglobosid. Dtsch. med. Wschr. 93, 1833 (1968).
Pilz, H., Sandhoff, K., Jatzkewitz, H.: Eine Gangliosidstoffwechselstörung mit Anhäufung von Ceramid-Lactosid, Monosialo-ceramid-lactosid und Tay-Sachs-Gangliosid im Gehirn. J. Neurochem. 13, 1273 (1966).
Pinsky, L., Powell, E., Callahan, J.: GM1-gangliosidosis types I and IL: enzymatic differences in cultured fibroblasts. Nature 228, 1093 (1970).
Rabinowitz, J.G., Sacher, M.: Gangliosidosis (GM1). A re-evaluation of the vertebral deformity. Amer. J. Roentgenol. 121, 155 (1974).
Robinson, D., Stirling, J.L.: N-acetyl-β -glucosamini-dases in human spleen. Biochem. J. 107, 312 (1968).
Sachs, B.: On arrested cerebral development, with special reference to its cortical pathology. J. nerv. ment. Dis. 14, 541 (1887).
Sacrez, R., Juif, J.G., Gigonnet, J.M., Grüner, J.E.: La maladie de Landing ou idiotie amaurotique infantile précoce avec gangliosidose généralisée de type GM1. Pédiatrie 22, 143 (1967).
Saifer, A., Perle, G., Valenti, G., Schneck, L.: Pre-and postnatal detection of Tay-Sachs disease. A comparative study of biochemical screening methods. In: Advanc. exp. Med. Biol., Vol. 19: Sphingolipids, Sphingolipidoses and Allied Disorders (S.M. Aronson, B.W. Volk, Eds.), p. 599–611. New York-London: Plenum Press 1972.
Saifer, A., Rosenthal, A.L.: Rapid test for detection of Tay-Sachs disease heterozygotes by serum hexosaminidase assay. Clin. chim. Acta 43, 417 (1973).
Samuels, S., Korey, S.R., Gonatas, J., Terry, R.D., Weiss, M.: Studies in Tay-Sachs disease. IV. Membranous cytoplasmic bodies. 1. Biochemistry. 2. Ultrastructure. J. Neuropath. exp. Neurol. 22, 81 (1963).
Sandhoff, K.: Auftrennung der Säuger-N-Acetyl-β-D-hexosaminidase in multiple Formen durch Elektro-fokussierung. Hoppe-Seylers Z. physiol. Chem. 349, 1095 (1968).
Sandhoff, K.: Variation of β-N-acetylhexosaminidase-pattern in Tay-Sachs disease. FEBS Letters 4, 351 (1969).
Sandhoff, K.: The hydrolysis of Tay-Sachs ganglioside (TSG) by human N-Acetyl-β-D-hexosaminidase A. FEBS Letters 11, 342 (1970).
Sandhoff, K., Andreae, K., Jatzkewitz, H.: Deficient hexosaminidase activity in an exceptional case of Tay-Sachs disease with additional storage of kidney globoside in visceral organs. Path. europ. 3, 278 (1968).
Sandhoff, K., Harzer, K., Wässle, W., Jatzkewitz, H.: Enzyme alterations and lipid storage in three variants of Tay-Sachs disease. J. Neurochem. 18, 2469 (1971).
Sandhoff, K., Jatzkewitz, H., Peters, G.: Die infantile amaurotische Idiotie und verwandte Formen als Gangliosid-Speicherkrankheiten. Naturwissenschaften 56, 356 (1969).
Sandhoff, K., Wässle, W.: Anreicherung und Charakterisierung zweier Formen der menschlichen N-Acetyl-β-D-Hexosaminidase. Hoppe Seylers Z. physiol. Chem. 352, 1119 (1971).
Schneck, L., Friedland, J., Valentin, C., Adachi, M., Amsterdam, D., Volk, B.W.: Prenatal diagnosis of Tay-Sachs disease. Lancet 1970 I, 582.
Schneck, L., Maisel, J., Volk, B.W.: The startle response and serum enzyme profile in early detection of Tay-Sachs disease. J. Pediat. 65, 749 (1964).
Schneck, L., Wallace, B.J., Saifer, A., Volk, B.W.: A Clinical, biochemical and electron microscopic study of late infantile amaurotic family idiocy. Amer. J. Med. 39, 285 (1965).
Scott, C.R., Lagunoff, D., Trump, B.F.: Familial neurovisceral lipidosis. J. Pediat. 71, 357 (1967).
