Abstract
The recent seventies have not been good times for toxicologists. Public confidence in us is shaken, mostly as a consequence of an unhappy sequence of spectacular failures: we have been surprised by a tragic transplacental carcinogenic effect of diethylstilbestrol, an old and widely prescribed synthetic estrogen. We are confronted with a small epidemic of an unusual liver tumor, angiosarcoma, induced by a simple chemical, vinylchloride, whose insiduous toxic potential we failed to recognize for years. Our clinical colleagues had to tell us about the ulcerogenic effect of as simple a substance as potassium chloride. We also just learned of an unusual toxic reaction, pseudolupus, developing in people taking a popular fixed-combination drug, Venocuran R. Admittedly, we could not have predicted this syndrome, even if we had considered the possibility.
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© 1976 Springer-Verlag Berlin Heidelberg
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Zbinden, G. (1976). Introduction. In: Progress in Toxicology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66292-8_1
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DOI: https://doi.org/10.1007/978-3-642-66292-8_1
Publisher Name: Springer, Berlin, Heidelberg
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