Pharmakologie des unteren Oesophagussphincters

  • H. M. Jennewein
  • F. Waldeck

Zusammenfassung

Pharmakologische Wirkungen auf den Oesophagus betreffen die Effekte von chemischen Substanzen auf die quergestreifte und glatte Muskulatur des Oesophagus und seiner Sphincteren. Im folgenden Kapitel werden in erster Linie die manometrisch erfaßbaren Wirkungen von Pharmaka referiert. Weiter können elektromyographische Untersuchungen, Oberflächenpotentialmessungen und Versuche an isolierten Muskelstreifen zum besseren Verständnis pharmakologischer Wirkungen beitragen. Schwer quantifizierbare Verfahren, wie z. B. Röntgenuntersuchungen, Endoskopie etc., die klinisch unentbehrlich geworden sind, haben demgegenüber für pharmakologische Untersuchungen keine Bedeutung.

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Literatur

  1. 1.
    Behar, J., Kastendieck, J.: Studies on sphincter competence. Gastroenterology 66, A180 (1974).Google Scholar
  2. 2.
    Betarello, A., Tuttle, S.G., Grossman, M.I.: Effect of autonomic drugs on gastroesophageal reflux. Gastroenterology 39, 340–346 (1960).Google Scholar
  3. 3.
    Boesby, S., Pedersen, S.A.: The effect of vasopressin on resting gastroesophageal sphincter pressure in man. Scand. J. Gastroenter. 9, 587–590 (1974).Google Scholar
  4. 4.
    Burnstock, G.: Purinergic nerves. Pharmacol. Rev. 24, 509–581 (1972).PubMedGoogle Scholar
  5. 5.
    Castell, D.O., Harris, L.D.: Hormonal control of gastroesophageal sphincter strength. New Engl. J. Med. 282, 886–889 (1970).PubMedCrossRefGoogle Scholar
  6. 6.
    Christensen, J., Daniel, E.E.: Effects of some autonomic drugs on circular esophageal smooth muscle. J. Pharmacol. exp. Ther. 159, 243–249 (1968).PubMedGoogle Scholar
  7. 7.
    Christensen, J.: Pharmacologic identification of the lower esophageal sphincter. J. clin. Invest. 49, 681–691 (1970).PubMedCrossRefGoogle Scholar
  8. 8.
    Christensen, J.: Patterns and origin of some esophageal responses to stretch and electrical stimulation. Gastroenterology 59, 909–916 (1970).PubMedGoogle Scholar
  9. 9.
    Christensen, J., Freeman, B.W., Miller, J.K.: Some physiological characteristics of the esophagogastric junction in the opossum. Gastroenterology 64, 1119–1125 (1973).PubMedGoogle Scholar
  10. 10.
    Christiansen, J., Borgeskov, S.: The effect of glucagon and the combined effect of glucagon and secretin on lower esophageal sphincter pressure in man. Scand. J. Gastroent. 9, 615–618 (1974).PubMedGoogle Scholar
  11. 11.
    Cohen, S., Lipshutz, W.: Hormonal regulation of human esophageal sphincter competence: Interaction of gastrin and secretin. J. clin. Invest. 50, 449–454 (1971).PubMedCrossRefGoogle Scholar
  12. 12.
    Cohen, S., Lipshutz, W., Hughes, W.: Role of gastrin supersensitivity in the pathogenesis of lower esophageal sphincter hypertension in achalasia. J. clin. Invest. 50, 1241–1247 (1971).PubMedCrossRefGoogle Scholar
  13. 13.
    Cohen, S., Green, F.: The mechanics of esophageal muscle contraction. Evidence of an inotropic effect of gastrin. J. clin. Invest. 52, 2029–2040 (1973).PubMedCrossRefGoogle Scholar
  14. 14.
    Cohen, S., Green, F.: Force-Velocity characteristics of esophageal muscle: Effect of acetylcholine and norepinephrine. Amer. J. Physiol. 226, 1250–1256 (1974).PubMedGoogle Scholar
  15. 15.
    Cohen, S.: Augmentation of the neural inhibitory response of the lower esophageal sphincter. Proc. Soc. exper. Biol. (N.Y.) 145, 1004–1007 (1974).Google Scholar
  16. 16.
    Cooke, A.L.: Smoking sidelines your sphincter. Gastroenterology 66, 474–475 (1974).Google Scholar
  17. 17.
    Dennish, G.W., Castell, D.O.: Inhibitory effect of smoking on the lower esophageal sphincter. New Engl. J. Med. 284, 1136–1137 (1971).PubMedCrossRefGoogle Scholar
