Zusammenfassung
Störungen der Leberfunktion führen häufig zu erhöhten Plasmalipidwerten. Mit der sich in den letzten Jahren entwickelten Analytik der Plasmalipoproteine hat sich eine Vielzahl von Hinweisen ergeben, die neue Einblicke in die Zusammenhänge dieser Störungen gestatten und darüber hinaus von differentialdiagnostischer Bedeutung sind.
So ist es gelungen, aus dem Plasma von Patienten mit intra- oder extrahepatischer Cholestase ein abnormes Lipoprotein (LP-X) zu isolieren, für das später eine einfache und empfindliche Nachweismethode entwickelt wurde. Dieser Parameter gilt heute als der sicherste klinischchemische Test zum Nachweis oder Ausschluß einer Cholestase. Zusätzlich können sich, besonders bei der cholestasebedingten Leberschädigung, triglyceridreiche Lipoproteine im Plasma ansammeln, die — durch einen Lipasemangel hervorgerufen — zu der Hypertriglyceridämie jener Patienten führen. Das Verschwinden der prä-β- und α-Lipoproteinbanden in der Agaroseelektrophorese als häufiges Zeichen einer schweren Leberschädigung gleich welcher Genese wird wahrscheinlich durch ein defektes Apolipoprotein A verursacht, dessen Bindungskapazität für bestimmte Lipidfraktionen vermindert oder aufgehoben ist.
Obgleich man heute noch weit davon entfernt ist, alle Mechanismen zu kennen, die bei Störungen der Leberfunktion zu den strukturellen Veränderungen der Plasmalipoproteine und zur Hyperlipoproteinämie führen, unterstreichen die neuen Befunde die zentrale Rolle, die die Leber in der Synthese und im Abbau der Plasmalipoproteine spielt.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Ahrens, E.H., Kunkel, H.G.: The relationship between serum lipids and skin xanthomata in 18 patients with primary biliary cirrhosis. J. clin. Invest. 28, 1565 (1949).
Ahrens, E.H., Jr., Kunkel, H.G.: The stabilization of serum lipid emulsions by serum phospholipids. J. exp. Med. 90, 409 (1949).
Alcindor, L.G., Infante, R., Caroli, J.: Plasma VLDL catabolism in cholestasis. Abstr. 5th meeting of the int. Ass. for the study of the liver. Versailes, July 1972.
Balfour, W.M.: Human plasma phospholipid formation: a study made with the aid of radiophosphorus. Gastroenterology 9, 686 (1947).
Barr, D.P., Russ, E.M., Eder, H.A.: Protein-lipid relationships in human plasma II. In atherosclerosis and related conditions. Amer. J. Med. 11, 480 (1951).
Blomhoff, J.P.: High density lipoproteins in cholestasis. Scand. J. Gastroent. 9, 591 (1974).
Brown, M.S., Goldstein, J.L.: Role of the low density Lipoprotein receptor in regulating the content of free and esterified cholesterol in human fibroblasts. J. clin. Invest. 55, 783 (1975).
Burstein, M., Caroli, J.: Isolement et étude des lipoprotéines sériques anormales au cours des ictères par rétention après floculation par le polyvinylpyrrolidone. Rev. franç. Etud. clin. Biol. 13, 387 (1968).
Byers, S.O., Friedman, M., Sugiyama, T.: Mechanism underlying phosphatide-induced hypercholesterolemia. J. biol. Chem. 237, 3375–3380 (1962).
Dietschy, J.M., Siperstein, M.D.: Cholesterolsynthesis by the gastrointestinal tract: Localization and mechanism of control. J. clin. Invest. 44, 1311 (1965).
Eder, H.A., Russ, E.M.: Plasma protein-lipid relationships in acute hepatitis. J. clin. Invest. 32, 564 (1953).
Eder, H.A., Russ, E.M., Pritchett, R.A.R., Wilber, M.M., Barr, D.P.: Protein-lipid relation-ships in human plasma: In biliary cirrhosis, obstructive jaundice, and acute hepatitis. J. clin. Invest. 34, 1147 (1955).