Seringe, P., Plainfosse, B., Lautmann, F., Jorilloux, J., Calamy, G., Berry, J.-P., Watchi, J.M.: Gangliosidose généralisée, du type Norman-Landing, à GM1. Ann. Pédiat. 44, 685 (1968).
Shanklin, W.M., Issidorides, M., Salam, M.: Histochemistry of the cerebral cortex from a case of amaurotic family idiocy. J. Neuropath. exp. Neurol. 21, 284 (1962).
Singer, H.S., Nankervis, G.A., Schafer, I.A.: Leukocyte beta-galactosidase activity in the diagnosis of generalized GM1-gangliosidosis. Pediatrics 49, 352 (1972).
Singer, H.S., Schafer, I.A.: Clinical and enzymatic variations in GM1 generalized gangliosidosis. Amer. J. hum. Genet. 24, 454 (1972).
Srivastava, S.K., Beutler, E.: Studies on human β-D-N-acetylhexosaminidases. III. Biochemical genetics of Tay-Sachs’ and Sandhoffs diseases. J. biol. Chem. 249, 2054 (1974).
Stanbury, J.B., Wyngaarden, J.B., Fredrickson, D.S. (Eds.): The metabolic basis of inherited disease, 3rd Ed. Book Company New York: McGraw Hill 1972.
Strecker, G., Montreuil, J.: Description d’une oligo-saccharidurie accompagnant une gangliosidose GM2 à déficit total en N-acétyl-hexosaminidases. Clin. chim. Acta 33, 395 (1971).
Suzuki, K.: Cerebral GM1-gangliosidosis: Chemical pathology of visceral organs. Science 159, 1471 (1968).
Suzuki, Y., Crocker, A.C., Suzuki, K.: GM1-ganglio-sidosis. Correlation of clinical and biochemical data. Arch. Neurol. (Chic.) 24, 58 (1971).
Suzuki, Y., Jacob, J.C., Suzuki, K., Kutty, K.M., Suzuki, K.: GM2-gangliosidosis with total hexosaminidase deficiency. Neurology (Minneap.) 21, 313 (1971).
Suzuki, Y., Suzuki, K.: Partial deficiency of hexosaminidase component A in juvenile GM2-ganglio-sidosis. Neurology (Minneap.) 20, 848 (1970).
Suzuki, K., Suzuki, K., Chen, G.C.: Morphological, histochemical and biochemical studies on a case of systemic late infantile lipidosis (generalized gangliosidosis). J. Neuropath. exp. Neurol. 27, 15 (1968).
Suzuki, K., Suzuki, K., Kamoshita, A.: Chemical pathology of GM1-gangliosidosis (generalized gangliosidosis). J. Neuropath. exp. Neurol. 28, 25 (1969).
Suzuki, K., Suzuki, K., Rapin, I., Suzuki, Y., Ishii, N.: Juvenile GM2-gangliosidosis. Clinical variant of Tay-Sachs disease or a new disease. Neurology (Minneap.) 20, 190 (1970).
Svennerholm, L.: The chemical structure of normal human brain and Tay-Sachs gangliosides. Biochem. biophys. Res. Commun. 9, 436 (1962).
Svennerholm, L.: Chromatographic separation of human brain gangliosides. J. Neurochem. 10, 613 (1963).
Tallman, J.F., Brady, R.O., Suzuki, K.: Enzymic activities associated with membranous cytoplasmic bodies and isolated brain lysosomes. J. Neurochem. 18, 1775 (1971).
Tallman, J.F., Johnson, W.G., Brady, R.O.: The metabolism of Tay-Sachs ganglioside: Catabolic studies with lysosomal enzymes from normal and Tay-Sachs brain tissue. J. clin. Invest. 51, 2339 (1972).
Tanaka, J., Garcia, J.H., Max, S.R., Viloria, J.E., Kamijyo, Y., McLaren, N.K., Cornblath, M., Brady, R.O.: Cerebral sponginess and GM3-ganglio-sidosis. Ultrastructure and probable pathogenesis. J. Neuropath. exp. Neurol. 34, 249 (1975).
Tay, W.: Symmetrical changes in the region of the yellow spot in each eye of an infant. Trans. Ophthal. Soc. U.K. 1, 155 (1881).
Terry, R.D., Korey, S.R.: Studies in Tay-Sachs disease. V. The membrane of membranous cytoplasmic body. J. Neuropath. exp. Neurol. 22, 98 (1963).
Terry, R.D., Korey, S.R.: Membranous cytoplasmic granules in infantile amaurotic idiocy. Nature 188, 1000 (1960).