  18. 18.
    Dennish, G.W., Castell, D.O.: Coffeine and the lower esophageal sphincter. Amer. J. dig. Dis. 17, 993–996 (1972).PubMedCrossRefGoogle Scholar
  19. 19.
    Dilawari, J.B., Misiewicz, J.J.: Action of oral metoclopramide on the gastroesophageal junction in man. Gut 14, 380–382 (1973).PubMedCrossRefGoogle Scholar
  20. 20.
    Dilawari, J.B., Newman, A., Poleo, J., Misiewicz, J.J.: Response of the human cardiac sphincter to circulating prostaglandins F2α and E2 and to antiinflammatory drugs. Gut 16, 137–143 (1975).PubMedCrossRefGoogle Scholar
  21. 21.
    Di Marino, A.J., Cohen, S.: The adrenergic control of lower esophageal sphincter function. An experimental model of denervation supersensitivity. J. clin. Invest. 52, 2264–2271 (1973).CrossRefGoogle Scholar
  22. 21a.
    Di Marino, A.J., Cohen, S.: The adrenergic control of lower esophageal sphincter function: response to Beta-2-adrenergic agonists. Proc. Soc. Exp. Biol. (N.Y.) 148, 1265–1269 (1975).Google Scholar
  23. 22.
    Douthwaite, A.H.: Achalasia of the cardia; treatment with nitrites. Lancet II, 353–354 (1943).CrossRefGoogle Scholar
  24. 23.
    Edwards, D.A.W.: The oesophagus. Gut 12, 948–956 (1971).PubMedCrossRefGoogle Scholar
  25. 24.
    Farrell, R.L., Roling, G.T., Castell, D.O.: Cholinergic therapy of chronic heartburn. A controlled trial. Ann. intern. Med. 80, 573–576 (1974).PubMedGoogle Scholar
  26. 25.
    Frank, S.A., Walker, C.O., Fordtran, J.S.: The effect of continuous pentagastrin (PG) infusion on lower esophageal sphincter pressure (LES). Gastroenterology 64, 728 (1973) Abstr.Google Scholar
  27. 26.
    Giles, G.R., Mason, M.C., Humphries, C., Clark, C.G.: Action of gastrin on the lower oesophageal sphincter in man. Gut 10, 730–734 (1969).PubMedCrossRefGoogle Scholar
  28. 27.
    Giles, G.R., Roszkowski, A.: Der Einfluß von Hormonen auf den unteren Oesophagus-sphincter beim Menschen. Leber Magen Darm 2, 20–22 (1972).PubMedGoogle Scholar
  29. 28.
    Glanville, G.N., Walls, W.D.: Effect of intravenous metoclopramide on gastroesophageal reflux. Gut 13, 31–32 (1972).PubMedCrossRefGoogle Scholar
  30. 29.
    Goyal, R.K., Rattan, S., Hersh, T.: Comparison of the effects of prostaglandins E, E2 and A2, and of hypovolumic hypotension on the lower esophageal sphincter. Gastroenterology 65, 608–612 (1973).PubMedGoogle Scholar
  31. 30.
    Guelrued, M.: Effect of intravenous metoclopramide on the incompetent lower esophageal sphincter. Amer. J. Gastroent: 61, 119–124 (1974).Google Scholar
  32. 30a.
    Hall, A.W., Moossa, A.R., Clerk, J., Cooley, G.R., Skinner, D.B.: The effects of premedication drugs on the lower oesophageal high pressure zone and reflux status of rhesus monkeys and man. Gut 16, 347–352 (1975).PubMedCrossRefGoogle Scholar
  33. 31.
    Harris, L.D.: The regulation of lower esophageal sphincter strength. In: Gastrointestinal Motility (Ed. Demling, L., Ottenjann, R.) p.32–46. Stuttgart: Thieme 1971.Google Scholar
  34. 32.
    Hayes, J.R., Ardill, J., Kennedy, T.L., Shanks, R.G., Buchanan, K.D.: Stimulation of gastrin release by catecholamines. Lancet 1, 819–820 (1972).PubMedCrossRefGoogle Scholar
  35. 33.
    Heitmann, P., Möller, N.: The effect of metoclopramide on the gastroesophageal junctional zone and the distal esophagus in man. Scand. J. Gastroenterol. 5, 621–625 (1970).Google Scholar
  36. 33a.
    Higgs, R.H., Castell, D.O.: Cholinergic stimulation of the lower esophageal sphincter in patients with vagotomy and antrectomy. Amer. J. dig. Dis. 20, 195–200 (1975).PubMedCrossRefGoogle Scholar
  37. 34.
    Higgs, R.H., Smyth, R.D., Castell, D.O.: Gastric alkalinization. Effect on lower oesophageal sphincter pressure and serum gastrin. New Engl. J. Med. 291, 486–490 (1974).PubMedCrossRefGoogle Scholar