Epstein, E.Z.: Cholesterol of the blood plasma in hepatic and biliary diseases. Arch. intern. Med. 50, 203 (1932).
Feigl, J.: Neue Untersuchungen über akute gelbe Leberatrophie. III. Fette und Lipide des Blutes. Chemische Beiträge zur Kenntnis der Entwicklung und Charakteristik spezifischer Lipämien. Biochem. Z. 86, 1 (1918).
Fellin, R., Seidel, D.: Behaviour of serum lipoproteins in cholestasis. 1. Int. Symp. on cholestasis, Florence, June 1973. Proc. in Press.
Flint, A., Jr.: Experimental researches into a new excretory function of the liver, consisting in the removal of Cholesterine from the blood, and its discharge from the body in the form of stercorine. Am. J. med. Sci. 44, 305 (1862).
Fredrickson, D.S., Levy, R.I., Lees, R.S.: Fat transport in lipoproteins—An integrated approach to mechanisms and disorders. N. Engl. J. Med. 276, 273 (1967).
Fredrickson, D.S., Loud, A.V., Hinkelmann, B.T., Schneider, H.S., Frantz, J.D.: The effect of ligation of the common bile duct on cholesterol synthesis in the rat. J. exp. Med. 99, 43 (1954).
Friedman, M.S., Byers, O., Rosenman, R.H.: Lipogenic hypercholesterolemia. A guide for reorientation in the consideration of lipid-cholesterol relationships. Arch. intern. Med. 116, 807 (1965).
Furman, R.H., Conrad, L.L.: Ultracentrifugal characterization of the lipoprotein spectrum in obstructive jaundice: Studies of serum lipid relationships in intra- and extrahepatic biliary obstruction. J. clin. Invest. 36, 713 (1957).
Furman, R.H., Conrad, L.L., Howard, R.P.: A serum lipoprotein pattern characteristic of biliary obstruction, with some comments on “jaundice due to methyltestosterone”. Circulation 10, 586 (1954).
Glomset, J.A., Nichols, A.V., Norum, K.B., Kind, W., Forte, T.: Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: Further studies on very low and low density lipoprotein abnormalities. J. clin. Invest. 52, 1078 (1973).
Gofman, J.: The serum lipoprotein transport system in health, metabolic disorders, atherosclerosis, and coronary artery diseases. Plasma 2, 484 (1954).
Hamilton, R.L., Havel, R.J., Kane, J.P., Blaurock, A.E., Sata, T.: Cholestasis: Lamellar structure of abnormal human serum lipoprotein. Science 172, 475 (1971).
Havel, R.J., Eder, H.A., Bragdon, J.H.: The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J. clin. Invest. 34, 1345 (1955).
Kattermann, R., Reimold, W.V.: Leberschaden und Lipidstoffwechsel. Acta hepatosplenol. (Stuttg.) 17, 75 (1970).
Klör, U., Ditschuneit, H.H., Rabow, D., Ditschuneit, H.: Further characterization of dyslipo-proteinemia in hepatic disease. Abstracts. Europ. J. clin. Invest. 2, 291 (1972).
Kunkel, H.G., Ahrens, E.H., Jr.: The relationship between serum lipids and the electrophoretic pattern, with particular reference to patients with primary biliary cirrhosis. J. clin. Invest. 28, 1575 (1949).
Kunkel, H.G., Slater, R.J.: Lipoprotein patterns of serum obtained by zone electrophoresis. J. clin. Invest. 31, 677 (1952).
DeLalla, L., Levine, L., Brown, R.K.: Immunologic studies of human high density lipoproteins. J. exp. Med. 106, 261 (1957).
Lemaire, A., Etienne, G., Etienne, J., Polonovski, J., Housset, E., Cottet, J.: Un nouveau test biologique de la cholestase. Presse Med. 78, 3245 (1965).