Terry, R.D., Weiss, M.: Studies in Tay-Sachs disease. II. Ultrastructure of the cerebrum. J. Neuropath. exp. Neurol. 22, 18 (1963).
Tomasi, L.G., Fukushima, D.K., Kolodny, E.H.: Steroid hexosaminidase activity in Tay-Sachs and Sandhoff-Jatzkewitz diseases. Neurology (Minneap.) 24, 1158 (1974).
Tsay, G.C., Dawson, G., Li, Y.-T.: Structure of the glycopeptide storage material in GM1-gangliosidosis. Sequence determination with specific endo-and exoglycosidases. Biochim. biophys. Acta (Amst.) 385, 305 (1975).
Volk, B.W.: In: Tay-Sachs Disease (B.W. Volk, Ed.), p. 36–77. New York: Grune & Stratton 1964.
Volk, B.W., Adachi, M., Schneck, L., Saifer, A., Kleinberg, W.: G5-ganglioside variant of systemic late infantile lipidosis. Generalized gangliosidosis. Arch. Path. 87, 393 (1969).
Volk, B.W., Aronson, S.M. (Eds.): Sphingolipids, Sphingolipidoses and allied disorders. Vol. 19 of: Advances in exp. Med. and Biol. New York-London: Plenum press 1972.
Volk, B.W., Schneck, L., Adachi, M.: Clinic, pathology and biochemistry of Tay-Sachs disease. In: Handbook of clinical neurology. Vol. 10: Leucodystrophies and Poliodystrophies (P.J. Vinken, G.W. Bruyn, Eds.), p. 385–426. Amsterdam: North Holland Publishing Company 1970.
Volk, B.W., Wallace, B.J.: The liver in lipidoses: An electron microscopic and histochemical study. Amer. J. Path. 49, 203 (1966).
Wallace, B.J., Lazarus, S.S., Volk, B.W.: Electron microscopic and histochemical studies of viscera in lipidoses. In: Inborn Disorders of Sphingolipid Metabolism (S.M. Aronson, B.W. Volk, Eds.), p. 107–120. New York: Pergamon press 1967.
Wallace, B.J., Volk, B.W., Lazarus, S.S.: Fine structural localization of acid phosphatase activity in neurons of Tay-Sachs disease. J. Neuropath. Exp. Neurol. 23, 676 (1964).
Wallace, B.J., Volk, B.W., Schneck, L., Kaplan, H.: Fine structural localization of two hydrolytic enzymes in the cerebellum of children with lipidoses. J. Neuropath. Exp. Neurol. 25, 76 (1966).
Wolfe, L.S., Callahan, J., Fawcett, J.S., Andermann, F., Scriver, C.R.: GM1-gangliosidosis without chondrodystrophy or visceromegaly, β -galactosidase deficiency with gangliosidosis and the excessive excretion of a keratan sulfate. Neurology (Minneap.) 20, 23 (1970).
Wolman, M.: The lipidoses. In: Handbuch der Histochemie, Vol. V: Lipids, 2nd part: Histochemistry of lipids in pathology (W. Graumann, K. Neumann, Eds.), p. 172–307. Stuttgart: Fischer 1964.
Yamamoto, A., Adachi, S., Kawamura, S., Takahashi, M., Kitani, T., Ohtori, T., Shinji, Y., Nishikawa, M.: Localized β-galactosidase deficiency. Occurrence in cerebellar ataxia with myoclonus epilepsy and macular cherry red spot—A new variant of GM1-gangliosidosis? Arch. Intern. Med. 134, 627 (1974).
Young, E.P., Ellis, R.B., Lake, B.D., Patrick, A.D.: Tay-Sachs disease and related disorders: fractionation of brain N-acetyl-β-hexosaminidase on DEAE-cellulose. FEBS Letters 9, 1 (1970).
Young, E.P., Ellis, R.B., Patrick, A.D.: Leukocyte β -galactosidase activity in GM1-gangliosidosis. Pediatrics 50, 502 (1972).
Zeman, W., Donahue, S., Dyken, P., Green, J.: The neuronal ceroid-lipofuscinoses (Batten-Vogt syndrome). In: Handbook of Clinical Neurology, Vol. 10: Leucodystrophies and Poliodystrophies (P.J. Vinken, G.W. Bruyn, Eds.), p. 588–679. Amsterdam: North-Holland publishing Co. 1970.
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Harzer, K., Benz, H.U. (1976). Gangliosidosen. In: Assmann, G., et al. Fettstoffwechsel. Handbuch der inneren Medizin, vol 7 / 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66302-4_28
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