  38. 35.
    Hogan, W.J., de Andrade, S.R.V., Winship, D.H.: Ethanol induced acute esophageal motor dysfunction. J. appl. Physiol. 32, 755–760 (1972).PubMedGoogle Scholar
  39. 36.
    Jennewein, H.M., Waldeck, F., Prahl, K.: Zur Beeinflussung des unteren Oesophaguss-phincters durch gastrointestinale Hormone beim Hund. Leber Magen Darm 2, 17–19 (1972).PubMedGoogle Scholar
  40. 37.
    Jennewein, H.M., Waldeck, F., Siewert, R., Weiser, F.: The effects of gastrointestinal hormones on the lower esophageal sphincter (LES) in man and dog. In: Function of the esophagus (Ed. Sørensen, H.R., Jepsen, O., Pederson, S.A.), p.2–9. Odense: University Press 1973.Google Scholar
  41. 38.
    Jennewein, H.M., Siewert, R., Waldeck, F.: Zur Beeinflussung des unteren Oesophagus-sphincters von Mensch und Hund durch Caerulea. Dtsch. med. Wschr. 98, 332–333 (1973).PubMedGoogle Scholar
  42. 39.
    Jennewein, H.M., Waldeck, F., Siewert, R., Weiser, F., Thimm, R.: The interaction of glucagon and pentagastrin on the lower oesophageal sphincter in man and dog. Gut 14, 861–864 (1973).PubMedCrossRefGoogle Scholar
  43. 40.
    Jennewein, H.M.: Unveröffentlichte Ergebnisse.Google Scholar
  44. 41.
    Jennewein, H.M., Hummelt, H., Siewert, R., Waldeck, F.: The motor-stimulating effect of natural motilin on the lower esophageal sphincter, fundus, antrum, and duodenum in dogs. Digestion 13, 246–250 (1975).PubMedCrossRefGoogle Scholar
  45. 42.
    Kantrowitz, P.A., Siegel, C.I., Hendrix, T.R.: Differences in motility of the upper and lower esophagus in man and its alteration by atropine. Bull. John. Hopk. Hosp. 118, 476–491 (1966).Google Scholar
  46. 43.
    Kline, M.M., Curry, N., Sturdevant, R.A.L., Mc Callum, R.W.: Effect of gastric alkalinization on lower esophageal sphincter pressure and serum gastrin. Gastroenterology 66, A 70/724 (1974).Google Scholar
  47. 44.
    Lind, J.F., Crispin, J.S., Mc Iver, D.K.: The effect of atropine on the gastroesophageal sphincter. Canad. J. Physiol. Pharmacol. 46, 233–238 (1967).CrossRefGoogle Scholar
  48. 45.
    Lipshutz, W., Cohen, S.: Physiological determinants of lower esophageal sphincter function. Gastroenterology 61, 16–24 (1971).PubMedGoogle Scholar
  49. 46.
    Lipshutz, W.H., Gaskins, R.D., Lukash, L.W.M., Sode, J.: Pathogenesis of lower sphincter incompetence. New Engl. J. Med. 289, 182–184 (1973).PubMedCrossRefGoogle Scholar
  50. 47.
    Mc Callum, R.W., Kline, M., Curry, N., Sturdevant, R.: Comparative effects of metoclopramide and mecholine on lower esophageal sphincter pressure in reflux patients. Gastroenterology 66, A 88/742 (1974).Google Scholar
  51. 48.
    Misiewicz, J.J., Waller, S.L., Anthony, P.P., Gummer, J.W.P.: Achalasia of the cardiapharmacology and histopathology of isolated cardiac sphincteric muscle from patients with and without achalasia. Quart. J. Med. 38, 17–30 (1969).PubMedGoogle Scholar
  52. 49.
    Misiewicz, J.J.: Clinical pharmacology and therapeutics of the oesophagus and the lower oesophageal sphincter. Postgrad. med. J. 50, 194–197 (1974).PubMedCrossRefGoogle Scholar
  53. 50.
    Niemann, H., Jakob, G.: Die Testung von Spasmolytika mittels der Oesophagusmanometrie beim Mensch. Arzneimittelforsch. 21, 1217–1221 (1971).PubMedGoogle Scholar
  54. 51.
    Orlando, R.C., Bozymski, E.M.: Clinical and manometric effects of nitroglycerin in diffuse esophageal spasm. New Engl. J. Med. 289, 23–25 (1973).PubMedCrossRefGoogle Scholar
  55. 52.
    Pedersen, S.A., Alstrup Nielsen, P., Rahbek-Sørensen, H.: The effect of atropine and hexamethonium in combination on the lower oesophageal sphincter. Scand. J. Gastroenterol. 9, 43–47 (1971).Google Scholar