Lindgren, F.T., Nichols, A.V.: Structure and function of human serum lipoproteins. In: The Plasma Proteins (F. Putnam, Ed.), Vol. 2, p. 1. New York: Academic Press 1960.
Di Luzio, N.R., Zilversmit, D.B.: Effect of intravenous phospholipid and Triton on lipids of normal and ethanoltreated rats. Amer. J. Physiol. 199, 991–994 (1960).
Man, E.B., Kartin, B.L., Durlacher, S.H., Peters, J.P.: The lipids of serum and liver in patients with hepatic diseases. J. clin. Invest. 24, 623 (1945).
Manzato, E., Fellin, R., Baggio, G., Neubeck, W., Seidel, D.: Formation of lipoprotein-X: Its relationship to bile compounds. In press.
Mills, G.L., Seidel, D., Alaupovic, P.: Ultracentrifugal characterization of a lipoprotein occuring in obstructive jaundice. Clin. chim. Acta 26, 239 (1969).
Müller, P., Fellin, R., Lambrecht, J., Agostini, B., Wieland, H., Rost, W., Seidel, D.: Hypertriglyceridaemia secondary to liver disease. Europ. J. clin. Invest. 4, 419 (1974).
Pearson, A.J.G.: Triglycerides in obstructive liver disease. Abstr. 5th meeting of the int. Ass. for the study of the liver, Versailes, July 1972.
Petersen, V.P.: The individual plasma phospholipids in acute hepatitis. Acta med. scand. 144, 333 (1953).
Phillips, G.B.: The lipid composition of serum in patients with liver disease. J. clin. Invest. 39, 1639 (1960).
Picard, J., Veissiere, D., Voyer, F.: Isolation and properties of abnormal serum lipoproteins in cholestasis. Protides Biol. Fluids 19, 249–253 (1972).
Poley, J.R., Alaupovic, P., Seidel, D., McConathy, W.J.: Differential diagnosis between neonatal hepatisis and extrahepatic biliary arteria in infants: A new test. Gastroenterology 58, 983 (1970).
Prexl, H.J., Petek, W.: Die Bedeutung des Lipoprotein-X und der Serumcholinesterase in der präoperativen Diagnostik des Verschlußikterus. Chirurg 44, 310 (1973).
Quarfordt, S.H., Oelschlager, H., Krigbaum, W.R., Jakobi, L., Davis, R.: Effect of biliary obstruction on canine plasma and biliary lipids. Lipids 8, 522 (1973).
Rittland, S., Blomhoff, J.P., Elgjo, K., Gjone, E.: Lipoprotein-X (LP-X) in liver disease. Scand. J. Gas-troent. 8, 155 (1973).
Rittland, S., Gjone, E.: Quantitative determination of LP-X in familial LCAT deficiency and during cholesterol esterification. Clin. chim. Acta 59, 109 (1975).
Rosti, D., Gaspari, G.C.: Valore diagnostico delia LP-X negli itteri neonatali. Abstract. Minerva Pediat. 1 (1974).
Rothschild, M.A., Felsen, J.: The cholesterol content of the blood in various hepatic conditions. Arch. intern. Med. 24, 520 (1919).
Russ, E.M., Raymunt, J., Barr, D.P.: Lipoproteins in primary biliary cirrhosis. J. clin. Invest. 35, 133 (1956).
Seidel, D., Agostini, A., Müller, P.: Structure of an abnormal plasma lipoprotein (LP-X) characterizing obstructive jaundice. Biochem. biophys. Acta (Amst.) 260, 146–152 (1972).
Seidel, D., Alaupovic, P., Furman, R.H.: A lipoprotein characterizing obstructive jaundice. I. Method for quantitative separation and identification of lipoproteins in jaundiced subjects. J. clin. Invest. 48, 1211 (1969).
Seidel, D., Alaupovic, P., Furman, R.H., McConathy, W.J.: A lipoprotein characterizing obstructive jaundice. II. Isolation and partial characterization of the protein moieties of low density lipoproteins. J. clin. Invest. 49, 2396 (1970a).
Seidel, D., Baggio, G.: Origin and Metabolism of lipoprotein-X. Europ. Soc. for the study of the liver. Barcelona, 11.–13. Sept. 1975.
Seidel, D., Buff, H.K., Fauser, U., Bleyl, K.: On the metabolism of lipoprotein-X. Clin. chim. Acta (1976), in press.
Seidel, D., Gjone, E., Blomhoff, J.P., Geisen, H.P.: Plasma lipoproteins in patients with familial plasma lecithin: cholesterol acyltransferase (LCAT) deficiency—Studies on the apolipoprotein composition of isolated fractions with identification of LP-X. Int. Symp. on Lipid Metabolism, Obesity and Diabetes mellitus, Impact upon Atherosclerosis, Wiesbaden, April 1972 b.
Seidel, D., Greten, H., Geisen, H.P., Wengeler, H., Wieland, H.: Further aspects on the characterization of high and very low density lipoproteins in patients with liver disease. Europ. J. clin. Invest. 2, 359 (1972a).
Seidel, D., Gretz, H., Ruppert, C.: Significance of the LP-X test in differential diagnosis of jaundice. Clin. chem. 19, 86 (1973).
Seidel, D., Schmitt, E.A., Alaupovic, P.: An abnormal low density lipoprotein in obstructive jaundice. II. Significance in differential diagnosis of jaundice. Dtsch. med. Wochenschr. 15, 671 (1970 b).
Smith, S.C., Scheig, R.L., Klatskin, G., Levy, R.I.: Lipoprotein abnormities in liver disease. Clin. Res. 15, 330 (1967).
Switzer, S.: Plasma lipoproteins in liver disease. I. Immunologically distinct low-density lipoproteins in patients with biliary obstruction. J. clin. Invest. 46, 1855 (1967).
Thannhauser, S.J., Schaber, H.: Über die Beziehungen des Gleichgewichtes Cholesterin und Cholesterinester in Blut und Serum zur Leberfunktion. Klin. Wochenschr. 5, 252 (1926).
Torsvik, H., Berg, K., Magnani, H.N., McConathy, W.J., Alaupovic, P., Gjone, E.: Identification of the abnormal cholestatic lipoprotein (LP-X) in familial lecithin: cholesterol acyltransferase deficiency. FEBS Letters 24, 165 (1973).
Vergani, C., Pietrogrande, M., Grondana, M.C., Pizzolato, A.: Studio di una lipoproteina anomala (LP-X) caratteristica della colestasi. Clin. Med. 64, 1461 (1973).
Wengeler, H., Greten, H., Seidel, D.: Serum cholesterol esterification in liver disease. Combined determination of lecithin: cholesterol acyltransferase and lipoprotein-X. Europ. J. clin. Invest. 1, 372 (1971).
Wieland, H., Seidel, D.: Eine neue und vereinfachte Methode zum Nachweis des LP-X, eines cholestase-spezifischen Lipoproteins. Dtsch. med. Wschr. 98, 1474 (1973).
Wollenweber, J., Kahlke, W.: Vergleichende Untersuchungen der Lipoproteine des Serums mit der Agarosegel-Elektrophorese und der Diskelektrophorese in Polyacrylamid-Gel. Clin. chim. Acta 29, 411 (1970).
Zieve, L.: Studies of liver function tests. III. Dependence of percentage cholesterol esters upon the degree of jaundice. J. Lab. clin. Med. 42, 134 (1953).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1976 Springer-Verlag Berlin · Heidelberg
About this chapter
Cite this chapter
Seidel, D. (1976). Hyperlipoproteinämie bei Erkrankungen der Leber. In: Assmann, G., et al. Fettstoffwechsel. Handbuch der inneren Medizin, vol 7 / 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66302-4_14
Download citation
DOI: https://doi.org/10.1007/978-3-642-66302-4_14
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-66303-1
Online ISBN: 978-3-642-66302-4
eBook Packages: Springer Book Archive