  56. 53.
    Shepard, J.K., Diamant, N.E.: Mecholyl test: Comparison of balloon kymography and intraluminal pressure measurement. Gastroenterology 63, 557–563 (1972).Google Scholar
  57. 54.
    Siewert, R., Hesch, R.D., Jennewein, H.M., Fuchs, K.: Die Beeinflussung der Magensekretion und des UOS durch Calcitonin. Langenbecks Arch., Suppl. Chir. Forum 241–244 (1972).Google Scholar
  58. 55.
    Siewert, R., Früh, E., Waldeck, F., Schmidt, H.: Zur Beeinflussung des unteren Oesophagus-sphincters durch Polypeptidhormone bei der Achalasie. Z. Gastroent. 12, 117–120 (1974).Google Scholar
  59. 56.
    Siewert, R., Weiser, F., Jennewein, H.M., Waldeck, F.: Clinical and manometric investigations of the lower oesophageal sphincter and its reactivity to pentagastrin in patients with hiatus hernia. Digestion 20, 287–297 (1974).CrossRefGoogle Scholar
  60. 57.
    Siewert, R., et al.: Nicht veröffentlichte Ergebnisse (1975).Google Scholar
  61. 58.
    Stadil, F., Rehfeld, J.F.: Release of gastrin by epinephrine in man. Gastroenterology 65, 210–215 (1973).PubMedGoogle Scholar
  62. 59.
    Stanciu, C., Bennet, J.R.: Smoking and gastroesophageal reflux. Brit. med. J. 1972III, 793–795.Google Scholar
  63. 60.
    Stanciu, C., Bennet, J.R.: Metoclopramide in gastroesophageal reflux. Gut 14, 275–279 (1973).PubMedCrossRefGoogle Scholar
  64. 61.
    Rattan, S., Hersh, T., Goyal, R.K.: Effect of prostaglandin F2α and gastrin pentapeptide on the lower esophageal sphincter. Proc. Soc. exp. Biol. (N.Y.) 141, 573–575 (1972).Google Scholar
  65. 62.
    Read, N.W., Grech, P.: Effect of cigarette smoking on competence of the pylorus. Brit. med. J. 1973III, 313–316.Google Scholar
  66. 63.
    Resin, H., Stern, D.H., Sturdevant, R.A.L., Isenberg, J.I.: Effect of the c-terminal octapeptide of cholecystokinin on lower esophageal sphincter pressure in man. Gastroenterology 64, 946–949 (1973).PubMedGoogle Scholar
  67. 64.
    Rogers, A.J., Rothman, S.L., Arostegni, M.: Lower esophageal sphincter (LES) responsiveness to postprandial antacids in humans. Gastroenterology 66, A 222/876 (1974).Google Scholar
  68. 65.
    Roling, G.T., Farrell, R.L., Castell, D.O.: Cholinergic response of the lower esophageal sphincter. Amer. J. Physiol. 222, 967–972 (1972).PubMedGoogle Scholar
  69. 66.
    Tuch, A., Cohen, S.: Lower esophageal sphincter relaxation: Studies on the neurogenic inhibitory mechanism. J. clin. Invest. 52, 14–20 (1973).PubMedCrossRefGoogle Scholar
  70. 67.
    Waldeck, F., Siewert, R., Jennewein, H.M., Weiser, F.: Das Druckprofil im unteren Oesophagussphincter beim Menschen und seine Beeinflussung durch Gastrin, Calcitonin und Glucagon. Dtsch. med. Wschr. 98, 1059–1063 (1973).PubMedCrossRefGoogle Scholar
  71. 68.
    Weisbrodt, N.W.: Response of the smooth muscle of the opossum esophagus to electrical stimulation. Gastroenterology 62, 827 (1972) Abstr.Google Scholar
  72. 69.
    Zfass, A.M., Prince, R., Allen, F.N., Farrar, J.T.: Inhibitory β-adrenergic receptors in the human distal esophageus. Amer. J. dig. Dis. 15, 303–310 (1970).PubMedCrossRefGoogle Scholar
  73. 70.
    Cohen, S., Booth, G.H.: Gastric acid secretion and lower esophageal sphincter pressure in response to coffee and coffeine, New England Journal of Medicine 293, 897–899 (1975).PubMedCrossRefGoogle Scholar
  74. 71.
    Cohen, S., Snape, W.J.: Action of metiamide on the lower esophageal sphincter, Gastroenterology 69, 911–919 (1975).PubMedGoogle Scholar

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© Springer-Verlag Berlin · Heidelberg 1976

Authors and Affiliations

  • H. M. Jennewein
  • F. Waldeck

There are no affiliations available

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